ライフサイエンスコーパス: TNF receptor-associated factor

1 ivation, and increased polyubiquitination of TNF receptor-associated factors.

2 TNF receptor-associated factor 1 (TRAF1) is a unique TRA

3 One of these proteins, TNF receptor-associated factor 1 (TRAF1), is highly regu

4 AITR associates with TRAF1 (TNF receptor-associated factor 1), TRAF2, and TRAF3, and

5 osome-linked IAP, Bcl-2, Bcl-x(L), Bfl-1/A1, TNF receptor-associated factor 1, and cellular Fas-assoc

6 The tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1) is a member of

7 bitor of apoptosis protein (c-IAP1), c-IAP2, TNF receptor-associated factor-1 (TRAF-1), TRAF-2, B-cel

8 romosome-linked IAP (XIAP), Bcl-2, Bfl-1/A1, TNF receptor-associated factor-1 (TRAF1), and Fas-associ

9 or necrosis factor (TNF) family members, and TNF receptor-associated factor-1 (TRAF1).

10 s (SAPKs, Jun NH2-terminal kinases) requires TNF receptor associated factor 2 (TRAF2).

11 B-inducing kinase-IKK was interrupted at the TNF receptor associated factor 2 and NF-kappa B-inducing

12 eptor 1-TNF receptor associated death domain-TNF receptor associated factor 2 NF-kappa B-inducing kin

13 The E3 ubiquitin ligase TRAF2 (TNF receptor associated factor 2) provides a critical si

14 , TNF receptor 2 (TNF-R2) interacts with the TNF receptor associated factors 2/1 (TRAF2/TRAF1) hetero

15 ding of CD154 (gp39, CD40L) to CD40 recruits TNF receptor- associated factor 2 (TRAF2) and TRAF3 to t

16 am of receptor-interacting protein (RIP) and TNF receptor- associated factor 2.

17 induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2) and intracellul

18 B and JNK activity associated with increased TNF receptor-associated factor 2 (TRAF2) and NF-kappaB e

19 We examined the contributions of TNF receptor-associated factor 2 (TRAF2) and TRAF3 to CD

20 The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential e

21 of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by s

22 TNF receptor-associated factor 2 (TRAF2) is a signal-tra

23 In addition, we also demonstrated that the TNF receptor-associated factor 2 (TRAF2) plays little ro

24 Furthermore, we found that TNF receptor-associated factor 2 (TRAF2) recruitment is

25 Both CD40 and CD120b bind TNF receptor-associated factor 2 (TRAF2) upon ligand sti

26 TNF receptor-associated factor 2 (TRAF2) was identified

27 we discovered that GAPDH interacts with the TNF receptor-associated factor 2 (TRAF2), a protein requ

28 and CD160 engagement induced recruitment of TNF receptor-associated factor 2 (TRAF2), but not TRAF3,

29 ptosis signal-regulating kinase 1 (ASK1) and TNF receptor-associated factor 2 (TRAF2), regulation of

30 aling by TRANCE-R appears to be dependent on TNF receptor-associated factor 2 (TRAF2), since JNK indu

31 aprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a r

32 wn to be important for CD40 association with TNF receptor-associated factor 2 (TRAF2), TRAF3, and TRA

33 One gene in particular, TNF receptor-associated factor 2 (TRAF2)-inhibiting prot

34 s and c-Jun NH(2)-terminal kinases) requires TNF receptor-associated factor 2 (TRAF2).

35 d to the TNF receptor 1 (TNF-R1) complex via TNF receptor-associated factor 2 (TRAF2).

36 K) is the recruitment to the TNF receptor of TNF receptor-associated factor 2 (TRAF2).

37 c-jun N-terminal kinase (JNK/SAPK) requires TNF receptor-associated factor 2 (TRAF2).

38 cells, along with the selective reduction of TNF receptor-associated factor 2 and impairment in the a

39 e/IkappaBalpha kinase was interrupted at the TNF receptor-associated factor 2 and NF-kappaB-inducing

40 Overexpression of a dominant negative TNF receptor-associated factor 2 construct, lacking the

41 d IL-6, and the cytoplasmic adaptor molecule TNF receptor-associated factor 2 is involved in both R-8

42 Tumor necrosis factor alpha (TNF-alpha) and TNF receptor-associated factor 2 protein were moderately

43 40 ligation, and inhibits the recruitment of TNF receptor-associated factor 2 to the CD40.

44 e essential for GAPDH-mediated activation of TNF receptor-associated factor 2 ubiquitination.

45 Cbl-b associates with TNF receptor-associated factor 2 upon CD40 ligation, and

46 at beta-arrestin-1 is associated with TRAF2 (TNF receptor-associated factor 2), an adaptor protein of

47 osis protein 1, Bcl-2, Bcl-xL, survivin, and TNF receptor-associated factor 2), proliferation (cyclin

48 F-alpha induced the ubiquitination of TRAF2 (TNF receptor-associated factor 2), which interacts with

49 ter gene expression activated by TNF, TNFR1, TNF receptor-associated factor 2, and NF-kappaB-inducing

50 eptor, TNF receptor-associated death domain, TNF receptor-associated factor 2, NF-kappa B-inducing ki

51 e activated by receptor-interacting protein, TNF receptor-associated factor 2, NF-kappaB-inducing kin

52 IKK-beta, TNF receptor-associated factor 6, TNF receptor-associated factor 2, receptor-interacting p

53 ulin were related to increased expression of TNF receptor-associated factor 2, the product of an NF-k

54 These data suggest that TNFR1, through a TNF receptor-associated factor 2-NF-kappaB signaling pat

55 rs or dominant-negative forms of p38 MAPK or TNF receptor-associated factor 2.

56 level of cIAP1 and, in some cases, cIAP2 and TNF receptor-associated factor 2.

57 eptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kappaB-inducing kina

58 cytoplasmic domain of CD40, while binding of TNF receptor-associated factors 2 and 3 is dispensable,

59 microscopy revealed that JAB1 interacts with TNF receptor-associated-factor 2 (TRAF2).

60 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and receptor-i

61 Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key compo

62 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key media

63 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an adaptor

64 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an intracel

65 ere, we identify that tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) knockdown (KD)

66 molecules, including tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2).

67 h the adapter protein tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2).

68 paB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that

69 (E2) Ubc13 for binding to the RING domain of TNF-receptor associated factor 2 (TRAF2), thereby inhibi

70 TNF-receptor-associated factor 2 (TRAF2), an E3 ubiquiti

71 RADD (TNF receptor-associated death domain), TNF receptor-associated factor-2 (TRAF-2), the Ser/Thr k

72 ptor proteins, including the docking protein TNF receptor-associated factor-2 (TRAF-2), which is beli

73 The subcellular localization of the TNF receptor-associated factor-2 (TRAF2) adaptor protein

74 In particular, Bcl-2, TNF receptor-associated factor-2 (TRAF2), and TRAF4 were

75 Because hCG also blocked TNF receptor-associated factor-2 and NF-kappaB-inducing

76 both knockdowns reduce expression of TRAF2 (TNF receptor-associated factor-2) protein, and small int

77 IP (receptor-interacting protein), or TRAF2 (TNF receptor-associated factor-2) were caused by apoptog

78 hibitor of apoptosis-1), cIAP-2, and TRAF-2 (TNF receptor-associated factor-2)) in an NF-kappaB-depen

79 tor 1, TNF receptor-associated death domain, TNF receptor-associated factor-2, NF-kappaB-inducing kin

80 tor 1, TNF receptor-associated death domain, TNF receptor-associated factor-2, NF-kappaB-inducing kin

81 by TNF receptor-associated death domain and TNF receptor-associated factor-2.

82 In this study, we show that TNF receptor associated factor 3 (TRAF3) plays a critica

83 alterations of key regulators of NF-kappaB, TNF receptor associated factor 3 (TRAF3), and cylindroma

84 as used to explore the in vivo expression of TNF receptor-associated factor 3 (TRAF-3), a putative si

85 PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TR

86 its additional signaling proteins, including TNF receptor-associated factor 3 (TRAF3) and TANK-bindin

87 D88 as a prototypical adaptor, we identified TNF receptor-associated factor 3 (TRAF3) as a new compon

88 Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator

89 vely regulated by the full-length isoform of TNF receptor-associated factor 3 (Traf3) as formation of

90 nonical NF-kappaB2 pathway and its component TNF receptor-associated factor 3 (TRAF3) by the VDRA par

91 The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical r

92 TNF receptor-associated factor 3 (TRAF3) is a signaling

93 The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signa

94 athway signaling by promoting degradation of TNF receptor-associated factor 3 (Traf3), a potent inhib

95 , but not RANKL, increased OCP expression of TNF receptor-associated factor 3 (TRAF3), an adapter pro

96 d the effect of selective deletion in TEC of TNF receptor-associated factor 3 (TRAF3), an inhibitor o

97 volves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this s

98 elated bone loss by promoting degradation of TNF receptor-associated factor 3 (TRAF3), levels of whic

99 inhibiting Lys(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3).

100 ine kinase RICK, which was then able to bind TNF receptor-associated factor 3 (TRAF3).

101 yubiquitylation of its target protein TRAF3 (TNF receptor-associated factor 3).

102 Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) regulates both

103 onstrate that loss of tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) results in con

104 in and failed to bind tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3), a TBK1 comple

105 uniparental disomy in tumor necrosis factor (TNF) receptor-associated factor 3 and TNFalpha-induced p

106 LTbetaR, not HveA, recruits TNF receptor-associated factor-3 (TRAF3), and LIGHT-indu

107 induces IDO and involves the recruitment of TNF receptor-associated factor-3 to the Toll-like recept

108 uous degradation by a tumor necrosis factor (TNF) receptor-associated factor-3 (TRAF3)-dependent E3 u

109 We identify TNF receptor associated factor 4 (TRAF4) as a novel Drap

110 TNF receptor-associated factor 4 (TRAF4) upregulation wa

111 f p47(phox) and recovered the orphan adapter TNF receptor-associated factor 4 (TRAF4).

112 ownstream gene-TRAF4 (tumor necrosis factor [TNF] receptor associated-factor 4)-that functions in cel

113 Here, we identify tumor necrosis factor (TNF)-receptor-associated factor-4 (TRAF4) as a new targe

114 The cytoplasmic signaling protein TNF receptor-associated factor 5 (TRAF5) has been implic

115 is inhibited by dominant negative mutants of TNF receptor-associated factor 5 (TRAF5), TRAF6, NF-kapp

116 p62 interacts with TNF receptor associated factor 6 (TRAF6) and is required

117 found to activate NF-kappaB in concert with TNF receptor associated factor 6 (TRAF6), we propose tha

118 l analyses revealed that DAB2 interacts with TNF receptor-associated factor 6 (TRAF6) and attenuates

119 r set, we identified the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) as a SOD1 inter

120 TNF receptor-associated factor 6 (TRAF6) associates with

121 NKL-induced NF-kappaB activation and delayed TNF receptor-associated factor 6 (TRAF6) deubiquitinatio

122 completely understood, but ubiquitination of TNF receptor-associated factor 6 (TRAF6) has recently be

123 autoantigenic sperm protein (sNASP) binds to TNF receptor-associated factor 6 (TRAF6) in the resting

124 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

125 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

126 TNF receptor-associated factor 6 (TRAF6) is identified a

127 , NDPK-D was required for the recruitment of TNF receptor-associated factor 6 (TRAF6) to mitochondria

128 TNF receptor-associated factor 6 (TRAF6), a verified tar

129 Upon LPS challenge, CREBH interacts with TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

130 This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

131 ptor (TIR) adaptor Myd88 adaptor-like (Mal), TNF receptor-associated factor 6 (TRAF6), and IkappaB ki

132 This activation requires TNF receptor-associated factor 6 (TRAF6), and U(L)37 con

133 urthermore, NOSTRIN interacted directly with TNF receptor-associated factor 6 (TRAF6), leading to the

134 1 receptor-associated protein kinase (IRAK), TNF receptor-associated factor 6 (TRAF6), phosphatidylin

135 rectly interacting with the TRAF-C domain of TNF receptor-associated factor 6 (TRAF6), resulting in i

136 thin a recently identified binding motif for TNF receptor-associated factor 6 (TRAF6).

137 se 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).

138 1 receptor-associated kinase 1 (IRAK-1), and TNF receptor-associated factor 6 (TRAF6).

139 -1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF6).

140 Lys-34 and required the E3 ubiquitin ligase TNF receptor-associated factor 6 after stimulation of ce

141 se-pair with sequences in the 3' UTRs of the TNF receptor-associated factor 6 and IL-1 receptor-assoc

142 ys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activate

143 nd prevents the dissociation of, IRAK-IRAK-4-TNF receptor-associated factor 6 from the TLR signaling

144 ion of IL-1 receptor-associated kinase 1 and TNF receptor-associated factor 6 protein levels.

145 ependent upon binding of the adapter protein TNF receptor-associated factor 6 to the cytoplasmic doma

146 ase) and subsequently integrates with TRAF6 (TNF receptor-associated factor 6) and/or c-fos signaling

147 ukin-1 receptor-associated kinase)1/4-TRAF6 (TNF receptor-associated factor 6), leading to integrin a

148 d expression of the signal transducer TRAF6 (TNF receptor-associated factor 6), leading us to conside

149 e system of IKK complex activation by TRAF6 (TNF receptor-associated factor 6), we show that these pe

150 AK1, TAB1 (TAK1 binding protein), and TRAF6 (TNF receptor-associated factor 6).

151 involving MyD88, IL-1R-associated kinase 1, TNF receptor-associated factor 6, and IkappaB kinase and

152 ts of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing

153 otein interactions with IKK-alpha, IKK-beta, TNF receptor-associated factor 6, TNF receptor-associate

154 leukin (IL)-1 receptor-associated kinase and TNF receptor-associated factor 6, two key adaptor/scaffo

155 luding MyD88, IL-1R-associated kinase 4, and TNF receptor-associated factor 6, while it inhibited the

156 terleukin-1 receptor-activated kinase-1, and TNF receptor-associated factor 6.

157 isolated NASPs act either via or upstream of TNF receptor-associated factor 6.

158 t signaling by disrupting the recruitment of TNF receptor-associated factor 6/c-Src complex to lipid

159 s of NF-kB signaling, tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and transformi

160 the molecular adaptor tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) exhibit a spec

161 Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key media

162 Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TR

163 es demonstrated that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a key ro

164 estigated the role of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor pr

165 Here we show that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor pr

166 d kinase (IRAK-1) and tumor-necrosis factor (TNF) receptor-associated factor 6 (TRAF6), which are kno

167 We also found that tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), which mediate

168 asomal degradation of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6).

169 a complex with Nedd4l and another E3 ligase, TNF-receptor associated factor 6 (Traf6).

170 luding IL-1 receptor-associated kinase 4 and TNF-receptor associated factor 6.

171 he CINC promoter by IL-17 in IEC-6 cells was TNF receptor-associated factor-6 (TRAF6), but not TRAF2,

172 r gene activity was 16-fold higher following TNF receptor-associated factor-6 transfection after IL-1

173 ly interacts with IL-1R-associated kinase-1, TNF receptor-associated factor-6, TGF-beta-activated kin

174 cells, is dependent upon a MyD88-dependent, TNF receptor-associated factor-6-independent signaling p

175 l survival by hindering interactions between TNF-receptor-associated factors, blocking their negative

176 We have identified a Drosophila TNF-receptor-associated factor, DTRAF1, by screening for

177 te that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in

178 Here we identified mutations in TRAF3IP1 (TNF Receptor-Associated Factor Interacting Protein 1) in

179 mary gland identified tumor necrosis factor (TNF) receptor-associated factor-interacting protein (TRI

180 eptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinas

181 paB activation pathways, including the TRAF (TNF receptor-associated factor) proteins, IKK, NF-kappaB

182 The adaptor protein TNF receptor associated factor (TRAF) 3 is required for

183 NOPO is the Drosophila homolog of human TNF receptor associated factor (TRAF)-interacting protei

184 aling (SOCS) 3, B-cell CLL/lymphoma (BCL) 3, TNF receptor-associated factor (TRAF) 1, and TNFAIP3-int

185 ation and proteasome-mediated degradation of TNF receptor-associated factor (TRAF) 2 and TRAF6, which

186 of c-IAP1 is blocked upon coexpression with TNF receptor-associated factor (TRAF) 2, and this is ach

187 receptor-associated kinase (IRAK) 4, IRAK1, TNF receptor-associated factor (TRAF) 6, TGF-beta-activa

188 TRAF1/2 and cIAP1/2 are members of the TNF receptor-associated factor (TRAF) and the inhibitor

189 The TNF receptor-associated factor (TRAF) family of molecule

190 In this report we identify the TNF receptor-associated factor (TRAF) family of signal t

191 act directly with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate

192 Through their interaction with the TNF receptor-associated factor (TRAF) family, members of

193 ng association with adaptor molecules of the TNF receptor-associated factor (TRAF) family.

194 TNF receptor-associated factor (TRAF) proteins associate

195 is: inhibitor of apoptosis(IAP)-1 and X-IAP, TNF receptor-associated factor (TRAF)-2, and factors OX4

196 rm prolactin receptors (PRLR-S), constrained TNF receptor-associated factor (TRAF)-dependent innate i

197 sponsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter pro

198 n-canonical K63-linked polyubiquitination of TNF receptor-associated factor (TRAF)-family adapter pro

199 HVEM activates NF-kappaB and AP-1 through a TNF receptor-associated factor (TRAF)-mediated mechanism

200 antiapoptotic factors Bcl-xL, A1/Bfl-1, and TNF receptor-associated factor (TRAF)1, all of which are

201 xpressing in B lymphocytes either Bcl-2 or a TNF receptor-associated factor (TRAF)2 mutant lacking th

202 receptor-associated death domain (TRADD), DN-TNF receptor-associated factor (TRAF)2, DN-receptor-inte

203 ein caused a shift in CD40 signaling through TNF receptor-associated factors (TRAF), including the TR

204 ransformation, binds tumour necrosis factor (TNF) receptor associated factor (TRAF) 1 and TRAF3 and t

205 e that IHPK2 binds to tumor necrosis factor (TNF) receptor-associated factor (TRAF) 2 and interferes

206 Tumor necrosis factor (TNF) receptor-associated factor (TRAF) 2 is an intracell

207 g by deubiquitinating tumor necrosis factor (TNF) receptor-associated factor (TRAF) 2, TRAF6, and NEM

208 ction is initiated by tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins,

209 Intracellular tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins,

210 nd is a member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family of putativ

211 A member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family was identi

212 Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associat

213 -kappaB, and binds to tumor necrosis factor (TNF)-receptor-associated factor (TRAF) proteins, but the

214 s on the ubiquitin-conjugating enzyme Ubc13, TNF receptor-associated factor TRAF2, the protein kinase

215 Furthermore, recruitment of the TNF-receptor-associated factor TRAF6 and activation of t

216 A family of proteins called TNF receptor associated factors (TRAFs) plays key roles

217 gnal transducers for TNFRs are the family of TNF receptor associated factors (TRAFs).

218 JNK) pathways through their interaction with TNF receptor-associated factors (TRAFs) and NF-kappaB-in

219 F) family receptor in its ability to recruit TNF receptor-associated factors (TRAFs) and TNF receptor

220 TNF receptor-associated factors (TRAFs) are recruited to

221 , the most recently identified member of the TNF receptor-associated factors (TRAFs) family of protei

222 mily members, including CD40, is mediated by TNF receptor-associated factors (TRAFs) that interact wi

223 its ligand initiates signaling by recruiting TNF receptor-associated factors (TRAFs) to the CD40 cyto

224 are believed to be mediated in part through TNF receptor-associated factors (TRAFs), a family of cyt

225 lecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced

226 The CD30 cytoplasmic tail interacts with TNF receptor-associated factors (TRAFs), which have been

227 d to be delivered through mediators known as TNF receptor-associated factors (TRAFs).

228 Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are critical si

229 Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are cytoplasmic

230 Intracellular tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are key element

231 Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are mediators o

232 in part, by engaging tumor necrosis factor (TNF) receptor-associated factors (TRAFs), which also med

233 Tumour necrosis factor (TNF)-receptor-associated factors (TRAFs) form a family o

234 membrane to the nucleus through cytoplasmic TNF-receptor-associated factors (TRAFs).

235 these bacteria resulted in the activation of TNF receptor associated factors, two recently described