ライフサイエンスコーパス: Tourette's syndrome

1 disorder and associated conditions, such as Tourette's syndrome.

2 e forms of obsessive-compulsive disorder and Tourette's syndrome.

3 untington's disease, tardive dyskinesia, and Tourette's syndrome.

4 internus (GPi) DBS in patient's with severe Tourette's syndrome.

5 tment for a subgroup of patients with severe Tourette's syndrome.

6 ve been proposed for the treatment of severe Tourette's syndrome.

7 ophrenia, obsessive compulsive disorder, and Tourette's syndrome.

8 attention deficit hyperactivity disorder and Tourette's syndrome.

9 ral mechanisms that govern tic generation in Tourette's syndrome.

10 gulatory control in children and adults with Tourette's syndrome.

11 latory control are disturbed in persons with Tourette's syndrome.

12 ttention deficit hyperactivity disorder, and Tourette's syndrome.

13 aintain task performance in individuals with Tourette's syndrome.

14 ubjects enrolled in three genetic studies of Tourette's syndrome.

15 o the development and clinical expression of Tourette's syndrome.

16 isk factor for increased symptom severity in Tourette's syndrome.

17 ttention-deficit/hyperactivity disorder, and Tourette's syndrome.

18 from the striatum is abnormal in adults with Tourette's syndrome.

19 the underlying pathophysiologic mechanism in Tourette's syndrome.

20 autoimmune etiology in a subset of cases of Tourette's syndrome.

21 ate an autoimmune etiology for some cases of Tourette's syndrome.

22 WAS in 2,723 cases (1,310 with OCD, 834 with Tourette's syndrome, 579 with OCD plus Tourette's syndro

23 igible patients (severe medically refractory Tourette's syndrome, age >/=20 years) from two clinics f

24 data were acquired from 13 individuals with Tourette's syndrome and 21 healthy comparison subjects d

25 egion was not significantly different in the Tourette's syndrome and comparison subjects.

26 de scan did not significantly differ between Tourette's syndrome and comparison subjects.

27 ation) increased by 21% in the subjects with Tourette's syndrome and did not change in the comparison

28 cal disorders such as autism, schizophrenia, Tourette's syndrome and epilepsy.

29 Seven adults with Tourette's syndrome and five age-matched comparison subj

30 d in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome.

31 roop task were similar between patients with Tourette's syndrome and healthy comparison subjects, the

32 Six patients with Tourette's syndrome and nine normal control subjects und

33 triatal circuits in children and adults with Tourette's syndrome and obsessive-compulsive disorder (O

34 created a transgenic mouse model of comorbid Tourette's syndrome and obsessive-compulsive disorder (T

35 to the prediction that the symptoms of human Tourette's syndrome and obsessive-compulsive disorder ar

36 synthesizing enzyme has been associated with Tourette's syndrome and obsessive-compulsive disorder, a

37 modulator histamine has been associated with Tourette's syndrome and obsessive-compulsive disorder.

38 Previous work has shown that Tourette's syndrome and OCD have some degree of shared g

39 ined genome-wide association study (GWAS) of Tourette's syndrome and OCD.

40 on our understanding of the pathogenesis of Tourette's syndrome and on principles for treatment of p

41 um of disease, supporting the unification of Tourette's syndrome and other tic disorders in future di

42 the genetic architecture and determinants of Tourette's syndrome and other tic disorders.

43 Tourette's PRS significantly predicted both Tourette's syndrome and tic spectrum disorders status in

44 nsmission in the mechanism and modulation of Tourette's syndrome and tics.

45 However, individuals with Tourette's syndrome appear to co-opt normal developmenta

46 Although genetic studies of Tourette's syndrome are common, studies of environmental

47 Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmen

48 ychiatric disorders, Alzheimer's disease and Tourette's syndrome, are compared to illustrate the effe

49 hood-onset obsessive-compulsive disorder and Tourette's syndrome, as well as rheumatic fever or Syden

50 tential applications to Parkinson's disease, Tourette's syndrome, attention-deficit/hyperactivity dis

51 ocesses may contribute to the development of Tourette's syndrome by releasing motor and vocal tics fr

52 enrichment analyses were conducted in 4,819 Tourette's syndrome case subjects and 9,488 control subj

53 Furthermore, OCD with co-occurring Tourette's syndrome/chronic tics may have different unde

54 ed when cases with both OCD and co-occurring Tourette's syndrome/chronic tics were included in the an

55 with Tourette's syndrome, 579 with OCD plus Tourette's syndrome/chronic tics), 5,667 ancestry-matche

56 st hoc analyses indicated that subjects with Tourette's syndrome deactivated these regions less with

57 , including schizophrenia, bipolar disorder, Tourette's syndrome, dementia, alcohol-induced delusions

58 wledge that uncomplicated cases of childhood Tourette's syndrome frequently have a favourable outcome

59 The Tourette's syndrome group exhibited stronger neural acti

60 In contrast, activity was weaker in the Tourette's syndrome group than in the healthy comparison

61 Activity within the Tourette's syndrome group was stronger during spontaneou

62 In contrast, Tourette's syndrome had a smaller, nonsignificant polyge

63 dhood-onset obsessive-compulsive disorder or Tourette's syndrome had significantly greater B cell D8/

64 However, Tourette's syndrome has been shown to occur at a prevale

65 ved regions significantly explained 92.4% of Tourette's syndrome heritability.

66 obsessive-compulsive disorder (OCD) or tics/Tourette's syndrome in childhood to antecedent group A s

67 haloperidol in the treatment of Gilles de la Tourette's syndrome in children and adolescents.

68 As our knowledge of Gilles de la Tourette's syndrome increases, so does our appreciation

69 Our study suggests an etiology for Tourette's syndrome involving the right basal ganglia.

70 Tourette's syndrome is a common developmental neuropsych

71 suggest that the underlying pathobiology in Tourette's syndrome is a phasic dysfunction of dopamine

72 Gilles de la Tourette's syndrome is a well-characterized disorder wit

73 anteromedial globus pallidus interna DBS for Tourette's syndrome is an effective and well-tolerated t

74 Tourette's syndrome is considered less common in people

75 Tourette's syndrome is more common in the male populatio

76 Importantly, I argue that Tourette's syndrome is not a unitary condition.

77 Tourette's syndrome is polygenic and highly heritable.

78 ng that the quality of life of patients with Tourette's syndrome is reduced and that there is a subst

79 ough still shrouded in mystery, Gilles de la Tourette's syndrome is widely regarded as an archetypal

80 nsities in 100 children and adolescents with Tourette's syndrome, obsessive-compulsive disorder (OCD)

81 A childhood diagnosis of Tourette's syndrome, OCD, or ADHD significantly increase

82 es was significantly higher in subjects with Tourette's syndrome, OCD, or ADHD than in healthy compar

83 en proposed as a treatment option for severe Tourette's syndrome on the basis of findings from open-l

84 d-onset obsessive-compulsive disorder and/or Tourette's syndrome or chronic tic disorder and 21 healt

85 is implicated as a fundamental mechanism in Tourette's syndrome pathogenesis.

86 rders such as obsessive-compulsive disorder, Tourette's syndrome, pathological gambling, and addictio

87 Sera from 12 additional Tourette's syndrome patients and 12 normal subjects (bot

88 e 136 children and adults, which included 66 Tourette's syndrome patients and 70 healthy comparison s

89 d a GWAS meta-analysis and probed aggregated Tourette's syndrome polygenic risk to test whether Toure

90 ymptoms of obsessive-compulsive disorder and Tourette's syndrome, rather than Sydenham's chorea, but

91 rders such as Parkinson's disease, dystonia, Tourette's syndrome, restless legs syndrome, and akathis

92 tween prenatal/perinatal adverse events with Tourette's syndrome severity as determined by tic severi

93 d with the presence of comorbid OCD in these Tourette's syndrome subjects.

94 posterior cingulate cortices in adults with Tourette's syndrome suggests the presence of greater dif

95 men dopamine release was seen in adults with Tourette's syndrome than in comparison subjects after a

96 In Tourette's syndrome, the absence of evident brain pathol

97 pectively, to the development of the tics of Tourette's syndrome, the obsessions of OCD, the binge ea

98 ces in dystonia, the primary motor cortex in Tourette's syndrome, the supplementary motor area in Par

99 nimal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in t

100 Tourette's syndrome (TS) is a chronic neuropsychiatric d

101 Tourette's syndrome (TS) is a developmental disorder tha

102 Tourette's syndrome (TS) is a genetically influenced dev

103 into a clinical perspective by referring to Tourette's Syndrome (TS).

104 years) with severe and medically intractable Tourette's syndrome underwent implantation of Medtronic

105 iginally considered very rare, in the 1980s, Tourette's syndrome was reported to be common.

106 isturbances in these circuits in adults with Tourette's syndrome, which leads to impaired regulation

107 Sera from 12 patients with Tourette's syndrome with high levels of antineural or an

108 bgroups of obsessive-compulsive disorder and Tourette's syndrome with repetitive behaviors.

109 en-level dependent response in patients with Tourette's syndrome with that of healthy comparison subj