ライフサイエンスコーパス: TNF receptor

1 nt and maintenance of recruited TRAF2 at the TNF receptor.

2 sion and promigration activity downstream of TNF receptors.

3 pathophysiological responses after engaging TNF receptors.

4 liver injury depends on hepatocyte-intrinsic TNF receptor 1 (p55, TNFR1).

5 TNF-alpha] and other immune markers [soluble TNF receptor 1 (sTNF-R1), sTNF-R2, C-reactive protein, a

6 Pretreatment with recombinant human soluble TNF receptor 1 (sTNFR1) in the intrathecal space at the

7 Activation of TNF receptor 1 (TNF-R1) can generate signals that promot

8 TNF receptor 1 (TNFR1) antagonist-neutralizing antibody

9 NF-induced Gal-9 expression was dependent on TNF receptor 1 (TNFR1) as TNF failed to induce Gal-9 in

10 Cs was blocked by neutralizing antibodies to TNF receptor 1 (TNFR1) but not to TNFR2 and was abolishe

11 n previous reports, simultaneous deletion of TNF receptor 1 (TNFR1) failed to rescue this severe phen

12 or-alpha (TNF-alpha) signaling and show that TNF receptor 1 (TNFR1) is necessary for the illness-indu

13 disease and cancer that were independent of TNF receptor 1 (TNFR1) signaling.

14 Here we show that TNF receptor 1 (TNFR1)-associated death domain (TRADD)-d

15 TNF receptor 1 (TNFR1)-induced necroptosis is known to r

16 tatin-1, or simultaneous genetic deletion of TNF receptor 1 (TNFR1).

17 their target tissues, which in turn express TNF receptor 1 (TNFR1).

18 aberrant signaling when the trimer binds to TNF receptor 1 (TNFR1).

19 ha-mediated NF-kappaB activation through the TNF receptor 1 (TNFR1)/IkappaB kinase (IKK) pathway.

20 trolled and progressive in absence of TNF or TNF receptor 1 (TNFR1)/TNFR2 (TNFR1R2) with increased in

21 stemic treatment of DKO animals with soluble TNF receptor 1 (TNFRI) prevented upregulation of Rho A s

22 ivation of T cells, were markedly reduced in TNF receptor 1 and 2 gene knockout mice.

23 dant surface protein of S. aureus, activates TNF receptor 1 and EGF receptor (EGFR) signaling cascade

24 TNFalpha is mediated by neuronally expressed TNF receptor 1 and requires activation of p38 MAPK, phos

25 EC/D3 expresses the receptors for TNF-alpha, TNF receptor 1 and TNF receptor 2, and for IFN-gamma.

26 In cells, SPATA2 is recruited to the TNF receptor 1 signaling complex and is required for CYL

27 f hepatocytes involves the rapid shedding of TNF receptor 1 to limit TNFalpha signaling.

28 protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and

29 f tumor necrosis factor (TNF)-alpha, soluble TNF receptor 1, interferon (IFN)-gamma, IFN-inducible pr

30 Rather, TWEAK induced TNFalpha secretion and TNF receptor 1-dependent assembly of a death-signaling c

31 however, the anti-Fn14s showed no effect on TNF receptor 1-induced cell death and P4A8 even blocked

32 s attenuated by loss or inhibition of TNF or TNF receptor 1.

33 omplexes by mediating RIP1 dissociation from TNF receptor 1.

34 th in the intestinal epithelium was mediated TNF receptor 1.

35 Of the examined markers, only TNF receptors 1 and 2 (TNFR1 and TNFR2) associated with

36 Elevated plasma concentrations of TNF receptors 1 and 2 (TNFR1 and TNFR2) predict developm

37 sed knockout mice to investigate the role of TNF receptors 1 and 2 (TNFR1 and TNFR2), CD44, or alpha2

38 of tumor necrosis factor alpha (TNF-alpha), TNF receptors 1 and 2, active caspase 8, active caspase

39 , tumor necrosis factor (TNF) alpha, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6

40 We have identified tumor necrosis factor (TNF) receptor 1 (TNFR1) as a critical modifier of TrkA a

41 MYD88 deficiency or tumour-necrosis factor (TNF) receptor 1 deficiency, demonstrating the importance

42 rosis factor (TNF)-alpha (p = .010), soluble TNF receptor-1 (sTNFR1; p < .001), and IL-1 receptor ant

43 tion obtained with baseline levels of plasma TNF receptor-1 (TNFR-1), TNFR-2, and kidney injury molec

44 led to increased cell surface expression of TNF receptor-1 (TNFR1) and sensitized NSCLC cells to cyt

45 -40), or inflammation (such as MCP-1, suPAR, TNF receptor-1 [TNFR-1], and TNFR-2) may identify childr

46 o determine whether genetic variation in the TNF receptor-1 gene (TNFR1) contributes to aging-related

47 Studies in mice deficient in TNF-alpha, TNF receptor-1, or TNF receptor-2 revealed that although

48 y etanercept, a soluble version of the human TNF receptor 2 (hTNFR2), is a well established strategy

49 ntrations of ICAM-1, E-selectin, and soluble TNF receptor 2 (sTNF-R2), a marker related to TNF-alpha,

50 as a transmembrane form tmTNF, signaling via TNF receptor 2 (TNFR2) and TNFR1, and a soluble form, so

51 Our study, using novel TNF receptor 2 (TNFR2) conditional KO mice with selectiv

52 s studies have established the importance of TNF receptor 2 (TNFR2) in the generation and/or activati

53 genes encoding tumor necrosis factor (TNF), TNF receptor 2 (TNFR2), and the signaling proteins stres

54 -9 after vaccination; peak levels of soluble TNF receptor 2 and monokine induced by IFN-gamma (MIG) o

55 in T cells are specifically mediated through TNF receptor 2 signaling.

56 e senescence involves an abrogation of tmTNF/TNF receptor 2 signaling.

57 receptors for TNF-alpha, TNF receptor 1 and TNF receptor 2, and for IFN-gamma.

58 -alpha (tmTNF-alpha) is the prime ligand for TNF receptor 2, which has been shown to mediate angiogen

59 PCSK9 (P = 0.001), TNF receptor-2 (P < 0.01), and IL-1 receptor antagonist

60 e deficient in TNF-alpha, TNF receptor-1, or TNF receptor-2 revealed that although TNF-alpha was not

61 Soluble tumor necrosis factor (TNF) receptor-2 (TNFR2) and interleukin-1 receptor antag

62 nflammatory pathways linked to Toll-like and TNF receptor activation and arachidonic acid metabolism

63 f target genes in response to Toll-like- and TNF-receptor activation.

64 r receptor families, including the TNF-alpha/TNF receptor and ErbB ligand/EGFR pathways.

65 f MyD88-independent receptors, including the TNF receptor and TLR3.

66 TNFalpha) by ADAM17, which in turn activates TNF receptors and canonical NF-kappaB signaling.

67 action by binding to Tumor Necrosis Factor (TNF) receptors and antagonizing TNFalpha.

68 We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RI

69 a inflammatory markers (IL-6, IL-10, soluble TNF-receptors, and C-reactive protein) in patients with

70 we show that monocytes deficient for TNF or TNF receptors are outcompeted by their wild-type counter

71 and MAPK signaling pathways mediated by the TNF receptor, as well as multiple pattern recognition re

72 chanistically, Pellino3 negatively regulated TNF receptor associated 6 (TRAF6)-mediated ubiquitinatio

73 The adaptor protein TNF receptor associated factor (TRAF) 3 is required for

74 NOPO is the Drosophila homolog of human TNF receptor associated factor (TRAF)-interacting protei

75 In this study, we show that TNF receptor associated factor 3 (TRAF3) plays a critica

76 We identify TNF receptor associated factor 4 (TRAF4) as a novel Drap

77 p62 interacts with TNF receptor associated factor 6 (TRAF6) and is required

78 A family of proteins called TNF receptor associated factors (TRAFs) plays key roles

79 (E2) Ubc13 for binding to the RING domain of TNF-receptor associated factor 2 (TRAF2), thereby inhibi

80 ownstream gene-TRAF4 (tumor necrosis factor [TNF] receptor associated-factor 4)-that functions in cel

81 TNF receptor-associated death domain (TRADD) is an essen

82 receptor-associated kinase (IRAK) 4, IRAK1, TNF receptor-associated factor (TRAF) 6, TGF-beta-activa

83 rm prolactin receptors (PRLR-S), constrained TNF receptor-associated factor (TRAF)-dependent innate i

84 n-canonical K63-linked polyubiquitination of TNF receptor-associated factor (TRAF)-family adapter pro

85 induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2) and intracellul

86 of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by s

87 Furthermore, we found that TNF receptor-associated factor 2 (TRAF2) recruitment is

88 we discovered that GAPDH interacts with the TNF receptor-associated factor 2 (TRAF2), a protein requ

89 aprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a r

90 e essential for GAPDH-mediated activation of TNF receptor-associated factor 2 ubiquitination.

91 IKK-beta, TNF receptor-associated factor 6, TNF receptor-associated factor 2, receptor-interacting p

92 PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TR

93 its additional signaling proteins, including TNF receptor-associated factor 3 (TRAF3) and TANK-bindin

94 Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator

95 vely regulated by the full-length isoform of TNF receptor-associated factor 3 (Traf3) as formation of

96 nonical NF-kappaB2 pathway and its component TNF receptor-associated factor 3 (TRAF3) by the VDRA par

97 The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical r

98 The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signa

99 athway signaling by promoting degradation of TNF receptor-associated factor 3 (Traf3), a potent inhib

100 d the effect of selective deletion in TEC of TNF receptor-associated factor 3 (TRAF3), an inhibitor o

101 volves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this s

102 inhibiting Lys(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3).

103 yubiquitylation of its target protein TRAF3 (TNF receptor-associated factor 3).

104 l analyses revealed that DAB2 interacts with TNF receptor-associated factor 6 (TRAF6) and attenuates

105 r set, we identified the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) as a SOD1 inter

106 NKL-induced NF-kappaB activation and delayed TNF receptor-associated factor 6 (TRAF6) deubiquitinatio

107 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

108 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

109 TNF receptor-associated factor 6 (TRAF6) is identified a

110 TNF receptor-associated factor 6 (TRAF6), a verified tar

111 This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

112 Upon LPS challenge, CREBH interacts with TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

113 ptor (TIR) adaptor Myd88 adaptor-like (Mal), TNF receptor-associated factor 6 (TRAF6), and IkappaB ki

114 urthermore, NOSTRIN interacted directly with TNF receptor-associated factor 6 (TRAF6), leading to the

115 1 receptor-associated protein kinase (IRAK), TNF receptor-associated factor 6 (TRAF6), phosphatidylin

116 rectly interacting with the TRAF-C domain of TNF receptor-associated factor 6 (TRAF6), resulting in i

117 thin a recently identified binding motif for TNF receptor-associated factor 6 (TRAF6).

118 se 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).

119 1 receptor-associated kinase 1 (IRAK-1), and TNF receptor-associated factor 6 (TRAF6).

120 -1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF6).

121 Lys-34 and required the E3 ubiquitin ligase TNF receptor-associated factor 6 after stimulation of ce

122 ys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activate

123 ase) and subsequently integrates with TRAF6 (TNF receptor-associated factor 6) and/or c-fos signaling

124 ukin-1 receptor-associated kinase)1/4-TRAF6 (TNF receptor-associated factor 6), leading to integrin a

125 e system of IKK complex activation by TRAF6 (TNF receptor-associated factor 6), we show that these pe

126 AK1, TAB1 (TAK1 binding protein), and TRAF6 (TNF receptor-associated factor 6).

127 otein interactions with IKK-alpha, IKK-beta, TNF receptor-associated factor 6, TNF receptor-associate

128 isolated NASPs act either via or upstream of TNF receptor-associated factor 6.

129 Here we identified mutations in TRAF3IP1 (TNF Receptor-Associated Factor Interacting Protein 1) in

130 paB activation pathways, including the TRAF (TNF receptor-associated factor) proteins, IKK, NF-kappaB

131 induces IDO and involves the recruitment of TNF receptor-associated factor-3 to the Toll-like recept

132 , the most recently identified member of the TNF receptor-associated factors (TRAFs) family of protei

133 lecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced

134 arious autoinflammatory disorders, including TNF receptor-associated periodic syndrome (TRAPS).

135 ver syndromes (familial Mediterranean fever, TNF receptor-associated periodic syndrome, and hyperimmu

136 its role in signal transduction as TRAF and TNF receptor-associated protein (TTRAP) and ETS1-associa

137 TRAP1 (TNF receptor-associated protein), a member of the HSP90

138 kappaB p100, which acts as an inhibitor, and TNF receptor-associated receptor 3 (TRAF3); however, a r

139 paB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that

140 in and failed to bind tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3), a TBK1 comple

141 es demonstrated that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a key ro

142 estigated the role of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor pr

143 d kinase (IRAK-1) and tumor-necrosis factor (TNF) receptor-associated factor 6 (TRAF6), which are kno

144 uous degradation by a tumor necrosis factor (TNF) receptor-associated factor-3 (TRAF3)-dependent E3 u

145 TNF-receptor-associated factor 2 (TRAF2), an E3 ubiquiti

146 Furthermore, recruitment of the TNF-receptor-associated factor TRAF6 and activation of t

147 New knock in animal models for TNF-receptor-associated periodic syndrome, and familial

148 APRIL binds two different TNF receptors, B cell maturation antigen (BCMA) and tran

149 ut rather, indirectly via IL-1 receptors and TNF receptors being expressed on glial cells in superfic

150 taining structures colocalize with activated TNF receptors but not with activated IL-1 receptors.

151 lation, PACRG was recruited to the activated TNF receptor complex and interacted with LUBAC component

152 vation of ATF-2 by separately inhibiting the TNF receptor complex and JNK pathway through a negative

153 While most studies focus on its role in the TNF-receptor complex, we here identify a novel component

154 However, blocking both Fas and TNF receptor death pathways inhibited their apoptosis an

155 tions of anti-TNF Abs, or interbreeding with TNF receptor-deficient mice.

156 ave proposed an alternate model in which the TNF-receptor dimer-sitting at the vertices of a large su

157 f a TB granuloma formation that includes TNF/TNF receptor dynamics to elucidate these mechanisms.

158 TNF antibody adalimumab, but not the soluble TNF receptor etanercept, paradoxically promoted the inte

159 Glucocorticoid-induced TNF receptor expression was evaluated in cytokine-treate

160 The tumor TNF receptor family member 4-1BB (CD137) is encoded by T

161 We report that the TNF receptor family member CD137 (TNFRSF9) is expressed

162 dy, we investigated the possibility that the TNF receptor family member CD27 is present on leukemia s

163 ed in patients with progressing disease, the TNF receptor family member CD30/TNFRSF8 was confirmed in

164 and TIE2, the glycoprotein TROP2, the small TNF receptor family member FN14, and the G protein-coupl

165 utely required for costimulation through the TNF receptor family member OX40 (also known as CD134).

166 We identified FN14 (TNFRSF12A), a TNF receptor family member, as a factor that promotes pr

167 y with the costimulatory pathways induced by TNF receptor family members (i.e., CD27, OX40, and 4-1BB

168 tream of NF-kappaB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-beta r

169 t NF-kappaB activation downstream of several TNF receptor family members mediates lymphoid organ deve

170 Tregs express several costimulatory TNF receptor family members that activate non-canonical

171 of T cell checkpoints, agonists of selected TNF receptor family members, and inhibitors of undesirab

172 CD40, a member of the TNF receptor family, is expressed on all mature B cells

173 Glucocorticoid-induced TNF receptor family-related protein (GITR) regulates the

174 The tumor necrosis factor (TNF) receptor family member CD40 plays an essential role

175 ing to treatment with etanercept, a modified TNF receptor-Fc fusion protein.

176 2 results in the release of pro-TNFalpha and TNF receptors from the cell surface, and pharmacological

177 ed mice administered with a TNF-neutralizing TNF receptor fusion molecule preserved their structure,

178 -TNF Abs (e.g., infliximab) as compared with TNF receptor fusion protein (etanercept).

179 ated by activation of glucocorticoid-induced TNF receptor (GITR) (expressed at high levels by these c

180 on gene 3 [LAG3], and glucocorticoid-induced TNF receptor [GITR]) were assessed at the mRNA level.

181 x protein P3 [FOXP3], glucocorticoid-induced TNF receptor [GITR], lymphocyte activation gene 3 [LAG3]

182 Loss of ADAM17, TNF and the TNF receptor Grindelwald in pigmented glial cells of the

183 ble TNF, recombinant methionyl human soluble TNF receptor I (p55-TNFRI), or adalimumab.

184 ptor interacting protein kinase (RIPK1) from TNF receptor I (TNFR1) to form a caspase-8 activating co

185 ncentrations of tumor necrosis factor (TNF), TNF receptors I and II (TNF-RI and TNF-RII), interleukin

186 TNF-receptor I (TNFRI) mutant mice were protected from i

187 but not osteoproliferation, was dependent on TNF-receptor I and mediated by stromal tmTNF overexpress

188 , PKCepsilon facilitates the assembly of the TNF receptor-I signaling complex to trigger NF-kappaB ac

189 also essential for NF-kappaB activation via TNF receptor, IL-1 receptor and toll-like receptor 4.

190 ion-promoting signals requires Myd88 but not TNF receptor, implicating host innate immune pathways bu

191 experiments and genetic ablation of IL-1 and TNF receptor in vivo.

192 Little is known about specific TNF receptors in regulating TNF-induced RBR in bone marr

193 factor (TNF) necessary for signaling via the TNF receptors in stromal cells.

194 Herein, we investigate the roles of TNF and TNF receptors in the control of Mycobacterium bovis baci

195 was observed only for tumor necrosis factor (TNF) receptors in the metabolic cluster (geometric mean

196 concentrations is restricted by noise at the TNF receptor level, whereas discernibility of high TNF c

197 uria is strongly associated with circulating TNF receptor levels but not TNFalpha levels (free or tot

198 The TNF receptor-ligand superfamilies (TNFRSF/TNFSF) are cen

199 ILC subsets expressed TNF receptor ligands, which limited sebocyte growth by r

200 d with futile inhibition of AP-1 and SP-1 in TNF receptor muted cells.

201 i-albumin Nb to generate Nb Alb-70-96 named "TNF Receptor-One Silencer" (TROS).

202 ranslational NFkappaB nuclear import, muting TNF receptor, overexpression, and physiological inductio

203 lammatory effects of TNF are mediated by the TNF receptor p55 (p55TNFR) (encoded by the Tnfrsf1a gene

204 Interestingly, using mice deficient in both TNF receptors p55 and p75, chimeric animals and anti-TNF

205 hway shows significant similarities with the TNF receptor pathway.

206 tenin signalling for the control of PD-1 and TNF receptor proteins.

207 This process involves activation of type-1 TNF receptors, recruitment of Src family kinases (SFK) a

208 lucocorticoid-induced tumor necrosis factor (TNF) receptor related gene (GITR), a member of TNF recep

209 Glucocorticoid-induced TNF receptor-related protein ligand (GITRL), a ligand fo

210 hermore inhibition of glucocorticoid-induced TNF-receptor-related and Ebi3 partially reverted in vitr

211 -member 18 (TNFRSF18, glucocorticoid-induced TNF-receptor-related) and EBV-induced-3 (EBI3, an IL-35

212 hts of defects in subcellular trafficking of TNF receptors, reported in various TNFRSF-associated dis

213 t LPS-induced iNOS expression leads to rapid TNF receptor shedding from the surface of hepatocytes vi

214 t showed that genetic inhibition of TNFalpha/TNF receptor signal transduction down-regulates beta amy

215 The TNF receptors signaled through interferon regulatory fac

216 naling and tumor necrosis factor-alpha (TNF)/TNF receptor signaling are known to contribute to these

217 ur results demonstrate that globally ablated TNF receptor signaling exacerbates pathogenesis and argu

218 eneralized to enable the inhibition of other TNF receptor signaling mechanisms that are associated in

219 h domain (TRADD) is an essential mediator of TNF receptor signaling, and serves as an adaptor to recr

220 directly on RIP1 and promote necroptosis in TNF receptor signaling, as the gene conferring the trait

221 r of NF-kappaB during Toll-like receptor and TNF receptor signaling.

222 he autoinflammatory disorder associated with TNF receptor signaling.

223 Dysregulation of tumor necrosis factor (TNF) receptor signaling is a key feature of various infl

224 hat by enabling linear ubiquitination in the TNF receptor signalling complex, SHARPIN interferes with

225 assembly complex, recruited to the CD40 and TNF receptor signalling complexes together with its othe

226 regulated through the production of soluble TNF receptors (sTNFRI and sTNFRII).

227 Our results indicate that TNF receptor subtype 1 but not 2 plays a critical role i

228 Here, we report that TNF receptor subtypes (TNFR1 and TNFR2) differentially m

229 The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of

230 focused on RANKL/OPG signalling, the TNF and TNF receptor superfamilies and the NF-kB pathway.

231 Members of the TNF receptor superfamily (TNFRSF) are key costimulators

232 4-1BB (CD137) is a TNF receptor superfamily (TNFRSF) member that is thought

233 rfamily (TNFSF) interact with members of the TNF receptor superfamily (TNFRSF).

234 Members of the TNF receptor superfamily activate diverse cellular funct

235 ully colonize in the brain, we reasoned that TNF receptor superfamily member 10A/10B apoptosis-induci

236 lial cells, led to upregulated expression of TNF receptor superfamily member 12a, also known as fibro

237 Heterozygous C104R or A181E TNF receptor superfamily member 13b (TNFRSF13B) mutation

238 TNF receptor superfamily member 14 (TNFRSF14, also calle

239 WT) mice with a deficiency in genes encoding TNF receptor superfamily member 1a (TNFR1; TNFR1 knockou

240 member 1a (TNFR1; TNFR1 knockout [KO] mice), TNF receptor superfamily member 1b (TNFR2; TNFR2 KO mice

241 he IFN-gamma-activated, nonapoptotic form of TNF receptor superfamily member 6 (Fas) in BMMSCs to a c

242 Also, TNF receptor superfamily member 6 (FAS) protein was over

243 ciated with variability in expression of the TNF receptor superfamily member 8 ( TNFRSF8) gene/locus

244 Signaling of the TNF receptor superfamily member CD27 activates costimula

245 e, we show that FGFR-1 can interact with the TNF receptor superfamily member fibroblast growth factor

246 The TNF receptor superfamily member OX40 (CD134) is a cell s

247 ng reading frame UL144 is an ortholog of the TNF receptor superfamily member, herpesvirus entry media

248 is factor receptor II (TNFRII) is one of the TNF receptor superfamily members and our recent patholog

249 response to signals mediated by a subset of TNF receptor superfamily members, NIK becomes stabilized

250 Similar to other TNF receptor superfamily members, we found that TWEAK in

251 units of DR5 and the structurally homologous TNF receptor superfamily members.

252 luding the negative co-receptor PD-1 and the TNF receptor superfamily proteins GITR and OX40.

253 n of FGF-inducible 14 (Fn14, a member of the TNF receptor superfamily) gene.

254 F) receptor related gene (GITR), a member of TNF receptor superfamily, by agonist antibodies or natur

255 e Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial d

256 Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendri

257 rus entry mediator (HVEM), a molecule of the TNF receptor superfamily, promoted HIF-1alpha activity i

258 y mediator (HVEM; TNFRSF14), a member of the TNF receptor superfamily, provides key signals for MPEC

259 Alike other members of the TNF receptor superfamily, TRAIL receptors contain a pre-

260 xpress members of the tumor-necrosis factor (TNF) receptor superfamily (TNFRSF), but the role of thos

261 Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in im

262 as the importance of tumour necrosis factor (TNF) receptor superfamily members in thymus medulla deve

263 vel markers from the tumour necrosis factor (TNF) receptor superfamily were also identified.

264 DR3), a member of the tumor necrosis factor (TNF) receptor superfamily, is up-regulated in human tubu

265 5 (DR5), a member of tumour necrosis factor (TNF)-receptor superfamily, as a substrate of RNF183.

266 The TNF-receptor superfamily member CD30 is expressed on nor

267 other structurally homologous members of the TNF-receptor superfamily, relies on ligand-stabilized tr

268 Expression of TNF-receptor-superfamily-member 18 (TNFRSF18, glucocorti

269 pe was attenuated by genetic ablation of the TNF receptor TNF-R1 in NEMO(Deltahepa)/p21(-/-) mice, de

270 /W-sh) mice engrafted with TNF-alpha(-/-) or TNF receptor (TNF-R)(-/-) MCs, we found that TNF-alpha a

271 For further analysis, antibodies to TNF receptor (TNFR) 1 or 2 were applied, or CSD was moni

272 Selective inhibition of TNF receptor (TNFR) 1 signaling holds the potential to g

273 Individual TNF receptor (TNFR) signaling in RBR was evaluated in BM

274 nal cell necroptosis, processes that involve TNF receptor (TNFR) signaling.

275 esponses, and costimulatory molecules in the TNF receptor (TNFR) superfamily are viewed as a major so

276 Agonistic anti-TNF receptor (TNFR) superfamily member antibodies are a

277 LMP1 functionally mimics TNF receptor (TNFR) superfamily member CD40, but LMP1 si

278 ligation of death receptors, a subset of the TNF receptor (TNFR) superfamily.

279 f TRIM28 strikingly suppressed expression of TNF receptor (TNFR)-1 and -2, decreased TNF-alpha-induce

280 s undertaken to investigate the influence of TNF receptor (TNFR)-costimulated lymphocytes on collagen

281 d revealed the antithetic effects of the two TNF receptors (TNFR) in the central nervous system, wher

282 ons of members of the tumor-necrosis factor (TNF) receptor (TNFR)-associated factor (TRAF) family in

283 itical regulators of tumour necrosis factor (TNF) receptor (TNFR)-mediated signalling.

284 ensitivity was associated with expression of TNF receptor TNFR1 and was abrogated by interfering with

285 Our results shown that activation of TNF receptor (TNFR1)-NFkappaB pathway known to suppress

286 r caused by missense mutations in the type 1 TNF receptor (TNFR1).

287 mice that are genetically deficient for the TNF receptor TNFR2.

288 tumor necrosis factor-alpha (TNF-alpha) and TNF receptors (TNFRs) from the cell surface.

289 host immune system is to encode homologs of TNF receptors (TNFRs) that block TNF-alpha function.

290 ockout mice that were also deficient in both TNF receptors ("triple knockout" mice) to remove the sec

291 VHD by Tregs was fully abolished by blocking TNF receptor type 2 (TNFR2) or by using TNF-deficient do

292 Long-term global inhibition of TNF receptor type I (TNF-RI) and TNF-RII signaling witho

293 Genetic abrogation of TNF receptor type I (TNFRI) in Tak1DeltaHEP mice reduced

294 nduced lupus nephritis and treated mice with TNF receptor type II (TNFRII) Ig after TNFalpha expressi

295 It was reported that TNF receptor type II signaling, which has the capacity t

296 cytoprotective signaling downstream of both TNF receptors, via unclear mechanisms.

297 Tnfrsf1a, or Tnfrsf1b (Tnfrsf1a and b encode TNF receptors) were injected with TNF or saline (control

298 rting enzyme (TACE) results in an unattached TNF receptor, which participates in the scavenging of sT

299 alysis show that, upon the engagement of the TNF receptor with TNF-alpha on ECs, CD31 becomes activat

300 Because APRIL shares binding of the TNF receptors with B cell activation factor, separating

301 sy was uncontrolled in the absence of TNF or TNF receptors with exacerbated inflammatory response, im