ライフサイエンスコーパス: UGT

1 UGT enzyme activity toward estrone was unchanged 1 day p

2 UGT enzyme activity was determined toward two prototypic

3 UGTs accelerate the metabolic elimination of bile acids,

4 UGTs catalyze the covalent addition of glucuronic acid s

5 UGTs compete with P450 enzymes, which bioactivate HAAs b

6 UGTs convert metabolites, dietary constituents, and envi

7 UGTs eliminate by glucuronidation a broad variety of end

8 UGTs, distributed primarily in liver, kidney, and gastro

9 In a subset of tumors (33%), UGT protein levels and activity exceeded that of paired

10 identify critical binding interactions of a UGT protein with UDP-sugar cofactors.

11 nzymes are required for plant life in that a UGT from Pisum sativum (PsUGT1) controls plant developme

12 constitutive or hydrogen peroxide-activated-UGTs demonstrated that reactive oxygen species-related o

13 nd gymnosperms, and identified an additional UGT group (group R) in seed plants.

14 ng chloroanilines in Arabidopsis, additional UGTs could compensate for the conjugation of TCP in the

15 nd K404 are strictly conserved in 70 aligned UGTs, except for S321, equivalent to K314, in UGT2B15 an

16 and regulatory variants at several CYP* and UGT* genes as well as corroborative evidence for interac

17 roducts in stomach UGT1A mRNA expression and UGT catalytic activities were investigated in a panel of

18 osyltransferase (UGT) protein expression and UGT messenger RNA (mRNA) levels were measured by Western

19 Microsomal UGT protein expression and UGT mRNA levels were unaltered after hepatectomy.

20 f BPD glucuronide diastereomer formation and UGT expression.

21 rces that support research on the kidney and UGT.

22 oligonucleotide probes for rat GST, ST, and UGT.

23 of hUGT1A1 with itself, but not with another UGT isoform, human UGT1A6, which differs only in the N-t

24 Anti-UGT-1168 antibody trapped 2B15-His-containing co-immunop

25 st K(M) (300 micromol/L) against SAHA of any UGT in vitro.

26 suggestive of a possible interaction between UGT genotype and hormones.

27 ithin the gene encoding the enzyme bilirubin UGT.

28 ile concomitantly inducing hepatic bilirubin UGT mRNA and protein expression.

29 trongly with both liver microsomal bilirubin UGT activity and liver UGT1A1 mRNA level (r(2) =.82 and.

30 Bilirubin-UGT activity in liver homogenates was 8%-12% of normal,

31 indwelling portal vein catheter in bilirubin-UGT-deficient jaundiced Gunn rats, mean serum bilirubin

32 Both UGTs also were active in vitro on select flavonoids.

33 m(s) that enable endoplasmic reticulum-bound UGT isozymes to convert innumerable structurally diverse

34 d with purifying endoplasmic reticulum-bound UGTs for structural studies, we carried out homology-bas

35 um distachyon, we show that the Bradi5g03300 UGT converts DON into D3G in planta.

36 tic UGT activities were mainly determined by UGT gene transcription levels.

37 nd HONH-AalphaC underwent glucuronidation by UGTs to form, respectively, N(2)-(beta-D-glucosidurony1)

38 owing how candidate drugs are metabolized by UGTs.

39 arding differential phosphate utilization by UGTs to function efficiently.

40 tringent criteria for selection of candidate UGTs were applied to ensure a more comprehensive taxon s

41 eem to significantly modulate ABP-catalyzing UGT in liver.

42 tudy aims to provide methods to characterize UGTs putatively involved in SVglys biosynthesis.

43 ) regulating phosphorylation of constitutive UGTs in LS180 cells and 10 different human UGT cDNA-tran

44 ls; there is no direct inhibition of control UGT using curcumin as substrate in the in vitro assay.

45 Similar studies found that different UGT isoforms or CYP3A4 immunoprecipitated along with the

46 ereospecific activity exhibited by different UGTs against BPD is consistent with tissue-specific patt

47 e uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes that catalyse t

48 In addition, we describe five Drosophila UGTs belonging to two families.

49 t provides ontology of the cell types during UGT development and the molecular hallmarks of those cel

50 This review examines in detail each UGT isozyme known to be associated with cancer and carci

51 oreover, mutation of three PKC sites in each UGT isozyme demonstrated that T73A/G and T202A/G caused

52 se results indicate that early and efficient UGT-mediated conjugation of DON is necessary and suffici

53 Eight UGTs were identified with activity against isoflavones,

54 pt expression patterns for each of the eight UGTs in Medicago organs and cell suspension cultures, an

55 s only the second example of a human estrone UGT.

56 y of colon cancer biopsies studies expressed UGT protein at levels greater than in HT29 cells but wit

57 Six of the recombinantly expressed UGTs conjugated the TNT-transformation products 2- and 4

58 Several human hepatic and extrahepatic UGT isozymes have been characterized with respect to the

59 For variants of active extrahepatic UGTs, the UGT1A8(173Ala/277Tyr) variant exhibited no det

60 patic UGTs 2B17 and 1A9 and the extrahepatic UGTs 1A8 and 1A10 exhibited the highest overall activity

61 All five UGTs contain a putative transmembrane domain at their C

62 The fourth UGT family, called UGT8, contains only one member that,

63 idine-diphosphate glycosyltransferase genes (UGTs) were selected based on their high transcript abund

64 DP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (

65 ization of a phenol UDP-glucosyltransferase (UGT) from the silkworm, Bombyx mori, which was named BmU

66 gene family of Group 1 glucosyltransferases (UGTs) of Arabidopsis thaliana revealed a gene, UGT84B1,

67 condary metabolism UDP-glucosyltransferases (UGTs).

68 Uridine diphosphate glucunosyltransferases (UGTs) metabolize 15% of FDA approved drugs.

69 The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzyme

70 uridine diphosphate glucuronosyltransferase (UGT) 1A1; we investigated its role in the association be

71 dine 5'-diphosphate glucuronosyltransferase (UGT) operates in opposition to glucuronidase (GUS) to co

72 iphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 were implicated in the absen

73 tion in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can lead to CNS toxicity, brain d

74 e diphosphate (UDP)-glucuronosyltransferase (UGT) protein expression and UGT messenger RNA (mRNA) lev

75 The human UDP-glucuronosyltransferase (UGT) 1A (UGT1A) locus is regulated in a tissue specific

76 ency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity.

77 ariation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast cancer susceptibility.

78 curonidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in

79 olizing enzyme--UDP-glucuronosyltransferase (UGT) 1A1--to prevent the onset of neonatal hyperbilirubi

80 asone-inducible UDP-glucuronosyltransferase (UGT) 2B13 RNA is related in sequence to a family of UGT

81 ate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5alpha-dihydrotestosterone (DHT) a

82 ects of TKIs on UDP-glucuronosyltransferase (UGT) activities, and to quantitatively evaluate their po

83 nt of bilirubin UDP-glucuronosyltransferase (UGT) activity and would be most pronounced in individual

84 yzed by the two UDP-glucuronosyltransferase (UGT) enzymes UGT2B15 and UGT2B17, is the major androgen

85 g half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alternative splicing, resulting in

86 The UDP-glucuronosyltransferase (UGT) family of enzymes is important in the metabolic eli

87 idation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

88 idation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

89 between several UDP-glucuronosyltransferase (UGT) isoforms and cytochrome P450 3A4.

90 The UDP-glucuronosyltransferase (UGT) isozyme system is critical for protecting the body

91 UDP-glucuronosyltransferase (UGT) isozymes catalyze detoxification of numerous chemic

92 UDP-glucuronosyltransferase (UGT) isozymes detoxify metabolites, drugs, toxins, and e

93 nsferase (GST), UDP-glucuronosyltransferase (UGT), and phenol sulfotransferase 1A1 (SULT1A1) were mea

94 nsferase (GST), UDP-glucuronosyltransferase (UGT), and sulfotransferase (ST) expression was evaluated

95 UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of benzo(a)pyrene-trans-7,

96 upregulation of UDP-glucuronosyltransferase (UGT).

97 atic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this syndrome.

98 ested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine glucuron

99 Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metaboli

100 UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic an

101 thetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as well as a number of new genes

102 enzyme and to UDP-glucuronosyltransferases (UGT).

103 ridine diphosphate glucuronosyltransferases (UGTs).

104 idine-5'-diphospho-glucuronosyltransferases (UGTs), the catalytic site of which is located within the

105 idine-5'-diphospho-glucuronosyltransferases (UGTs), whose catalytic site is located within the smooth

106 Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the e

107 n catalyzed by UDP-glucuronosyltransferases (UGTs) and now report on the role of glucuronidation in d

108 UDP-glucuronosyltransferases (UGTs) are critical to the detoxification of numerous dru

109 UDP-glucuronosyltransferases (UGTs) are highly expressed in liver, intestine and kidne

110 UDP-glucuronosyltransferases (UGTs) are important enzymes that detoxicate many procarc

111 UDP-glucuronosyltransferases (UGTs) are membrane-bound proteins localized to the endop

112 19 functional UDP-glucuronosyltransferases (UGTs) in humans, UGT2B7 is involved in the metabolism of

113 o-UDP-GlcUA to UDP-glucuronosyltransferases (UGTs) in intact, but not in detergent-disrupted, ER vesi

114 ation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells following curcumin treatment led to

115 onides) by the UDP-glucuronosyltransferases (UGTs) is a significant metabolic pathway that facilitate

116 ha (PPARalpha)-UDP-glucuronosyltransferases (UGTs) signalling is an important determinant of bile aci

117 an recombinant UDP-glucuronosyltransferases (UGTs) was characterized and compared with the glucuronid

118 es a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and remo

119 inding site of UDP-glucuronosyltransferases (UGTs).

120 II superfamily UDP-glucuronosyltransferases (UGTs).

121 gene family of UDP-glucuronosyltransferases (UGTs).

122 es such as the UDP-glucuronosyltransferases (UGTs).

123 human hepatic UDP-glucuronosyltransferases (UGTs).

124 uses the traditional UDP-glycosyltransferase UGT co-substrate UDP-glucuronic acid.

125 150 different family 1 glycosyltransferase (UGT) genes.

126 ying four UDP-dependent glycosyltransferase (UGT) genes as wound-induced and 12-OH-JA-related, namely

127 y 1 UDP-sugar dependent glycosyltransferase (UGT) to facilitate acetophenone accumulation in the plan

128 of uridine diphosphate glycosyltransferase (UGT) enzymes in drug and chemical metabolism, cofactor b

129 The human UDP glycosyltransferase (UGT) superfamily comprises four families of enzymes that

130 UDP-glycosyltransferase (UGT) plays a major role in the diversity and reactivity

131 nzymes of the human UDP-glycosyltransferase (UGT) superfamily typically catalyze the covalent additio

132 known to produce a UDP-glycosyltransferase (UGT) that negatively regulates ecdysone signaling.

133 ila melanogaster, a UDP-glycosyltransferase (UGT), as well as a short chain dehydrogenase/reductase a

134 entified four family 1 glycosyltransferases (UGTs) that catalyze 3-O-glucosylation of the sapogenins

135 rated by UDP-dependent glycosyltransferases (UGTs) play critical roles in plant interactions with the

136 ntbretia UDP-dependent glycosyltransferases (UGTs), CcUGT1 and CcUGT2, catalyze the formation of the

137 ne URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASES (UGTs) from Arabidopsis (Arabidopsis thaliana).

138 by uridine-diphosphate glycosyltransferases (UGTs), that achieve their activity by transferring sugar

139 nt uridine diphosphate glycosyltransferases (UGTs).

140 dine diphosphate (UDP) glycosyltransferases (UGTs) from Arabidopsis thaliana (Arabidopsis).

141 cluster of eleven UDP-glycosyltransferases (UGTs) involved in monomeric capsianoside biosynthesis.

142 Hepatic UGT activities were mainly determined by UGT gene transc

143 For active hepatic UGTs, the UGT2B7(268Tyr) variant exhibited significant (

144 into the genetic network regulating hepatic UGTs.

145 The hepatic UGTs 2B17 and 1A9 and the extrahepatic UGTs 1A8 and 1A10

146 e UGTs in LS180 cells and 10 different human UGT cDNA-transfected COS-1 systems.

147 osyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endog

148 UDP-glucuronic acid binding domain of human UGT isoform 2B7 (UGT2B7), which catalyzes the conjugativ

149 th human liver microsomes, recombinant human UGT isoforms, and human hepatocytes.

150 Using recombinant human UGT isoforms, we show that glucuronic acid conjugation o

151 this review focuses on the role of the human UGT genetic polymorphisms in carcinogenesis, chemopreven

152 Two human UGT homologues, HUGT1 and HUGT2, exist that share 55% id

153 avonoid glucosyltransferases indicates human UGTs share a common catalytic mechanism.

154 f having a complete set of recombinant human UGTs for comparative functional analyses.

155 brogated activity, strongly suggesting human UGTs also utilize a serine hydrolase-like catalytic mech

156 However, as yet not all of the human UGTs have been cloned and characterized.

157 2- to 4-fold interindividual differences in UGT activity and qualitative differences between individ

158 of immunodetectable [(33)P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following

159 metabolites and functional polymorphisms in UGTs 2B10 and 2B17 was analyzed in urine specimens from

160 ve form of human PXR show markedly increased UGT activity toward steroid, heme, and carcinogens, enha

161 bidopsis mutants with abolished or increased UGT gene expression.

162 o the expression of at least nine individual UGT genes.

163 The affinity of individual UGT enzymes as determined by K(m) analysis was UGT1A10 >

164 Indinavir was found to competitively inhibit UGT enzymatic activity (K(I) = 183 microM) while concomi

165 ereas saquinavir also competitively inhibits UGT activity, this drug has not been associated with hyp

166 ings provide insight into the role of insect UGTs in host plant adaptation, the mechanistic basis of

167 Interestingly, UGT activity toward tertiary amines and some steroid hor

168 found that UGT76E1 and UGT76E2 are 12-OH-JA-UGTs, with UGT76E1 contributing a major in vivo UGT acti

169 Hence, although higher liver UGT activity may protect the liver against ABP, it incre

170 and characterization of several rabbit liver UGT cDNAs.

171 expression for all other forms of rat liver UGT and ST isozymes that were tested was not significant

172 CRISPR-Cas9 knockouts of the three main UGT gene clusters of Spodoptera frugiperda revealed that

173 Major UGT isoforms were examined for their capacity to metabol

174 curonosyltransferase 1A7 (UGT1A7) is a major UGT contributing to the glucuronidation of xenobiotic ph

175 The UGT1A1 enzyme is a major UGT involved in estradiol glucuronidation.

176 ystal structure of any region of a mammalian UGT drug metabolism enzyme.

177 functional polymorphisms in TAM-metabolizing UGTs, including UGT2B7 and potentially UGT1A8, may be im

178 33+/-6.3, and 24+/-2.4 nL x min(-1) x microg UGT protein(-1), respectively), with UGT2B17 exhibiting

179 Microsomal UGT protein expression and UGT mRNA levels were unaltere

180 However, microsomal UGT activities in colon were up to 96-fold lower for man

181 The new UGT has been designated UGT2B16.

182 nal biologic role(s) for the truncated novel UGT proteins.

183 ectrometry for their profile and activity of UGT isozymes and screened for effective inhibitors of gl

184 Findings uncover new aspects of UGT functions diverging from their transferase activity.

185 eage-specific expansions and contractions of UGT groups were detected in angiosperms, with the total

186 tion of MD simulations to the elucidation of UGT-aglycone interactions.

187 The UGT2B subfamily is a major family of UGT enzymes expressed in human liver.

188 13 RNA is related in sequence to a family of UGT genes.

189 Inhibition of UGT activity by PKCepsilon-specific antagonist peptide o

190 Furthermore, inhibition of UGT phosphorylation and activity by treatment with PKCep

191 tudy was to identify the specific isoform of UGT involved in SN-38 glucuronidation.

192 The lack of selection for higher levels of UGT capacity in the colon cells suggests that high level

193 nes in generalist species but high levels of UGT gene pseudogenization in the specialist Spodoptera p

194 as tested in vitro, in the Gunn rat model of UGT deficiency, and in HIV-infected patients with and wi

195 identified a relatively conserved number of UGT genes in generalist species but high levels of UGT g

196 Inhibition kinetic profiles of a panel of UGT enzymes (UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10,

197 sm involving PKC-mediated phosphorylation of UGT such that phosphoserine/threonine regulates substrat

198 A range of UGT aglycones were capable of modulating glucuronidation

199 to be the most important trans-regulators of UGT transcription (median and range of correlation coeff

200 been carried out to characterize the role of UGT pharmacogenetics in several types of cancer, and the

201 In addition to predicting common sites of UGT conjugation, like hydroxyl groups, it can also accur

202 computational method for predicting sites of UGT-mediated metabolism on drug-like molecules.

203 yzed whether NGT and both splice variants of UGT (UGT1 and UGT2) are able to interact with four diffe

204 lso resolved the phylogenetic association of UGTs from free-sporing plants and gymnosperms, and ident

205 ted in angiosperms, with the total number of UGTs per genome remaining constant generally.

206 though much is known regarding the number of UGTs that make up the UGT1 and UGT2 gene families, as de

207 nctionally relevant genetic polymorphisms of UGTs are reviewed.

208 anges that confer sugar donor selectivity on UGTs, and demonstrates the usefulness of natural variati

209 tures that are different from those of other UGTs and related to the enzyme's functions and substrate

210 contains only one member that, unlike other UGTs, is considered biosynthetic.

211 ranscript abundance in comparison with other UGTs in vegetative tissues of Nicotiana benthamiana and

212 enates from HEK293 cell lines overexpressing UGT wild-type or variant UGT were used.

213 nse elements (AREs), the mechanism of phenol UGT induction has remained unclear.

214 The evolution of plant UGTs has previously been explored, but with a limited ta

215 the overall evolutionary landscape of plant UGTs, the phylogenomic analysis also resolved the phylog

216 Thus, we propose that intestinal PPARalpha-UGTs and downstream FXR-FGF15 signalling play vital role

217 ation of the intestinal peroxisome PPARalpha-UGTs pathway.

218 ribe a simple heuristic model for predicting UGT-mediated sites of metabolism that performs nearly as

219 and dual substrate inhibitors, but not pure UGT substrates, are significantly associated with high D

220 Further analysis indicated that only pure UGT inhibitors and dual substrate inhibitors, but not pu

221 More than 60 SVglys and 68 putative UGTs have been identified in Stevia rebaudiana.

222 d on the surface of a representative group Q UGT (PgUGT95B2), away from the active site, suggesting t

223 Branch-site analyses of the group Q UGT gene tree allowed for identification of branches and

224 The loss of group Q UGTs in Poales and Brassicales, rather than functional c

225 ies, was supported by a gene tree of group Q UGTs sampled from many species, and further corroborated

226 enthamiana, functionality of the recombinant UGT can be tested simply and directly in plants expressi

227 eted functional screening of the recombinant UGTs for their biological substrates was performed by ac

228 NA and activation of curcumin-down-regulated UGTs with typical PKC agonists verified a central PKC ro

229 ctionally characterize nine ripening-related UGTs (UDP-glucosyltransferases) in Fragaria that functio

230 ce of type 2 innate immunity for restricting UGT tissue damage in Chlamydia-infected mice, and in ini

231 e expression vectors containing the stevia's UGT, enables functionality testing with many substrates

232 rted intermediate inhibition against several UGTs (i.e., UGT1A7 by lapatinib; UGT1A1 by imatinib; UGT

233 The cancer-related substrates for several UGTs are summarized, and the functionally relevant genet

234 found to exhibit broad inhibition on several UGTs, particularly potent competitive inhibition against

235 These results suggest that several UGTs may play an important role in the overall glucuroni

236 Overall, these results suggest that several UGTs play an important role in the metabolism of SAHA an

237 In total, we identified six UGTs that catalyze the glucosylation of C(13)-apocaroten

238 Some UGTs showed a rather broad substrate tolerance and gluco

239 QO1, GST, and SULT1A1, but not with striatal UGT.

240 or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s).

241 PKC-dependent signaling evidently sustaining UGT phosphorylation and activity.

242 n, we examined UDP-glucurono-syltransferase (UGT) activity in parental and resistant cells by TLC.

243 Analysis of recombinant His-tag UGTs from the 1A family for their ability to glucuronida

244 ordihydroguaiaretic acid, reversibly targets UGTs causing inhibition without affecting protein levels

245 All tested UGTs preferred UDP-glucose as sugar donor.

246 We found that UGT expression and activity were highly variable among t

247 These data suggest that UGT isoforms may form complexes (dimers, tetramers, etc.

248 In summary, we demonstrate that UGTs are located in gastrointestinal mucosa, have vast o

249 curcumin treatment led to the discovery that UGTs require phosphorylation.

250 Our results show that UGTs play an integral role in the biochemical mechanism

251 These data suggest that UGTs 2B10 and 2B17 play important roles in the glucuroni

252 fense gene families, including the ABCC, the UGT, and the CYP families, have undergone expansion in t

253 In addition, the UGT isoforms tested here may have interacted with CYP3A4

254 isms have been identified for almost all the UGT family members.

255 Although AR and FOXA1 bound the UGT promoters in AR-positive/ERalpha-negative breast can

256 We have characterized the UGT-catalyzed metabolic products of AalphaC and the geno

257 Importantly, the UGT sequelae were significantly reduced in mice immunize

258 To examine whether polymorphisms in the UGT enzymes responsible for the glucuronidation of activ

259 mation and tissue repair are elicited in the UGT of Chlamydia-infected women.

260 An asparagine (Asn-391) in the UGT signature sequence of UGT3A1 is necessary for utiliz

261 evidence for the lumenal orientation of the UGT active site, and support the view that translocation

262 d support the view that translocation of the UGT cosubstrate is a rate-limiting step of the glucuroni

263 mino-acid identity with other members of the UGT family.

264 Identification of the UGT responsible for glucuronidation of SN-38 and the ant

265 cent biochemical evidence indicates that the UGT proteins may oligomerize in the membrane, but conclu

266 Both enzymes belong to the UGT family d-clade and are specific for flavonol glycosi

267 e involvement of the 2B17 isoform within the UGT protein family.

268 As the UGTs from both the resistant and susceptible types of B.

269 ns involved in drug disposition, such as the UGTs, significantly improves the ability to evaluate and

270 dinitrotoluenes, were also conjugated by the UGTs, but to a lesser extent.

271 To characterize the UGTs active against SAHA, homogenates from HEK293 cell l

272 d to identify the expression patterns of the UGTs in human tissues, paying particular attention to ex

273 In previous work, expression of these UGTs in N. benthamiana resulted in small amounts of kaem

274 Overexpression of two of these UGTs, 743B4 and 73C1, in Arabidopsis resulted in increas

275 iption factors (TFs) known to regulate these UGTs were quantified.

276 ical substrate but also disclosed that these UGTs may add to the production of further glycoconjugate

277 To date other substrates for this UGT have not been identified and there has been no sugge

278 Thus, UGTs, usually important enzymes in the detoxication of m

279 he residues that confer sugar specificity to UGT family members and suggests a primate-specific innov

280 equires regulated phosphorylation similar to UGTs already analyzed.

281 do not cause permanent upper genital tract (UGT) damage.

282 arance and reduction of upper genital tract (UGT) pathological sequelae.

283 from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases.

284 f the developing mammalian urogenital tract (UGT).

285 (CYP), uridine glucuronic acid transferase (UGT), and sulfotransferase (SULT)) in their biotransform

286 idine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of glucuronide conju

287 UDP-galactose transporter (UGT; SLC35A2) and UDP-N-acetylglucosamine transporter (N

288 ruce bud burst and shoot growth revealed two UGTs, PgUGT5 and PgUGT5b, that glycosylate pungenol.

289 ines overexpressing UGT wild-type or variant UGT were used.

290 ll lines overexpressing wild-type or variant UGTs were examined for their activities against TAM meta

291 ne of the Drosophila families and vertebrate UGTs.

292 eir C terminus as is the case for vertebrate UGTs where it is required for enzymatic activity.

293 further biotransformed into glucuronides via UGT-mediated pathways.

294 s, with UGT76E1 contributing a major in vivo UGT activity, as deduced from Arabidopsis mutants with a

295 eme oxygenase expression was higher, whereas UGT expression was lower, in neonatal compared with adul

296 Drug interactions with UGT enzymes may independently predict DILI, and their co

297 homa isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that

298 cent and co-immunoprecipitation studies with UGT-transfected cells showed co-localization of UGT1A7Hi

299 different clades, and several clustered with UGTs annotated as glycosylating non-flavonoid substrates

300 rachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree.