ライフサイエンスコーパス: TSH receptor

1 G(s) and G(q) compete for activation by the TSH receptor.

2 ated a series of LHR mutants and chimeric LH-TSH receptors.

3 ies against the thyroid-stimulating hormone (TSH) receptor.

4 along with the thyroid-stimulating hormone (TSH) receptor and adenylyl cyclase isotypes differing wi

5 lso occur in the extracellular domain of the TSH receptor, and support a model in which the extracell

6 icularly thyroid peroxidase and thyrotropin (TSH) receptor] and of high affinity monoclonal antibodie

7 AM, and porin could be abolished by K1-70, a TSH-receptor antagonist, suggesting a TSH receptor-media

8 firmed the increased affinity of stimulating TSH receptor antibodies for the shed A subunit rather th

9 ermined by clinical assessment, detection of TSH-receptor antibodies and, if necessary, radionuclide

10 ccording to the currently most reliable anti-TSH receptor antibody-ELISA used to diagnose Graves dise

11 1, 2013, from a thyroid-stimulating hormone (TSH)-receptor antibody (TRAb) test register in south Wal

12 roxine and free-triiodothyronine levels, and TSH-receptor autoantibodies in patients with GD.

13 and activation to the hTSH chimera, whereas TSH receptor binding and activation were abolished.

14 ment of the seat-belt was more important for TSH receptor binding and signal transduction than the Cy

15 hCG chimera that bound to and activated the TSH receptor but not the CG/lutropin (LH) receptor.

16 ractionation chromatography, activated human TSH receptors, but not LH and FSH receptors, and showed

17 se of human FSH/thyroid-stimulating hormone (TSH) receptor chimeras suggested a novel mechanism for r

18 ch shares equal identity to the FSH, LH, and TSH receptors from mammals.

19 TSH/cAMP-induced negative regulation of the TSH receptor gene in thyrocytes, suppression of MHC clas

20 Direct sequencing of the TSH receptor gene revealed a mutation in one allele resu

21 vating somatic mutations in the thyrotropin (TSH) receptor have been identified as a cause of hyperfu

22 To examine thyrotropin (TSH) receptor homophilic interactions we fused the human

23 r homophilic interactions we fused the human TSH receptor (hTSHR) carboxyl terminus to green fluoresc

24 d FSH receptors, and showed high affinity to TSH receptors in a radioligand receptor assay.

25 -70, a TSH-receptor antagonist, suggesting a TSH receptor-mediated action.

26 the fetal pars tuberalis (PT) and consequent TSH receptor-mediated effects on tanycytes lining the 3(

27 Fluorescent TSH receptors on the plasma membrane were functional as

28 The thyroid-stimulating hormone (TSH) receptor signals via G(s) to produce cAMP and via G

29 n in the anterior pituitary known to express TSH receptors suggested a paracrine mechanism.

30 of the physiological roles of extra-thyroid TSH receptor systems and the structural-functional basis

31 viously reported that the human thyrotropin (TSH) receptor tagged with green fluorescent protein (TSH

32 54-alpha(s) was co-expressed with either the TSH receptor that activates both alpha(s) and alpha(q) o

33 ssociated with mutations in the thyrotropin (TSH) receptor, the cause of thyroid agenesis is unknown.

34 internalization in thyroid cells, endogenous TSH receptors traffic retrogradely to the trans-Golgi ne

35 The gene for the TSH receptor (TSH-R) was expressed in intestinal T cells

36 ghput screening to identify a small-molecule TSH receptor (TSHR) agonist that was modified to produce

37 been associated with activating mutations in TSH receptor (TSHR) and G(s)alpha encoding genes.

38 eam of thyroid-stimulating hormone (TSH) and TSH receptor (TSHR) and is indispensable for TSH/TSHR-me

39 TSH receptor (TSHR) engagement stimulates the production

40 teoclastic bone resorption, mediated via the TSH receptor (TSHR) found on osteoblast and osteoclast p

41 stem, the expression and distribution of the TSH receptor (TSHr) has been studied by immunoprecipitat

42 ch requires TSH binding to both sites of the TSH receptor (TSHR) homodimer, and TSH-stimulated IP1 pr

43 g affinity (negative cooperativity) requires TSH receptor (TSHR) homodimerization, the latter involvi

44 tested whether persistent cAMP signaling by TSH receptor (TSHR) is dependent on internalization.

45 Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein alpha subunit (GNA

46 ed cAMP production involving coupling of the TSH receptor (TSHR) to Gs at low TSH doses and to G(i/o)

47 responsive BM cells defined by expression of TSH receptor (TSHR) using flow cytometry were selectivel

48 Thyrotropin (TSH) activation of the TSH receptor (TSHR), a 7-transmembrane-spanning receptor

49 (GPCR)The receptor for TSH receptor (TSHR), a G protein coupled receptor (GPCR)

50 the constitutively active ligand-independent TSH receptor (TSHR).

51 Thyrotropin (TSH) receptor (TSHR) A and B subunits are formed by intr

52 o gain insight into the thyrotropin hormone (TSH) receptor (TSHR) cleavage, we sought to convert the

53 The thyrotropin (TSH) receptor (TSHR) is a member of the heterotrimeric G

54 The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four

55 ent bind to the thyroid stimulating hormone (TSH) receptor (TSHR) with high affinity, inhibit labelle

56 athogenic autoantibodies to the thyrotropin (TSH) receptor (TSHR), can be treated but not cured.

57 y acting on the thyroid-stimulating hormone (TSH) receptor (TSHR), TSH negatively regulates osteoclas

58 he thyrotropin [thyroid-stimulating hormone (TSH)] receptor (TSHR) is known to acutely and persistent

59 TSHR (TSH receptors) were confirmed in cardiomyocytes, and exp