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1 VCD amide I data for the 22mer (n = 4) in D2O indicate t
2 VCD analysis provided a clear explanation for these expe
3 VCD analysis with respect to hypothetical localized mode
4 VCD and absorption IR spectra in methanol solutions can
5 VCD and FTIR spectra over the amide I and II bands of 23
6 VCD chiroptical analysis of a SynOxA derivative with thr
7 VCD experiments associated with DFT calculations confirm
8 VCD is shown to selectively destroy small ovarian follic
9 VCD spectroscopy itself is found to have the ability to
10 the per-protocol population, there were 176 VCD cases (with 11,793 person-years at risk) in the vacc
11 -years at risk) in the vaccine group and 221 VCD cases (with 5809 person-years at risk) in the contro
13 ch cohort were confirmed to be VCD, with 319 VCD episodes (4.6 episodes per 100 person-years) occurri
14 years) occurring in the Asian cohort and 389 VCD episodes (2.9 episodes per 100 person-years) occurri
15 the most important experimental aspects of a VCD-based AC determination and explains the theoretical
16 in 208 patients (6.9%) assigned to receive a VCD and 119 patients (7.9%) assigned to manual compressi
17 d patients, 3015 were randomly assigned to a VCD group (1509 received intravascular VCD and 1506 rece
19 D-TDV dengue vaccine was efficacious against VCD and severe VCD and led to fewer hospitalizations for
24 the ab initio predictions of absorption and VCD spectra obtained with density functional theory usin
28 0.001, p < 0.05), mean difference in AL and VCD between the affected and control eyes was 0.56 +/- 0
31 ber depth (ACD), lens thickness (LT), AL and VCD of eyes with RVO were compared with those of fellow
33 e biaryls was determined using TDDFT ECD and VCD calculations, the combination of which however did n
36 FTIR, electronic and vibrational CD (ECD and VCD) spectra for these small peptides are comparable to
37 and vibrational circular dichroism (ECD and VCD), as well as NMR spectroscopy have been utilized to
41 level theoretical simulations of the IR and VCD band shapes are used to analyze the spectra and to c
46 ment of the conformationally averaged IR and VCD spectra of 1 and 2, predicted using DFT, provides un
51 ce (NMR), ECD, Raman, ROA, infrared (IR) and VCD spectral parameters are computed for the eight possi
52 eous solution, we used isotopic labeling and VCD to demonstrate that the alpha-helix noncooperatively
53 were verified experimentally through NMR and VCD spectroscopy and allowed rationalization of the ster
54 on of severe seizures among control, OVX and VCD-treated mice, OVX+E mice exhibited seizures of a sig
55 IR, isotropic Raman, anisotropic Raman, and VCD spectra in terms of a mixture of three conformations
57 %, and 47%) of patients (VDCR, VDR, VCD, and VCD-mod, respectively); the corresponding 1-year progres
58 reated MM, and, based on this trial, VDR and VCD-mod are preferred for clinical practice and further
60 ndergoing transfemoral coronary angiography, VCDs were noninferior to manual compression in terms of
63 Acute febrile episodes were determined to be VCD by means of a nonstructural protein 1 antigen immuno
64 episodes in each cohort were confirmed to be VCD, with 319 VCD episodes (4.6 episodes per 100 person-
67 C and the absolute configuration assigned by VCD technique in combination with ab initio Hartree-Fock
70 pathway in untreated cells and is induced by VCD via both Nrf2-dependent transcription and protein st
72 ign, thus leading to a reversal of the (13)C VCD pattern and explaining the large shift in the (13)C
74 on the use of the DeVoe theory to calculate VCD, oriented VCD, IR absorption, and IR linear dichrois
79 bited shorter than normal vitreous chambers (VCDs) and thickened choroids, while BMP2 was down-regula
81 in 31 patients with endoscopically confirmed VCD (+/- asthma), 29 asthmatics with no history of VCD a
84 illness and virologically confirmed dengue (VCD) in 3424 healthy children, 2 to 16 years of age, in
85 symptomatic, virologically confirmed dengue (VCD), regardless of disease severity or serotype, occurr
86 NO2 tropospheric vertical column densities (VCDs) are seen to be increasing by as much as 10%/year,
89 cate a TEG using Virtual Cathode Deposition (VCD), a novel high deposition rate PVD tool, for the fir
91 r axial length (AL), vitreous chamber depth (VCD) and both central (CRVO) and branch retinal vein occ
92 iameters of the eye, vitreous chamber depth (VCD) and dilated pupil diameter was performed on 111 occ
93 lens thickness (LT), vitreous chamber depth (VCD), and retinal thickness (RT) were measured in the op
94 f axial length (AL), vitreous chamber depth (VCD), anterior chamber depth (ACD), lens thickness (LT),
95 l corneal thickness, vitreous chamber depth (VCD), anterior chamber depth (ACD), lens thickness (LT),
96 (TRI), and use of a vascular closure device (VCD) are thought to mitigate percutaneous coronary inter
100 The impact of vascular closure devices (VCDs) via the femoral arterial access site on short-term
101 h bortezomib-cyclophosphamide-dexamethasone (VCD) as induction before high-dose therapy and autologou
102 nsitivity of vibrational circular dichroism (VCD) allow determination of the segment sequence of unfo
103 d calculated vibrational circular dichroism (VCD) and electronic circular dichroism (ECD) spectra.
105 to calculate vibrational circular dichroism (VCD) and infrared (IR) absorption spectra of four polyri
106 the form of vibrational circular dichroism (VCD) and Raman optical activity (ROA), expands the numbe
107 an enhanced vibrational circular dichroism (VCD) couplet in the amide I' band region that is nearly
108 m (ECD), and vibrational circular dichroism (VCD) experiments and were compared to those of cryptopha
109 etermined by vibrational circular dichroism (VCD) in combination with density functional theory (DFT)
110 form-IR, and vibrational circular dichroism (VCD) spectra by means of a novel algorithm which utilize
111 (FT-IR), and vibrational circular dichroism (VCD) spectra by means of recently developed algorithms.
112 sm (ECD) and vibrational circular dichroism (VCD) spectra for 23 proteins, matrix descriptors encompa
113 red (IR) and vibrational circular dichroism (VCD) spectra for Ac-(Ala)(4)-NH(2), Ac-(Aib-Ala)(2)-NH(2
116 on of IR and vibrational circular dichroism (VCD) spectra of 1 and 3-5, calculated using DFT, to expe
117 c Raman, and vibrational circular dichroism (VCD) spectra of Ac-Ala-Ala-Aib-OMe, Ac-Ala-Aib-Ala-OMe,
118 alculate the vibrational circular dichroism (VCD) spectra of the R and S enantiomers of CClHDT adsorb
119 red (IR) and vibrational circular dichroism (VCD) spectra were measured for a series of isotopically
125 igated using vibrational circular dichroism (VCD) spectroscopy, electronic circular dichroism (ECD) s
126 eveloped for vibrational circular dichroism (VCD) spectroscopy, to automatically match IR spectra and
128 alysis using vibrational circular dichroism (VCD) spectroscopy; (3) reinterpretation of the ECD exper
129 tions of its vibrational circular dichroism (VCD) spectrum, electronic circular dichroism (ECD) spect
130 ified by the vibrational circular dichroism (VCD) studies revealing transfer from chiral monomers to
131 nsitivity of vibrational circular dichroism (VCD) to the formation and development of amyloid fibrils
132 sm (ECD) and vibrational circular dichroism (VCD), are highly sensitive techniques to probe molecular
133 rmined using vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and optical r
134 hods, namely vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and optical r
135 lculation of vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and transpare
138 cal methods (vibrational circular dichroism, VCD, and Raman optical activity, ROA) provide more relia
139 ration using vibrational circular dichrosim (VCD) and simplify its usage will advance this technique
141 oxic chemical, 4-vinylcyclohexene diepoxide (VCD), selective for primary and primordial follicles, is
143 t test-retest reliability and differentiated VCD vs. healthy (Mann-Whitney U-test: z = -5.390, P < 0.
144 e show that the variable cytoplasmic domain (VCD) is required for trafficking and organelle tubulatio
145 that its unique variable cytoplasmic domain (VCD) is the critical one for Wnt pathway inhibition.
146 VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs.
154 individual components of AL were evaluated, VCD had the greatest contributing effect (SRC = -0.99; S
155 es of vascular complications were evaluated, VCDs were associated with fewer hematomas (OR, 0.69 [CI,
157 e VCD spectra of 1 and 2 to the experimental VCD spectra of the natural products, (+)-1 and (+)-2, le
159 vascular VCD and 1506 received extravascular VCD) and 1509 patients were randomly assigned to the man
161 0.5 minute [IQR, 0.2-1.0]), vs extravascular VCD (2.0 minutes [IQR, 1.0-2.0]; P <.001) and closure de
162 ng those with intravascular vs extravascular VCD (80 patients [5.3%], vs 184 patients [12.2%]; P < .0
163 here it is shown that the sign of the fibril VCD pattern correlates with the sense of supramolecular
164 study shows that the combination of the film VCD and ECD techniques is a relatively straightforward m
165 re VCD and led to fewer hospitalizations for VCD in five Latin American countries where dengue is end
166 These findings demonstrate the potential for VCD to be used for real-time monitoring of the compositi
167 the amounts of protein samples required for VCD measurements on films are approximately 2 orders of
170 transform vibrational circular dichroism (FT-VCD) to follow changes in the percent enantiomeric exces
173 peptides is the locally achiral amide group, VCD senses the polymeric structure through amide couplin
174 dual methods for AC determination as AXRD >> VCD > ECD, while the synergy of all three methods provid
175 more than a decade of development, however, VCD utilization has neither been routine in the U.S. nor
176 increasing Aib content, the overall amide I VCD intensity becomes weaker and the amide I couplet bec
177 nt, but they have very weak negative amide I VCD, both reflecting experimental patterns seen in aggre
179 rger variation was predicted in the amide II VCD, which had added complications due to non-hydrogen-b
180 pectral analyses and the mixed amide I' + II VCD plus ECD analysis are comparable for the helix and s
183 structure leads to a significant increase in VCD intensity, while the parallel structure was not as d
185 microscopy (SEM), we demonstrate that indeed VCD supramolecular chirality is correlated not only by t
186 ndomized to hemostasis with an intravascular VCD, extravascular VCD, or manual compression in a 1:1:1
187 to a VCD group (1509 received intravascular VCD and 1506 received extravascular VCD) and 1509 patien
188 ly shorter among patients with intravascular VCD (0.5 minute [IQR, 0.2-1.0]), vs extravascular VCD (2
191 Application of the third chiroptical method, VCD, indicates unique spectral features for all eight Sy
193 pectroscopic techniques (IR absorption, NMR, VCD, and EPR) we gained clear evidence that both compoun
195 icroscopic examination indicates that normal VCD fibrils have a left-handed twist, whereas reversed V
197 l calculations we conclude that the observed VCD amplification finds its origin in vibronic coupling
199 l character has been the main application of VCD for peptides and proteins, although this is now rein
202 systematic approach for rapid calculation of VCD/IR spectra and comparison with corresponding measure
203 concerted application of DFT calculations of VCD, ECD, and OR to the determination of the AC of a nat
206 y of 80.2% (95% CI 73.3 to 85.3; 61 cases of VCD in the TAK-003 group vs 149 cases of VCD in the plac
208 olase, a key enzyme in the detoxification of VCD, and increases the oxidative stress in cells that is
215 ork provides the first example of the use of VCD spectroscopy to discriminate between structural isom
216 applications and highlight the usefulness of VCD as a tool for probing amyloid fibril formation.
219 the DeVoe theory to calculate VCD, oriented VCD, IR absorption, and IR linear dichroism (LD) spectra
223 (-1), with the extreme forms having positive VCD for highly helical proteins and negative VCD for hig
228 e asthma symptoms were considered to reflect VCD, and the treatment for bronchial asthma was stepped
229 the basic pattern of amide I and II relative VCD intensities still differs between alpha- and 3(10)-h
230 ddition to enabling faster and more reliable VCD assignments of absolute configuration, the ability t
231 s have a left-handed twist, whereas reversed VCD fibrils are flat-like aggregates with no obvious hel
232 FT-VCD, as opposed to dispersive scanning VCD, eliminates the need to scan the VCD spectrum in tim
233 microscope, we demonstrate a point scanning VCD instrument capable of acquiring spectra rapidly acro
234 ation of chiral preparative HPLC separation, VCD measurements, and theoretical calculations allows th
235 ccine was efficacious against VCD and severe VCD and led to fewer hospitalizations for VCD in five La
238 d significant trends across all risk strata: VCD+BIV versus no BAS, odds ratio (95% CI) range: first
241 eory simulated counterparts establishes that VCD is the more reliable technique to assign absolute co
250 ence of 0.57 +/- 0.15 mm (p < 0.001) and the VCD was significantly shorter with a mean difference of
252 s filament-like structures, organized by the VCD with monomers delivered by the WH2 array, that can t
253 with the results for Au40, we calculate the VCD spectra of the R and S enantiomers of CClHDT adsorbe
254 for the first time, we also demonstrate the VCD imaging performance of our instrument for site-speci
261 We show that, for each adsorption mode, the VCD spectra are distinctly different for the Au40(R)-ClH
262 we show that, for each adsorption mode, the VCD spectra are mirror symmetric but otherwise essential
264 t has been demonstrated that the sign of the VCD band pattern from filament chirality can be controll
266 olecule, whereas deletion or excision of the VCD or replacement of the Pcdh-gammaA3 cytoplasmic domai
270 mitant quantum mechanical predictions of the VCD, ECD, and ORD for monomeric tert-butylphenylphosphin
271 canning VCD, eliminates the need to scan the VCD spectrum in time to monitor the % EE at more than on
272 ric aggregate is discussed; in solution, the VCD spectra strongly suggest only monomeric species are
273 j] were significantly more accurate than the VCD ones, which may result from the longer range length
275 Truncations or internal deletions within the VCD defined a 26-amino acid segment required for traffic
277 was that femoral hemostasis achieved through VCD is noninferior to manual compression in terms of vas
280 In addition, the review summarizes unique VCD studies carried out in the period 2008-2018 that foc
281 lthough the etiology of the VCD was unknown, VCD is more common in young women, so stress and persona
283 BIV alone, 20.8% used TRI alone, 26.8% used VCD alone, 5.4% used TRI+BIV, and 25.6% used VCD+BIV.
288 al and a relatively unusual example of using VCD carbonyl multiplets, the absolute configuration coul
289 , 24%, 22%, and 47%) of patients (VDCR, VDR, VCD, and VCD-mod, respectively); the corresponding 1-yea
290 l pressure [including external clamp] versus VCD) and 30-day mortality was examined in a national rea
295 overs the range of peptide studies done with VCD and extends them to compare with example protein and
296 s was significantly shorter in patients with VCD (1 minute [interquartile range {IQR}, 0.5-2.0]), vs
298 ortality was lower in the group treated with VCD compared with manual pressure (hazard ratio [HR], 0.