ライフサイエンスコーパス: URI

1 URI (unconventional prefoldin RPB5 interactor protein) i

2 URI inhibits aryl hydrocarbon (AhR)- and estrogen recept

3 URI is a member of the amidohydrolase superfamily (AHS),

4 URI is phosphorylated upon androgen treatment, suggestin

5 URI severity was scored using a questionnaire and the de

6 URI was determined by testing nasal mucus for upper resp

7 sociations between indoor allergens and: (1) URI; (2) URI + cold symptoms; (3) URI + cold symptoms +

8 P = 0.004), respectively, and those from 140 URI samples from hematopoietic cell transplantation reci

9 ted with and without saline spray during 142 URIs from immunocompetent subjects were 96% and 86% (P =

10 s between indoor allergens and: (1) URI; (2) URI + cold symptoms; (3) URI + cold symptoms + pulmonary

11 eive either echinacea or placebo for up to 3 URIs over a 4-month period.

12 s and: (1) URI; (2) URI + cold symptoms; (3) URI + cold symptoms + pulmonary eosinophilic inflammatio

13 that occurred in 407 children, including 337 URIs treated with echinacea and 370 with placebo.

14 n of exhaled nitric oxide >=20 ppb); and (4) URI + cold symptoms + reduced lung function (percent pre

15 We evaluated 519 URIs, and 37 illnesses in 31 patients met the criteria f

16 Data were analyzed on 707 URIs that occurred in 407 children, including 337 URIs t

17 0% vs 11%, (P =.70); and an aggregation of 8 URI symptoms, 3% in both groups (P>.99).

18 racial and ethnic disparities in acquiring a URI but not in the severity of infection.

19 The X-ray structure of Bh0493, a URI from Bacillus halodurans, was determined in the pres

20 n Slx1p-like predicted nuclease containing a URI domain.

21 e written for children diagnosed as having a URI or nasopharyngitis (common cold), and 4.7 million (9

22 ompleted their study period without having a URI.

23 nce interval [CI], 0.99-1.40), the odds of a URI + cold symptoms + pulmonary eosinophilic inflammatio

24 1.31, 95% CI, 1.10-1.57), and the odds of a URI + cold symptoms + reduced lung function by 45% (OR =

25 lergen concentration increased the odds of a URI with cold symptoms by 18% (odds ratio [OR] = 1.18, 9

26 spersed little S. aureus in the absence of a URI.

27 CI, 1.16-1.94) were more likely to report a URI than those who identified as White.

28 n were more than twice as likely to report a URI than White children (aOR, 2.28; 95% CI, 1.31-3.95).

29 dispersal of S. aureus in association with a URI may be an important mechanism of transmission of S.

30 ciations between allergen concentrations and URI-associated outcomes accounting for age, sex, study m

31 associated with ED visits for pneumonia and URI.

32 t Ser-371, resulting in PP1gamma release and URI-mediated OGT inhibition.

33 onsmoke PM(2.5), particularly for asthma and URIs.

34 rred in patients with ALCs of >1000/mm(3) at URI onset.

35 Associations between URI and pulmonary eosinophilic inflammation or lung func

36 there was no difference in duration between URIs treated with echinacea or placebo (P =.89).

37 In the presence of glucose, PP1gamma-bound URI increases OGT and c-MYC levels.

38 iated transcription is achieved, in part, by URI binding and regulation of androgen receptor trapped

39 s decreased following recruitment of PP2A by URI.

40 functional complex between the co-chaperone URI, PP1gamma, and OGT, the enzyme catalyzing O-GlcNAcyl

41 that included a principal diagnosis of cold, URI, or bronchitis.

42 bing for children diagnosed as having colds, URIs, and bronchitis, conditions that typically do not b

43 Consistently, URI expression in human HCC is associated with poor surv

44 s study aimed to demonstrate whether current URI symptoms induce aggravation of perioperative atelect

45 While Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent rec

46 H2O +/- 6.2, and 25.5 cm H2O +/- 3.0 during URI (p < 0.05 for each), respectively.

47 mm Hg +/- 1.1 and 95.1% +/- 1.0, and during URI, 43.9 mm Hg +/- 2.1 (p < 0.05) and 95.0% +/- 1.0 (NS

48 whether race/ethnicity is a risk factor for URI-associated pulmonary eosinophilic inflammation or de

49 rate profiles for k(cat) and k(cat)/K(m) for URI from Escherichia coli are bell-shaped and indicate t

50 ; 52 (27%) of observations were positive for URI.

51 bin air recirculation increases the risk for URI symptoms in passengers traveling aboard commercial j

52 ent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes.

53 % confidence interval: 2%, 6%) in visits for URI and an 8% increase (95% confidence interval: 4%, 13%

54 e pulmonary disease, 1.001 (1.000-1.011) for URIs, and 1.004 (1.004-1.004) for bronchitis.

55 Use of guideline-discordant antibiotics (for URIs), radiography (for URIs and back pain), computed to

56 outpatients were prescribed antibiotics for URIs, despite viral etiologies identified among 75% of t

57 of patients were prescribed antibiotics for URIs.

58 viral testing in antibiotic prescribing for URIs in outpatient oncology settings merits further stud

59 ant antibiotics (for URIs), radiography (for URIs and back pain), computed tomography (CT) or magneti

60 There were 2710 visits for URIs for which routine cultures did not reveal a viral e

61 eveloped sinusitis experienced more frequent URIs, compared to children whose URIs remained uncomplic

62 ia by the shelter staff and additionally had URI were included in the study, for a total of 22 study

63 generation of Uniform Resource Identifiers (URIs) to uniquely identify any record in a collection.

64 entities using Unified Resource Identifiers (URIs), and sharing information using Resource Descriptio

65 cytial virus was detected more frequently in URI visits that led to sinusitis, compared to in uncompl

66 inflammation reinstates ISC proliferation in URI-depleted mice.

67 = 63,359), and upper respiratory infection (URI) (n = 359,246) among children 0-4 years of age were

68 e/ethnicity and upper respiratory infection (URI) and (2) whether race/ethnicity is a risk factor for

69 ter duration of upper respiratory infection (URI) and overall use and average dose of ICS.

70 ebo) on risk of upper respiratory infection (URI) in older adults.

71 cation of viral upper respiratory infection (URI).

72 inical signs of upper respiratory infection (URI).

73 upper and lower respiratory-tract infection (URI and LRI, respectively).

74 Upper respiratory tract infection (URI) symptoms are known to increase perioperative respir

75 sion from upper respiratory tract infection (URI) to LRD.

76 ing acute upper respiratory tract infection (URI) was assessed in patients with various forms of neur

77 nfluenza, viral upper respiratory infection [URI], bronchiolitis, bronchitis, nonsuppurative OM) as a

78 Viral upper respiratory infections (URIs) are common and often precipitate acute otitis medi

79 bing for acute upper respiratory infections (URIs) is a high-priority target for antimicrobial stewar

80 onary disease, upper respiratory infections (URIs), and bronchitis, from five states in the western U

81 ceptibility to upper respiratory infections (URIs).

82 ted with viral upper respiratory infections (URIs).

83 cts during 146 upper respiratory infections (URIs); the sensitivities for reverse transcription (RT)-

84 ology of upper respiratory tract infections (URIs) in children over a period of many years has not be

85 tment of upper respiratory tract infections (URIs).

86 at unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular c

87 he unconventional prefoldin RPB5 interactor (URI) is a new regulator of AR transcription and is criti

88 of unconventional prefoldin RPB5 interactor (URI) leads to a multistep process of HCC development, wh

89 by unconventional prefoldin RPB5 interactor (URI), control R-spondin production to guide ISC prolifer

90 Genetic intestinal URI ablation in mice injures TA cells, reducing their su

91 scription factor Upstream Regulator of IRT1 (URI) acts as an essential part of the iron deficiency si

92 Uronate isomerase (URI) catalyzes the reversible isomerization of D-glucuro

93 ciency, supplemental vitamin D did not lower URI risk overall.

94 Incidence of reporting new URI symptoms within 1 week of the flight.

95 We functionally characterize the novel URI-KAP1-PP2A complex, demonstrating a role of URI in re

96 uencing (ChIP-seq) reveals direct binding of URI to promoters of many iron-regulated genes, including

97 Whereas depletion of URI enhances AR-mediated gene transcription, overexpress

98 Further, depletion of URI increases the expression of the AR target gene NKX-3

99 g in prostate cancer cells upon depletion of URI or Art-27 reveals substantially overlapping patterns

100 ths was associated with a longer duration of URI, but with a decrease in the occurrence of lower resp

101 Thirteen episodes of URI developed in 10 patients.

102 We propose that the phosphorylated form of URI accumulates under Fe deficiency, forms heterodimers

103 ess of iron status, a phosphorylated form of URI only accumulates under iron deficiency.

104 esting that it is the phosphorylated form of URI that is capable of forming heterodimers in vivo.

105 These data unveil a new nuclear function of URI and identify a novel post-transcriptional regulation

106 However, the influence of URI symptoms on anaesthesia-induced atelectasis in child

107 -1 and L1PA2 retroelements upon knockdown of URI.

108 diated gene transcription, overexpression of URI suppresses AR transcriptional activation and anchora

109 I-KAP1-PP2A complex, demonstrating a role of URI in retrotransposon repression, a key function previo

110 The correlation between severity of URI and degree of atelectasis was analysed by multiple l

111 rence in the overall estimate of severity of URI symptoms between the 2 treatment groups (median, 33

112 mical mechanism and active site structure of URI were investigated in an attempt to improve our under

113 We conducted a prospective study of URI and LRI in adults with hematologic malignancies duri

114 hildren had only one or two mild symptoms of URI, which were not associated with the atelectasis scor

115 cyte count (ALC) </=100/mm(3) at the time of URI onset were significantly associated with disease pro

116 The median duration of URIs was 9 days (95% confidence interval, 8-10 days); th

117 cribe the clinical and virologic features of URIs that remain uncomplicated and those that precede an

118 The median number of URIs per subject per year was 1 (range 0-9) in uncomplic

119 dingly, mice expressing non-phosphorylatable URI (S371A) in hepatocytes exhibit high OGT activity and

120 Phosphorylated URI is subject to proteasome-dependent degradation durin

121 ron resupply, and turnover of phosphorylated URI is dependent on the E3 ligase BTS.

122 the activation of PKA, which phosphorylates URI at Ser-371, resulting in PP1gamma release and URI-me

123 ber of a family of proteins with a predicted URI nuclease domain and PHD-type zinc finger.

124 primary outcome was self-report of a recent URI at 1-year follow-up.

125 ffect of vitamin D supplementation on recent URI was nonsignificant (odds ratio [OR], 0.96 [95% confi

126 After experimental induction of a rhinovirus URI, physician 4's airborne dispersal of S. aureus witho

127 ession to LRD in 181 HCT recipients with RSV URI.

128 s able to dereference a single ontology term URI, and then output RDF/eXtensible Markup Language (XML

129 Our work uncovers that URI-regulated OGT confers c-MYC-dependent survival funct

130 atment, suggesting communication between the URI and AR signaling pathways.

131 her clinical data at first encounter for the URI through day 14.

132 sinusitis with those identified early in the URI.

133 arental global assessment of severity of the URI (P =.67).

134 ed at surveillance visits, on Day 3-4 of the URI, and on Day 10, when sinusitis was diagnosed.

135 set of symptoms and continued throughout the URI, for a maximum of 10 days.

136 s showed significant correspondence with the URI severity (odds ratio 1.36, 95% confidence interval 1

137 during viral URIs versus AOMs following the URIs, when compared to sOP children.

138 s; however, rash occurred during 7.1% of the URIs treated with echinacea and 2.7% of those treated wi

139 osure may predispose children with asthma to URIs with colds and lower respiratory outcomes.

140 in this study, was not effective in treating URI symptoms in patients 2 to 11 years old, and its use

141 efficacy and safety of echinacea in treating URIs in children.

142 per year was 1 (range 0-9) in uncomplicated URI subjects and 3 (range 1-9) in sinusitis subjects (P

143 d to sinusitis, compared to in uncomplicated URIs (10.8% vs 3.4%; P = .05).

144 ion), pharyngitis ($21.3 million), and viral URI ($19.1 million).

145 erent nasopharyngeal responses between viral URI events and the following AOM episodes in both sOP an

146 ponses initiated in the early phase of viral URI contribute to preventing the development of AOM.

147 d higher), viral URIs (P < .0001), and viral URIs followed by AOMs (P < .0001) than the NOP children.

148 P = .002), and IL-17 (P = .007) during viral URIs versus AOMs following the URIs, when compared to sO

149 ine levels in the nasopharynxes during viral URIs, and examined the different nasopharyngeal response

150 ES; P = .002) than NOP children during viral URIs.

151 e that sOP children have more frequent viral URIs than NOP children, due to deficient antiviral nasop

152 episodes per child (8.86-fold higher), viral URIs (P < .0001), and viral URIs followed by AOMs (P < .

153 ureus into the air in association with viral URIs.

154 yncytial virus (RSV) and parainfluenza virus URIs on the frequency of AOM caused by Streptococcus pne

155 ncluding bHLH38/39/100/101 but not FIT While URI transcript and protein are expressed regardless of i

156 re frequent URIs, compared to children whose URIs remained uncomplicated.

157 piratory muscle strength in association with URI.

158 patients at an ambulatory cancer center with URI diagnoses from 1 October 2015 to 30 September 2016.

159 bHLH38/39/100/101, coimmunoprecipitate with URI mainly under Fe-deficient conditions, suggesting tha

160 d the protein phosphatase PP2A interact with URI.

161 In patients with URI, mean baseline VC, MIP, and MEP were 1.16 L +/- 0.14

162 44% of patients with common colds, 46% with URIs, and 75% with bronchitis.

163 ted in a substantial number of children with URIs and concomitant AOM.

164 m a cohort of 1532 infants and children with URIs who were prospectively followed for an average of 2

165 o induces atelectasis, which may worsen with URIs and yield detrimental outcomes.