ライフサイエンスコーパス: TSP

1 TSP was scored using haematoxylin-eosin stained slides.

2 TSP-1 blockade also prevents the PH in a second model, c

3 TSP-1 disruption abrogated age-associated capillary rare

4 TSP-1 disruption did not significantly affect weight gai

5 TSP-1 upregulation in the diabetic heart prevents chambe

6 TSP-1(-/-) AOM-treated mice had a reduced rate of neurol

7 TSP-1(-/-) mice administered AOM had reduced liver injur

8 TSP-1(-/-) mice treated with AOM had reduced TGFbeta1 si

9 TSP-2 gene and protein expression were significantly up-

10 TSP-2 knockdown induced anti-inflammatory M2 macrophage

11 TSPs are also critically important in the development an

12 TSPs mediate a range of processes at the surface of the

13 + transients, synaptogenic thrombospondin 1 (TSP-1) release, and synapse formation.

14 Basal muscle expression of thrombospondin 1 (TSP-1) was approximately 900% greater in 14d- and 28d-tr

15 (VEGF), but high levels of thrombospondin 1 (TSP-1), predicted liver dysfunction after resection.

16 he anti-angiogenic protein thrombospondin-1 (TSP-1 PM).

17 n reported to complex with thrombospondin-1 (TSP-1) in specialized structures termed supramolecular a

18 Thrombospondin-1 (TSP-1) is a glycoprotein considered as a key actor withi

19 Thrombospondin-1 (TSP-1) is a large extracellular matrix protein secreted

20 how TGF-beta activation by thrombospondin-1 (TSP-1) is both required and sufficient for the developme

21 Thrombospondin-1 (TSP-1) is one of the anti-angiogenic factors whose synth

22 creasing evidence suggests thrombospondin-1 (TSP-1), a potent proatherogenic matricellular protein, a

23 f a synaptogenic molecule, thrombospondin-1 (TSP-1), apart from supporting neuronal integrity.

24 ed pinpoint this factor as thrombospondin-1 (TSP-1).

25 t can activate TGFbeta1 is thrombospondin-1 (TSP-1).

26 the angiogenesis inhibitor thrombospondin-1 (TSP-1).

27 retinal space mediated by thrombospsondin-1 (TSP-1) activation of CD47.

28 anti-angiogenic peptides (thrombospondin-1, TSP-1; and endostatin) as well as pro-angiogenic factors

29 f intraluminal delivery of thrombospondin-2 (TSP-2) small interfering RNA (siRNA).

30 late (TSP)), P=0.014; high dose (247 mg/m(3) TSP), P=0.02) and significant tumor metastasis to variou

31 in endothelial cells (EC) thrombospondin-4 (TSP-4), a secreted extracellular matrix (ECM) protein, i

32 surface-exposed EC2 domain from Sm-TSP-2, a TSP from Schistosoma mansoni and one of the better prosp

33 Eighty healthy humans were tested with a TSP protocol and underwent structural and resting-state

34 s of hUTC-conditioned media was spared after TSP knockdown, indicating that hUTCs secrete additional

35 a demonstrate that NOL7 significantly alters TSP-1 expression and may be a master regulator that coor

36 As TSP-12 and TSP-14 are conserved in mammals, our findings suggest th

37 These findings indicate that TSP-12 and TSP-14 are required for the recycling of DAF-4/BMPRII.

38 Animals lacking both TSP-12 and TSP-14 exhibit reduced cell-surface levels of the BMP ty

39 ndings suggest that the mammalian TSP-12 and TSP-14 homologs may also function in regulating transmem

40 n patterns of endogenously tagged TSP-12 and TSP-14 proteins.

41 We found that TSP-12 and TSP-14 share overlapping expression patterns in multiple

42 panins in Caenorhabditis elegans, TSP-12 and TSP-14, function redundantly to promote bone morphogenet

43 odies confirmed localization of Ov-TSP-2 and TSP-3 to the adult fluke tegument.

44 Ov-TSP-2 and TSP-3 were detected in whole worm extracts and excretory

45 PM2.5 and TSP atmospheric SigmaOPE concentrations varied over an o

46 For PbA in PM2.5 and TSP, slopes were generally positive but not significant.

47 Stroke increases CD36 and TSP-1/2 mRNA levels in the ipsilateral hemisphere at acu

48 TSP-2 gene expression (3.1-fold) at 24 h and TSP-2 protein expression, cell proliferation, and collag

49 We identified pretransplant weight loss and TSP as strong independent predictors of relapse and deat

50 search consortium assay) and by PA, MAP, and TSP in the <10 mum fraction (inhalation-ingestion bioacc

51 Using Thbs4(-/-) mice and TSP-4 shRNA, we found that TSP-4 mediated pro-angiogenic

52 The T3R and TSP-C domains as well as wild-type Thbs4 and the calcium

53 protein, Nell2, which lacks only the T3R and TSP-C domains, did not cause these effects.

54 cytes, as were the type III repeat (T3R) and TSP-C domains, while the LamG domain localized to the Go

55 r to control levels, but both basal VEGF and TSP-1 were elevated (P < 0.05).

56 Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribut

57 As TSP-12 and TSP-14 are conserved in mammals, our findings

58 erefore, the aim of this study was to assess TSP-1 during acute liver failure and HE pathogenesis.

59 istration and examine the role of astrocytic TSP-alpha2delta-1 signaling in cocaine-induced silent sy

60 in the soluble fraction of Pb in atmospheric TSP were similar suggesting that TSP is an important sou

61 We proposed two frameworks, by averaging TSP scores or by combining P-values from individual stud

62 l basis for the physical interaction between TSP-1 and BMP-4.

63 ide a general model for interactions between TSPs, membranes, and other proteins.

64 Animals lacking both TSP-12 and TSP-14 exhibit reduced cell-surface levels of

65 identified three potential biomarkers CD163, TSP-1 and IL-1RII whose response to steroids was signifi

66 iated antiangiogenic pathway induced by CD36-TSP-1 interaction that inhibits VEGFR2 signaling and the

67 We hypothesized that CD36-TSP-1 interaction recruits Src homology 2 domain-contain

68 In the developing CNS, TSP-1 is involved in neuronal migration and adhesion, ne

69 the total suspended particle concentration (TSP) in the sampling area.

70 included vesicles and SMAPs which contained TSP-1, perforin, and granzyme B.

71 In contrast, TSP was negatively correlated with FC between individual

72 At D14 and D28, TSP-1 protein was not different compared to baseline lev

73 heart, we generated and characterized db/db TSP-1(-/-) (dbTSP) mice.

74 on the biochemical properties of the direct TSP/alpha(2)delta-1 interaction using an ELISA-style lig

75 crop critical temperature thresholds during TSP exist in real world cropping landscapes?

76 o the large extracellular loop (LEL) of each TSP were produced in recombinant form and antibodies wer

77 gous tetraspanins in Caenorhabditis elegans, TSP-12 and TSP-14, function redundantly to promote bone

78 Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were a

79 pronociceptive individuals have an enhanced TSP response compared with antinociceptive individuals,

80 riptional networks, suggesting that enhanced TSP-1 expression may help restore tissue homeostasis dur

81 udy indicates that individuals with enhanced TSP have facilitated ascending nociceptive processing an

82 Following Schistosoma exposure, TSP-1 levels in the lung increase, via recruitment of ci

83 nsitive periods (anthesis and grain-filling; TSP) of wheat crop development.

84 Finally, TSP-dependent H2S production was observed in yeast, worm

85 The four TSPs, TSP1-4, attach to the phage baseplate forming a br

86 ticle size distributions were generated from TSP samples only, while steroid analysis was conducted o

87 ted extracellular matrix (ECM) proteins from TSP family, which consists of five homologous members.

88 Furthermore, TSP was positively correlated with the extent of imbalan

89 ular pair-wise gene evaluation methods, e.g. TSP and TSG, are helpless for discovering pair-wise inte

90 Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechan

91 vely, pronociceptive subjects showed greater TSP responses.

92 ripheral mononuclear cells (PBMCs) in 14 HAM/TSP patients, 34 MS patients and 20 healthy controls (HC

93 al disability scores were measured in 18 HAM/TSP patients, 4 asymptomatic carriers (ACs) of HTLV-1, 1

94 In 2 HAM/TSP patients, spinal cord cross-sectional area was measu

95 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 relapsing-remitting MS [RRMS], 17 secondary prog

96 y exert therapeutic benefits for ATL and HAM/TSP patients.

97 a (ATL), an aggressive blood cancer, and HAM/TSP, a progressive neurological and inflammatory disease

98 Both HAM/TSP patients followed longitudinally showed thoracic thi

99 Definite HAM/TSP developed in 5 (1.47%) patients.

100 Of 414 subjects, 76 had definite HAM/TSP, 87 had possible or probable HAM/TSP, and 251 subjec

101 repertoire 'signature' could distinguish HAM/TSP patients from healthy controls, as well as from pati

102 patients who do not fulfill criteria for HAM/TSP present with neurological complaints related to sens

103 lls may be a viable treatment option for HAM/TSP.

104 tudinal analysis of TCR repertoires from HAM/TSP patients demonstrated a correlation of the TCR clona

105 ent of isolated PBMCs and CNS cells from HAM/TSP patients with an antibody that targets CCR4+ T cells

106 nal cord cross-sectional area (SCCSA) in HAM/TSP and MS patients to that of healthy volunteers (HVs).

107 rage spinal cord cross-sectional area in HAM/TSP and progressive MS show spinal cord atrophy.

108 ytokines, are prominently deregulated in HAM/TSP and underlie many of the characteristic immune abnor

109 cervical cord, most of the pathology in HAM/TSP is seen in the thoracolumbar cord, which in turn may

110 The entire spinal cord in HAM/TSP patients was thin compared to HVs, whereas only the

111 Despite higher TCR clonal expansions in HAM/TSP patients, no disease-specific TCRs were shared among

112 In HAM/TSP patients, SCCSA extensively correlated with Ambulati

113 We further hypothesize in HAM/TSP that is possible that neuroglial loss from a thoraci

114 the more extensive cord atrophy seen in HAM/TSP.

115 o T9 spinal cord cross-sectional area in HAM/TSP.

116 mmatory neurological disorders including HAM/TSP, associated with human T-cell lymphotropic virus typ

117 The incidence of HAM/TSP and new signs and neurologic symptoms were computed

118 uation of CSF and spinal cord lesions of HAM/TSP patients revealed the presence of abundant CD4+CCR4+

119 plays a key role in the pathogenesis of HAM/TSP.

120 myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma.

121 myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS).

122 myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS).

123 myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive inflammatory myelopathy occurring

124 myelopathy/tropical spastic paraparesis (HAM/TSP), observed in up to 5% of infected individuals.

125 myelopathy/tropical spastic paraparesis (HAM/TSP), or adult T cell leukemia/lymphoma (ATL).

126 myelopathy/tropical spastic paraparesis (HAM/TSP).

127 myelopathy/tropical spastic paraparesis (HAM/TSP).

128 ite HAM/TSP, 87 had possible or probable HAM/TSP, and 251 subjects had no neurologic manifestation an

129 thus a promising therapeutic approach to HAM/TSP with the potential of being more effective than sing

130 s showed atrophy in a pattern similar to HAM/TSP.

131 While HAM/TSP patients showed a higher clonal T-cell expansion com

132 perative alpha-granule release profile (high TSP-1/low VEGF) showed substantially worse postoperative

133 V. myrtillus berries showed much higher TSP, TMA, RSA and FRAP values than V. uliginosum subsp.

134 ecipitation confirmed that recombinant human TSP-1 can bind BMP-2 and -4 and antagonize their effects

135 1 in diabetic atherosclerosis, hyperglycemic TSP-1(-/-)/ApoE(-/-) double knockout mice were compared

136 has emerged over the past decade identifies TSPs as important mediators of cellular homeostasis, ass

137 Our data identify TSP-1 as a p53 target that contributes to maintaining Ra

138 e found large interindividual differences in TSP responses, which were positively correlated with fun

139 te (EHDPP; 610 +/- 220 pg m(-3)) measured in TSP samples were significantly higher than nighttime con

140 Changes in Pb isotope ratios in TSP depositions in these years indicate that leaded gaso

141 that the N-terminal 168 residues involved in TSPs complex assembly are disordered in the absence of p

142 for all machine learning methods, including TSP.

143 miR-18a was shown to increase TSP-1 and decrease VEGF by reducing PAI-1 (plasminogen a

144 AOM-treated mice had increased TSP-1 and TGFbeta1 mRNA and protein expression in the li

145 ied with inhibition of hyperglycemia-induced TSP-1 expression and reduced protein O-glycosylation fol

146 g-standing cardiovascular benefits, inhibits TSP-1 expression in glucose-stimulated human aortic smoo

147 Interestingly, TSP-1 counteracted the increased neuronal excitability a

148 p-Scoring Pair (TSP), k-Top-Scoring Pairs (k-TSP), Top-Scoring Triplet (TST) and Differential Rank Co

149 C57Bl/6 or TSP-1 knockout (TSP-1(-/-)) mice were injected with azoxymethane (AOM) t

150 Salmonella Anatum O-antigen via an e15-like TSP, DettilonTSP.

151 A P22-like TSP confers specificity for the Salmonella Typhimurium O

152 tients in the metabolic high-risk group (low TSP and weight loss) had an increased risk for relapse (

153 ascular endothelial growth factor) and lower TSP-1 (thrombospondin-1) levels than control BEC; and th

154 cytometry analysis revealed that, in males, TSP-1 knockout reduced macrophage infiltration and phago

155 als, our findings suggest that the mammalian TSP-12 and TSP-14 homologs may also function in regulati

156 hway from the sensory thalamus that mediates TSP.

157 t-like synoviocytes (FLSs) expressed minimal TSP-1 mRNA levels with high transcript levels of NR4A2,

158 therapeutic strategies designed to modulate TSP-1 synthesis in conditions that simulate tumor and pe

159 Moreover, TSP-1 inhibited the action of serum BMPs.

160 betic db/db mice exhibited marked myocardial TSP-1 upregulation in the interstitial and perivascular

161 at full-length pentameric TSP-4, but neither TSP-5/COMP of the pentamer-forming subgroup B nor TSP-2

162 how that in cultured rat spinal cord neurons TSP-1 decreased neuronal excitability by reducing the ac

163 /COMP of the pentamer-forming subgroup B nor TSP-2 of the trimer-forming subgroup A directly interact

164 le promoter:BvLz lines, compared to 0.07% of TSP (0.56 mg/kg) in single promoter:BvLz lines.

165 accumulation was further boosted to 11.5% of TSP (82.5 mg/kg) through event stacking by re-transformi

166 red rice codon usage comprises up to 7.8% of TSP in hypoxic transgenic seedlings.

167 eurologic decline, and molecular analyses of TSP-1 and TGFbeta1 signaling were performed.

168 Lastly, the plasma concentration of TSP-1 is significantly increased in subjects with sclero

169 consistent with evolutionary conservation of TSP-mediated H2S as a mediator of DR benefits with broad

170 The contribution of TSP-1 upregulation to the modulation of tumorigenesis in

171 In these mice, deletion of TSP-1 ameliorated loss in volume and mass of the moderat

172 ogical assessment indicated that deletion of TSP-1 reduced inflammatory cell infiltration of muscle f

173 expression levels and tissue distribution of TSP-1.

174 ort that the von Willebrand type C domain of TSP-1 is likely responsible for this BMP-2/4-binding act

175 lloproteinase-9, the downstream effectors of TSP-2.

176 The effects of TSP-1 on GlyRs were dependent on the activation of excit

177 We investigated the effects of TSP-1 on neurons with mature synapses using immunocytoch

178 ro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growt

179 provide new insights into the involvement of TSP-1 in the BMP-2/-4 mechanisms of action.

180 Lack of TSP-1 prevented lesion formation in hyperglycemic ApoE(-

181 First, we found that levels of TSP-1 are elevated in blood of non-ambulant dysferlinopa

182 LSs resulted in inverse expression levels of TSP-1 compared with NR4A2, IL-8, and VEGF.

183 T2 MRI parameters revealed that loss of TSP-1 modestly inhibited inflammation only in gluteal mu

184 Thus, modulation of TSP-1 expression is achieved through anti-tumor necrosis

185 that together make up the complex network of TSP-1 regulation both at the transcriptional and post-tr

186 In the presence of TSP-1, AMPARs were less stabilized at synapses, increasi

187 These results suggest a role of TSP-1 in controlling the balance between excitation and

188 To confirm a direct role of TSP-1 in diabetic atherosclerosis, hyperglycemic TSP-1(-

189 To study the role of TSP-1 in remodeling of the diabetic heart, we generated

190 (ApoE(-/-)) mice and elucidated the role of TSP-1 in this process.

191 al evidence that supports a specific role of TSP-4 among the TSPs in mediating the binding to neurona

192 ein, is not caused by decreased secretion of TSP-4, and is mediated by activation of SMAD3.

193 mRNAs, suggesting that the stabilization of TSP-1 may be part of a larger novel mechanism.

194 Cellular synthesis of TSP-1 is tightly regulated by different intermediate bio

195 umor growth, in part through upregulation of TSP-1.

196 Upregulation of TSP-4 does not require the synthesis of new protein, is

197 The identity and lineage potential of TSPs remains unclear.

198 ect of the phasing out of leaded gasoline on TSP and seawater Pb chemistry in the Northern GOA; the r

199 -beta) through a ligand, thrombospondin one (TSP-1).

200 C57Bl/6 or TSP-1 knockout (TSP-1(-/-)) mice were injected with azox

201 nd are deficient in either integrin beta8 or TSP-1, known activators of latent TGF-beta1.

202 Ov-TSP-2 and TSP-3 were detected in whole worm extracts and

203 elonging to the CD63 family (Ov-TSP-2 and Ov-TSP-3) that are abundantly expressed in the tegument pro

204 etraspanins belonging to the CD63 family (Ov-TSP-2 and Ov-TSP-3) that are abundantly expressed in the

205 Antibodies confirmed localization of Ov-TSP-2 and TSP-3 to the adult fluke tegument.

206 Temporal summation of pain (TSP), the perception of increasingly greater pain evoked

207 d stimuli [i.e., temporal summation of pain (TSP)] reflects attributes of their "pain connectome," na

208 The top scoring pair (TSP) algorithm is an example that applies a simple rank-

209 TSP, like its predecessor, Top Scoring Pair (TSP), is a parameter-free classifier relying only on ran

210 analysis and includes the Top-Scoring Pair (TSP), k-Top-Scoring Pairs (k-TSP), Top-Scoring Triplet (

211 er effect than the total suspended particle (TSP) content as a whole on the spatial-temporal variabil

212 0) measurements or total suspended particle (TSP) measurements.

213 d in samples of total suspended particulate (TSP) aerosols, seawater, and suspended and sinking parti

214 n (WSOC) in the total suspended particulate (TSP) load at a high elevation site in the Colorado Rocky

215 ter (PM2.5) and total suspended particulate (TSP) samples.

216 se (100 mg/m(3) total suspended particulate (TSP)), P=0.014; high dose (247 mg/m(3) TSP), P=0.02) and

217 Total suspended particulates (TSP), PM10, and PM2.5 were collected for particle size a

218 expression of the transsulfuration pathway (TSP) enzyme cystathionine gamma-lyase (CGL), resulting i

219 demonstrate that, through this new pathway, TSP-1 is responsible for the remote AC-mediated recovery

220 Three size fractions of particle-bound PbA (TSP, PM10, and PM2.5) data with different averaging time

221 one of the following: polyethylenimine (PEI)+TSP-2 siRNA, saline, PEI only, or PEI+control siRNA.

222 Treatment with PEI+TSP-2 siRNA significantly suppressed TSP-2 gene expressi

223 Our data reveal that full-length pentameric TSP-4, but neither TSP-5/COMP of the pentamer-forming su

224 nd its relation to tumour-stroma-percentage (TSP) and expression of HIF1A and VEGFA.

225 ing a critical temperature sensitive period (TSP) determines sexual fate of the individual rather tha

226 The concentration of total soluble phenols (TSP), tannins (TT) and flavonoids (TF) were determined.

227 ium phosphate (MAP), triple super phosphate (TSP), and bone meal biochar] and hematite were applied a

228 Total soluble polyphenols (TSP), total monomeric anthocyanins (TMA), radical scaven

229 Hamiltonian of a traveling salesman problem (TSP).

230 ter the entry of thymus-seeding progenitors (TSPs).

231 ically relevant thymus settling progenitors (TSPs).

232 ng with serum levels of total serum protein (TSP), albumin, C-reactive protein, and leptin were colle

233 ation reached 1.4% of total soluble protein (TSP) (10.0 mg BvLz/kg culm mass) in stacked multiple pro

234 lds are up to 1.8% of total soluble protein (TSP) in transformed rice cells.

235 this work, we studied the tailspike protein (TSP) of the bacteriophage Sf6.

236 ctors as the thrombospondin family proteins (TSPs), TSP1, TSP2, and TSP4.

237 that highly specialized tailspike proteins (TSPs) are necessary to attach the particle to LPS.

238 20 encodes four distinct tailspike proteins (TSPs).

239 of O-antigen composition and the recognizing TSP.

240 Ectopic NR4A2 expression led to reduced TSP-1 mRNA and protein levels with concomitant increases

241 Silencing TSP expression in hUTCs, using small RNA interference, e

242 for the functional role of Sm-TSP-2- and Sm-TSP-2-mediated TEMs.

243 re of the surface-exposed EC2 domain from Sm-TSP-2, a TSP from Schistosoma mansoni and one of the bet

244 The identification of further Sm-TSP-2-mediated TEM proteins increases the available cand

245 rther evidence for the functional role of Sm-TSP-2- and Sm-TSP-2-mediated TEMs.

246 , eight potential protein constituents of Sm-TSP-2-mediated TEMs were also identified.

247 ntial vaccine antigens, suggests that the Sm-TSP-2-mediated TEMs could be disrupted via multiple targ

248 icromagnetic simulation framework and solved TSPs of size 26-city and 15-city with an accuracy of 100

249 led to the design of the first serum stable TSP-1 mimetic agonist peptide able to trigger selective

250 In summary, TSP-1 appears to play an accessory role in modulating Mp

251 ith PEI+TSP-2 siRNA significantly suppressed TSP-2 gene expression (3.1-fold) at 24 h and TSP-2 prote

252 localization patterns of endogenously tagged TSP-12 and TSP-14 proteins.

253 est that gabapentin does not directly target TSP/alpha(2)delta-1 interaction to alleviate neuropathic

254 Targeting TSP-1-dependent activation of TGF-beta could thus be a t

255 al is learning a traveling salesperson task (TSP) across multiple trials.

256 In Det7, at permissive temperatures TSPs mediate O-antigen cleavage and couple cell surface

257 The tetraspanins (TSPs) are a family of integral membrane proteins that ar

258 We conclude that TSP-1 production in endothelial cells depends on not onl

259 genesis models and cultured EC document that TSP-4 mediates upregulation of angiogenesis by TGF-beta1

260 We found that TSP-12 and TSP-14 share overlapping expression patterns

261 bs4(-/-) mice and TSP-4 shRNA, we found that TSP-4 mediated pro-angiogenic functions in cultured EC a

262 d healthy controls, supporting the idea that TSP-1 levels are correlated with disease progression.

263 These findings indicate that TSP-12 and TSP-14 are required for the recycling of DAF-

264 We propose that TSP-1 could regulate bioavailability of BMPs, either pro

265 assertion based on sequence similarity that TSP-1 shares with the von Willebrand type C domain of Cr

266 These data suggest that TSP-1 may be a mediator of capillary regression with det

267 atmospheric TSP were similar suggesting that TSP is an important source of Pb in this area.

268 mississippiensis), eggs incubated during the TSP at 33 degrees C (male producing temperature: MPT) yi

269 minimum and maximum temperatures during the TSP explain a greater amount of variation in wheat crop

270 ming average minimum temperatures during the TSP had a greater negative impact on wheat crop yield th

271 f temperature variation occurring during the TSP on wheat crop yield be detected using remote sensing

272 impacts of temperature variation during the TSP on wheat crop yield in real world cropping landscape

273 ication of 4N1K decapeptide derived from the TSP-1/CD47 binding epitope.

274 n of NR4A2 levels resulted in a shift in the TSP-1/VEGF expression ratio.

275 tion crystal structure of TSP2 (ORF211), the TSP that confers phage specificity towards E. coli O157:

276 oth of which significantly contribute to the TSP behavior.

277 rase expression through interaction with the TSP-1 3'UTR at both the mRNA and protein levels.

278 supports a specific role of TSP-4 among the TSPs in mediating the binding to neuronal alpha(2)delta-

279 These results suggest that therapeutic TSP-1 inhibition may have important atheroprotective pot

280 B form, which comprises four thrombospondin (TSP) domains and one Ig-like domain and binds NLG-1.

281 ypical matricellular protein thrombospondin (TSP)-1, a potent angiostatic molecule and crucial activa

282 lar matrix proteins from the thrombospondin (TSP) family have been identified as ligands of alpha(2)d

283 O-fucosylation sites in the thrombospondin (TSP) type 1 repeats.

284 udy was to determine whether thrombospondin (TSP)-1 promotes macrophage activity and disease progress

285 Thrombospondins (TSPs) are secreted extracellular matrix (ECM) proteins f

286 Moreover, we identified thrombospondins (TSPs) as the hUTC-secreted factors that mediate the syna

287 agonizes the interaction of thrombospondins (TSPs) with the alpha2delta-1 receptor, and thus may reve

288 part by astrocyte-released thrombospondins (TSPs) and activation of their neuronal receptor, alpha2d

289 Astrocyte-secreted thrombospondins (TSPs) induce the formation of structural synapses, which

290 In summary, we identified for the first time TSP-1 as a BMP-2/-4 antagonist and presented a structura

291 In contrast to TSP, kTSP has comparable accuracy to standard genomics c

292 Taken together, TSP-1 is an activator of TGFbeta1 signaling during AOM-i

293 the individual neural mechanisms underlying TSP within individuals has implications for developing p

294 c apparatus employed by phage vB_EcoM_CBA120 TSPs.

295 d modules seen in other phage vB_EcoM_CBA120 TSPs.

296 In vitro, TSP-1 stimulation increased macrophage, but not endothel

297 recruitment of circulating monocytes, while TSP-1 inhibition or knockout bone marrow prevents TGF-be

298 hagocytic activity, which is consistent with TSP-1-enhanced phagocytosis and pro-inflammatory cytokin

299 ng machinery and specifically interacts with TSP-1 mRNA through its 3'UTR.

300 then crossed dysferlinopathic BlaJ mice with TSP-1 knockout mice and assessed disease progression lon