ライフサイエンスコーパス: UDP glucuronic acid

1 cal polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid.

2 nal UDP-glycosyltransferase UGT co-substrate UDP-glucuronic acid.

3 ), UDP-N-acetylglucosamine (UDP-GlcNAc), and UDP-glucuronic acid.

4 lyzes two oxidations of UDP-glucose to yield UDP-glucuronic acid.

5 ntermediate that is synthesized by ArnA from UDP-glucuronic acid.

6 pose a pathway for l-Ara4N biosynthesis from UDP-glucuronic acid.

7 6-dehydrogenase leads to the accumulation of UDP-glucuronic acid.

8 oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteog

9 1) or a transcriptional factor NRG1 suppress UDP-glucuronic acid accumulation and 5-FC resistance in

10 combinant UAS homologs all form UDP-Api from UDP-glucuronic acid albeit in different amounts.

11 Mutations in a previously identified UDP-glucuronic acid allosteric binding site decreased th

12 We found that depletion of UDP-glucuronic acid altered the expression of PPAR-gamma

13 ities for the sugar donors UDP-galactose and UDP-glucuronic acid, although UDP-glucose was always pre

14 uccessive oxidations of UDP-glucose to yield UDP-glucuronic acid, an essential precursor for matrix p

15 UDP-glucose dehydrogenase (Ugd) generates UDP-glucuronic acid, an important precursor for the prod

16 copyranosiduronic acids (glucuronides) using UDP-glucuronic acid and acceptor substrates such as drug

17 Mutations in UXS1 lead to accumulation of UDP-glucuronic acid and alterations in nucleotide metabo

18 (+)-dependent oxidation of the 4''-OH of the UDP-glucuronic acid and decarboxylation of the UDP-4-ket

19 rt to its ability to sequester intracellular UDP-glucuronic acid and inhibition of hyaluronan synthas

20 showed that the resulting mutant lacked both UDP-glucuronic acid and its downstream product, UDP-xylo

21 ponsible for the oxidation of UDP-glucose to UDP-glucuronic acid and its subsequent decarboxylation t

22 y, we propose a binding model for NAD(+) and UDP-glucuronic acid and the involvement of residues T(43

23 UXNAcS is specific and cannot utilize UDP-glucuronic acid and UDP-galacturonic acid as substra

24 involved in HA synthesis and uses cytosolic UDP-glucuronic acid and UDP-GlcNAc as substrates.

25 s that synthesize the building blocks of HA, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as wel

26 HA synthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as subst

27 rategy, we used purified S. equisimilis HAS, UDP-glucuronic acid, and UDP[beta-32P]-Glc-NAc to radiol

28 The UGT1 and UGT2 enzymes use UDP-glucuronic acid, and UGT3 enzymes use UDP-N-acetylgl

29 oded by the ORF atu2297, with UDP-glucose or UDP-glucuronic acid as sugar donors.

30 .8-A resolution apo crystal structure of the UDP-glucuronic acid binding domain of human UGT isoform

31 he encoded protein is closely related to the UDP-glucuronic acid binding site consensus sequence, and

32 Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH

33 2 nM) enhanced the potency of UDPG (but not UDP-glucuronic acid) by 7-fold.

34 The synthesis of UDP-glucuronic acid can alter the NAD(+)/NADH ratio via

35 s at residues predicted to interact with the UDP-glucuronic acid cofactor exhibited significantly imp

36 n the content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression lev

37 acid (UDP-GlcA) is irreversibly catalyzed by UDP-glucuronic acid decarboxylase (UXS).

38 Biosynthesis of UDP-xylose is mediated by UDP-glucuronic acid decarboxylase, which converts UDP-gl

39 II transmembrane protein that functions as a UDP-glucuronic acid decarboxylase.

40 yptococcal sequence as putatively encoding a UDP-glucuronic acid decarboxylase.

41 Consequently, loss of UXS1-mediated UDP-glucuronic acid decarboxylation causes sequestration

42 m adenosine diphosphate-activated platelets, UDP-glucuronic acid-dependent bilirubin conjugation was

43 We demonstrated that lpsL encoded a UDP-glucuronic acid epimerase activity that was reduced

44 al high-resolution crystal structures of the UDP-glucuronic acid epimerase from Bacillus cereus The g

45 psL, a gene previously predicted to encode a UDP-glucuronic acid epimerase.

46 d C-4" oxidation and C-6" decarboxylation of UDP-glucuronic acid, followed by the C-4" transamination

47 ion and C-6" decarboxylation of [alpha-(32)P]UDP-glucuronic acid, followed by transamination to gener

48 Extracts of the mutants completely lacked UDP-glucuronic acid:Galbeta1,3Gal-R glucuronosyltransfer

49 AS) is a membrane-bound enzyme that utilizes UDP-glucuronic acid (GlcUA) and UDP-GlcNAc to synthesize

50 ae catalyzes sugar transfer from UDP-Glc and UDP-glucuronic acid (GlcUA) to a polymer with the repeat

51 MU and without depletion of the HA precursor UDP-glucuronic acid (GlcUA).

52 The oxidative decarboxylation of UDP-glucuronic acid is catalyzed by the 345-residue C-te

53 UDP-glucuronic acid is converted to UDP-galacturonic aci

54 t depletion of the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhibit several mes

55 In mammalian organisms, UDP-glucuronic acid is typically used in the transfer re

56 gar residues in the capsule are derived from UDP-glucuronic acid or its metabolites.

57 We propose that the regulation of UDP-glucuronic acid production in a specific subset of v

58 and indicating that an alternate pathway for UDP-glucuronic acid production was not used.

59 mutations in genes known to be required for UDP-glucuronic acid synthesis (UGD1) or a transcriptiona

60 capI(Ssp) show homology to genes involved in UDP-glucuronic acid synthesis.

61 ponents may be linked to the availability of UDP-glucuronic acid; therefore UGDH is an intriguing the

62 micals by linking glucuronic acid donated by UDP-glucuronic acid to a lipophilic acceptor substrate.

63 n encoded by PsUGT1 catalyzes conjugation of UDP-glucuronic acid to an unknown compound.

64 e unprecedented oxidative decarboxylation of UDP-glucuronic acid to form uridine 5'-(beta-l-threo-pen

65 AD(+)-dependent oxidative decarboxylation of UDP-glucuronic acid to generate a UDP-4'-keto-pentose su

66 (i) the NAD(+)-dependent decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and (ii) the

67 One activity is to decarboxylate UDP-glucuronic acid to UDP-beta-l-threo-pentopyranosyl-4

68 usly shown to encode an enzyme that converts UDP-glucuronic acid to UDP-xylose for capsule biosynthes

69 FUR1, UXS1 (encoding an enzyme that converts UDP-glucuronic acid to UDP-xylose) and URA6 contribute t

70 e C. neoformans gene catalyzed conversion of UDP-glucuronic acid to UDP-xylose, as confirmed by NMR a

71 lucuronic acid decarboxylase, which converts UDP-glucuronic acid to UDP-xylose.

72 NAD+-dependent oxidative decarboxylation of UDP-glucuronic acid to yield the UDP-4''-ketopentose, ur

73 y the authentic sugar nucleotide precursors, UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylglucosami

74 Api) together with UDP-xylose is formed from UDP-glucuronic acid (UDP-GlcA) by UDP-Api synthase (UAS)

75 The biosynthesis of UDP-Xyl from UDP-glucuronic acid (UDP-GlcA) is irreversibly catalyzed

76 UDP-glucuronic acid (UDP-GlcA) is the precursor of many

77 alyzing (1) the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcA) to the UDP-4' '-ketopento

78 UDP-xylose synthase 1 (UXS1), which converts UDP-glucuronic acid (UDP-GlcA) to UDP-xylose in the prot

79 and is synthesized by the decarboxylation of UDP-glucuronic acid (UDP-GlcA).

80 sphate (Glc-6-P) --> Glc-1-P --> UDP-Glc --> UDP-glucuronic acid (UDP-GlcUA) --> (GlcUA-Glc)(n).

81 disaccharide units from the donor molecules UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosam

82 neumoniae requires UDP-glucose (UDP-Glc) and UDP-glucuronic acid (UDP-GlcUA) for production of the [3

83 he presence of protein-mediated transport of UDP-glucuronic acid (UDP-GlcUA) in rat liver endoplasmic

84 UDP-glucuronic acid (UDP-GlcUA) is a nucleotide sugar es

85 -d-GlcUA-(1-] from UDP-glucose (UDP-Glc) and UDP-glucuronic acid (UDP-GlcUA) is catalysed by the type

86 Although UDP-glucuronic acid (UDP-GlcUA) is most commonly employe

87 substrate for all glucuronidation reactions, UDP-glucuronic acid (UDP-GlcUA), was determined using a

88 yces cerevisiae expressing SQV-7 transported UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-

89 i enzyme that converts one sugar nucleotide (UDP-glucuronic acid, UDPGA) to another (UDP-xylose), is

90 HA synthase for UDP-N-acetylglucosamine and UDP-glucuronic acid were estimated to be approximately 7

91 The uxs1 mutants accumulate UDP-glucuronic acid, which appears to down-regulate expr

92 y catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is essential for the biosynth