ライフサイエンスコーパス: Toll-like receptor 3

1 he expression of the innate immune receptor, Toll-like receptor 3.

2 ary and sufficient to stimulate WIHN through toll-like receptor 3.

3 ze with U1 RNA in solution to associate with toll-like receptor 3.

4 nents to endosomal compartments that contain Toll-like receptor-3.

5 ch no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stran

6 RNA expression of protein kinase R (PKR) and Toll-like receptors 3, 7, and 9 was also measured from c

7 responses to RSV that correlated with lower Toll-like receptor 3/7 transcript and decreased expressi

8 heir potential to activate monocytes via the toll-like receptor 3/7: DAMP axis.

9 (L), along with a co-stimulatory signal from Toll-like receptor 3, activate the receptor-interacting

10 Toll-like receptor 3-activated macrophages confer anti-H

11 Prestimulation of MSCs with a toll-like receptor 3 agonist further enhanced the therap

12 The toll-like receptor 3 agonist poly I:C increased expressi

13 We show that toll-like receptor 3 agonist Poly I:C, combined with exo

14 ted, polyinosinic:polycytidylic acid (PIC, a Toll-like receptor 3 agonist) was highly effective as an

15 A toll-like receptor 3 agonist, polyinosinic:polycytidylic

16 sion in SeV-infected cells demonstrated that Toll-like receptor 3, although essential for gene induct

17 Toll-like receptor 3, an innate pattern recognition rece

18 Toll-like receptor 3 and 4 agonists, tumor necrosis fact

19 We set to determine the role of toll-like receptor 3 and the binding of double-stranded

20 incorporating FADD is largely independent of Toll-like receptor 3 and the dsRNA-dependent kinase PKR,

21 and IPS-1 adaptor cytosolic pathway and the Toll-like receptor 3 and TIR domain-containing adaptor-i

22 ophage pro-inflammatory responses, represses Toll-like receptor 3 and virus-induced expression of IFN

23 Cathelicidins were induced via toll-like receptor-3 and were inhibited by IL-4/IL-13 th

24 This applies to toll-like receptors 3 and 4 (TLR3, TLR4), which sense do

25 e disease viruses or after engagement of the Toll-like receptors 3 and 4 by double-stranded RNA and l

26 retinoic acid-inducible gene I (RIG-I), and toll-like receptors 3 and 7 (TLR3/7), but animal testing

27 ), pathogen recognition receptors RIG-I, and Toll-like receptors 3 and 7.

28 Cotransfection of human Toll-like receptors 3 and 9 (receptors for dsRNA and CpG

29 e innate pattern-recognition receptor TLR-3 (Toll-like receptor 3) and resulted in a marked inhibitio

30 ng the production of type I interferons in a Toll-like receptor 3- and Toll-like receptor 7-dependent

31 terferon-beta (-/-), and wild-type mice with toll-like receptor 3 antibody neutralization.

32 e that has been previously shown to activate toll-like receptor 3 by the parent peptide LL-37.

33 We show that prenatal immune activation of toll-like receptor 3, by the viral mimetic polyinosinic-

34 re clearly defined with the observation that Toll-like receptor 3 can sense self RNA released from ne

35 We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157, on experimental HRV-16 i

36 metabolic reprogramming of HSCs through the toll-like receptor 3/cyclooxygenase-2/cyclooxygenase-2 p

37 gative lines were no longer able to induce a Toll-like receptor 3-dependent hyperinflammatory cytokin

38 Additionally, pretreatment with toll-like receptor 3/double-stranded RNA ligand inhibito

39 A toll-like receptor 3/double-stranded RNA ligand inhibito

40 double-stranded RNA from injured cells with toll-like receptor 3 drives the acute inflammatory respo

41 Toll-like receptor 3 expression was analyzed in postmort

42 Toll-like receptor 3 expression was higher in patients a

43 thimazole markedly decreased virally induced Toll-like receptor-3 expression and signaling and signif

44 otype and increased surface translocation of toll-like receptor 3 from the endosome to the surface.

45 in the toll-like receptor 2 gene (TLR2), the toll-like receptor 3 gene (TLR3), the toll-like receptor

46 In this issue, studies demonstrate that Toll-like receptor 3 has an important role in signaling

47 r the genetic dissection of inborn errors of Toll-like receptor 3 immunity.

48 Mechanistically, NET stimulation of toll-like receptor 3 induced cyclooxygenase-2 activation

49 ion of double-stranded RNA signaling through Toll-like receptor 3 is mediated by the viral protease N

50 Toll-like receptor-3 is critically involved in host defe

51 TLR3 (Toll-like receptor 3) is a receptor for double-stranded

52 elanoma differentiation associated gene 5 or toll-like receptor 3, is the cytoplasmic sensor for intr

53 C57BL/6J wild-type and toll-like receptor 3 knockout mice.

54 Rationale: The Toll-like receptor 3 Leu412Phe (TLR3 L412F) polymorphism

55 The Toll-like receptor 3 ligand, polyinosinic-polycytidylic

56 , such as an agonistic anti-CD40 antibody or Toll-like receptor 3 ligand.

57 To test this idea, we encapsulated the Toll-like receptor-3 ligand poly(inosinic:cytidylic acid

58 showed reduced stimulation of T cells after Toll-like receptor 3 ligation.

59 on caused by poly(I:C)-induced activation of toll-like receptor 3 localized in intracellular vesicles

60 se (IKK)-epsilon) are critically involved in Toll-like receptor-3-mediated IFN-beta production throug

61 ession of IFN-alpha, IFN-beta, and the PRRs: Toll-like receptor 3, melanoma differentiation-associate

62 Alveolar macrophages from toll-like receptor 3 (-/-) mice had a lower early apopto

63 oceeded normally in macrophages deficient in Toll-like receptor 3 or 7.

64 Neither NK cells nor signaling via Toll-like receptor 3 or MyD88 were essential for viral c

65 ation of type I IFN responses through either Toll-like receptor 3 or retinoic acid-inducible gene I/m

66 s caused by defects in the activation of the Toll-like receptor 3 pathway, overall contributed to the

67 We observed that IHH possesses a functional Toll-like receptor 3 pathway.

68 TLR3 (Toll-like receptor 3) recognizes dsRNA, a potent indicat

69 Toll-like receptor 3 responses that were unaffected in A

70 on, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activati

71 ses, the vaccine was adjuvanted with a novel toll-like receptor 3/RIG-I agonist (Riboxxim(TM)), consi

72 Compared with wild-type septic mice, toll-like receptor 3 septic mice had attenuated abdomina

73 Early induction of Myd88-independent Toll-like receptor 3 signaling results in a significant

74 lication of the HGC, in which we generated a Toll-like receptor 3-specific connectome useful for the

75 reactivation capacity further increased upon Toll-like receptor 3 stimulation with poly(I.C) double-s

76 ion, and macrophage apoptosis was reduced in toll-like receptor 3 (-/-), TIR-domain-containing adapte

77 Unilateral lung contusion was induced in toll-like receptor 3 (-/-), TIR-domain-containing adapte

78 In the presence of 4-1BB ligation and Toll-like receptor 3 (TLR)3 and/or TLR4 triggering, CD8

79 model of brain inflammation by injecting the Toll-like receptor 3 (TLR-3) agonist polyinosinic:polycy

80 Mice deficient in Toll-like receptor 3 (TLR-3) also developed this same sy

81 molecule that is critically involved in the Toll-like receptor 3 (TLR-3) and TLR-4 signaling pathway

82 an cell line competent for signaling through Toll-like receptor 3 (TLR-3) and TLR-5.

83 Experiments with astrocytes from Toll-like receptor 3 (TLR-3) knockout mice indicated tha

84 The dsRNA signaling moieties Toll-like receptor 3 (TLR-3), retinoic acid-inducible ge

85 ne cytokine network activation and increased toll like receptor 3 (TLR3) levels for viral double-stra

86 ding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic

87 (ISG15) E3 ligase, HERC5, in the context of Toll-like receptor 3 (TLR3) activation and IFN induction

88 nhances double-stranded RNA (dsRNA)-mediated Toll-like receptor 3 (TLR3) activation.

89 -1 but did inhibit responses to poly(I.C), a Toll-like receptor 3 (TLR3) activator that does not sign

90 olyinosine-polycytidylic acid (poly(I:C)), a Toll-like receptor 3 (TLR3) agonist used as a mimetic to

91 rough in vivo administration of poly(I:C), a Toll-like receptor 3 (TLR3) agonist.

92 eceptor activation reveals that PVP-057 is a Toll-like receptor 3 (TLR3) agonist.

93 are emerging; in particular, dsRNA receptors Toll-like receptor 3 (TLR3) and cytosolic helicases expr

94 of the mRNA to evade activation of endosomal Toll-like receptor 3 (TLR3) and downstream innate immune

95 ich is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors

96 Poly(I:C) acts through two dsRNA sensors, Toll-like receptor 3 (TLR3) and melanoma differentiation

97 This induction is mediated through toll-like receptor 3 (TLR3) and protein kinase R (PKR),

98 Viral double-stranded RNA, a ligand for Toll-like Receptor 3 (TLR3) and the cytoplasmic RNA rece

99 physical and functional relationship between Toll-like receptor 3 (TLR3) and the pattern recognition

100 infection of EECs significantly reduced both Toll-like receptor 3 (TLR3) and TLR4 mRNA expression at

101 naling of the pathogen recognition receptors Toll-like receptor 3 (TLR3) and TLR4.

102 ucing signals from intracellularly signaling Toll-like receptor 3 (TLR3) and TLR4.

103 lts were observed by activating endolysosome Toll-like receptor 3 (TLR3) and TLR7/8.

104 UVB-damaged keratinocytes were dependent on Toll-like receptor 3 (TLR3) and Toll-like receptor adapt

105 anded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subseque

106 ter activation in response to stimulation of Toll-like receptor 3 (TLR3) by extracellular double-stra

107 The innate immune receptor Toll-like receptor 3 (TLR3) can be present on the surfac

108 Toll-like receptor 3 (TLR3) can signal the production of

109 The structure of the human Toll-like receptor 3 (TLR3) ectodomain (ECD) was recentl

110 ns, we used CRISPR genome editing to disrupt Toll-like receptor 3 (TLR3) function in the human oviduc

111 s nonsynonymous variant (c.2324C > T) in the Toll-like receptor 3 (TLR3) gene resulting in formation

112 us 1 (HSV-1), children with inborn errors of toll-like receptor 3 (TLR3) immunity are prone to HSV-1

113 Here, we report a role for toll-like receptor 3 (TLR3) in cone-rod dystrophy (CORD)

114 idylic acid sodium salt (poly I:C) to target Toll-like receptor 3 (TLR3) in endosomes.

115 N) leads to a reduction in the expression of Toll-like receptor 3 (TLR3) in macrophages from young do

116 Toll-like receptor 3 (TLR3) is a key effector of the inn

117 Toll-like Receptor 3 (TLR3) is a pattern recognition rec

118 Toll-like receptor 3 (TLR3) is an endosomal receptor exp

119 Toll-like receptor 3 (TLR3) is an innate immune system r

120 Finally, we found that Toll-like receptor 3 (TLR3) is not required for either p

121 We previously showed that Toll-like receptor 3 (TLR3) is the critical pattern reco

122 We show that Toll-like receptor 3 (TLR3) is the major endosomal PRR e

123 86, and CD40) expression and did not inhibit Toll-like receptor 3 (TLR3) ligand [poly(I:C)]-induced m

124 of innate immunity by viral infection or the toll-like receptor 3 (TLR3) ligand on liver regeneration

125 Here we show that the Toll-like receptor 3 (TLR3) ligand poly(I:C) (PIC) induc

126 Toll-like receptor 3 (TLR3) mediates antiviral response

127 ants impaired IFN-beta production induced by Toll-like receptor 3 (TLR3) or TLR4 agonists but failed

128 Defects in genes of the Toll-like receptor 3 (TLR3) pathway are associated with

129 ral dsRNA through two distinct pathways; the Toll-like receptor 3 (TLR3) pathway detects dsRNA phagoc

130 d loss-of-function studies, we find that the toll-like receptor 3 (TLR3) pathway enables efficient in

131 )-stimulator of interferon genes (STING) and Toll-like receptor 3 (TLR3) pathways.

132 iation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways.

133 Toll-like receptor 3 (TLR3) recognizes double-stranded R

134 Toll-like receptor 3 (TLR3) recognizes dsRNA and initiat

135 a (TNF-alpha) and has been implicated in the Toll-like receptor 3 (TLR3) response to double-stranded

136 horylation, leading to inefficient RIG-I and Toll-like receptor 3 (TLR3) responses.

137 ole-genome CRISPR-Cas9 screening showed that Toll-like receptor 3 (Tlr3) signaling regulated b2m expr

138 tic properties, acts as a novel regulator of Toll-like receptor 3 (TLR3) signaling to interferon (IFN

139 Systemic activation of toll-like receptor 3 (TLR3) signaling using poly(I:C), a

140 We investigated whether Toll-like receptor 3 (TLR3) stimulation would protect th

141 ular vesicles and subsequently recognized by toll-like receptor 3 (TLR3) to activate TBK1 and downstr

142 -1B, which mediates the polarized sorting of Toll-like receptor 3 (TLR3) towards the basolateral side

143 Recognition of viral RNA by Toll-like receptor 3 (TLR3) triggers activation of the t

144 ver, double-stranded RNA (dsRNA) sensing via Toll-like receptor 3 (TLR3) was heterogeneous, as was si

145 Recognition of double-stranded RNA by Toll-like receptor 3 (TLR3) will increase the production

146 y of RNA interference by directly activating Toll-like receptor 3 (TLR3), a double-stranded RNA immun

147 lock type I interferon signaling mediated by Toll-like receptor 3 (TLR3), a receptor we have previous

148 Toll-like receptor 3 (TLR3), an innate immune sensor for

149 e 561 mRNA by exogenous dsRNA is mediated by Toll-like receptor 3 (TLR3), and it requires no new prot

150 tremendously when HEK293 cells overexpressed Toll-like receptor 3 (TLR3), and the increased secretion

151 sm through both its membrane-bound receptor, Toll-like receptor 3 (TLR3), as well as cytoplasmic rece

152 agonist that recognizes the cellular sensor Toll-like receptor 3 (TLR3), in regulating Valpha14iNKT

153 Differentiation-associated gene 5 (MDA5) and Toll-Like Receptor 3 (TLR3), induces the TANK-Binding Ki

154 d the modulatory effects of Th2 cytokines on Toll-like receptor 3 (TLR3), interferon-responsive facto

155 egfr1) siRNA suppressed CNV via cell-surface toll-like receptor 3 (TLR3), its adaptor TRIF, and induc

156 uce its stability and prevent its binding to Toll-like receptor 3 (TLR3), leading to decreased inflam

157 erleukin-1 (IL-1)/Toll receptor superfamily, Toll-like receptor 3 (TLR3), recognizes double-stranded

158 his family of pattern recognition receptors, toll-like receptor 3 (TLR3), recognizes viral double-str

159 se HCV dsRNAs also induced the expression of Toll-like receptor 3 (TLR3), retinoic acid-inducible gen

160 wnstream of several viral sensors, including Toll-like receptor 3 (TLR3), RIG-I, and MDA5.

161 ors, respectively, and with the exception of Toll-like receptor 3 (TLR3), signal via the adaptor mole

162 N-gamma, and granzyme B production following Toll-like receptor 3 (TLR3), TLR4, and TLR7/TLR8 agonist

163 CL22, CD274, and CD273 and downregulation of Toll-like receptor 3 (TLR3), TLR5, and TLR7.

164 gnificantly increase expression of endosomal toll-like receptor 3 (TLR3), TLR7, TLR8, and TLR9 in per

165 altered viral responses when stimulated with Toll-like receptor 3 (TLR3), TLR7/TLR8, and TLR9 agonist

166 eltaE3L is unaffected by genetic ablation of Toll-like receptor 3 (TLR3), TRIF, TLR9, and MyD88.

167 Influenza stimulates toll-like receptor 3 (TLR3), which can increase RhoA act

168 merous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate imm

169 n (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory f

170 This triggers Toll-like receptor 3 (TLR3)- and TIR domain-containing a

171 mal organization to the selective control of toll-like receptor 3 (TLR3)- and TLR4-mediated proinflam

172 rmore, preexposure of LC to L3 did not alter Toll-like receptor 3 (TLR3)- or TLR4-mediated expression

173 These interferon responses attributed to toll-like receptor 3 (TLR3)-activated Kupffer and liver

174 rived extracellular vesicles (EVs) in innate Toll-like receptor 3 (TLR3)-dependent antiviral immunity

175 Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and R

176 Inborn errors in Toll-like receptor 3 (TLR3)-IFN type I and III pathways

177 hat West Nile virus (WNV) is able to inhibit Toll-like receptor 3 (TLR3)-mediated activation of inter

178 Here we report that EV68 inhibits Toll-like receptor 3 (TLR3)-mediated innate immune respo

179 nse to viral infection is often triggered by Toll-like receptor 3 (TLR3)-mediated signaling by double

180 Huh7 hepatoma cells by ectopic expression of Toll-like receptor 3 (TLR3).

181 ed by signalling through the dsRNA receptor, toll-like receptor 3 (TLR3).

182 ntiviral signaling (MAVS) but independent of toll-like receptor 3 (TLR3).

183 ) from necrotic keratinocytes that activates Toll-like receptor 3 (TLR3).

184 f the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3).

185 een identified as an endogenous activator of Toll-like receptor 3 (TLR3).

186 ed (ds) RNA-induced innate responses through Toll-like receptor 3 (TLR3).

187 FNa/B by inducing eATP-endogenous retrovirus-Toll-like receptor 3 (TLR3)/mitochondrial antiviral sign

188 g the caspase-11 pathway in vivo with LPS or Toll-like receptor-3 (TLR3) agonist resulted in high mor

189 Toll-like receptor-3 (TLR3) is crucial for the innate im

190 Toll-like receptor-3 (TLR3) senses double-stranded RNA,

191 We found that Toll-like receptor-3 (TLR3) senses HCV infection in cult

192 Toll-like receptor-3 (TLR3), a member of the pathogen re

193 The innate immune receptor Toll-like-Receptor 3 (TLR3) was upregulated after ZIKV i

194 s well as following exposure to poly(I.C) (a Toll-like receptor 3 [TLR3] stimulus) and 5' poly(U) HCV

195 lectively on keratinocytes triggered through Toll-like receptor 3(TLR3).

196 on of ds-virus mimetic poly I:C (to activate Toll-like receptor 3, TLR3) and ss-virus mimetic resiqui

197 pothesized that small-molecule activators of toll-like receptor 3, together with external microenviro

198 e Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.

199 kinase, 2'5'-oligoadenylate synthetase, and Toll-like receptor 3, transcripts that encode dsRNA-resp

200 is sensed by the human epithelial cells via Toll-like receptor 3, triggering Interferon Regulating F

201 eover, a direct interaction between PAR2 and Toll-like receptor 3 was observed.

202 This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon a