ライフサイエンスコーパス: WD40 repeat

1 a dominant-negative form containing only the WD40 repeats.

2 kDa protein named PAFAH1B1 containing seven WD40 repeats.

3 , and six tandemly arranged carboxy-terminal WD40 repeats.

4 protein of 341 amino acid residues with four WD40 repeats.

5 itin hydrolase) that interact with the F-box/WD40 repeats.

6 a family of conserved proteins with multiple WD40 repeats.

7 In silico analysis confirmed the presence of WD40 repeats.

8 a Y-microtubule interaction motif built from WD40 repeats.

9 paf-1 through specific interactions with the WD40 repeats.

10 rotein (HELP) motif and a variable number of WD40 repeats.

11 e variants in nearby amino acids outside the WD40 repeats.

12 ted factors (DCAFs), including 14 containing WD40 repeats.

13 ino acids and a protein with multiple G-beta WD40 repeats.

14 nly one significant alteration in the WDR36 (WD40-repeat 36) gene.

15 nd subsequent degradation and that Cdt2 is a WD40 repeat adaptor protein for Cullin-4-based ubiquitin

16 FANCL, which possesses three WD40 repeats and a plant homeodomain (PHD), is the putat

17 ients, we confirm the importance of specific WD40 repeats and a putative microtubule-binding domain f

18 SEL-10 bound Notch4 via the WD40 repeats and bound preferentially to a phosphorylate

19 a novel mouse protein, Bop1, which contains WD40 repeats and is highly conserved through evolution.

20 inase (MEKKalpha) that contains an F-box and WD40 repeats and plays a complex role in regulating cell

21 family of proteins that contain an F-box and WD40 repeats and that target specific proteins for degra

22 patients result in truncated protein lacking WD40-repeats and the SH3 domain; disease was hitherto at

23 ACK1-RACK1 dimer-binding site within the 4th WD40 repeat, and application of the 4th WD40 repeat or a

24 in includes putative GTPase, protein kinase, WD40 repeat, and leucine-rich repeat (LRR) domains of un

25 t regions, which do not contain recognizable WD40 repeats, are required for the ability of TRIP-1 to

26 TRAF7 also contains seven WD40 repeats at its C terminus.

27 mediates UV-B-dependent interaction with the WD40 repeats-based predicted beta-propeller domain of CO

28 WD40-repeat beta-propellers are found in a wide range of

29 gene and its mouse homologue contain several WD40 repeats, but lack homology to known proteins.

30 studies, and enzyme assays, we find that the WD40 repeats confer a salt-sensitive second-site binding

31 ll of which disrupt one or more of the seven WD40 repeats contained in the LIS1 protein.

32 The WD40 repeats containing zinc finger protein 106 (ZFP106)

33 We identified WDR20, a WD40-repeat containing protein, as a common binding part

34 of the pathway, FANCD2, is activated by the WD40-repeat containing UAF1 protein through formation of

35 We termed this gene WDR14 (WD40 repeat-containing gene deleted in VCFS).

36 45B, along with WIPI1 and WIPI2, belong to a WD40 repeat-containing phosphatidylinositol-3-phosphate

37 WD40 repeat-containing protein 91 (WDR91) regulates earl

38 WDR62 is a WD40 repeat-containing protein expressed in neuronal pre

39 1K) in PfRad5 and an intronic SNP in PfWD11 (WD40 repeat-containing protein on chromosome 11), appear

40 WDR34 encodes a WD40 repeat-containing protein orthologous to Chlamydomo

41 rotein TRIP-1 was originally identified as a WD40 repeat-containing protein that has the ability to a

42 rated that Ubp15 physically interacts with a WD40 repeat-containing protein, Cdh1, by copurification

43 WDR48, a WD40 repeat-containing protein, interacts with USP12 and

44 is study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS

45 nal co-repressors Sin3, Pst1 and Pst2, and a WD40 repeat-containing protein, Prw1.

46 cells containing stoichiometric amounts of a WD40 repeat-containing protein, USP1 associated factor 1

47 utation (p.Tyr446Cys) in TBL1XR1, encoding a WD40 repeat-containing protein, which is a component of

48 WD40 repeat-containing proteins (WD40 proteins) serve as

49 WD40 repeat-containing proteins form a large family of p

50 e other DUBs that specifically interact with WD40 repeat-containing proteins, Cdh1 does not function

51 The corresponding cDNAs encoded two WD40 repeat-containing proteins, Grg2 and Grg6.

52 sel-10 encodes a WD40-repeat-containing F-box protein that likely mediate

53 king FbxA/ChtA, a previously described F-box/WD40-repeat-containing protein, suggesting CulA and FbxA

54 function as scaffolds that, along with F-box/WD40-repeat-containing proteins, mediate the ubiquitinat

55 ein 1, DDB1, bridges an estimated 90 or more WD40 repeats (DDB1-binding WD40, or DWD proteins) to the

56 rtical region of the cell, whereas the F-box/WD40 repeats direct ubiquitin-mediated MEKKalpha degrada

57 WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclea

58 s characterized by a RING-finger motif and a WD40 repeat domain [1].

59 nger followed by a coiled-coil domain, and a WD40 repeat domain at the C-terminus.

60 AgtA possesses a WD40 repeat domain C-terminal to its single catalytic do

61 E3-ubiquitin ligase F-box and WD40 repeat domain containing-7 (FBXW7), a negative regu

62 with and inhibited substrate binding to the WD40 repeat domain of Cdh1.

63 d domain that associates with the C-terminal WD40 repeat domain of KOG1.

64 Interactions between WD40 repeat domain protein 5 (WDR5) and its various part

65 east to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interac

66 rea of the ss-propeller assembly of the COP1 WD40 repeat domain through both hydrophobic and ionic in

67 otein containing a leucine-rich repeat and a WD40 repeat domain, interacts with the origin replicatio

68 We report that the conserved WD40 repeat domain-containing cartwheel protein Poc1 is

69 a highly conserved, leucine-rich repeats and WD40 repeat domain-containing protein 1 (LRWD1) or ORC-a

70 Here we characterized the WD40 repeat domain-mediated interactions of COP1 with HY

71 0A also alters the ability of the C-terminal WD40-repeat domain of ATG16L1 to interact with an amino

72 description of the architecture of its WD40 (WD40 repeat) domain (Apc1(WD40)).

73 t the region that codes the highly conserved WD40 repeat domains and the C-terminal region of the pro

74 gy to several eukaryotic proteins containing WD40 repeat domains, which commonly have beta-propeller

75 the F-box-containing leucine-rich repeat and WD40 repeat families, but not for the suppressor of cyto

76 more N-terminal missense mutation impairing WD40-repeat formation.

77 r, the PCAF complex has a novel subunit with WD40 repeats having a similarity to hTAF(II)100.

78 uitination and degradation through the F-box/WD40 repeats in a cell-type-specific and temporally regu

79 These results indicate that the WD40 repeats in Elp2 are required neither for subunit-su

80 adation require the F-box and the C-terminal WD40 repeats in FBW7alpha.

81 Our analysis defines the requirement for the WD40 repeats in preserving TFIID and SAGA function, demo

82 The presence of 16 WD40 repeats in the carboxyl terminus of the TEP1 protei

83 are evolutionarily conserved proteins with 5 WD40 repeats in the middle portion of the protein, and a

84 ypeptide of 370 amino acids containing seven WD40 repeats, is highly homologous to proteins of unknow

85 d in silico analysis suggest that these nine WD40 repeats may form the first of two WD40 propellers l

86 urally similar to Gbeta, each exhibiting the WD40 repeat motif.

87 codes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein-protein intera

88 s a 1749-residue protein that contains seven WD40 repeats near the amino terminus and a putative nucl

89 between Dronc-CARD and both the CARD and the WD40 repeats of a nearby Dark protomer are indispensable

90 esults revealed the involvement of all seven WD40 repeats of betaTrCP1 in GLI3 interaction.

91 WD40 repeats of Cdc20, Cdh1, and Cdc16 and tetratricopep

92 Mutations T1031A and T1040C in one of the WD40 repeats of Eed, which account for the hypomorphic a

93 Here, we demonstrate that the WD40 repeats of FANCL are required for interaction with

94 An amino acid substitution in the WD40 repeats of RFWD3 (I639K) found in a new FA subtype

95 present in effector proteins, as well as the WD40 repeats of WDR5, reveals critical contacts between

96 a novel region located within the first nine WD40-repeats of TPL.

97 4th WD40 repeat, and application of the 4th WD40 repeat or a peptide derivative to hippocampal slice

98 identified a novel FPR1-interacting protein, WD40 repeat protein (WDR)-26, which negatively regulates

99 We have generated an allelic series for WD40 repeat protein 1 (Wdr1), the mammalian homolog of A

100 pore for the detection and quantification of WD40 repeat protein 5 (WDR5), a chromatin-associated hub

101 This methylation is recognized by WD40 repeat protein BUB3, which subsequently recruits ub

102 We identify the WD40 repeat protein Caf4p as a Fis1p-associated protein

103 pac1 encodes a WD40 repeat protein closely related to anthocyanin regul

104 Here, we reveal that WDR26, a member of the WD40 repeat protein family, directly bound free Gbetagam

105 ants in WDR37, which encodes a member of the WD40 repeat protein family.

106 We have cloned and characterized a WD40 repeat protein gene from Medicago truncatula (MtWD4

107 The WD40 repeat protein Mdv1/Net2 promotes cell death, consi

108 1313-1318) demonstrate that the WD40 repeat protein p55 binds a structured region of H4

109 he function of Arabidopsis thaliana NEDD1, a WD40 repeat protein related to the animal NEDD1/GCP-WD p

110 We show here that the F-box/WD40 repeat protein SEL-10 negatively regulates Notch re

111 ritical region (DGCR) at 22q11 and encodes a WD40 repeat protein similar to yeast Hir1p and Hir2p.

112 We have recently identified WDR26 as a novel WD40 repeat protein that binds Gbetagamma and promotes G

113 Actin-interacting protein 1 (AIP1) is a WD40 repeat protein that enhances actin filament disasse

114 in Drosophila C/D scaRNAs, we purified a fly WD40 repeat protein that UV crosslinks to RNA in a C/D C

115 We previously identified the WD40 repeat protein WDR-23 as a repressor of Caenorhabdi

116 umulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL

117 on: the importin beta homolog Kap122 and the WD40 repeat protein Wtm1.

118 he other encodes a truncated form of a novel WD40 repeat protein, named Bopl, which is conserved from

119 p55, a predicted WD40 repeat protein, recognizes the first helix of histo

120 previously reported the identification of a WD40 repeat protein, STRAP, that associates with both ty

121 of bHLH and MYB transcription factors, and a WD40 repeat protein, TRANSPARENT TESTA GLABRA1 (TTG1), a

122 p36 is a WD40 repeat protein, which is 46% identical to the p39 s

123 Furthermore, Hat2p is a WD40 repeat protein, which is found in many histone modi

124 component: Fizzy-related/Hec1/Cdh1 (Fzr), a WD40 repeat protein.

125 er, sequence analysis indicates that it is a WD40 repeat protein.

126 We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb

127 r results are the first demonstration that a WD40-repeat protein acts as a module for recognition of

128 SlMSI2 encodes a WD40-repeat protein and negatively involves cell prolife

129 t active DYRK1A exists in a complex with the WD40-repeat protein DCAF7 that stabilizes and tethers DY

130 The WD40-repeat protein DDB2 is essential for efficient reco

131 NLE1 is a member of the large WD40-repeat protein family, and is thought to signal via

132 Slimb, an F-box/WD40-repeat protein functioning in the ubiquitin-proteas

133 ) homolog that encodes a nucleolar-localized WD40-repeat protein involved in processing 18S preriboso

134 GAG3 encodes a novel WD40-repeat protein previously found to interact with Dn

135 The slimb gene encodes a conserved F-box/WD40-repeat protein related to Cdc4p, a protein in buddi

136 in LST8, an essential gene encoding a seven WD40-repeat protein required for targeting of amino acid

137 r NCoR, histone deacetylase 3 (HDAC3), and a WD40-repeat protein TBL1.

138 ecifically recognized by beta-Trcp, an F-box/WD40-repeat protein that also associates with Skp1, an e

139 also depends on its interaction with WDR5, a WD40-repeat protein that exists as part of several chrom

140 lation factor subunit-2 (PFS-2), a conserved WD40-repeat protein that interacts with multiple subcomp

141 hSet1 H3 K4 methyltransferase complexes, the WD40-repeat protein WDR5, directly associates with histo

142 romatin also depends on interaction with the WD40-repeat protein WDR5.

143 tin (Ub) ligase complex containing the F-box/WD40-repeat protein, beta-TrCP, a vertebrate homolog of

144 SP-46) and its associated regulatory protein WD40-repeat protein-20 (WDR-20) in regulating local inse

145 WD40 repeat proteins are frequently involved in processi

146 However, how the WD40 repeat proteins facilitate enzymatic activities of

147 WD40 repeat proteins have been shown to bind the histone

148 ons within each clade have led to additional WD40 repeat proteins in particular species, with all mut

149 findings have several implications: 1) that WD40 repeat proteins may interact with each other; 2) th

150 lear autoantigen (SG2NA), are highly related WD40 repeat proteins of previously unknown function and

151 WD40 repeat proteins regulate biosynthesis of anthocyani

152 urther show, in contrast with COP1, that the WD40 repeat proteins REPRESSOR OF UV-B PHOTOMORPHOGENESI

153 These data demonstrate that WD40 repeat proteins use various surfaces to direct the

154 e Gbeta subunit belongs to a large family of WD40 repeat proteins with a circular beta-bladed propell

155 xpression of basic helix-loop-helix factors, WD40 repeat proteins, and MYB27- and MYBx-like repressor

156 nd bHLH transcription factors, stabilized by WD40 repeat proteins, regulates gene transcription for p

157 s to build a phylogenetic tree of homologous WD40 repeat proteins, revealing an ancestral gene duplic

158 rating a diversity of histone recognition by WD40 repeat proteins.

159 t CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DT

160 The WD40-repeat proteins are a large family of scaffold mole

161 d WDR1 protein has high sequence identity to WD40-repeat proteins in budding yeast (Saccharomyces cer

162 The two WD40-repeat proteins RUP1 and RUP2 provide negative feed

163 member of a previously undescribed family of WD40-repeat proteins that we demonstrate binds 3-phospho

164 in Caenorhabditis elegans We found that the WD40-repeat proteins WDR-20 and WDR-48 bind and stimulat

165 We and others previously showed that the WD40-repeat proteins WDR-48 and WDR-20 bind to and stimu

166 Recently, two highly conserved WD40-repeat proteins, Cdc20 and Cdh1/Hct1, have been ide

167 analysis, we then identify a novel family of WD40-repeat proteins, which directly bind to the double-

168 MSI1 belongs to a family of histone binding WD40-repeat proteins.

169 study of histone binding by chromodomain and WD40-repeat proteins.

170 he C-terminal, two proline-rich regions, one WD40 repeat region and one suppressor of cytokines signa

171 phosphorylated degron motif of TRIM9 and the WD40 repeat region of beta-TrCP prevented beta-TrCP from

172 iled coil for dimerization, and a C-terminal WD40 repeat region that binds Dnm1.

173 o acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1

174 ession of MEKKalpha or MEKKalpha lacking the WD40 repeats results in very delayed development and a s

175 biochemical approaches, we then revealed the WD40 repeat scaffold protein RECEPTOR FOR ACTIVATED C KI

176 ta-catenin was direct and dependent upon the WD40 repeat sequences in beta-TrCP and on phosphorylatio

177 We show that the WD40 repeats target MEKKalpha to the cortical region of

178 n, with most clustering within the conserved WD40 repeats; thus, the C terminus of TAF90p is required

179 Yeast homologue with 5 WD40 repeats, Trm82, is the non-catalytic subunit of a t

180 1 on RACK1 using peptides encoding the seven WD40 repeat units of human RACK1.

181 terization of small molecule ligands for the WD40 repeat (WDR) protein family.

182 th missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked gene product, w

183 forming step catalyzed by a metal-dependent WD40-repeat (WDR) protein.

184 The family of WD40-repeat (WDR) proteins is one of the largest in euka

185 The WD40-repeat (WDR) proteins WDR20 and WDR48/UAF1 have bee

186 p80 is a novel protein containing WD40 repeats, which are frequently involved in protein-p