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1 res to the amplification associated with the TATA box.
2 n start sites and a proximal Sp1 site but no TATA box.
3 core motifs located downstream from the p21 TATA box.
4 ergo nucleosome remodeling tend to contain a TATA box.
5 ity to stabilize the binding of TFIID to the TATA box.
6 ) core promoter motif is associated with the TATA box.
7 y as the start was moved downstream from the TATA box.
8 tinct preference for the DPE relative to the TATA box.
9 s are not the only selective pressure on the TATA box.
10 dependent on other bases within a particular TATA box.
11 making them similar to those on a consensus TATA box.
12 residues directly upstream of the SV40 early TATA box.
13 ding protein (TBP/Spt15) associated with the TATA box.
14 rated promoter-like activity and possessed a TATA box.
15 d by its separation distance relative to the TATA box.
16 mutational target size and the presence of a TATA box.
17 t multiple sites 40-120 bp downstream of the TATA box.
18 ctivator-recruited SAGA transfers TBP to the TATA box.
19 tiator sequence downstream of a nonconsensus TATA box.
20 upstream and within the major groove of the TATA Box.
21 ce preference for the downstream half of the TATA box.
22 f CRELD2, this region is GC-rich and lacks a TATA box.
23 e general transcription factors requires the TATA box.
24 ng sites (TFBSs) and their distance from the TATA box.
25 T, Est-1, Oct-1, CNBP, and NFkB, but lacks a TATA box.
26 endent on sequences upstream of the archaeal TATA box.
27 transcriptional initiation sites and lacks a TATA box.
28 sive contacts upstream and downstream of the TATA box.
29 identified core promoter elements, such as a TATA box.
30 ich our data suggest is positioned by a weak TATA box.
31 open chromatin configuration at the fbp1(+) TATA box.
32 ownstream core promoter region (DPR) and the TATA box.
33 for an extended distance of 1.2 kb from the TATA box.
34 etween positions -70 and -9, centered on the TATA box.
35 iched in other well-known motifs such as the TATA box.
36 strongly at the tandem CCAAT motifs near the TATA box.
37 mine (poly-T), as well as to the traditional TATA box.
38 TATA box to the same extent as the consensus TATA box.
39 binds to core promoter DNA, recognizing the TATA-box.
40 s and are embedded with precisely positioned TATA boxes.
41 m, may help initiate transcription from weak TATA boxes.
42 for the low transcription levels of the weak TATA boxes.
43 ption factor binding sites and high affinity TATA boxes.
44 cleosome is positioned over its three-phased TATA boxes.
45 ate with either transcription start sites or TATA boxes.
46 nlike TBP, TRF2 fails to bind DNA containing TATA-boxes.
47 n from nucleotides -372 to +814, a canonical TATA box (-38/-32), and putative transcription factor bi
48 ecruit the TATA-binding protein (TBP) to the TATA box, a critical step in eukaryotic gene regulation.
49 D-dominated genes, RNR3 contains a consensus TATA-box, a feature of SAGA-regulated core promoters.
50 instead of binding together with TBP at the TATA box, activator-recruited SAGA transfers TBP to the
51 ion motifs enriched in the bimodal gene set (TATA boxes, alternative promoters, methlyation) have kno
52 by eukaryotic RNA polymerases to bind to the TATA box, an eight-basepair DNA promoter element, to ini
54 iption from core promoters containing both a TATA box and an Initiator (INR) element but not from "TA
56 omoter sequence (1389 bp) showed a consensus TATA box and cis-acting binding sites for several potent
59 olled by many different elements such as the TATA box and downstream core promoter element (DPE).
62 ID shown to bind specific DNA sequences (the TATA box and initiator, respectively), raising the quest
65 scription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE).
66 specific core promoter elements such as the TATA box and the initiator (INR) remains unclear and cor
67 P II forms an open promoter complex near the TATA box and then scans the template DNA strand for star
68 y to expectation, a nucleosome occluding the TATA box and transcription start sites did not impede tr
70 ences are flexible with the exception of the TATA box and TSS, which are rigid regions irrespective o
72 The 5' flanking regions contain putative TATA boxes and cAMP-response elements (CREs), but the TA
73 s and cAMP-response elements (CREs), but the TATA boxes and CREs exhibit gene-specific sequences, and
74 opy genes, duplicate genes tended to contain TATA boxes and less DNA methylation in the promoter regi
78 The most conserved promoter (P3) contains a TATA-box and displays in vivo enhancer activity in a pat
81 ed influences of several factors such as the TATA-box and microRNA targeting on intrinsic or extrinsi
83 es around - 34 to - 23 (expected position of TATA box) and the TSS were informative in discriminating
84 Only 29 TSS were associated with a canonical TATA box, and 14 initiated within or near the previously
85 egion, a third has a 17-bp deletion near the TATA box, and a fourth contains a Ds insertion in exon1.
86 of core promoter motifs, e.g. the initiator, TATA box, and the downstream core promoter element (DPE)
87 core promoter sequence elements such as the TATA box appear to be much less frequent than thought.
89 example, recent studies have pointed to the TATA box as a sequence feature that can influence expres
90 ears to be a duality between the DPR and the TATA box, as many promoters contain one or the other ele
93 th the N-terminal domain actively modulating TATA box binding by TBP and nonionic detergent modulatin
95 n of histone H3 at Lys-4, and recruitment of TATA box binding protein (TBP) and RNA polymerase II, bu
96 ce that inducibly express one copy of mutant TATA box binding protein (TBP) at different ages by tamo
97 esses trpEGCFBAD transcription by preventing TATA box binding protein (TBP) binding to the TATA box s
98 activating protein complex (SNAP(c)) and the TATA box binding protein (TBP) for basal transcription,
102 etail the interactions of initiation factors TATA box binding protein (TBP), transcription factor IIB
105 ractors identified the PHD finger of TAF3, a TATA box binding protein-associated factor with importan
106 HD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF
107 hdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in
108 der these experimental conditions identified TATA-Box Binding Protein (TBP) and Importin 8 (IPO8) to
109 of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerat
113 pression of the general transcription factor TATA-box binding protein (TBP) leads to increased RNA sy
117 between HCMVpp65(422-439) and TAF9(134-144) (TATA-box binding protein associated factor 9, TAF9) was
118 archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of
120 t of proteins (e.g alpha-synuclein, insulin, TATA-box binding protein, Sup35, p53), independent of th
124 tion factor D (TFIID) complex is composed of TATA box-binding protein (TBP) and 13 TBP-associated fac
125 se I, and chemical cross-linking assays with TATA box-binding protein (TBP) and Rep68 indicate that b
128 pha DNA-binding domain binds directly to the TATA box-binding protein (TBP) and, through this interac
130 found to be dependent not upon the canonical TATA box-binding protein (TBP) but instead upon the TBP-
132 ssays that binding interactions of the human TATA box-binding protein (TBP) were disrupted on 2-chlor
134 s of the RNA polymerase (I, II, or III), the TATA box-binding protein (TBP), and transcription factor
135 en shown previously that ICP4 interacts with TATA box-binding protein (TBP), TFIIB, and the TBP-assoc
136 n complex (OC) composed of the promoter DNA, TATA box-binding protein (TBP), transcription factor B (
141 nits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TA
142 t1 (modifier of transcription 1) dissociates TATA box-binding protein (TBP):DNA complexes, offering a
143 DNA through interactions with promoter-bound TATA box-binding protein and transcription factor IIB.
147 model that expresses one copy of the mutant TATA box-binding protein gene, which encodes a 105-gluta
148 polymerase II (RNAPII), enhanced binding of TATA box-binding protein to RNAPII and selectively promo
150 ion of TFIID in a simple system, we depleted TATA box-binding protein-associated factor (TAF)1 from D
152 ral transcription factor TFIID comprises the TATA-box-binding protein (TBP) and approximately 14 TBP-
153 0 (Rplp0), non-POU domain containing (Nono), TATA-box-binding protein (Tbp) and eukaryotic translatio
154 or 1, a multisubunit complex composed of the TATA-box-binding protein (TBP) and three TBP-associated
159 be overcome by cooperative interactions with TATA-box-binding protein at a U6 promoter but not at a U
160 nalysis of the heat-shock gene hsp82 and the TATA-box-binding protein gene tbp in multiple bdelloid s
161 approach and identified the Drosophila TBP (TATA-box-binding protein)-related factor 2 (TRF2) as an
162 biochemistry, and genetics to show that TBP (TATA-box-binding protein)-related factor 2 (TRF2) select
163 -initiation complex by M. thermautotrophicus TATA-box-binding protein, transcription factor B, and RN
166 ment over the promoter region tend to have a TATA box buried in an NPS and tend to be highly regulate
167 eam regions of the genes lack a conventional TATA box but contain CpG islands, cCpG-I and cCpG-II for
169 and transcription factor IIB and requires a TATA box but not a transcription factor IIB recognition
170 n of the BHLF1 transcript or deletion of the TATA box, but not the putative ATG initiation codon, red
171 es not require either the forward or reverse TATA boxes, but is instead dependent on residues in the
173 expression, affected by the sequence of the TATA box, can be beneficial after an acute change in env
174 al gamma-gene promoter, i.e. CACCC, CCAAT or TATA box, can be disrupted without affecting the activat
175 C-terminal extension interacts with the TBP/TATA box complex and contributes to the recruitment of B
182 -RACE experiments that established a second, TATA box-containing promoter (P2) upstream of the third
185 nd that the p21 core promoter directs rapid, TATA box-dependent assembly of RNAP II preinitiation com
187 usion protein is able to recruit pol III for TATA box-directed transcription of linear and supercoile
188 (containing the TA-rich region, GCC-box, and TATA-box) displayed a 30-fold induction by MeJA treatmen
189 at TAF11/TAF13 competes for TBP binding with TATA-box DNA, and also with the N-terminal domain of TAF
191 T-rich promoter category the position of the TATA-box does not correlate with the transcription start
194 la homeotic (Hox) gene promoters, which lack TATA-box elements, contain functionally important DPE mo
195 sequence located proximally upstream of the TATA box enhances transcription from a minimal CYC1 prom
197 the early promoter, with one adjacent to the TATA box (ERR1) and one approximately 600 bp upstream fr
201 moter P2, located upstream of P1, contains a TATA box, GC boxes, a CCAAT box and GATA and ets consens
202 M1BP and GAF genes, a significant portion of TATA box genes appear to be controlled at preinitiation
203 xpression in a predictable fashion, stronger TATA boxes have very little effect on noise in our synth
205 TSSs) occur about 30-35 bp downstream of the TATA box in metazoans, TSSs are located 40-120 bp downst
208 R inhibits gene transcription by binding the TATA boxes in the transcriptional regulatory region, but
209 ectly regulates gene expression by targeting TATA boxes in transcriptional regulatory regions as well
211 Finally, we show that although stronger TATA boxes increase expression in a predictable fashion,
213 SCP1 contains four core promoter motifs-the TATA box, initiator (Inr), motif ten element (MTE) and d
214 d consist of functional elements such as the TATA box, initiator, and downstream core promoter elemen
215 functional core promoter motifs (such as the TATA-box, initiator [Inr], and downstream core promoter
216 in which canonical sequence features such as TATA-box, Initiator, and GC content do play a significan
217 several criteria including identification of TATA boxes, INRs, and DPEs plus support from proteomic a
219 ic protein-DNA recognition events, the PwTBP-TATA box interaction is accompanied by a large negative
220 other functional class, conservation of the TATA box is highly predictive of iHMR maintenance, refle
221 RNA Pol II recruitment to the target gene TATA box is not required for the intergenic transcriptio
222 ase II transcription machinery that binds to TATA boxes located in the core promoter regions of many
223 ic stability of complexes on a non-consensus TATA box, making them similar to those on a consensus TA
224 tein interactions, such as those involved in TATA-box-mediated transcription initiation and the utili
228 5'-flanking region showed that the classical TATA-box motif near transcription initiation sites was a
229 contains a high GC content, a non-canonical TATA box, multiple stimulating protein 1 (SP1)/GC elemen
230 in whole-cell extracts or in vivo with these TATA box mutants indicated that factors, other than thos
232 tems, utilizing reduction of noise levels by TATA box mutations and noise propagation in transcriptio
235 ranscriptionally favorable locations for the TATA box near the nucleosomal DNA-entry site and at dyad
237 TATA binding protein (TBP) and TFIID to the TATA box of core promoters and ICP4 has been shown to in
238 ze the binding of either TBP or TFIID to the TATA box of representative early, late, and INR-mutated
243 can no longer stabilize TFIID binding to the TATA box of the late promoter and requires the additiona
245 equence (TGTAAATA) is a perfect match to the TATA box of the RNA polymerase III-transcribed U6 small
248 demonstrate that the effect of changing the TATA box on gene expression is the same for all syntheti
249 we analyze the effects of different strength TATA boxes on various aspects of combinatorial cis-regul
250 me transcription start site, and depend on a TATA box or AT-rich region but not the downstream promot
251 the presence of consensus motifs such as the TATA box or initiator elements, which attract and direct
254 activation, whereas disrupting the predicted TATA boxes or Oct-1 binding elements had no effect.
256 depletion irrespective of the presence of a TATA-box, possibly reflecting a weaker contribution to T
258 es transcription of the IMPDH gene (IMD2) at TATA box-proximal "G" sites, producing attenuated transc
259 a transcription factor binding site and the TATA box region in an inducible yeast promoter and measu
260 The Mig1 repressor binding and putative TATA box regions were unchanged among four mutant promot
261 ported that the region upstream of the UL127 TATA box repressed expression from the UL127 promoter.
262 escribed repressor element that overlaps the TATA box restored promoter activity in TBP-het cells, su
263 eliminate the RNA Pol II PIC by deleting the TATA-box resulted in loss of transcription, but enhancer
264 omoter CpG methylation nearby site-alpha and TATA box, reversible after DNA methyltransferase 1 deple
266 the TATA binding protein to bind a distinct TATA box sequence and promote antimicrobial peptide expr
271 mal kinetics even in the absence of the PHO5 TATA box, showing that transcription of the gene itself
273 ately upstream and downstream of the BRE and TATA box suggest that the composition and structure of a
274 ith codon usage is comparable to that of the TATA box, suggesting that the effect of translation on n
275 affected by helical phasing relative to the TATA box, suggesting that Z-DNA effects transcription wi
276 ss evident at promoters containing canonical TATA boxes, suggesting a model where transcription initi
277 c promoter libraries with different strength TATA boxes, suggesting that many of the salient aspects
280 omain-wide remodeling, while deletion of the TATA box that nearly abolishes transcription is permissi
281 One critical element of promoters is the TATA box, the docking site for the RNA polymerase holoen
283 ther independently or cooperatively with the TATA box to direct PIC formation and transcription; and
284 mble studies, TBP was found to bend a mutant TATA box to the same extent as the consensus TATA box.
286 A" element (-32/-27), a "weak" but essential TATA box, to bring TBP/TFIID to the transcription start
288 and unbending revealed that on the consensus TATA box two kinetically distinct populations of TBP-DNA
289 ) to create hundreds of thousands of DPR (or TATA box) variants, each with known transcriptional stre
290 T-ACRAMTU adducts in the minor groove of the TATA box was varied by selective elimination of potentia
292 o the sequence requirements for a functional TATA box, we performed transcription reactions using hig
293 nd complexes between TBP and a non-consensus TATA box were kinetically unstable even at 50 mM KCl.
294 single operator site was moved closer to the TATA box, whereas for multiple operator-containing promo
295 transcriptional mechanism from the canonical TATA box, which does not correlate with paused Pol II on
296 n to have an essential element suggestive of TATA boxes, which are potential targets for the TATA-bin
297 nontranscribed regions of the genome include TATA boxes, which are the initial regions of genome repl
298 ited sharp bends at points downstream of the TATA box, with an important consequence: The DNA at the
299 lexes to closely opposed forward and reverse TATA boxes, with forward transcription being transiently