ライフサイエンスコーパス: UTR

1 Our successful functional assignment of a 3' UTR sRNA from a non-standard growth condition supports t

2 f UTRs, the optimal combination of 5' and 3' UTR are identified and termed NASAR, which are 5- to 10-

3 ote accumulation of chromatin-associated, 3' UTR-extended, nascent transcripts, through inhibition of

4 genesis of the single canonical conserved 3' UTR miR-290-binding site of Pfn2 or overexpression of th

5 selection and consequently their distinct 3' UTR isoforms are more likely to have functional conseque

6 one mRNA levels, on activity of a histone 3' UTR reporter, and ultimately on MERVL regulation could a

7 demonstrate that precise mutation of hth 3' UTR sites for BX-C miRNAs or deletion of its neural 3' U

8 luding Sox2, which partially protects its 3' UTR from miR-21-mediated degradation.

9 on observed in the proximal region of its 3' UTR.

10 in IPF lung fibroblasts by targeting its 3' UTR.

11 similar capacities to induce a lengthened 3' UTR landscape in an ectopic setting.

12 80S ribosomes that migrate into the mRNA 3' UTR independent of canonical translation.

13 ucleotide-long sequence in the LdNT3 mRNA 3' UTR that is predicted to adopt a stem-loop structure.

14 fects gene expression in the slow mutant: 3' UTR shortening and gene derepression by premature transc

15 for BX-C miRNAs or deletion of its neural 3' UTR extension containing most of these sites both induce

16 ific deployment of highly extended neural 3' UTR isoforms, generated by alternative polyadenylation (

17 lack of coherence among the regulation of 3' UTR isoforms is a proxy for selective pressures acting u

18 nce to demethylate promoter, gene body or 3' UTR regions to activate a set of SAGs.

19 the half-lives of mRNAs based on overall 3' UTR structure formed by base pairing.

20 1 and S2, respectively) in the pestiviral 3' UTR.

21 ng 12-nucleotide sequence in the proximal 3' UTR of MTCH2 is the necessary signal for SCR.

22 rocessed from the 3' untranslated region (3' UTR) of the oppABCDF and carAB operons, respectively, an

23 atures within the 3' untranslated region (3' UTR) often direct mRNAs for decay.

24 2 isoforms in the 3' untranslated region (3' UTR), 2640 of which are novel and do not fall within 10

25 icroRNA (miRNA)-mediated silencing in the 3' UTR of a subset of mRNAs through its interaction with RN

26 irectly binds to miR-33a/b, AGO2, and the 3' UTR of ABCA1 Finally, we show that mice overexpressing h

27 rizing candidate NarS that represents the 3' UTR of nitrate transporter NarK whose gene is silent dur

28 tivation of the aptazyme, inserted in the 3' UTR of the target gene, resulted in rapid self-cleavage

29 ed at stop codons and could move into the 3' UTR to reinitiate translation.

30 ucing the overall structure by fusing the 3' UTR with an unstructured sequence.

31 promoters and alternative splicing of the 3' UTR.

32 APA leading to 3' UTR shortening (3' US) is a common feature of most cance

33 by generating mRNA isoforms with varying 3' UTR lengths.

34 viral luciferase reporter carrying the WT 3' UTR of RXFP1 was significantly repressed in IPF lung fib

35 druplex forming sequences (pG4) in 5' and 3' UTRs are selectively constrained, and enriched for cis-e

36 Combining 3' UTRs and splice isoforms, we identified 28,858 full-leng

37 Our data show that sRNAs from 3' UTRs serve as autoregulatory elements allowing negative

38 Small noncoding RNAs (sRNAs) from mRNA 3' UTRs seem to present a previously unrecognized layer of

39 mall ORFs in the 3' untranslated regions (3' UTRs) of human and zebrafish mRNAs and found that many a

40 te levels of mRNAs with highly structured 3' UTRs as well as highly structured circular RNAs.

41 function of translated small ORFs in the 3' UTRs (downstream (d)ORFs) is unknown.

42 ates that MARF1 predominantly binds their 3' UTRs via its LOTUS domains to promote their decay.

43 chment of G-quadruplex sequences in their 3' UTRs, suggesting that FMRP recognizes them to promote RN

44 ions of piRNAs with target mRNAs in their 3' UTRs, which activates translation through coupling with

45 3'UTR variations may occur through different processes, in

46 24 post-transcriptionally regulates Parp-1 3'UTR activity in a dopaminergic neuronal cell model.

47 that miR-124 directly binds to the Parp-1 3'UTR and mutations in the seed sequences abrogate binding

48 y, the binding region of miR-124 in Parp-1 3'UTR overlapped with the target sequence of miR-125b, ano

49 dies revealed that miR-124 binds to Parp-1 3'UTR with greater affinity and confers a dominant post-tr

50 s that retarget mir-35 to the mutant egl-1 3'UTR.

51 Using a utrophin 5'3'UTR reporter assay, we performed a high-throughput scree

52 the RNA secondary structure of three CHIKV 3'UTR variants that differ in their ability to replicate i

53 d that miR-125b negatively regulates CPSF6 3'UTR-driven luciferase activity.

54 t miR-125b physically interacts with CPSF6 3'UTR.

55 egulatory effect of the miRNA on the CPSF6 3'UTR.

56 A polymerase II transcripts with different 3'UTR lengths.

57 rgeting a non-CUG sequence within the DMPK 3'UTR has demonstrated benefit on the key DM1 phenotypes o

58 strated that expression of the mutant DMPK 3'UTR is sufficient to elicit these features of DM1.

59 RNA foci and DMPK 3'UTR mRNA levels were reduced in both the heart and skele

60 ics package, named APAlyzer, for examining 3'UTR APA, intronic APA and gene expression changes using

61 by RNase E-mediated maturation of the fabB 3'UTR, and, together with Hfq, inhibits the expression of

62 zinc-finger mutant ZFP36L1, bound to HIF1A 3'UTR and mediated HIF1A mRNA degradation, leading to redu

63 many sRNA-sRNA interactions and involving 3'UTR-derived sRNAs.

64 ed the expression of CD24 by targeting its 3'UTR (untranslated region) and could be inhibited by SIRT

65 rojections and reflects precise gene-level 3'UTR changes.

66 P1 regulates the balance of short and long 3'UTR isoforms by inhibiting NMD, in addition to its previ

67 factor UPF1 preferentially recognizes long 3'UTR products of APA, leading to their systematic downreg

68 n between MIR200C-3p and the occludin mRNA 3'UTR identified sites of interaction.

69 the nucleotide bases in the occluding mRNA 3'UTR that interact with MIR200C-3p.

70 that RBM24 directly binds to the Sox2 mRNA 3'UTR, which is dependent on AU-rich elements (ARE) presen

71 expression via direct binding to the mRNA 3'UTR.

72 ch elements (ARE) present in the Sox2 mRNA 3'UTR.

73 ility and secondary structures of multiple 3'UTR variants of CHIKV that are known to affect virus rep

74 c acetylcholine receptor beta2 (nAcRbeta2) 3'UTR fail to grow properly and pupariate.

75 d to the putative seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF

76 By generating 1130 novel 3'UTR alleles across all predicted targets, we identified

77 as miRNAs that might bind to the occludin 3'UTR.

78 stability and levels through an effect on 3'UTR shortening.

79 , we found that one factor, Clp1, promotes 3'UTR shortening associated with higher transcript stabili

80 Overexpression of PTEN 3'UTR also statistically decreased DU145 proliferation com

81 on, while the original study reported PTEN 3'UTR increased PTENP1 levels (Figure 4A; Poliseno et al.,

82 We found PTEN 3'UTR overexpression in DU145 cells did not impact PTENP1

83 ceRNAs) in DU145 cells did not impact PTEN 3'UTR regulation using a reporter, while the original stud

84 ectly bound to the 3' untranslated region (3'UTR) of Claudin-5, and lentivirus-mediated ablation of m

85 hat would bind the 3' untranslated region (3'UTR) of occludin mRNA; regions that interacted with micr

86 of miR-124 in the 3'-untranslated region (3'UTR) of Parp-1 mRNA.

87 n tract within the 3' untranslated region (3'UTR) of the dystrophia myotonica protein kinase (DMPK) g

88 miR binding to its 3' untranslated region (3'UTR).

89 However, expression of the RPS28B 3'UTR alone is insufficient to drive PB assembly.

90 Here, we demonstrate that the RPS28B 3'UTR is important for PB assembly, consistent with it har

91 ted in cis from an mRNA bearing the RPS28B 3'UTR, physically interacts more strongly with Edc3 than R

92 display a pronounced preference for short-3'UTR transcript isoforms in mTECs, a feature preceding Ai

93 Further, we demonstrate that Sox2 3'UTR AREs are necessary for RBM24-based elevation of Sox2

94 ssed TGFbeta1 gene expression and TGFbeta1 3'UTR activity.

95 TGFbeta1 expression and TGFbeta1 3'UTR-luciferase activity was quantified.

96 n through direct interaction with TGFbeta1 3'UTR.

97 of orthologous genes and demonstrated that 3'UTR sequence variations affect protein production.

98 We show that 3'UTR shortening leads to transcripts with higher mRNA sta

99 nd Bacillus subtilis mRNAs, we showed that 3'UTR variability is widespread in bacteria.

100 one using sites in nsP3 (genomic RNA), the 3'UTR (genomic and subgenomic RNAs) and after a second sub

101 impact PIF4 regulation while those at the 3'UTR affect mRNA stability to generate variations in SAUR

102 ggy Bac (PBac) transposon insertion in the 3'UTR and RNAi flies, we determined that fly rrp4 was also

103 By reducing m(6)A levels at the 3'UTR and the mRNA stability of two phosphodiesterase gene

104 associated with noncoding variants in the 3'UTR of a short isoform of HGF encoding hepatocyte growth

105 An in silico analysis revealed that the 3'UTR of CPSF6 contains a miR-125b-binding site that is co

106 ionally regulates CPSF6, we introduced the 3'UTR of CPSF6 mRNA into a luciferase reporter and found t

107 targeted to a non-CUG sequence within the 3'UTR of DMPK.

108 increased AD risk and localized within the 3'UTR of FERMT2, induced a downregulation of FERMT2 expres

109 ion of VEGF-A and VEGF-C via targeting the 3'UTR of mRNAs at a post-transcriptional level.

110 We constructed chimeric mRNAs carrying the 3'UTR of orthologous genes and demonstrated that 3'UTR seq

111 in interacting with another protein in the 3'UTR of the mRNA which encoded it, which in turn stimulat

112 that HuR binds to a U-rich element in the 3'UTR of TRIM21 mRNA and activates its translation, thereb

113 with intron 24 of Apob pre-mRNA, with the 3'UTR of Uqcrb, and with the 5'UTR of Ndufb6 mRNA, thereby

114 OC553103 directly binds and stabilizes the 3'UTR region of STMN1 mRNA.

115 revealed that EBV-miR-BART12 binds to the 3'UTR region of Tubulin Polymerization-Promoting Protein 1

116 A duplication in the 3'UTR that enhances viral replication in mosquito cells le

117 Two SNPs in the 3'UTR were found to abolish miRNA binding and thus may enh

118 e in the amount of unstructured RNA in the 3'UTR.

119 several novel RNA structures within these 3'UTR variants.

120 In addition to 3'UTR length, numerous transcriptome changes that could co

121 Using 3'UTR-luciferase reporter assays, translational regulation

122 mentary to the let-7c binding site in UTRN 3'UTR, with the goal of inhibiting let-7c interaction with

123 oocytes, a function recapitulated with YFP-3'UTR reporters.

124 er, we found decreased activity when ceRNA 3'UTRs were overexpressed, while the original study report

125 mRNA decay (NMD) substrates with extended 3'UTRs that gene- or transcript-level analyses of NMD ofte

126 suggested that species-specific functional 3'UTRs might be specifically selected during evolution.

127 pread transcript shortening through APA in 3'UTRs and in introns.

128 parison to NTCs, downstream stop codons in 3'UTRs are recognized less efficiently by ribosomes, sugge

129 ct miRNAs that target Aicda and Prdm1 mRNA-3'UTRs through inhibition of histone deacetylation (HDAC)

130 iferase reporter assays with WT and mutant 3'UTRs of CYCLIN D1 and c-MYC mRNAs revealed that binding

131 ranscripts differed in their dependence on 3'UTRs and RNA binding proteins, suggesting diverse regula

132 hortening of mRNA 3'-untranslated regions (3'UTRs) and switches to shorter mRNA isoforms due to usage

133 The 3' untranslated regions (3'UTRs) of mRNAs include regulatory elements that modulate

134 oduces transcript 3' untranslated regions (3'UTRs) with distinct sequences, lengths, stabilities and

135 ding the conservation analyses to specific 3'UTRs, as well as the entire set of Escherichia coli and

136 rent staphylococcal species confirmed that 3'UTRs were also variable in length.

137 presence of high sequence diversity in the 3'UTRs of orthologous genes.

138 ence of the potential GAIT elements in the 3'UTRs of several of these mRNAs.

139 ZFP36L1 specifically bound to the 3'UTRs of these targets for mRNA degradation, thus suppres

140 r work unveils an evolutionary bias within 3'UTRs that results in species-specific non-coding sequenc

141 Our results indicate that MBEs in ZIKV 3'UTRs occur predominantly in unpaired, single-stranded st

142 orter plasmid harboring the TOP2alpha/170 3'-UTR together with either miR-9-3p or miR-9-5p mimics res

143 hermore, we show that expression of ABCC2 3'-UTR lengths varies significantly between human healthy t

144 s, we show that expression of short ABCC2 3'-UTR variants leads to a significant loss of miR-379/ABCC

145 In conclusion, the presence of altered 3'-UTR lengths in ABC transporters could lead to functional

146 Alternative 3'-UTR lengths may contribute to variable ABCC transporter

147 rotein ORF1ab (n = 9), ORF10 (n = 1), and 3'-UTR (n = 2).

148 ession level, and poly(A) tail length and 3'-UTR length.

149 based on the sequences of CDS, 5'-UTR and 3'-UTR region covering 34%, 14%, 23%, respectively.

150 Our results implicate CYP2B11 3'-UTR mutations as a cause of decreased CYP2B11 enzyme exp

151 mulation of specific mRNAs with elongated 3'-UTR (untranslated region).

152 and do not fall within 10 bp of existing 3'-UTR data sets and annotations.

153 Hence, 3'-UTR length variability may be considered as a further me

154 ing sites, and increased heterogeneity in 3'-UTR forms of metabolic genes.

155 Analysis of malM 3'-UTR mutants showed that tight RNA binding by the ProQ NT

156 ene regulatory process that dictates mRNA 3'-UTR length, resulting in changes in mRNA stability and l

157 ding the strongest cluster within the MYC 3'-UTR.

158 ivity by binding to two sites in the NOX2 3'-UTR.

159 Survival analyses reveal a subset of 3'-UTR alterations that independently characterize a poor p

160 In the present study, we report on 3'-UTR variants of ABCC1, ABCC2, and ABCC3 mRNA.

161 t segment and the 3'-untranslated region (3'-UTR) of the SCoV2 genome, their large-scale production a

162 miRNA) binding to 3'-untranslated region (3'-UTR) plays an important role in the control of ATP-bindi

163 tions in the gene 3'-untranslated region (3'-UTR).

164 ing sites in the 3' untranslated regions (3'-UTR) of both Cyp6g1 and Cyp6g2 in vitro.

165 that defines the 3'-untranslated regions (3'-UTR) of MOR-1Bs and stabilizes mMOR-1Bs mRNAs.

166 sites of TTP to 3'-untranslated regions (3'-UTR) of NOX2 mRNA.

167 ead, recurrent, and functionally relevant 3'-UTR alterations associated with gene expression changes

168 n be used to: (i) provide sample specific 3'-UTR reannotation; extending or truncating default annota

169 ed a conserved miR378a-3p sequence in the 3'-UTR of both mouse and human MOR-1B(S) transcripts throug

170 se studies, miRs predicted to bind to the 3'-UTR of mouse MR were profiled by qRT-PCR after aldostero

171 sistant RNA (xrRNA) structures within the 3'-UTR.

172 NA editing at a single adenosine in their 3'-UTR.

173 mapped to nonsense, and 19 SNPs mapped to 3'-UTR regions.

174 Using 3'-UTR luciferase reporter constructs, CYP2B11-H3 showed ma

175 We disclosed various 3'-UTR length variants of ABCC1, C2, and C3 mRNA, with loss

176 mimics or inhibitors in conjunction with 3'-UTR luciferase activity assays.

177 ' reporter cell line in which the 5'- and 3'-UTRs of human UTRN sequences flank luciferase, for repor

178 ment of post-termination 70S complexes in 3'-UTRs.

179 in expression of 3'-untranslated regions (3'-UTRs) with varying lengths.

180 irmed miR-466 binding to both MR and SGK1 3'-UTRs.

181 The 3'-UTRs of the flavivirus genome also contain distinct shor

182 sines located in 9 sites within the HIV-2 5' UTR and performed substitution analyses.

183 Analysis of both 5' UTR and synonymous mutations in the PEST-like domain tha

184 uding noncoding exons) revealed decreased 5' UTR usage of Hnrnph1 and immunoblot analysis identified

185 Furthermore, 5' UTR-driven Elavl4 isoform-specific translation depends o

186 Molecular cloning of the Hnrnph1 5' UTR containing all four variants (but none of them indiv

187 egulatory element within a Homeobox (Hox) 5' UTR, we identify a modular stem-loop within this element

188 structure of a stem-loop within the c-JUN 5' UTR recognized by eIF3 and essential for specialized tra

189 RNA library composed of over one million 5' UTR variants.

190 directly targets the alpha-synuclein mRNA 5' UTR at the designed site.

191 binding to m(6)A residues within its own 5' UTR.

192 's unusually long 5' untranslated region (5' UTR) negatively regulates its expression via posttranscr

193 eral sites in the 5' untranslated region (5' UTR) of HIV-1 RNA that are bound by nucleocapsid (NC) pr

194 ment (IRE) in its 5' untranslated region (5' UTR) that controls its translation.

195 er a key role for 5' untranslated region (5' UTR)-miR760 interactions.

196 peron through its 5' untranslated region (5' UTR).

197 that binds to a conserved site in ATXN1's 5' UTR to induce RNA degradation and translational inhibiti

198 has considerable complementarity with the 5' UTR and is predicted to form an extensive secondary stru

199 , those located within stem-loop 1 of the 5' UTR had the most significant effects.

200 the nitrate-responsive cis-element at the 5' UTR of the gene.

201 tion of a (GGN)13 repeat found within the 5' UTR of the potassium 2-pore domain leak channel Task3 mR

202 -riboswitch, cbiMCbl (140 bp), within the 5' UTR that controls the expression of downstream genes.

203 rther alterations to the structure of the 5' UTR to accommodate these complexes.

204 Since C241T is in the 5' UTR with uncertain significance and the characteristics

205 he RNA level to functional domains of the 5' UTR, could also potentially impact the secondary/tertiar

206 th an activating seed sequence within the 5' UTR.

207 ce for miRNA-mediated gene regulation via 5' UTR binding, and raise the possibility that noncoding mu

208 onstrated that eIF2 and eIF3 travel along 5' UTRs with scanning 40Ss to successively dissociate upon

209 lay between distinct RBPs and alternative 5' UTRs in neuronal development and underscore the risk of

210 early neurons depends on its alternative 5' UTRs.

211 As (miRNAs) can interact with both 3' and 5' UTRs to regulate their target genes, we identify miR760

212 f Satb1 transcript variants with distinct 5' UTRs occurs in a stage-specific manner during T-cell dev

213 We test 35,212 truncated human 5' UTRs and 3,577 naturally occurring variants and show tha

214 Small ORFs in 5' UTRs (upstream (u)ORFs) often repress translation of the

215 ctedly, an unstructured A-rich element in 5' UTRs destabilizes mRNAs in the absence of translation, a

216 ng of the cis-regulatory code embedded in 5' UTRs, we devised massively parallel reporter assays from

217 gorithm, we use the model to engineer new 5' UTRs that accurately direct specified levels of ribosome

218 nly identify diverse sequence features of 5' UTRs that control mRNA translatability, but they also re

219 ence elements in 5' untranslated regions (5' UTRs) remains a fundamental challenge.

220 ranslation of mRNAs containing structured 5' UTRs by interacting with eukaryotic translation initiati

221 ak Shine-Dalgarno sequences or structured 5' UTRs, in addition to a variety of cellular processes bey

222 of E2F1/3 mRNAs through their structured 5' UTRs, PDCD4, and eIF4A1 and provides novel insight into

223 revealed that the MTE interacts with the 5' UTRs of both genomic RNA and subgenomic RNA1 via long-di

224 By examining the 5' UTRs of HIF-1alpha, FGF-9, and p53 mRNAs and using fluor

225 eIF4GI and DAP5 specifically bind to the 5' UTRs of these cap-independently translated mRNAs.

226 ities of eIF4GI and DAP5 binding to these 5' UTRs correlate with the efficiency with which these fact

227 importance of specific guanosines in HIV-2 5'UTR in mediating genome packaging.

228 cterized by the four signature SNVs C241T (5'UTR), C3037T (nsp3 F924F), C14408T (nsp12 P4715L), and A

229 t translation of mRNA transcripts with low 5'UTR GC content.

230 ate the ease and power of CAMIO by mapping 5'UTR sequences crucial for chinmo's post-transcriptional

231 rongly inhibited the translation of a PHO1 5'UTR-luciferase construct in protoplasts.

232 E1s by cooperatively engaging sites in the 5'UTR and stimulating local deposition of repressive histo

233 RNA, with the 3'UTR of Uqcrb, and with the 5'UTR of Ndufb6 mRNA, thereby regulating the splicing of A

234 agnosed with DBA carrying a variant in the 5'UTR of RPL9 (uL6).

235 encing reduced translation mediated by the 5'UTR of various cellular genes and HCV-like IRESs.

236 Metabolic profiles of cells carrying the 5'UTR variant reveal an increased metabolism of amino acid

237 Cells carrying the 5'UTR variant stabilize TP53 and impair the growth and dif

238 recruitment of the 40S-eIF complex to the 5'UTR, leading to translation initiation.

239 ribosomal interaction with low GC-content 5'UTRs.

240 ized by different 5' Untranslated Regions (5'UTRs), whereby translation of a subset of these isoforms

241 ion, particularly of mRNAs with structured 5'UTRs.

242 nslation of reporter mRNAs with structured 5'UTRs.

243 motif from the first intron of the barley 5'-UTR led to a significant increase in the transcription o

244 s designed based on the sequences of CDS, 5'-UTR and 3'-UTR region covering 34%, 14%, 23%, respective

245 In summary, we show that defined 5'-UTR RNA-structures represent a valid tool to systematica

246 e transcriptome and suggest U2AF1a-driven 5'-UTR alternative splicing as a molecular mechanism of mTO

247 ctional data illustrate the importance of 5'-UTR regions in translation regulation and underline the

248 hin an intron or when introduced into the 5'-UTR and coding sequences of an intronless construct, dem

249 GC-content and position were added to the 5'-UTR of a fluorescent reporter gene.

250 we characterized how a novel IRES at the 5'-UTR of a viral RNA assembles a functional initiation com

251 We found that the 5'-UTR of PHO2 contains two PHR1 binding sites (P1BSs) and

252 ture miR399 guides the Ago protein to the 5'-UTR of PHO2 transcripts.

253 a bicistronic reporter that contained the 5'-UTR of the Cd40 mRNA.

254 thesis, whereby RNA structures within the 5'-UTR regulate translation rates of specific mRNAs.

255 mRNAs with atypically long and structured 5'-UTRs and has been implicated in drug resistance.

256 All UTR showed color changes from yellow (control) to green

257 before therapy, whereas (iii) the UTR-5 and UTR-7 haplotypes were significantly associated with a be

258 e discovery of expressed non-coding RNAs and UTRs from RNA-seq reads mapped to a reference genome.

259 ld more efficient than the tested endogenous UTRs.

260 Our results establish UTR G4s as important cis-regulatory elements and point t

261 LmxHSP78+/-) were generated using a flanking UTR-based multifragment ligation strategy and the CRISPR

262 dent of the haplotype, (ii) homozygosity for UTR-1 or UTR-2 genotypes were significantly associated w

263 ts and point to a link between disruption of UTR pG4 and disease.

264 tive selection acting on central guanines of UTR pG4s is comparable to that of missense variation in

265 genous gene expression and de novo design of UTRs, the optimal combination of 5' and 3' UTR are ident

266 he haplotype, (ii) homozygosity for UTR-1 or UTR-2 genotypes were significantly associated with metas

267 At multiple GWAS-implicated SNPs within pG4 UTR sequences, we find robust allelic imbalance in gene

268 1, and ISL1, are distributed over promoters, UTRs, and multiple transcription factor binding sites.

269 cer sequences in the 5' untranslated region (UTR) and rare codons at the beginning of their coding se

270 ary structure in the 5' untranslated region (UTR) are translated more efficiently in G2019S LRRK2 neu

271 R-33a/b) bind to the 3' untranslated region (UTR) of ABCA1 and repress its posttranscriptional gene e

272 binding site in the 3' untranslated region (UTR) of PELI3 and demonstrated that increasing PELI3 lev

273 ecific region of the 3'-untranslated region (UTR) of the 14-3-3zeta mRNA is likely to be involved in

274 exp)] located in the 3' untranslated region (UTR) of the dystrophia myotonica protein kinase gene.

275 s are present in the 3'-untranslated region (UTR) of TOP2alpha/170.

276 ed guanosines in the 5' untranslated region (UTR) play an important role in Gag:RNA interactions lead

277 ments (RgE)', in the 5'-untranslated region (UTR) to impact translation efficiency.

278 s and one SNV in the 5' untranslated region (UTR) were identified and provided a direct interpretatio

279 e middle of the mRNA 5' untranslated region (UTR), our assay robustly detects small changes in buddin

280 bind to the TGFbeta1 3' untranslated region (UTR), thereby inhibiting its transcription.

281 binds within the HCV 5' untranslated region (UTR), whereas the broadly expressed let-7 and miR-17 fam

282 variants within the 5' untranslated region (UTR).

283 lement (CITE) in its 3' untranslated region (UTR).

284 nts (ARE) located in 3'untranslated regions (UTR) to mediate mRNA decay.

285 s, typically of the 3' untranslated regions (UTR).

286 een identified in untranslated mRNA regions (UTRs) across eukaryotes.

287 3 mRNAs through the 5' untranslated regions (UTRs) of E2F1 and E2F3 (E2F1/3) mRNAs.

288 uences are abundant in untranslated regions (UTRs) of human messenger RNAs, but their functional impo

289 long antisense RNAs or untranslated regions (UTRs) of mRNA transcripts.

290 In this work, the untranslated regions (UTRs) of mRNAs are systematically engineered in order to

291 argeting the 5' and 3' untranslated regions (UTRs) of utrophin mRNA significantly limit the magnitude

292 ome RNA flanked by the untranslated regions (UTRs).

293 ns with both 5' and 3' untranslated regions (UTRs).

294 on of host and viral "untranslated regions" (UTRs) to create N-terminally extended viral proteins or

295 The ultrasound treated rutin (UTR) nanocrystal strands had <820 nm in diameter but sho

296 Rutin/UTR had no significant influence on the production of ma

297 new role for eIF3, where eIF3 bridges BYDV's UTRs, stabilizes the long-range 5'-3' interaction, and f

298 Also, thermal analysis indicated that UTR-citric acid had two polymorphs identified by melting

299 umor cells before therapy, whereas (iii) the UTR-5 and UTR-7 haplotypes were significantly associated

300 anel of highly complex RNA structures in the UTRs with critical functions.

301 ants affecting G-quadruplex formation within UTRs may also contribute to phenotypic variation.