ライフサイエンスコーパス: T-cell receptor

1 hybrid lymphocyte that expresses both B and T cell receptors.

2 constant alpha and beta domains of the human T-cell receptor, a technology known as bispecific engage

3 lin BTN3A1 inhibits tumor-reactive alphabeta T cell receptor activation by preventing segregation of

4 We further found that T cell receptor activation induces the formation of CRAC

5 K) has been shown to play a critical role in T cell receptor activation-induced remodeling of energy

6 We found that mimicking T-cell receptor activation in Jurkat leukemia cells indu

7 ral TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whe

8 Immune mobilizing monoclonal T Cell receptors against virus (ImmTAV) molecules repres

9 intra- and inter-method reproducibility for T cell receptor alpha (TRA) and T cell receptor beta (TR

10 e-based single-cell RNA sequencing of paired T cell receptor alpha and beta chain sequences show pron

11 r staining and coexpression of CD161 and the T-cell receptor alpha variable gene TRAV1-2 were strongl

12 ures of immunoglobulin H (IgH), Igkappa, and T cell receptor-alpha (TCRalpha) loci during B lymphopoi

13 Using single-cell T cell receptor analysis, we provide evidence that neoan

14 iles of immune cells, coupled with assembled T cell receptor and B cell receptor sequences, we analyz

15 pathways affected in these disorders include T cell receptor and B cell receptor signaling, cytokine

16 also identified Epstein-Barr virus-specific T cell receptors and EBV(+) lymphocytes in the affected

17 as a centralized resource for those studying T cell receptors and their recognition.

18 The tyrosine phosphatase PTPN2 attenuates T-cell receptor and cytokine signaling in T cells to mai

19 ing of automatically prepared libraries from T-cell receptor and immunoglobulin gene rearrangements i

20 mple, transcriptional activation of both the T-cell receptor and programmed cell death protein 1 path

21 ive cell therapy, including chimeric antigen T-cell receptors and other novel T-cell receptor-based t

22 nx, but OT1 mice fail to do so because their T cell receptors are engineered to recognize a single ov

23 igands for stimulation and co-stimulation of T-cell receptors are presented via the fluid, synthetic

24 fect phosphorylation of Zap70 (zeta chain of T cell receptor-associated protein kinase 70).

25 family tyrosine kinase (LYN), zeta chain of T-cell receptor-associated protein kinase 70 (ZAP-70), a

26 This study delineated a stromal Lama5-T cell receptor axis that can be targeted for immune tol

27 ric antigen T-cell receptors and other novel T-cell receptor-based therapies.

28 TOF) and next-generation sequencing of B and T cell receptor (BCR and TCR) repertoires, we demonstrat

29 a repository of currently >14 million B and T cell receptor (BCR and TCR) sequences from the blood o

30 ntigen (HLA) receptors as well as B cell and T cell receptors (BCR and TCR).

31 ecific engagement by antibodies based on the T-cell receptor (BEAT).

32 quency, which prompted us to investigate the T cell receptor beta (TCRbeta) repertoire in the CP and

33 In this study, we performed T cell receptor beta (TCRbeta) sequencing of virus-speci

34 cibility for T cell receptor alpha (TRA) and T cell receptor beta (TRB) TCR chains.

35 anistically, this was a T cell-intrinsic and T cell receptor beta-chain variable-dependent phenomenon

36 k adaptive immunity had no lung disease, and T-cell receptor beta chain (Tcrb)(-/-) STING N153S anima

37 ty of IDH1 mutants to the CDR3 domain of the T-cell receptor beta chain (TRB).

38 cer patients, with a focus on studies of the T-cell receptor beta chain locus.

39 However, common usage or pairings of T-cell receptor beta variable or joining genes, specific

40 We studied the T-cell receptor beta-chain (TCRbeta) usage and phenotype

41 ssociated with oligoclonality and restricted T-cell receptor beta-chain V-J pairing in CD8(+) but not

42 e class T epitope on SEB overlapped with the T-cell receptor binding site, whereas other evidence sug

43 II complex stability, beta167-169 RGD loop, T-cell receptor binding, formation of homodimer of alpha

44 here ICI are effective, with concomitant low T-cell receptor clonalities.

45 By mapping T cell receptor clonality, we find that responding patie

46 l and self-immunopeptidomes and intratumoral T cell receptor clonality.

47 type, transcriptome, epigenetic profile, and T cell receptor clonotype, the authors provide evidence

48 r and regulatory T-cell subsets with diverse T-cell receptor clonotypes in the periphery.

49 Thymus structure, immunophenotyping, T-cell receptor clonotypes, T-cell function, immune resp

50 around anchor pockets 1 and 9, as potential T-cell receptor contacts, in the areas for CD4 binding a

51 +) T cell differentiation by ensuring normal T cell receptor density and signaling.

52 least 91 unique clones expressing different T-cell receptors) directed against HLA*02:01-restricted

53 Additionally, T-cell receptor diversity, cytolytic activity score (CYT

54 getic and biosynthetic programs and licences T cell receptor driven proteome reprogramming.

55 the multi-phenotypic impact of disrupting 25 T cell receptor-driven kinases.

56 nical benefit demonstrated overexpression of T cell receptor-encoding genes.

57 avior in mice and was partially dependent on T cell receptor engagement and commensal-derived signals

58 tched, control C57BL/6 mouse LNSC suppressed T-cell receptor engagement by anti-CD3/CD28 via MHC-inde

59 Adoptive transfer of T cell receptor-engineered (TCR-engineered) T cells is a

60 a recombinant CHIKV strain encoding a CD8(+) T cell receptor epitope from ovalbumin, as well as a vir

61 r severe combined immunodeficiency using the T-cell receptor excision circle assay.

62 Infants with T-cell receptor excision circle values of less than a de

63 owed TCR V-beta repertoire usage and diluted T-cell receptor excision circles confirm that DN T cells

64 ly arises from a small subset of gamma/delta T-cell receptor-expressing lymphocytes.

65 CD8+ Tem and Temra cells showed some unique T cell receptor features in terms of overlap and variabl

66 Here, we report that T cell receptor fusion constructs (TRuCs) comprising an

67 ficile infection showed increased IL-17A and T cell receptor gamma chain expression, and IL-17 produc

68 e, but molecular testing identified the same T-cell receptor gamma rearrangement present in the gastr

69 Molecular analysis revealed a clonal T-cell receptor gamma rearrangement.

70 functional avidity of selected gamma9delta2 T cell receptors (gamma9delta2TCRs), was not associated

71 merase chain reaction-based investigation of T-cell receptor gene rearrangement to detect clonality.

72 ntitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements.

73 cell clones through paired sequencing of the T cell receptor genes and high-dimensional single-cell s

74 combination assembles and diversifies Ig and T cell receptor genes in developing B and T lymphocytes.

75 Furthermore, we isolated a number of cognate T cell receptor genes with tumor reactivity.

76 ulation critically enhanced signaling by the T cell receptor in the formation of functional immune sy

77 Crystal structures of T cell receptors in complex with HLA-DQ2.5 bound to two

78 rming deep single-cell sequencing of RNA and T cell receptors in patients with different types of can

79 ofiles of various populations of T cells and T cell receptors in tumours, normal adjacent tissue, and

80 Signals downstream of the T cell receptor influence whether individual clones bear

81 rate to the thymus to give rise to embryonic T cell receptor-invariant T cells.

82 The effectiveness of pathogen detection by T cell receptor is limited by chemical similarity of for

83 the antigenic specificity of the gammadelta T cell receptors is incompletely understood.

84 to reach the stationary concentration of the T-cell-receptor-ligand-activated complex, which transfer

85 on of a network of inhibitory and activating T cell receptors may be a critical step in the developme

86 and fatty acid oxidation, without affecting T cell receptor-mediated activation.

87 ory triggers that can enhance or even bypass T cell receptor-mediated signals-substantially broadenin

88 synapse is classically described between the T-cell receptor of CD4-positive lymphocytes and MHC II o

89 d presentation of a resulting peptide to the T cell receptor on classical peptide-recognizing CD4(+)

90 As well as binding T cell receptors on CD8(+) T cells, HLA class I molecule

91 lls coengineered with a Fas DNR and either a T cell receptor or chimeric antigen receptor exhibited e

92 of activation mediated by engagement of the T-cell receptor or of CD16.

93 T cell receptor phosphorylation by Lck is an essential s

94 Our theoretical method models T cell receptor phosphorylation events as a sequence of

95 g thymocyte development, requires myriad pre-T cell receptors (preTCRs) and alphabetaTCRs.

96 on of T cells, measured through increases of T-cell receptor productive frequencies, mirrored ctDNA r

97 onse, profound immune exhaustion with skewed T cell receptor repertoire and broad T cell expansion.

98 ed self-antigen representation and increased T cell receptor repertoire diversity.

99 includes critical variables, such as MHC and T cell receptor repertoire, is needed.

100 We identified a highly oligoclonal T cell receptor repertoire, which we localized to activa

101 T cell neogenesis and diversification of the T cell receptor repertoire.

102 T-cell receptor repertoire analyses showed similar clona

103 (UC) using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry.

104 T-cell receptor repertoire analysis, flow cytometry, mul

105 We evaluated the T-cell receptor repertoire associated with 72 primary Me

106 ell carcinomas and correlated metrics of the T-cell receptor repertoire with clinicopathologic charac

107 immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones an

108 transport into the endoplasmic reticulum and T-cell receptor repertoire, also contribute to the immun

109 ubsets and systemic remodeling of peripheral T cell receptor repertoires.

110 d ability to induce c-Jun/AP-1 expression on T cell receptor restimulation, a mechanism that may cont

111 ate-like T cells expressing a semi-invariant T cell receptor restricted to the non-classical MHC clas

112 T cell receptor sequence comparison between patients ide

113 matical modeling and statistical analyses of T cell receptor sequencing data, we develop a quantitati

114 T cell receptor sequencing monitored repertoires during

115 enrichment of immune-related processes, and T cell receptor sequencing revealed increased clonality

116 RNase H-dependent PCR-enabled T-cell receptor sequencing (rhTCRseq) can be used to det

117 tumors, we conducted whole genome, RNA, and T-cell receptor sequencing, immunohistochemistry and rev

118 solve the spatial and temporal resolution of T cell receptor signaling in the context of immune respo

119 ever, the relative contributions of IL-2 and T cell receptor signaling to this process are unknown.

120 tyrosine phosphosites that mediate proximal T cell receptor signaling, cytoskeletal organization, an

121 Here, we review the current understanding of T-cell receptor signaling and their intersection with IC

122 TNFalpha (tumor necrosis factor-alpha), and T-cell receptor signaling pathways, cytokines involved i

123 cts, including posttranscription regulation, T-cell receptor signaling, and metabolic function.

124 3-kinase/AKT/mTOR activation independent of T-cell receptor signaling.

125 h CD8 T cells engineered to express anti-SIV T-cell receptor specificities enables direct experimenta

126 hibiting T cell proliferation in response to T cell receptor stimulation and mediating fibroblast cel

127 Expression of TOX is driven by chronic T cell receptor stimulation and NFAT activation.

128 T cell receptor stimulation induces depletion of the end

129 s in TILs was induced by the coordination of T cell receptor stimulation, microenvironmental stressor

130 vels of peripheral blood engraftment with E6 T-cell receptor T cells 1 month after treatment (median,

131 thermore, we were able to isolate and verify T cell receptors targeting KRASG12D mutation.

132 T cell receptor (TCR) activation is modulated by mechani

133 amily kinases (pSFK), LAT and PLC-gamma over T cell receptor (TCR) alone.

134 CD8alphabeta is a coreceptor for the T cell receptor (TCR) and binds to the same cognate pMHC

135 analyzing the cytokine production following T cell receptor (TCR) and co-receptor stimulation with a

136 perior antitumor reactivity, we isolated the T cell receptor (TCR) and demonstrated specific recognit

137 es through concomitant crosslinking of their T cell receptor (TCR) and FcgammaRI.

138 The assembly of T cell receptor (TCR) and immunoglobulin (Ig) genes by V

139 immune tolerance whose activity depends upon T cell receptor (TCR) and mTORC1 kinase signaling, but t

140 four previously described Valpha3.2 Vbeta14 T cell receptor (TCR) cDNAs, the dominant clonotype gene

141 Two genes encoding the endogenous T cell receptor (TCR) chains, TCRalpha (TRAC) and TCRbet

142 hat a subpopulation of T cells expresses two T cell receptor (TCR) clonotypes, though the extent and

143 Crystal structures of the MAIT T cell receptor (TCR) complexed with MR1-DB28 and MR1-NV

144 We found that T cell receptor (TCR) engagement induces the selective p

145 itive selection in the thymus when their new T cell receptor (TCR) engages and signals in response to

146 However, the role of T cell receptor (TCR) in this process remains unclear.

147 The T cell receptor (TCR) initiates the elimination of patho

148 T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide variety o

149 Mechanosensing by T cells through the T cell receptor (TCR) is at the heart of immune recognit

150 imeric antigen receptor (CAR) or a classical T cell receptor (TCR) is revolutionizing cancer treatmen

151 Moreover, neoantigen-reactive T cells and a T cell receptor (TCR) isolated from the CD8+PD-1+ subset

152 T cell receptor (TCR) ligand discovery is crucial to mon

153 T cell receptor (TCR) ligand discovery is essential for

154 nds whether they represent direct gammadelta T cell receptor (TCR) ligands.

155 cells engineered to express an HBV-specific T cell receptor (TCR) may achieve cure of HBV infection

156 gy to study OT-1 T cells, revealing that the T cell receptor (TCR) mechanically samples antigens carr

157 A T cell receptor (TCR) mediates antigen-induced signaling

158 l-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leuko

159 de CRISPR-Cas9 screening to establish that a T cell receptor (TCR) recognized and killed most human c

160 ruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics.

161 r TILs, TSA-reactive TILs possess a distinct T cell receptor (TCR) repertoire and unique gene feature

162 respond to nickel but the involved alphabeta T cell receptor (TCR) repertoire has not been comprehens

163 Monitoring the T cell receptor (TCR) repertoire in health and disease c

164 The T cell receptor (TCR) repertoire is diverse, thus allowi

165 of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and i

166 y, but its influence on the antigen-specific T cell receptor (TCR) repertoire is unknown.

167 The alphabeta T cell receptor (TCR) repertoire on mature T cells is se

168 ported by a combination of immunophenotypic, T cell receptor (TCR) repertoire, functional, and transc

169 multifaceted impact on the exhausted CD8(+) T cell receptor (TCR) repertoire.

170 +)CD4(+) conventional T cells with a diverse T cell receptor (TCR) repertoire.

171 s, leading to a detrimental reduction of the T cell receptor (TCR) repertoire.

172 t peptidome variation contributes to shaping T cell receptor (TCR) repertoires and hence individual i

173 B cell receptor (BCR) and T cell receptor (TCR) repertoires are generated through

174 ation of commonalities and differences among T cell receptor (TCR) repertoires from different individ

175 The study of T cell receptor (TCR) repertoires has generated new insi

176 els parameterized by deep neural networks to T cell receptor (TCR) repertoires.

177 Activation of the T cell receptor (TCR) results in binding of the adapter

178 clude selecting an appropriate repertoire of T cell receptor (TCR) self-affinities in the thymus, reg

179 T cell receptor (TCR) sequence analysis demonstrated tha

180 tigens, T cells generate a vast diversity of T cell receptor (TCR) sequences.

181 We utilized the complementary approaches of T cell receptor (TCR) sequencing and cytometry by time-o

182 ere assessed with single-cell RNA and paired T cell receptor (TCR) sequencing of 30,604 T cells from

183 Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous gammade

184 Transcriptional profiling coupled with T cell receptor (TCR) sequencing reveal lineage connecti

185 In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconve

186 Both the T cell receptor (TCR) signal and environmental cues cont

187 ntified an interaction between Trib1 and the T cell receptor (TCR) signaling activator, MALT1, which

188 T cells through the phosphatase SHP1 reduced T cell receptor (TCR) signaling and preformed CD40 ligan

189 It is known that antigen recognition and T cell receptor (TCR) signaling depend on forces applied

190 sphorylating substrates involved in proximal T cell receptor (TCR) signaling.

191 theta) is an important component of proximal T cell receptor (TCR) signaling.

192 re, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these c

193 Naive CD4(+) T cells experience weak T cell receptor (TCR) signals induced by self-peptides p

194 ity in BDC2.5XNOD mice carrying a transgenic T cell receptor (TCR) specific for a beta cell autoantig

195 nt cardiac autoantigen and that T cells with T cell receptor (TCR) specificity to MYHCA acquired a Tr

196 T cell receptor (TCR) stimulation activates diverse kina

197 Moreover, NKT2 cells receive and require T cell receptor (TCR) stimulation for continuous IL-4 pr

198 arker up-regulation, and proliferation after T cell receptor (TCR) stimulation.

199 ng an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram

200 ted by signaling molecules downstream of the T cell receptor (TCR) that are organized by adaptor prot

201 T cell receptor (TCR) transductants and BTN3-deficient h

202 In marked contrast to the biased T cell receptor (TCR) usage associated with HLA-DQ2.5-me

203 (SEB), which naturally links a proportion of T cell receptor (TCR) Vbeta subtypes to MHC-II, present

204 integrates signal strength downstream of the T cell receptor (TCR) within activated thymocytes and pe

205 l, we report that, similar to the endogenous T cell receptor (TCR), antigen engagement triggers the f

206 The T cell receptor (TCR)-CD3 complex comprises a diverse al

207 ule Qa-1, which disrupts Qa-1 binding to the T cell receptor (TCR)-CD8 complex and impairs the CD8 Tr

208 mmadelta T cell population that respond in a T cell receptor (TCR)-dependent manner to phosphoantigen

209 pivotal regulators of immune tolerance, with T cell receptor (TCR)-driven activated T reg (aT reg) ce

210 t are based on vaccination or on infusion of T cell receptor (TCR)-engineered T cells.

211 dozens of unique barcoded templates into the T cell receptor (TCR)-locus revealed gene constructs tha

212 e.g., virus-infected cells, which depends on T cell receptor (TCR)-mediated activation of beta(2)-int

213 The T cell receptor (TCR)-peptide-MHC (pMHC) interaction is

214 Adoptively transferred T cell receptor (TCR)-transgenic T cells (TCR-T cells) a

215 ellular interactions with the Vgamma9Vdelta2 T cell receptor (TCR).

216 ll related to the chains that constitute the T cell receptor (TCR).

217 e different ligand binding half-lives to the T cell receptor (TCR).

218 erized, in part, by the TRAV1-2(+) alphabeta T cell receptor (TCR).

219 nising MHC-related protein-1 (MR1) via their T cell receptor (TCR).

220 molecular modeling, we established that the T cell receptor (TCR):CD3 complex is required for USSN-i

221 on concurrent signaling by Notch and the pre-T cell receptor (TCR); however, it is unclear how these

222 ineering chimeric antigen receptors (CAR) or T cell receptors (TCR) helps create disease-specific T c

223 l neoantigens featuring an oligo-/monoclonal T cell-receptor (TCR) repertoire.

224 veloping biomarkers based on analysis of the T-cell receptor (TCR) alpha repertoire to assist in the

225 We studied an insulin-reactive T-cell receptor (TCR) alpha-chain transgenic NOD mouse o

226 iciencies received 155 mismatched grafts: 30 T-cell receptor (TCR) alphabeta/CD19-depleted grafts, 43

227 tivation by enabling interaction between the T-cell receptor (TCR) and human leukocyte antigen class

228 Virtually all T-PLL expressed a T-cell receptor (TCR) and/or CD28-coreceptor without ove

229 omote activation of T cells by strengthening T-cell receptor (TCR) binding to cognate peptide-MHC com

230 ) can be used to determine paired alpha/beta T-cell receptor (TCR) clonotypes in single cells or perf

231 (9-23)) specificity, and mutation of the key T-cell receptor (TCR) contact residue within the epitope

232 peptide elution, mixed lymphocyte reaction, T-cell receptor (TCR) deep sequencing, tetramer-guided n

233 y and clonality index of T cells by means of T-cell receptor (TCR) immunosequencing in a discovery da

234 Knockout (KO) of the endogenous T-cell receptor (TCR) in CD19-CAR-T cells may be a promi

235 e clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determi

236 We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-reg

237 vC2-V5 single-genome amplification (SGA) and T-cell receptor (TCR) repertoires assessed.

238 The diversity of T-cell receptor (TCR) repertoires is achieved by a combi

239 udy, we developed statistical classifiers of T-cell receptor (TCR) repertoires that distinguish tumor

240 with a substantial increase in the number of T-cell receptor (TCR) sequences and their cognate antige

241 Pre-T-cell receptor (TCR) signal transduction is required fo

242 The suppressor of T-cell receptor (TCR) signaling (Sts) proteins Sts-1 and

243 T-cell receptor (TCR) signaling strength is a dominant f

244 To determine how LAIR-1 affects T-cell receptor (TCR) signaling, we compared 1) T cells

245 ine residues in response to Listeria-induced T-cell receptor (TCR) stimulation in both naive and memo

246 d tissue and generated an affinity-optimized T-cell receptor (TCR) with specificity to AFP/HLA-A*02(+

247 or a range of immunoreceptors, including the T-cell receptor (TCR), and show that this generic ligand

248 ng through multiple receptors, including the T-cell receptor (TCR), co-receptors, and cytokine recept

249 ructural determinants with those utilized by T-cell receptor (TCR), killer-cell immunoglobulin-like r

250 potent antigens in vivo despite their strong T-cell receptor (TCR)-binding affinities.

251 The T-cell receptor (TCR)-CD3 complex is composed of a diver

252 d in many immune responses, mediated through T-cell receptor (TCR)-dependent and/or independent activ

253 T-cell receptor (TCR)beta screening showed tremelimumab

254 T-cell receptors (TCR) have considerable potential as th

255 The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive

256 The regulation of T cell receptor Tcra gene rearrangement has been extensi

257 n the binding of pathogenic superantigens to T cell receptors (TCRs) and/or major histocompatibility

258 T cell receptors (TCRs) are critical molecules of the ad

259 cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies for viral i

260 Recombinant T cell receptors (TCRs) can be used to redirect naive T

261 can correctly identifies cognate antigens of T cell receptors (TCRs) from viral and human genome-wide

262 histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet ca

263 Four T cell receptors (TCRs) made up the TIL infusion and rec

264 ntiation (CD)8(+) T cells, by means of their T cell receptors (TCRs) recognizing intracellular target

265 cocultured T cells expressing MCPyV-specific T cell receptors (TCRs) show increased cytokine producti

266 e of Vdelta1, three CD1b-specific gammadelta T cell receptors (TCRs) showed clear differences in the

267 T cells express clonotypic T cell receptors (TCRs) that recognize peptide antigens

268 threats in an antigen-specific manner using T cell receptors (TCRs) that recognize short peptide ant

269 e distinctive nature of DURTs and gammadelta T cell receptors (TCRs) to investigate the involvement o

270 The binding of T cell receptors (TCRs) to their target peptide MHC (pMH

271 High-avidity CBFB-MYH11 epitope-specific T cell receptors (TCRs) transduced into CD8+ T cells con

272 Studying the composition of T cell receptors (TCRs) using next-generation sequencing

273 eron-gamma-producing Vdelta1(+) IELs bearing T cell receptors (TCRs) with a shared non-germline-encod

274 ng the associations of particular gammadelta T cell receptors (TCRs) with specific anatomical sites.

275 on other cells, much like MHC molecules and T cell receptors (TCRs).

276 T-cell receptors (TCRs) are immune proteins that primari

277 their signature feature, the clonal-specific T-cell receptors (TCRs) for antigen.

278 The interaction between T-cell receptors (TCRs) of T-cells and potentially immun

279 T-cell receptors (TCRs) recognize pathogens to ignite im

280 We studied oligoclonal T-cell receptors (TCRs) that recognize a shared neoepito

281 sly described GLIPH, an algorithm to cluster T-cell receptors (TCRs) that recognize the same epitope

282 T cells use their T-cell receptors (TCRs) to scan other cells for antigeni

283 gineered T cells expressing antigen-specific T-cell receptors (TCRs), is an appealing therapeutic app

284 i-CD1d antibodies that block CD1d binding to T-cell receptors (TCRs).

285 ough bivalent engagement and dimerization of T-cell receptors (TCRs).

286 ce is influenced by clonotypically expressed T-cell receptors (TCRs).

287 Neonatal thymocytes expressing T cell receptors that engage IA(b)-Padi4 with moderate d

288 ex (MHC) class I, MHC class II and alphabeta T cell receptors, the antigenic specificity of the gamma

289 For immunology, the binding of a T cell receptor to an antigen-presenting pMHC initiates

290 oteins interact to transmit signals from the T-cell receptor to the nucleus.

291 c variability of the immunoglobulin (Ig) and T cell receptor (TR) gene loci.

292 ribe a variant of spontaneous EAE in the 2D2 T cell receptor transgenic mouse (2D2(+) mouse) that pre

293 Using a CD8(+) T-cell receptor transgenic model, we show that the CXCL1

294 al of GBM-bearing mice in both syngeneic and T-cell receptor transgenic models.

295 T-cell receptor transgenic TEa CD4 cells that recognized

296 trate rigidity, implying that early steps in T cell receptor triggering are not mechanosensitive.

297 To address this, sequencing of the T-cell receptor variable-region beta-chain was performed

298 ransmit signals akin to those from activated T-cell receptors when bound to a cell surface target.

299 enes such as IFNA, MRC1, immunoglobulins and T-cell receptors which contribute to defend against path

300 utic strategy combining an affinity-enhanced T Cell receptor with an anti-CD3 T Cell-activating moiet