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1 an adapter TNF receptor-associated factor 4 (TRAF4).
2 F5, and TRAF6, but not with TRAF2, TRAF3, or TRAF4.
3  which is associated with Rac1 activation by TRAF4.
4 f p47(phox) and the conserved TRAF domain of TRAF4.
5 sociate and binds to human TRAF1, TRAF2, and TRAF4.
6 t contribute to anti-HER2 resistance, making TRAF4 a viable target for treating HER2 + breast cancer.
7               Furthermore, overexpression of TRAF4 abrogated the ability of dimerization to prevent t
8                          An active mutant of TRAF4 activated the NADPH oxidase downstream of the Rho
9 KK4 binds the TRAF domain of TRAF4 and MEKK4/TRAF4 activation of JNK is inhibited by expression of th
10                                              TRAF4 also inhibited the NF-kappaB response, whereas TRA
11 er basic signaling cassettes at the level of TRAF4 and an NAD(P)H oxidase.
12  and Axin each bind and activate MEKK4, with TRAF4 and Axin binding to the kinase domain and GADD45 b
13 we show that similar to the interaction with TRAF4 and Axin, the kinase domain of MEKK4 interacts wit
14 es in NOD2 are required for interaction with TRAF4 and inhibition of NOD2 signaling because mutation
15 pathways in the embryo; however, the role of TRAF4 and its association with MAP3K4 in the placenta is
16 tructural basis for the atypical function of TRAF4 and its atypical role in NOD2 signaling.
17                Here, we show that endogenous TRAF4 and MEKK4 associate in both human K562 cells and m
18 urther demonstrated by the colocalization of TRAF4 and MEKK4 in cells.
19  activate JNK independently, coexpression of TRAF4 and MEKK4 results in synergistic activation of JNK
20               MEKK4 binds the TRAF domain of TRAF4 and MEKK4/TRAF4 activation of JNK is inhibited by
21                                              TRAF4 and misshapen (MSN) act downstream of Draper to ac
22 sisting of Smurf1-mediated ubiquitination of TRAF4 and Rac1 activation.
23               Mechanistically, we found that TRAF4 and TRAF6 used the same TRAF binding sites on Act1
24 RAF4 in TS cells and highlight these MAP3K4, TRAF4, and HDAC6 associations during placental developme
25 , we examine the relationships among MAP3K4, TRAF4, and HDAC6 in the developing placenta, finding a p
26 -associated protein complex containing HER2, TRAF4, and SMURF2 has been observed.
27                 The interaction of MEKK4 and TRAF4 are further demonstrated by the colocalization of
28 pression, breast cancer cells overexpressing TRAF4 are more resistant to stress-induced death.
29                           We have identified TRAF4 as a p53-regulated gene in a microarray screen usi
30        Our results uncover new functions for TRAF4 as a Smurf1-regulated mediator of BMP and Nodal si
31 llowed by bioinformatic screening identified TRAF4 as a substrate for IKKalpha.
32 s factor (TNF)-receptor-associated factor-4 (TRAF4) as a new target of Smurf1, which polyubiquitylate
33 ecrosis factor receptor-associated factor 4 (TRAF4) as a novel direct target of miR-29s and revealed
34 e identify TNF receptor associated factor 4 (TRAF4) as a novel Draper binding partner that is require
35 ctor-associated factor (TRAF) family member, TRAF4, as a key negative regulator of NOD2 signaling.
36 ecrosis factor receptor-associated factor 4 (TRAF4) at K190.
37                              However, unlike TRAF4, Axin, and GADD45, GSK3beta inhibits MEKK4 activit
38 se mutation of these residues abrogated both TRAF4 binding and inhibition of NOD2.
39                   Additionally, it defines a TRAF4 binding motif within NOD2 involved in termination
40 ecrosis factor receptor-associated factor 4 (TRAF4) binds MAP3K4 and promotes MAP3K4 activation of do
41 xpression of the p47(phox) binding domain of TRAF4 blocked endothelial cell JNK activation by TNFalph
42 mechanism, we showed that the TRAF domain of TRAF4 bound to the N-terminal TRAF-like region of the de
43  levels, indicating endogenous regulation of TRAF4 by Smurf1.
44 addition, a fusion between p47(phox) and the TRAF4 C terminus constitutively activated JNK, and this
45  defined CD40-responsive genes cIAP2, TRAF1, TRAF4/CART and DR3 were unaffected.
46 icroenvironment and described a novel miR-29-TRAF4-CD40 signaling axis modulated by BCR activity.
47  found that IL-25 responses were impaired in Traf4 (-/-) cells.
48                                              TRAF4-deficient mice are born with a constricted upper t
49                           Primary cells from TRAF4-deficient mice displayed markedly enhanced IL-17-a
50     To address this issue, we have generated TRAF4-deficient mice.
51  MOG35-55 specific wild-type Th17 cells into TRAF4-deficient recipient mice induced an earlier onset
52                                              TRAF4 directly associated with the focal contact scaffol
53                            Overexpression of TRAF4 enhances IGF1-induced IGFR-IRS-1 interaction, IRS-
54  complex with TRAF4 in TS cells and promotes TRAF4 expression in the absence of HDAC6 deacetylase act
55             We demonstrate that, like HDAC6, TRAF4 expression is increased in MAP3K4 kinase-inactive
56                                              TRAF4 expression is positively correlated with SRC-3 exp
57 ing embryo, as well as in the adult, lack of TRAF4 expression results in a localized, developmental d
58                                              TRAF4, GADD45, and Axin each bind and activate MEKK4, wi
59                  Moreover, downregulation of TRAF4 has decreased the AKT/mTOR signaling.
60                        Importantly, although TRAF4 has little or no ability to activate JNK independe
61     In contrast to its other family members, TRAF4 has not been shown to bind to a member of the tumo
62                                              TRAF4 has previously been shown to activate JNK through
63 of a normal immune system, the importance of TRAF4 has remained unclear.
64                       Knockdown of embryonic TRAF4 impairs signaling, neural crest development and ne
65                        Therefore the role of TRAF4 in a signaling pathway has not yet been establishe
66 udy reveal the necessity of a unique role of TRAF4 in restricting the effects of IL-17 signaling and
67             Despite widespread expression of TRAF4 in the developing embryo, as well as in the adult,
68 chanisms of MAP3K4 and HDAC6 coregulation of TRAF4 in TS cells and highlight these MAP3K4, TRAF4, and
69 ound that HDAC6 forms a protein complex with TRAF4 in TS cells and promotes TRAF4 expression in the a
70                Coexpression of p47(phox) and TRAF4 increased oxidant production and JNK activation, w
71 on of olfactory receptor gene transcription, TRAF4 increases intracellular cAMP levels and boosts E2F
72         Interestingly, the overexpression of TRAF4 induces apoptosis and suppresses colony formation.
73                                              TRAF4 inhibits NOD2-induced NF-kappaB activation and dir
74                                       Active TRAF4 initiated robust membrane ruffling through Rac1, P
75                                 Furthermore, TRAF4 interacted with dimeric p75(NTR), whereas TRAF2 in
76 dary screen of endothelial cell proteins for TRAF4-interacting partners yielded a number of proteins
77                                              TRAF4 interacts with the kinase domain of MEKK4.
78                                              TRAF4 is a member the TRAF family of adaptor proteins th
79                               Like IKKalpha, TRAF4 is atypical within its family because it is the on
80 lacenta single-cell RNA-Seq data showed that Traf4 is coexpressed with Map3k4 in trophoblast stem (TS
81                         We further show that TRAF4 is essential for the migration of both normal mamm
82                                              TRAF4 is highly expressed in CRPCs and promotes CRPC dev
83                                              TRAF4 is one of six identified members of the family of
84                  These data demonstrate that TRAF4 is required to regulate the anastomosis of the upp
85                                              TRAF4 is specifically regulated by p53 in response to te
86 ignaling during Trastuzumab treatment, while TRAF4 knockdown reduced HER2 stability and improved Tras
87 t target of miR-29s and revealed that higher TRAF4 levels increase CLL responsiveness to CD40 activat
88 interfering RNA knockdown of Smurf1 elevates TRAF4 levels, indicating endogenous regulation of TRAF4
89                                 In addition, TRAF4, like p47(phox), was recovered largely in the cyto
90                                              TRAF4 localizes to the cytoplasm and appears to remain i
91  correlation that the orphan adaptor protein TRAF4 may play a role in p53-mediated proapoptotic signa
92                                         This TRAF4-mediated inhibition of HAUSP then led to the loss
93 underlying molecular mechanism for SRC-3 and TRAF4-mediated resistance to cytotoxic agents.
94                Here we provide evidence that TRAF4-mediated ubiquitination of IRS-1 is physiologicall
95                       Administering IL-25 to Traf4 (-/-) mice resulted in blunted airway eosinophilia
96                  In the frog Xenopus laevis, TRAF4 mRNA is stored maternally in the egg animal pole,
97      TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic d
98                           Here we identified TRAF4 overexpression as one of the putative mechanisms f
99 rest development and neural folding, whereas TRAF4 overexpression boosts signaling and expands the ne
100 ast cancers and further found that SRC-3 and TRAF4 overexpression diminished cytotoxic stress-induced
101 h this cellular function, we also found that TRAF4 overexpression in breast cancer patients was assoc
102                              TRAF2-p75(NTR), TRAF4-p75(NTR), and TRAF6-p75(NTR) interactions modulate
103 usceptibility protein, NOD2, is required for TRAF4 phosphorylation and subsequent inhibition of NOD2
104 ion of AR mediated by an E3 ubiquitin ligase TRAF4 plays an important role in this process.
105 leukin, or Toll-like receptors, we find that TRAF4 potentiates BMP and Nodal signaling.
106                                   The murine TRAF4 promoter contains a functional p53 DNA-binding sit
107 ough site-directed mutagenesis we found that TRAF4 promotes an atypical K29-linked ubiquitination at
108 dac6 shRNA knockdown in TS(KI) cells reduces TRAF4 protein expression.
109                             Mechanistically, TRAF4 recruited the E3-ligase SMURF2, to degrade the IL-
110                             Mechanistically, TRAF4 regulates HER2 level through its impact on SMAD sp
111 identify MEKK4 as the MAPK kinase kinase for TRAF4 regulation of the JNK pathway.
112  HER2 signaling regulation that involves the TRAF4-SMURF2 complex, a possible mechanism that might co
113                    This study indicates that TRAF4-SMURF2-mediated DAZAP2 degradation is a crucial in
114                        Our data suggest that TRAF4 specifies a molecular address within focal complex
115 ated it leading to HER2 degradation, whereas TRAF4 stabilized HER2 by degrading SMURF2 and inhibiting
116                                 Furthermore, TRAF4 stimulates MEKK4 kinase activity by promoting MEKK
117  resides within an exaggerated beta-bulge in TRAF4 that is not present in the other TRAF proteins, an
118                               The ability of TRAF4 to promote cell migration is also dependent on Smu
119 ation is required for proper localization of TRAF4 to tight junctions in confluent epithelial cells.
120 ew target of Smurf1, which polyubiquitylates TRAF4 to trigger its proteasomal destruction.
121 d TRAF family proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, and TRAF6), whereas the TD of SPOP interac
122 to TRAF2 and TRAF3, direct binding of TRAF1, TRAF4, TRAF5, or TRAF6 to CD40 was not detected.
123 roach, we identified a SRC-3 downstream gene-TRAF4 (tumor necrosis factor [TNF] receptor associated-f
124  expression via MYC, allowing for concurrent TRAF4 upregulation and stronger CD40-NF-kB signaling.
125            TNF receptor-associated factor 4 (TRAF4) upregulation was discovered to be associated with
126 ential substrate for the E3 ubiquitin ligase TRAF4 using an unbiased screen.
127               Notably, IL-25R recruitment of TRAF4 was required for the ACT1/IL-25R interaction.
128  IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.
129 ssion of proapoptotic proteins caspase-9 and TRAF4 was seen in endothelial cells and smooth muscle ce
130                    Using the K190R mutant of TRAF4, we demonstrate that Smurf1-induced ubiquitination
131 NF receptor-associated factor-2 (TRAF2), and TRAF4 were clearly inducible via CD40 in B cells but not
132 se adaptor p47(phox) and its binding partner TRAF4 were sequestered within nascent, focal complexlike
133  as the proapoptotic molecules caspase-3 and TRAF4, which are downregulated during development, and t
134 the coexpression of Traf4 with Map3k4 versus Traf4 with Hdac6 during differentiation of the placental
135 iously unknown switch in the coexpression of Traf4 with Map3k4 versus Traf4 with Hdac6 during differe
136 g sites on Act1, allowing the competition of TRAF4 with TRAF6 for the interaction with Act1.

 
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