ライフサイエンスコーパス: UK

1 UK Aid from the UK Government, Dutch Ministry of Foreign

2 UK Medical Research Council, British Heart Foundation, P

3 UK Medical Research Council, Cancer Research UK, British

4 UK Medical Research Council, Economic and Social Researc

5 UK Medical Research Council, National Institute for Heal

6 UK Research and Innovation Global Challenges Research Fu

7 UK Research and Innovation, National Institutes for Heal

8 henotypic and genomic data from over 100,000 UK Biobank participants, the authors sought to systemati

9 MR was performed in up to 440,000 UK Biobank and 54,451 CKDGen participants.

10 aracterize optic nerve photographs of 67,040 UK Biobank participants and use a multitrait genetic mod

11 ived left ventricular measurements in 36,041 UK Biobank participants, with replication in 2184 partic

12 tal) = 675,898; BioBank Japan (n = 179,066), UK Biobank (n = 361,194) and FinnGen (n = 135,638)).

13 eduled to have primary teeth extracted in 12 UK centers.

14 l, randomized clinical trial conducted at 17 UK hospitals.

15 r) design, we recruited participants from 17 UK hospitals.

16 G, AND PARTICIPANTS: Cohort study of 451 186 UK Biobank participants of European ancestry (aged 40-70

17 a factor of about 2.6 compared with the 2018 UK National Atmospheric Emissions Inventory.

18 itically ill patients with COVID-19 from 208 UK intensive care units.

19 Data from 281,228 UK Biobank participants were used to estimate the releva

20 ntaneous pneumothorax were recruited from 24 UK hospitals during a period of 3 years.

21 off-the-shelf parts for less than pound 300 (UK Sterling).

22 Analysis of 485,346 UK Biobank samples through the use of hap-IBD with 12 co

23 nism linking mLOY to disease risk in 206,353 UK males.

24 d, placebo-controlled randomised trial in 39 UK hospital centres.

25 We apply FastSMC to 487,409 UK Biobank samples and detect ~214 billion IBD segments

26 d fractures was further evaluated in 279,435 UK (MAF = 0.05%, heel bone estimated BMD P-value = 1.2 x

27 ominant-wrist acceleration to PAEE in 96,476 UK Biobank participants (mean age 62 years, 56% female).

28 In analyses of 49 UK Biobank traits (average n = 318,000), PolyFun + SuSiE

29 We used information from 337,536 UK Biobank participants and performed hypothesis-free ph

30 risk score (GRS) for AD (AD-GRS), in 406,536 UK Biobank participants with European ancestry and witho

31 associations arising from an analysis of 648 UK Biobank GWAS and evaluate whether targets identified

32 rs from the United Kingdom, alongside 13 722 UK Biobank controls and a validation cohort of 92 SCAD s

33 In 376 776 UK Biobank participants enrolled between 2006 and 2010,

34 tive women undergoing immediate IBBR from 81 UK breast and plastic surgical units.

35 obtained consent from 4096 patients from 97 UK centres, of whom 1361 were assigned to the 40 Gy sche

36 for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR test

37 he Optimum Patient Care Research Database, a UK national primary care database, we constructed an ope

38 ealth Improvement Network (THIN) database, a UK primary healthcare database.

39 arately for LDL-C and TG with weights from a UK Biobank-based genome-wide association study with ~324

40 Using data from a UK cohort study with data linkage to national schooling

41 res predicted their population trends from a UK-wide dataset.

42 cts of tuberculosis cases participating in a UK cohort study.

43 building and occupancy related factors, in a UK context.

44 uring pregnancy, infancy, and childhood in a UK population-based birth cohort.Methods: Individual exp

45 r current and potential food production in a UK urban setting.

46 enic mice and performed genetic studies in a UK-based human cohort.

47 , from brain banks and the PROSPECT study, a UK-wide longitudinal study of patients with atypical par

48 e use data (6429 records) gathered through a UK-wide citizen science programme (BeeWatch) to determin

49 We included patients recruited to a UK hospital-based, multicentre observational study of ad

50 Project), 2) maternal family history of AD (UK Biobank), and 3) paternal family history of AD (UK Bi

51 bank), and 3) paternal family history of AD (UK Biobank).

52 All UK nests derived from the European zone of secondary col

53 All UK pancreas transplant units were surveyed between 2017

54 We analyzed UK primary care records from the Clinical Practice Resea

55 terval [CI] 1.59-2.03; p = 2.26 x 10-21) and UK Biobank (OR 2.26; 95% CI 1.92-2.65; p = 1.17 x 10-22)

56 lism and Atherosclerosis Clinic (n=552); and UK Biobank cohorts (n=306).

57 Lipid Genetics Consortium (n = 188,577) and UK Biobank Cardiovascular Magnetic Resonance substudy (n

58 Canada (43.8%), but infrequent in Italy and UK.

59 ngs from the Nord-Trondelag Health Study and UK Biobank and replicated our findings using 222,368 sib

60 In addition, US and UK URs are not directly comparable due to fundamental sy

61 20 scientific societies based in the US and UK, and provides guidelines on how societies can success

62 e the incidence, TBI and treatment in US and UK-led military MTF to ascertain if differences in deplo

63 absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negati

64 and one shared paper between New Zealand and UK met the inclusion criteria.

65 Total annual UK NH(3) emissions from gasoline passenger cars are esti

66 with the highest mortality differed between UK Biobank (a population predominantly comprising people

67 'probable' CIDP, from Serbia and Birmingham, UK.

68 ospital and Heartlands Hospital, Birmingham, UK, N = 878), (2) Salford Kidney Study (SKS, Salford Roy

69 rn in Bradford (BiB), conducted in Bradford, UK (P = 0.0002).

70 with intellectual disabilities in Cambridge (UK).

71 from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020.

72 diction (POP) study, conducted in Cambridge, UK, to identify predictive metabolites.

73 oundation, Deutsche Krebshilfe, Blood Cancer UK, Associazione Italiana per la Ricerca sul Cancro, Can

74 er Research UK, AstraZeneca, Prostate Cancer UK, the Prostate Cancer Foundation, the Experimental Can

75 Research Oxford Biomedical Research Centre, UK Medical Research Council, Health Data Research UK.

76 lling >=60-year-old women in South Cheshire, UK.

77 ity as a trait in a large population cohort (UK Biobank, n = 363,705).

78 pathogenic bacteria from soils in Cornwall (UK).

79 Current UK decontamination methods performed in sequence were pa

80 se data provide an evidence base for current UK, Australian, and European guidelines for the treatmen

81 ct across three population-imaging datasets: UK Biobank, Brain Genomics Superstruct Project, and Enha

82 ), and (3) Renal Risk in Derby (RRID, Derby, UK, N = 1,739).

83 The Against Malaria Foundation, UK Department for International Development, Innovative

84 tional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nono

85 We use data from UK and Estonian biobanks (UKB, EB) as well as case-contr

86 Here we integrate data from UK Biobank and a large-scale international collaborative

87 events in 357 882 unrelated individuals from UK Biobank.

88 up to 275,596 independent participants from UK Biobank.

89 to the number of pancreatic transplants from UK registry data during the same time period.

90 an observational study in 256,661 women from UK Biobank, born between 1939 and 1970.

91 -4 centiMorgan (cM) IBD segments in the full UK Biobank data.

92 dditional case/control samples from Germany, UK, and USA identified five variant carriers among AD pa

93 ystalline rock system (Carnmenellis Granite, UK) corroborate these results.

94 In this study, healthy UK and Senegalese adults aged 18-50 yr (average, 29 yr)

95 compared to a Caucasian PCOS biobank in Hull UK (108 with PCOS, 69 controls).

96 respiratory samples from 719 critically ill UK patients with COVID-19 and suspected pulmonary asperg

97 In UK Biobank, a combination of coronary heart disease and

98 forced expiratory volume in 1 s (FEV(1)) in UK Biobank (n = 321,047) by using two-sample Mendelian r

99 s of PD (n=1276) and controls (n=500 406) in UK Biobank.

100 We also conducted a follow-up analysis in UK Biobank, which showed that amongst individuals with a

101 OR 0.90; 95% CI 0.83-0.98; p = 0.011) and in UK Biobank (OR 0.90; 95% CI 0.80-1.02; p = 0.104), but t

102 n metabolites in 1C metabolism are common in UK women in early pregnancy and are independently associ

103 g 367,643 individuals of European descent in UK Biobank who were 37 to 73 years of age when recruited

104 study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter

105 nine risk factors of heat-related illness in UK dogs under primary veterinary care in 2016.

106 ons most highly associated with mortality in UK Biobank and 12 of the top combinations in the Taiwan

107 5% CI 1.41-2.68; p = 4.68 x 10-5) but not in UK Biobank (OR 1.12; 95% CI 0.65-1.93; p = 0.686).

108 er variants associated with schizophrenia in UK Biobank and 9063 individuals who did not carry any of

109 ched for potential causal effects of SHBG in UK Biobank (N = 334 977) and followed-up our top finding

110 We then apply DBSLMM to analyze 25 traits in UK Biobank.

111 ced by case stratification and survival into UK Biobank may distort the associations of PRS derived f

112 Coupling SOX to the Joint UK Land Environment Simulator (JULES) LSM, we conducted

113 Declines in breeding seabirds on St Kilda, UK, have been linked to climate change and predation fro

114 vice (NHS) Trusts within the United Kingdom (UK).

115 ple subtidal habitats in the United Kingdom (UK).

116 HCWs were screened for SARS-CoV-2 in a large UK teaching hospital.

117 n reductions in BP similar to those in large UK trials.

118 In this large UK cohort, we found persuasive evidence that South Asian

119 n an inner-city maternity service in London (UK), but there is no impact on most outcomes for this po

120 lant skin surveillance clinics: 1 in London, UK and 1 in Philadelphia, USA.

121 Diploid males were found in many UK nests, while microsatellite analysis showed that nest

122 increased risk of stroke in the MEGASTROKE, UK BioBank, and FinnGen studies.

123 ffusion (Mast Group Ltd., Bootle Merseyside, UK), Etest (bioMerieux, Inc., Durham, NC), and MIC test

124 in this geographically dispersed multicenter UK cohort indicates that this condition should be consid

125 Using a national UK general practice database linked to hospitalizations

126 with celiac disease included in the National UK Biobank, which contains experimental medical data fro

127 We used nationwide UK primary care medical records, 2001-2017, to identify

128 ics and other anthropogenic fibres in native UK shark species and highlights the pervasive nature of

129 human immunodeficiency virus (HIV)-negative UK cohort of 333 tuberculosis contacts.

130 In a new UK cohort of 333 HIV-negative tuberculosis contacts with

131 on and there was a limited representation of UK ethnic minority groups in the study cohort.

132 Using two baseline subsamples of UK Biobank: prevalent CAD cases (N = 10 287) and individ

133 Thousands of UK doctoral students and early-career researchers shared

134 cted a case-control study in 23-38 years old UK-born White adults with first tuberculosis episode, an

135 he UK in Trioza anthrisci, but its impact on UK crops is unknown.

136 own ground-truth subclasses, particularly on UK Biobank brain imaging data and transcriptome data fro

137 admissions with COVID-19 during the ongoing UK 'lockdown'.

138 on of 92 728 people residing in Oxfordshire, UK.

139 d network within 112 regions of Oxfordshire, UK.

140 EME) Programme, an MRC and NIHR partnership, UK Multiple Sclerosis Society, and US National Multiple

141 Adjuvant treatment was given as per UK standard local practice.

142 V prevalence statistics for Germany, Poland, UK, and Chile.

143 d and whether the drugs prescribed reflected UK licensing and guidelines.

144 Cancer Research UK, AstraZeneca, and Puma Biotechnology.

145 Cancer Research UK, AstraZeneca, Prostate Cancer UK, the Prostate Cancer

146 UK Medical Research Council, Cancer Research UK, British Heart Foundation, US Centers for Disease Con

147 l, British Heart Foundation, Cancer Research UK, Kadoorie Charitable Foundation, China Ministry of Sc

148 Cancer Research UK, MRC Clinical Trials Unit, and Canadian Cancer Societ

149 Cancer Research UK, National Institute for Health Research, the UK Natio

150 Cancer Research UK, the National Health and Medical Research Council Aus

151 Cancer Research UK, UK Medical Research Council, Health Research Board i

152 Public Health England, Health Data Research UK, and the National Institute for Health Research Oxfor

153 dical Research Council, Health Data Research UK.

154 Study (SKS, Salford Royal Hospital, Salford, UK, N = 861), and (3) Renal Risk in Derby (RRID, Derby,

155 p, pragmatic equivalence trial, men in seven UK hospitals with bothersome lower urinary tract symptom

156 reams to the main river in the River Thames, UK.

157 Studies with YY4-yne revealed that UK-5099, an alpha-cyanocinnamate inhibitor of the MPC co

158 The UK Biobank is a prospective study of more than 500 000 p

159 The UK Biobank study, with all 500,000 participants having u

160 The UK healthcare system has transitioned to predominantly S

161 In September 2015, the UK implemented 4CMenB into the national infant immunisat

162 Between 11 March and 14 July 2020, the UK National Mycology Reference Laboratory received 1,267

163 Twelve studies from: the USA (n = 6); the UK (n = 3); Australia (n = 2); and one shared paper betw

164 ICU-acquired infections occurred across the UK ICU network linked with the first few years of a nati

165 variability in access to testing across the UK.

166 ralia, Europe, Japan, North America, and the UK between Jan 1, 1988, and Dec 31, 2016.

167 study with 69,716 Norwegian samples and the UK Biobank data with 408,910 White British samples, we s

168 or Depressive Disorder Working Group and the UK Biobank.

169 ce, Germany, Italy, Taiwan, the USA, and the UK into seven cohorts of patients with different INI1-ne

170 Medical Research Council and the UK National Institute of Health Research in part through

171 nce, Italy, Greece, the Netherlands, and the UK, and eight academic centres in the USA.

172 found among populations from Iberia and the UK.

173 centres in Canada, Denmark, Ireland, and the UK.

174 t, Greece, Albania, Cyprus, Tunisia, and the UK.

175 ge-scale human phenomic projects such as the UK Biobank and the All of Us resources.

176 Because the UK Biobank population is healthier than the general popu

177 compared with 3.0 +/- 1.7 kt reported by the UK national inventory.

178 loped using a 6-step process informed by the UK sugar and salt reduction programs.

179 Graphite calorimetry, the UK primary standard, has been employed to measure the do

180 In 2018, JUUL entered the UK market, where EU regulations limit liquid nicotine co

181 es from the Human Mortality Database for the UK (2015); body mass index distribution from the Health

182 We derive control policies for the UK that minimise the number of infected farms during an

183 Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer

184 less of suicidal intent) using data from the UK Biobank (n > 156,000).

185 ain magnetic resonance imaging data from the UK Biobank (n = 8185; age range, 45-78 years), we examin

186 and female (n = 227, 235) controls from the UK Biobank (recruited aged 40-69 from the UK general pop

187 ns of thousands of genetic siblings from the UK Biobank (UKB), for whom we have SNP genotypes, health

188 of TSEA-DB includes 4423 data sets from the UK Biobank (UKBB) and 596 from other resources (GWAS Cat

189 49,960 exome-sequenced individuals from the UK Biobank and 1934 phenotypes (1821 overlapping with UK

190 wide analysis for asthma using data from the UK Biobank and the Trans-National Asthma Genetic Consort

191 ne on 461 outcomes in 161,268 males from the UK Biobank study.

192 ropeans (150 cases; 1,309 controls) from the UK Biobank study.

193 derived DNA of 482,789 participants from the UK Biobank(10).

194 Using data from the UK Biobank, 23andMe and the International Handedness Con

195 Using data from the UK Biobank, predictors have been constructed using penal

196 In this analysis of data from the UK Biobank, we found that regardless of the presence of

197 n, Denmark, and 334,691 individuals from the UK Biobank.

198 ied to simulated data and real data from the UK Biobank.

199 he UK Biobank (recruited aged 40-69 from the UK general population).

200 UK Aid from the UK Government, Dutch Ministry of Foreign Affairs, UNDP/U

201 on and externally validated on data from the UK Joint Theatre Trauma Registry.

202 en, recruited between 2009 and 2014 from the UK Pregnancies Better Eating and Activity Trial (UPBEAT)

203 Live donor dataset was obtained from the UK Transplant Registry and a comparator nondonor cohort

204 s of more than 600,000 participants from the UK, Estonian, and Vanderbilt University Medical Center's

205 S population, combining information from the UK-based OpenSAFELY study with mortality rates by age an

206 a validation cohort of 36 children from the UK.

207 h countries but is twice as prevalent in the UK (39% of transplants) vs the US (20%).

208 ting NIHR Biomedical Research Centres in the UK (all tertiary centres with emergency departments).

209 two different early pregnancy cohorts in the UK (cohort 1; n = 244 and cohort 2; n = 60) with anthrop

210 g from 40% of TEVARs in the US to 72% in the UK (p < 0.001).Mean intact TAA (iTAA) diameter varied fr

211 t of Lso in cultivated carrot growing in the UK and raises concern for the carrot and potato growing

212 hed by WHO and public health agencies in the UK and the USA.

213 and FTO show evidence of replication in the UK Biobank (European ancestry n ~ 320,000), while coloca

214 m both the patient reported phenotype in the UK Biobank (h(2)(SNP) = 0.035, p = 7.12 x 10(-4)) and th

215 nificantly decreased sepsis mortality in the UK Biobank (hazard ratio, 0.77 [95% CI, 0.59-1.00] per 1

216 yed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sec

217 iation with musculoskeletal disorders in the UK Biobank (p = 4.88 x 10(-7)).

218 ), these relationships were validated in the UK Biobank (P<0.0001).

219 associated with neck or shoulder pain in the UK Biobank cohort, two of which were weakly supported in

220 se to define proxy cases and controls in the UK Biobank for a genome-wide association by proxy, which

221 tudies (GWAS) of complex human traits in the UK Biobank has not been investigated.

222 re computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci (P < 1x10

223 associated with neck or shoulder pain in the UK Biobank samples.

224 from 394,388 cancer-free participants in the UK Biobank study were analyzed.

225 tic information for clinical outcomes in the UK Biobank, a population-based cohort.

226 predisposition to AF, and incident AF in the UK Biobank, a prospective cohort study.

227 In the UK Biobank, age differences in individual connectome ele

228 In the UK Biobank, circadian strain markers (sleep length, chro

229 ation codes from 320,644 participants in the UK Biobank, representing a large and heterogeneous popul

230 ic blood pressure, and pulse pressure in the UK Biobank, we estimate that 9.3%, 3.9%, 1.6%, and 12.5%

231 subset of participants (n = 157,366) in the UK Biobank.

232 cific cancers for 367,703 individuals in the UK Biobank.

233 e fine-scale geographical confounding in the UK Biobank.

234 reatinine ratio previously identified in the UK Biobank.

235 ], 46% male, 95% white) were analysed in the UK Biobank; this longitudinal study collected data betwe

236 Serbian cohort and in 23/118 (19.5%) in the UK cohort.

237 s between 05.30 hours and 21.00 hours in the UK could make a meaningful contribution to reducing chil

238 Here, we present and analyse trends in the UK distributions of over 5,000 species of invertebrates,

239 ral diversity-of secoiridoids present in the UK group may provide a robust reservoir of anti-feeding

240 see days above 40 degrees C somewhere in the UK have a return time of 100-300 years at present, but,

241 irth Defects in the Genomic Age' held in the UK in November 2019, identifying key hurdles in the fiel

242 s bacterium has previously been found in the UK in Trioza anthrisci, but its impact on UK crops is un

243 ghted fine-scale population structure in the UK on a North-West to South-East cline, but the impact o

244 a clear and robust adaptive signature in the UK population by using a haplotype-based statistic, the

245 tandard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low d

246 Seven different regions in the UK were explored and improvements in efficiency from the

247 nrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary

248 e double-reading process that is used in the UK, and found that the AI system maintained non-inferior

249 ase 3 trial done across 117 hospitals in the UK, Australia, New Zealand, Mexico, South Korea, and Ire

250 CIG) trial done at 117 hospital sites in the UK, Australia, New Zealand, Mexico, South Korea, and Rep

251 sus allopurinol in patients with gout in the UK, Denmark, and Sweden.

252 fficulties adapting to their new life in the UK, including within their role as a nurse, but also in

253 Numbers decreased in the UK, Ireland, and in the Netherlands, while numbers were

254 were enrolled from 14 health centres in the UK, the USA, Israel, France, Switzerland, and South Kore

255 tional nurses being recruited to work in the UK, this review raises concerns based on the need to eff

256 in midwives nor any studies conducted in the UK, with most studies conducted in the US, Italy and Tai

257 rs (5:30 AM to 9:00 PM) on television in the UK.

258 was undertaken at six clinical sites in the UK.

259 ive output and success of nests found in the UK.

260 ada, but slightly more than one death in the UK.

261 y centres and 50 referring hospitals) in the UK.

262 controlled trial done at 39 hospitals in the UK.

263 rolled trial was done at 22 hospitals in the UK.

264 rained picture of genetic relatedness in the UK.

265 it Right First Time" (GIRFT) program in the UK.

266 c delays due to the COVID-19 pandemic in the UK.

267 pregnancy and adverse child outcomes in the UK: population based cohort study.

268 participants were not representative of the UK as a whole.

269 nclude the lack of representativeness of the UK Biobank sample, that self-harm was self-reported, and

270 450,000 individuals (age 40-69 years) of the UK Biobank, a population-based cohort study.

271 scenario, with indices in all regions of the UK increasing to indicate very high hazard of decay.

272 hydrate diet (LCD) or not in a sample of the UK population.

273 The announcement of the UK SDIL was associated with reductions in volume and sug

274 ch published since 2010 and focussing on the UK as the host country.

275 rd were to mothers who were born outside the UK.

276 cted at 24 trauma hospitals representing the UK Major Trauma Network that included 1548 patients aged

277 National Institute for Health Research, the UK National Health Service, Medtronic, and the Medical R

278 ce images from a population-based study, the UK Biobank, using an automated machine-learning-based an

279 any, Israel, Italy, South Korea, Sweden, the UK, and the USA.

280 We therefore recommend that the UK should deploy neurosurgeons to forward military MTF w

281 We applied our approaches to the UK Biobank data of 488 366 study samples with 2492 sampl

282 Using the UK Biobank population imaging-genetics cohort (n = ~40,0

283 ociated with the risk of infection using the UK Biobank sample and the iPSYCH Danish case-cohort stud

284 ed a population-based cohort study using the UK Clinical Practice Research Datalink linked to the Hos

285 Using the UK Clinical Practice Research Datalink, we formed a coho

286 uscle paresis in patients with ALS using the UK Medical Research Council (MRC) scoring system; we sub

287 use mortality in independent data within the UK Biobank: the estimated hazard ratios per standard dev

288 We utilise observations to relate local to UK mean extremes and apply the resulting relationships t

289 & Melinda Gates Foundation, Wellcome Trust, UK Department for International Development, and Medical

290 aged 18 years and older were enrolled at two UK clinical research facilities, in an age-escalation ma

291 Cancer Research UK, UK Medical Research Council, Health Research Board in Ir

292 The study was carried out in Canada, US, UK, Australia, Sweden, and Israel, from 2016 to 2019.

293 Here, we used UK Biobank data to reproduce several well-known associat

294 lone transplants between 2003 and 2018 using UK Transplant Registry data.

295 effect of SNPs on the ITIH3 expression using UK Brain Expression Consortium database; validating the

296 A retrospective cohort study using UK primary care electronic health records from the Clini

297 mother's migrant status (foreign-born versus UK/Irish-born).

298 ling dippers at 15 sites across South Wales (UK).

299 temperate marsh system in Southampton Water, UK.

300 These findings support a model where UK-5099 inhibits the MPC complex by binding to C54 of MP

301 k and 1934 phenotypes (1821 overlapping with UK Biobank) in 21,866 members of the Healthy Nevada Proj