ライフサイエンスコーパス: TRPA1 channel

1 otentials, and is therefore intrinsic to the TRPA1 channel.

2 mpound para-benzoquinone (pBQN) on the human TRPA1 channel.

3 e both activation and desensitization of the TRPA1 channel.

4 pase C, and the transient receptor potential TRPA1 channel.

5 influences intrinsic characteristics of the TRPA1 channel.

6 ntracellular acidification, which could gate TRPA1 channels.

7 rough the selective and direct activation of TRPA1 channels.

8 salicylic acid may be useful in the study of TRPA1 channels.

9 roduce both potentiation and inactivation of TRPA1 channels.

10 l inhibition and siRNA-mediated knockdown of TRPA1 channels.

11 he trafficking and signalling machineries to TRPA1 channels.

12 the transient receptor potential ankyrin 1 (TRPA1) channel.

13 pain responses following application of the TRPA1 channel activator mustard oil.CONCLUSIONOur study

14 Mechanistically, O(2) suppresses TRPA1 channel activity by protein internalization via O(

15 ermined whether block or genetic deletion of TRPA1 channels affected LTP of Schaffer collateral to CA

16 vates TRPC channels other than the TRPV1 and TRPA1 channels already known to be targets in rat and mo

17 influx in cells expressing cloned or native TRPA1 channels, and these responses were attenuated by a

18 alcium responses were blocked by a selective TRPA1 channel antagonist, HC-030031.

19 ximately 6 mum and are almost abolished by a TRPA1 channel antagonist.

20 TRPA1 channels are a member of the transient receptor po

21 Mammalian TRPA1 channels are activated by chemically reactive irri

22 TRPA1 channels are activated by endogenous products of o

23 Transcripts of noxious stimulus-detecting TrpA1 channels are alternatively spliced.

24 TRPA1 channels are expressed in nociceptive neurons, whe

25 Thus, TRPA1 channels are proposed to mediate transduction in b

26 TRPA1 channels are required for neuronal excitation, the

27 anscriptional profiling approach to identify TRPA1 channels as infrared receptors on sensory nerve fi

28 These data establish endothelial cell TRPA1 channels as neuronal activity sensors that initiat

29 s restricted to mammalian (rodent and human) TRPA1 channels, as the drosophila and zebrafish TRPA1 or

30 ONE (10-100 microm) was mediated entirely by TRPA1 channels, based on the absence of responses in C-f

31 y disruption of the endothelium and when the TRPA1 channel blocker HC-030031 was present in the arter

32 in HEK293 cells stably overexpressing human TRPA1 channels, but not in regular HEK293 cells.

33 biosensors, our data indicate that astrocyte TRPA1 channels contribute to basal Ca(2+) levels and are

34 te resting Ca(2+) concentrations mediated by TRPA1 channels decreased interneuron inhibitory synapse

35 We conclude that TRPA1 channels do not drive autonomic thermoregulatory r

36 e have shown that 9-OA-NO(2) activates human TRPA1 channels (EC(50), 1 microM), whereas oleic acid ha

37 conclude that Ca(2+) influx via endothelial TRPA1 channels elicits vasodilation of cerebral arteries

38 Furthermore, URB597 activated TRPA1 channels endogenously expressed in a population of

39 suggest that IL-1B-induced Ca(2+) entry via TRPA1 channels engenders MAPK-dependent mesangial cell p

40 sufficient to mediate responses to CO(2) as TRPA1 channels expressed in HEK-293 cells, but not TRPV1

41 that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to

42 ght into how calcium and CaM tightly control TRPA1 channel function to promote nociceptive signaling.

43 The transient receptor potential ankyrin 1 (TRPA1) channel functions as an irritant sensor and is a

44 mediated by transient receptor potential A1 (TRPA1) channels gave rise to frequent and highly localiz

45 dent transient receptor potential ankyrin-1 (TRPA1) channel has been hypothesized to serve as a tempe

46 TRPA1 channels have been implicated in mechanical and co

47 nd reproducible repeated activation of snake TRPA1 channels heterologously expressed in non-neuronal

48 in mice and pharmacological blockade of the TRPA1 channel in rats.

49 t NGF increases functional activities of the TRPA1 channel in trigeminal ganglion neurons.

50 A new study shows that trafficking of TRPA1 channels in and out of the cell membrane in brains

51 We hypothesized that TRPA1 channels in capillary endothelial cells are stimul

52 scores the evolutionarily conserved role for TRPA1 channels in chemical avoidance.

53 Consistent with this mechanism, TRPA1 channels in excised patches were activated in a do

54 To further clarify the functions of TRPA1 channels in vertebrates, we analyzed their roles i

55 Second, TRPA1 channels inactivate in hyperpolarized cells but re

56 NA or TRPA1-deficient mice, we show that the TRPA1 channel is a sole target through which WIN and mus

57 In particular, TRPA1 channel is involved in nociception and in sensory

58 s region is involved in binding or gating of TRPA1 channels is discussed.

59 The transient receptor potential ankyrin 1 (TRPA1) channel is a Ca(2+)-permeable cation channel whos

60 The transient receptor potential A1 (TRPA1) channel is an evolutionarily conserved detector o

61 ansient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved in many forms

62 The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain.

63 The transient receptor potential A1 (TRPA1) channel is the molecular target for environmental

64 yte-neuron interactions by demonstrating how TRPA1 channel-mediated fluxes contribute to astrocyte ba

65 ere, we explored a recently discovered novel TRPA1 channel-mediated transmembrane Ca(2+) flux pathway

66 ntinocifensive actions via activation of the TRPA1 channel on sensory neurons.

67 olutionary convergent strategies that target TRPA1 channels on sensory nerve endings to achieve chemi

68 Because TRPV1 and TRPA1 channels play important roles in controlling hyper

69 The TRPA1 channel plays a key role in the processing of noxi

70 tly limiting their utilities in the study of TRPA1 channel properties and biological functions.

71 TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic

72 ndent inhibition of heterologously expressed TRPA1 channels, resulting from a reduction of single-cha

73 Analysis of chimeric Drosophila and mouse TRPA1 channels reveal a critical role for the fifth tran

74 del whereby AnxA2 limits the availability of TRPA1 channels to regulate nociceptive signaling in vert

75 TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 tr

76 herbivores, likely through the activation of TRPA1 channels via (E)-2-alkenal compounds.

77 the functional expression of ATP receptors, TRPA1 channels, voltage-gated calcium-, potassium-, and

78 By comparing human and rattlesnake TRPA1 channels, we have identified two portable heat-sen

79 TRPA1 channels were found to be present in native endoth

80 TRPA1 channels were strongly activated by hypochlorite a

81 reover, allicin and DADS activate the cloned TRPA1 channel when expressed in heterologous systems.

82 Most rat cold thermosensors expressed TRPA1 channels, whereas mouse cold thermosensors did not

83 ivate heterologously expressed human and rat TRPA1 channels, whereas two other FAAH inhibitors (i.e.,

84 mperatures (19-24 degrees C) depended on the TRPA1 channel, which functioned downstream of a phosphol

85 sponse was at approximately 25 degrees C via TRPA1 channel, which is expressed in the AC neurons.

86 additional sensory roles for the Drosophila TRPA1 channel, which was known to function in thermosens

87 lar and behavioral responses depended on the TRPA1 channel, whose activity responded to the rate of t

88 ctivation and deactivation of the vertebrate TRPA1 channel with violet and green light, respectively.

89 Thus, reversible coupling of the TRPA1 channels with O(2)-dependent protein translocation