ライフサイエンスコーパス: T-cell depletion

1 erative states and no evidence of regulatory T cell depletion.

2 ng of the early steps of HIV-1 infection and T cell depletion.

3 eir concerted effect in inducing resting CD4 T cell depletion.

4 site of ongoing viral replication and CD4(+) T cell depletion.

5 o and can induce peripheral and systemic CD4 T cell depletion.

6 ment of CAV but inhibited the effect of CD25 T cell depletion.

7 sma cells/plasmablasts was reduced following T cell depletion.

8 mice suppressed HIV replication and reversed T cell depletion.

9 transplanted mice in the absence of systemic T cell depletion.

10 ration that follows antibody-mediated CD4(+) T cell depletion.

11 s a major site of HIV replication and CD4(+) T cell depletion.

12 llmark of HIV-1 and SIV infections is CD4(+) T cell depletion.

13 site of viral replication and severe CD4(+) T cell depletion.

14 of SIV infection despite the mucosal CD4(+) T cell depletion.

15 increased HIV infection, virus release, and T cell depletion.

16 e of calcineurin inhibitors, steroids or pan-T cell depletion.

17 zed immune activation and progressive CD4(+) T cell depletion.

18 th increasing serum and tissue levels during T cell depletion.

19 nfection and the homeostatic response to CD4 T cell depletion.

20 oss of antibody production depends on CD4(+) T cell depletion.

21 o explain the mechanism of HIV-1 Env-induced T cell depletion.

22 even in the context of a significant CD4(+) T cell depletion.

23 and a failure of disease to recur after CD3 T cell depletion.

24 ivation of the inflammasome resulting in CD4 T cell depletion.

25 importance of abortive infection in driving T cell depletion.

26 necropsy, and no virus emerged after CD8(+) T cell depletion.

27 d ongoing EAE, which was abrogated by CD8(+) T cell depletion.

28 14, and 28 d postinfection even after CD4(+) T cell depletion.

29 ation, chronic immune activation, and CD4(+) T cell depletion.

30 to AA rupture, which was attenuated by CD8+ T cell depletion.

31 ion largely manifests itself in vivo as CD4+ T cell depletion.

32 ed with chronic immune activation and CD4(+) T cell depletion.

33 hisms (SNPs) in the ZNRD1 region with CD4(+) T-cell depletion.

34 antibody responses in the setting of CD4(+) T-cell depletion.

35 ll transplantation that incorporates in vivo T-cell depletion.

36 , where HIV-1 infection causes severe CD4(+) T-cell depletion.

37 n that contribute to enhanced fusion and CD4 T-cell depletion.

38 noma even in the context of CD25+ regulatory T-cell depletion.

39 esulted in acute, resolving viremia and CD4+ T-cell depletion.

40 hase inhibitor (aminoguanidine) or by CD4(+) T-cell depletion.

41 r human immunodeficiency virus entry and CD4 T-cell depletion.

42 iency virus (SIV) and a site for severe CD4+ T-cell depletion.

43 ), of these, 129 (64.5%) received an in vivo T-cell depletion.

44 nged with HBV after antibody-mediated CD4(+) T-cell depletion.

45 id tissue (LT) fibrosis, which causes CD4(+) T-cell depletion.

46 donor (D-) transplants and is exacerbated by T-cell depletion.

47 ys in the monkey with the most extensive CD4 T cell depletion (5%) and in all other monkeys at 10 to

48 umbers of effector T cells in the tumor, and T cell depletion abolished the reduced tumor growth obse

49 Delayed CD4 T cell depletion abrogated CD4 T cell recruitment to the

50 ombination with CD40-CD154 blockade and CD8+ T-cell depletion abrogated transplant arteriosclerosis (

51 Total T-cell or selective regulatory T-cell depletion abrogates the atheroprotective effect o

52 Finally, CD4 T cell depletion alone did not prevent or accelerate dev

53 e hallmarks of HIV-1 pathogenesis are CD4(+) T cell depletion and abnormal cellular activation.

54 levels, and ultimately caused marked CD4(+) T cell depletion and AIDS-defining conditions.

55 t viral replication in the context of CD4(+) T cell depletion and elevated immune activation associat

56 ted directly with the levels of total CD4(+) T cell depletion and immune activation.

57 c therapies may offer approaches to moderate T cell depletion and improve immune reconstitution durin

58 ction from either systemic or mucosal CD4(+) T cell depletion and no improved survival.

59 However, after ex vivo CD8(+) T cell depletion and phorbol myristate acetate treatment

60 ocyte antigen antibodies and the kinetics of T cell depletion and recovery among pediatric renal tran

61 gery, respectively, followed by total CD4(+) T cell depletion and recovery from this depletion.

62 sIL-15 complexes in response to Ab-mediated T cell depletion and TBI, suggesting products of cell de

63 lung experiences severe and sustained CD4(+) T cell depletion and tissue disruption.

64 of SVV antigen in multiple tissues upon CD4 T cell depletion and virus reactivation suggests a criti

65 sidered today as the driving force of CD4(+) T-cell depletion and acquired immunodeficiency syndrome

66 After antibody-mediated CD8(+) T-cell depletion and another viral challenge, the reboun

67 ction is characterized by progressive CD4(+) T-cell depletion and CD8(+) T-cell expansion, and CD4(+)

68 he two signature events in HIV infection-CD4 T-cell depletion and chronic inflammation-and creates a

69 Lung CD4(+) T-cell depletion and dysfunction, CD8(+) T-cell alveolit

70 y virus (HIV) infection, resulting in CD4(+) T-cell depletion and generalized immune activation.

71 Regulatory T-cell depletion and IL-10 neutralization led to increas

72 cts helper CD4(+) T cells, and causes CD4(+) T-cell depletion and immunodeficiency.

73 Although T-cell depletion and intensive immunosuppression are eff

74 hese data suggest mechanisms for mucosal CD4 T-cell depletion and interventions that might aid in the

75 FIV-C36 causes fulminant disease with CD4(+) T-cell depletion and neutropenia but no significant path

76 isition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly

77 Observations on splenic T-cell depletion and post lipopolysaccharide interleukin

78 ng (RIC), nonmyeloablative (NMA) transplant, T-cell depletion and variations in graft vs. host diseas

79 s not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens

80 ave evidence of ongoing inflammation, CD4(+) T cell depletion, and perhaps even inflammation-associat

81 and compared their replication efficiencies, T cell depletion, and the activation status of infected

82 netics and extent of SIV replication, CD4(+) T cell depletion, and the onset of AIDS were comparable

83 of homeostatic proliferation and regulatory T cell depletion, and which promote tumor rejection via

84 onor hematopoietic cell infusion, chimerism, T cell depletion, and/or co-stimulation blockade.

85 virus match, conditioning intensity, type of T-cell depletion, and graft type.

86 graft after adoptive transfer, without prior T-cell depletion, and whether the large amounts of circu

87 diation exposure, light skin color, sex, and T-cell depletion are risk factors for cutaneous malignan

88 , we sought to determine the level of CD4(+) T cell depletion as well as the degree and extent of HIV

89 ression was not associated with rapid CD4(+) T cell depletion, as CD4(+) T cell decline resembled oth

90 (TBI), cyclophosphamide, or Thy1 Ab-mediated T cell depletion, as well as in RAG(-/-) mice; interesti

91 on induced by memory helper T cells, and CD8 T cell depletion at the time of transplantation or deple

92 ts employing costimulation blockade-based or T-cell depletion-based conditioning with 1 or 3 Gy total

93 ng graft survival during the time than other T-cell depletion-based protocols.

94 rotein-specific Ab responses, and gammadelta T cell depletion before infectious challenge did not abl

95 Finally, CD4 T-cell depletion before inoculation of a normally rapidl

96 ti-TCRgammadelta antibody-induced gammadelta T-cell depletion blunted Ang II-induced SBP rise and end

97 Anti-CD3 administration induces transient T cell depletion both in preclinical and in clinical stu

98 The mechanism does not rely on direct T cell depletion, but the anti-CD4 mAb prevents the prol

99 T cell depletion can prevent hypertension in experimenta

100 Similarly, total CD4(+) T cell depletion caused an increase in adhesion of CD8(+

101 ti-IL-7 receptor blocking antibody following T cell depletion, combined with the mammalian target of

102 ade 3-4 adverse events, many associated with T-cell depletion, compared with 13 in the placebo group,

103 Regulatory T cell depletion completely reverses this immune downmod

104 ceptor alpha (IL-7Ralpha) alone or following T cell depletion confers an advantage for allograft surv

105 Subsequent CD8(+) T cell depletion confirmed the absence of SIV infection

106 t reduced infectious ZIKV levels, and CD8(+) T cell depletions confirmed that CD8(+) T cells mediated

107 Peripheral CD4(+) T-cell depletion correlated with granulomas that contain

108 Peripheral CD4(+) T-cell depletion correlated with increased M. tuberculos

109 However, CD8(+) T-cell depletion decreased chemokine (CC-motif) ligand s

110 We further evidenced that CD8(+) T-cell depletion decreased levels of mature monocytes an

111 and usually does not induce significant CD4+ T cell depletion despite high levels of virus replicatio

112 CD8 T cell depletion did not abrogate B6.muMT(-/-) mice reje

113 Consistent with this observation, CD4(+) T cell depletion did not affect the DENV-specific IgG or

114 are markedly CD4(+) T cell dependent, CD4(+) T cell depletion did not impact quantities of IgG cross-

115 CD4+ T cell depletion did not induce any changes in the fract

116 erleukin-10 (IL-10), although in vivo CD8(+) T cell depletion did not significantly alter Mtb burden.

117 kine (CXC-motif) ligand 1 expression, CD8(+) T-cell depletion did not directly affect monocyte recrui

118 e control, because 2B4 blockade after CD8(+) T-cell depletion did not further aggravate symptoms of E

119 treatment with cyclophosphamide or specific T cell depletion does not impact the course of disease o

120 Thus, significant CD4(+) T cell depletion does occasionally follow SIV infection

121 were evaluated, including pharmacokinetics, T-cell depletion, dose response and kinetics, depletion/

122 a revised paradigm wherein severe GALT CD4+ T cell depletion during acute pathogenic HIV and SIV inf

123 Progressive T cell depletion during chronic human immunodeficiency v

124 ost pathway that plays a central role in CD4 T cell depletion during disease progression to AIDS.

125 tive understanding of the mechanisms driving T cell depletion during HIV infection.IMPORTANCE In HIV-

126 osis in bystander CD4 T cells.IMPORTANCE CD4 T cell depletion during HIV-1 infection involves the dem

127 despite similar viral replication and CD4(+) T cell depletion during primary SIV infection, CD4(+) T

128 ery are similar to those that blunted CD4(+) T cell depletion during the time before HAART became ava

129 The mechanism of CD4(+) T-cell depletion during chronic human immunodeficiency v

130 e show that PD-L1 blockade together with CD4 T cell depletion effectively rescued deeply exhausted CD

131 Nonselective T-cell depletion effectively prevents severe aGvHD but p

132 ditioning (RIC), neither ex vivo nor in vivo T-cell depletion (eg, antithymocyte globulin) convincing

133 ation diminished skeletal metastasis whereas T-cell depletion enhanced it, even in the presence of zo

134 u, chronic inflammation and Ag exposure, CD4 T-cell depletion, etc., alone does not cause poly- and a

135 mmune activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of A

136 Adoptive transfer of serum and T-cell depletion experiments demonstrated a dominant rol

137 calreticulin, prophylactic immunization and T-cell depletion experiments showed that melphalan admin

138 T-cell depletion experiments suggested that T cells were

139 New strategies including naive T-cell depletion, focused cytokine and chemokine inhibit

140 ATG induced profound T-cell depletion followed by CD8(+) T-cell reexpansion e

141 However, T cell depletion from the BALB.B donor prior to cardiac

142 his study demonstrates that generalized CD4+ T cell depletion from the blood and mucosal tissues is n

143 t, because it was eliminated by local CD4(+) T cell depletion from the cornea.

144 Compared with no T-cell depletion, grade 2-4 acute and chronic GVHD rates

145 By contrast, CD8(+) T cell depletion had no apparent impact on osteoblast ab

146 protocols use unmanipulated (without ex vivo T-cell depletion) haploidentical grafts combined with en

147 While CD4(+) T cell depletion has been considered the major cause of

148 r data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppre

149 Although pan-T-cell depletion has reduced GVHD, novel strategies that

150 m and redox state are associated with CD4(+) T cell depletion, immune activation, and inflammation.

151 arks of human HIV infection including CD4(+) T-cell depletion, immune activation, and development of

152 rate that alphaCD3 alone induced substantial T-cell depletion, impacting both conventional T cells (T

153 nization are associated with generalized CD4 T-cell depletion, impaired antigen-specific proliferatio

154 CD4(+) T cell depletion improved the survival of ST-infected CD

155 in controlling infection by carrying out CD8 T cell depletion in an additional two animals of each sp

156 utoimmune T cell activation after regulatory T cell depletion in an established model of systemic aut

157 CD8(+) T cell depletion in animals with controlled viremia caus

158 0 and BAF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lungs but only treatment w

159 e gut-associated lymphoid tissue (GALT) CD4+ T cell depletion in lentiviral infections was assessed b

160 We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella estab

161 demonstrated that acute, SIV-induced CD4(+) T cell depletion in sooty mangabeys does not result in i

162 Here we show that T cell depletion in the chronic phase of this model incr

163 In this study, the effects of T cell depletion in the development of antibody-mediated

164 CD8(+) T cell depletion in the effector phase of disease attenu

165 tion plays a significant role in HIV-induced T cell depletion in the human thymus.

166 nfected humans, our data suggest that CD4(+) T cell depletion in the setting of HIV disease may refle

167 isms have been invoked to account for CD4(+) T cell depletion in this setting, but the quantitative c

168 ike helper functions upon SIV-induced CD4(+) T cell depletion in this species.

169 IV-2 and HIV-1 support similar levels of CD4 T cell depletion in vitro despite HIV-2 Vpx-mediated deg

170 tant mechanism underlying progressive CD4(+) T cell depletion in vivo.

171 Importantly, CD4(+) T cell depletion in wild-type or GR(lck-Cre) mice led to

172 Alloreactive CD8 T-cell depletion in (NOD x CBA)F1 mice treated with cost

173 ve conditioning was used in 80%, and in vivo T-cell depletion in 81%, of cases.

174 cted chimpanzees revealed significant CD4(+) T-cell depletion in all infected individuals, with evide

175 ollers spontaneously control viremia and CD4 T-cell depletion in contrast to viremic patients.

176 Antibody-mediated CD4(+) T-cell depletion in HF mice (starting 4 weeks after liga

177 Antibody-mediated CD8(+) T-cell depletion in high-fat diet-fed Ldlr(-/-) mice dec

178 The mechanism of CD4(+) T-cell depletion in human immunodeficiency virus type 1

179 Rag2(-/-) mice, an effect mimicked by CD8(+) T-cell depletion in immunocompetent mice.

180 (+) T cells in PLCgamma2(-/-) mice or CD8(+) T-cell depletion in Lyn(-/-) mice normalized tumor growt

181 Viremia remained undetectable after CD8(+) T-cell depletion in seven vaccinated animals that had su

182 Generalised T-cell depletion in the absence of specific depletion of

183 T-cell depletion in the R+/D- setting may actually, ther

184 ficient mice but was abrogated completely by T-cell depletion in vivo, suggesting T-cell dependence.

185 Furthermore, T-cell depletion in wild-type mice after transverse aort

186 CD4 T cell depletion increased the number of bacteria associ

187 protection was significantly reduced by CD8 T cell depletion, indicating a critical role for CD8 T c

188 T cell depletion induced by FNB anti-CD3 mAb was indepen

189 Orai1(-/-) mice showed strong resistance to T cell depletion induced by injection of anti-CD3 Ab.

190 Of 5172 patients, 941 (18%) received T-cell depletion induction, 1635 (32%) received interleu

191 Blockade of CD154 alone or combined with T cell depletion inhibits generation of the humoral immu

192 otential new therapeutics, centered on naive T-cell depletion, interleukin-17/21 inhibition, kinase i

193 CD4(+) T cell depletion is a fundamental component of HIV infec

194 T cell depletion is commonly used in organ transplantati

195 T cell depletion is in development for several condition

196 CD4 T-cell depletion is a hallmark of HIV/AIDS, but the unde

197 blood transplantation (CBT) without in vivo T-cell depletion is increasingly used to treat high-risk

198 tion and CD8(+) T-cell expansion, and CD4(+) T-cell depletion is linked directly to the risk for oppo

199 CD4+ T-cell depletion is the hallmark of AIDS pathogenesis.

200 suggests that the subtype 5-associated CD4+ T-cell depletion is unlikely to simply reflect higher le

201 transmission and replication as well as CD4+ T-cell depletion, it is important to understand the natu

202 are usually nonselective and cause wholesale T cell depletion leaving the individual in a severely im

203 ven by IL-7 as a homeostatic response to CD4 T cell depletion, levels of phosphorylated STAT-5 were f

204 itioning regimen consisting of pretransplant T cell depletion, low-dose total body irradiation and po

205 These data suggest that in vivo T-cell depletion lowers GVHD without compromising LFS am

206 which two show severe and persistent CD4(+) T cell depletion (<50/mm(3)).

207 de following anti-CD4- and anti-CD8-mediated T cell depletion markedly prolonged skin allograft survi

208 Concomitant NK and T cell depletion may be undesirable in transplant recipi

209 Lower risks were found for T-cell depletion methods that remove both T and B cells

210 In vivo T-cell depletion might contribute to the delayed immune

211 CD8 T cell depletion mitigates clearance of PyV in K(b-/-)D(

212 Progression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited b

213 191) or alemtuzumab (n = 132) and no in vivo T-cell depletion (n = 392).

214 Using Cox regression, outcomes after in vivo T-cell depletion (n = 584 antithymocyte globulin [ATG];

215 Despite lower GVHD rates after in vivo T-cell depletion, nonrelapse mortality, relapse, overall

216 Acute T cell depletion occurred in the ATG group, with slow re

217 by lymphocyte IFN-gamma secretion), and CD8+ T cell depletion of mice prior to injection of MB49 cell

218 utilizing B-cell-deficient mice or targeted T cell depletions of wild-type mice demonstrated that B

219 ct of NKG2C(pos) NK cells on HLA-E(high) CD8 T cells, depletion of NKG2C(pos) NK cells enhanced Ag-sp

220 nd effector/memory conversion of Ag-specific T cells, depletion of peripheral CD4(+) T cells in hemat

221 sks were strongly associated (P < .001) with T-cell depletion of the donor marrow, antithymocyte glob

222 To test effects of T cell depletion on cardiac function, we gave CKD mice a

223 odels of GVHD to evaluate the effect of CD4+ T cell depletion on GVL versus GVHD and revealed that de

224 l-dependent Ab response, without evidence of T cell depletion or cytokine release.

225 In this study, we establish that either CD8+ T cell depletion or exposure to restraint stress permit

226 lymphocyte infiltration and are abolished by T cell depletion or interferon-gamma neutralization.

227 nors (RR = 3.8) was limited to patients with T-cell depletion or ATG use (P = .004).

228 Transplantation using T-cell depletion or HLA-mismatched or umbilical cord don

229 Ab treatment in vivo, CXCR3 blockade, CD8(+) T cell depletion, or IFN-gamma neutralization each inhib

230 dynamics of acute viral replication, CD4(+) T cell depletion, or preinfection levels of microbial tr

231 n and treatment with costimulation blockade, T-cell depletion, or rapamycin.

232 A generally accepted concept is that graft T cell depletion performed to avoid GVHD yields poorer i

233 In multivariate analyses, naive T-cell depletion, phenotypic activation (CD38(+) and HLA

234 tion, although short-term (3-d) local CD4(+) T cell depletion postinfection did not influence chemoki

235 ak viral replication and the nadir of CD4(+) T cell depletion predominantly in lamina propria leukocy

236 y, both type I IFN receptor blockade and CD8 T cell depletion prevented infection-induced barrier lea

237 o CD40-CD154 costimulation blockade and CD8+ T-cell depletion prevented its development.

238 ears old, without high-risk primary disease, T-cell depletion, previous vaccination for cytomegalovir

239 HIV disease characterized by increasing CD4+ T-cell depletion, profound lymphoid depletion or destruc

240 Development of future long-term T cell depletion protocols specific to visceral fat may

241 ral integration has a central role in CD4(+) T-cell depletion, raising the possibility that integrase

242 T-cell depletion reduces chronic GVHD but has some incre

243 To investigate the contribution of CD4+ T cell depletion relative to other mechanisms of SIV-ind

244 Antifungal treatment or autoreactive CD4 T cell depletion rescues, whereas oral fungal administra

245 T cell depletion resulted in elevated viral loads and em

246 We found that only CD4 T-cell depletion resulted in FRC loss in both species an

247 neither spontaneous nor experimental CD4(+) T cell depletion results in substantial levels of in viv

248 T cell depletion significantly improved both diastolic f

249 T-cell depletion significantly increased renal calcifica

250 llers had significant LT fibrosis and CD4(+) T-cell depletion, similar to noncontrollers, but the so-

251 was significantly reduced by systemic CD4(+) T cell depletion starting before infection, although sho

252 Specifically, neonatal CD25(high) T cell depletion stimulated asthma susceptibility in nor

253 Subsequent T-cell depletion stimulates a 3- to 5-log increase in th

254 T cell depletion strategies are an efficient therapy for

255 these studies will facilitate development of T-cell depletion strategies to augment the feasibility o

256 recently described hamster model, along with T-cell depletion strategies, we show that CD4(+) T cells

257 It is clear from knockout mice and T cell depletion studies using Chlamydia muridarum that

258 CD4(+) T-cell depletion studies or the adoptive transfer of WT

259 However, T-cell depletion studies suggested that both CD4 and CD8

260 CD4 T cell depletion subsequent to CD4 T cell CNS migration

261 vivo cannot account for the extent of CD4(+) T cell depletion, suggesting indirect or bystander mecha

262 show that MRV infects the thymus and causes T-cell depletion, suggesting that other roseoloviruses m

263 hermore, IL-7 inhibition in combination with T cell depletion synergized with either CTLA-4Ig adminis

264 -induced protection of mice was evaluated by T-cell depletion; T lymphocytes were not essential for t

265 nti-human CD2 antibody (LoCD2), by assessing T-cell depletion (TCD) and graft survival.

266 T-cell depletion (TCD) reduces the incidence of graft-ve

267 tiviral pathways perturbed by in vivo CD8(+) T cell depletion that may contribute to noncytolytic con

268 aracterized by the rapid onset of intestinal T-cell depletion that initiates the progression to AIDS.

269 sepsis characterized by hypercytokinemia and T-cell depletion, the vaccinated mice displayed moderate

270 T-cell depletion therapy is associated with diminished i

271 s antibody-mediated in vivo CD4(+) or CD8(+) T-cell depletion, thus indicating a role for the BM in m

272 Regulatory T cell depletion using PC61 antibody was used to examine

273 Finally, regulatory T cell depletion via anti-CD25 Abs blocked CS-mediated i

274 de evidence for profound lung mucosal CD4(+) T-cell depletion via a Fas-dependent activation-induced

275 t of tolerance induction by CD3 mAb-mediated T-cell depletion, warranting caution in their use for th

276 Importantly, CD4+ T cell depletion was associated with a rapid, significan

277 slightly (R(2) = 0.346, P < 0.001) when CD4 T cell depletion was taken into account.

278 ne induction, T-cell stimulation, regulatory T cell depletion-was observed at all dose levels.

279 V/SIV replication, dissemination, and CD4(+) T cell depletion, we profiled miRNA expression in colon

280 In addition to CD4 T-cell depletion, we found increased effector T-cell fre

281 ell responses on the magnitude of the CD4(+) T-cell depletion, we investigated the effect of CD8(+) l

282 Levels of acute mucosal CD4+ T-cell depletion were similar for treated and nontreated

283 is donor type (mother) and GVHD prophylaxis (T-cell depletion) were also significant predictors of aG

284 to the proliferating pool in response to CD4 T cell depletion, whereas naive CD8 T cell proliferation

285 d by anti-IL-2-neutralizing Ab and by CD4(+) T cell depletion, which abrogated the Gag-specific respo

286 Here, TMEV infection induced splenic T cell depletion, which was associated with lower anti-v

287 /FasL pathway does play a role in regulatory T-cell depletion, which is likely a result of increased

288 To determine whether in vivo T-cell depletion, which lowers GVHD, abrogates the antil

289 Recipient conditioning consisted of T cell depletion with CD3-immunotoxin, and 100 cGy total

290 served in nontransplanted mice and after CD8 T cell depletion with mAb instead of mATG.

291 d-party cardiac allografts and by regulatory T-cell depletion with anti-CD25 antibody.

292 ndomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG;

293 rates were significantly lower after in vivo T-cell depletion with ATG (relative risk [RR] = 0.66; P

294 Simultaneous T-cell depletion with ATG and costimulatory blockade, co

295 T-cell depletion with mATG combined with CTLA4Ig and SRL

296 We hypothesized that CAR T-cell depletion with optimal timing after AML eradicati

297 eased SIV reservoir size and accelerated CD4 T-cell depletion with progression to AIDS despite decrea

298 (+) individuals demonstrated profound CD4(+) T-cell depletion with reduced CD4/CD8 T-cell ratios in b

299 cautious approach to routine use of in vivo T-cell depletion with RIC regimens.

300 macaques showed distinct patterns of CD4(+) T-cell depletion, with a selective loss of memory cells