ライフサイエンスコーパス: Weibel-Palade body

1 by inhibiting the release of the contents of Weibel-Palade bodies.

2 ocalized with P-selectin and was confined to Weibel-Palade bodies.

3 to the cytoplasmic tail to localize them in Weibel-Palade bodies.

4 rated vesicular storage of FVIII with vWf in Weibel-Palade bodies.

5 etylated LDL and the presence of cytoplasmic Weibel-Palade bodies.

6 iated with rod-shaped structures, typical of Weibel-Palade bodies.

7 Endothelial cells showed Weibel-Palade bodies.

8 ave structural similarities to intracellular Weibel-Palade bodies.

9 in protein on the cell surface as well as in Weibel-Palade bodies.

10 obilization of P-selectin from intracellular Weibel-Palade bodies.

11 yed impaired PDI secretion and exocytosis of Weibel-Palade bodies.

12 stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies.

13 pression was increased with the formation of Weibel-Palade bodies.

14 e (WT) mice indicated an elevated release of Weibel-Palade bodies.

15 red by MSU likely results from exocytosis of Weibel-Palade bodies.

16 have endothelial cells that are deficient in Weibel-Palade bodies.

17 s stored with von Willebrand factor (VWF) in Weibel-Palade bodies.

18 mediated in part by P-selectin contained in Weibel-Palade bodies.

19 in endothelial cells, where it is stored in Weibel-Palade bodies.

20 ce of NOS2 is correlated with the release of Weibel-Palade bodies.

21 VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 thr

22 s inflammatory mediators leads to release of Weibel--Palade bodies and therefore to exocytosis of bot

23 ce upon release from storage granules called Weibel-Palade bodies and is also transcriptionally upreg

24 ute inflammation by stimulating secretion of Weibel-Palade bodies and P-selectin-mediated leukocyte r

25 in costorage of FVIII and VWF in endothelial Weibel-Palade bodies and restores normal levels and acti

26 In contrast to multimeric VWF stored within Weibel-Palade bodies and secreted rapidly in response to

27 Weibel-Palade bodies and the von Willebrand factor antig

28 red tubules within storage organelles called Weibel-Palade bodies, and tubular packing is necessary f

29 ubunit, and are not preferentially stored in Weibel-Palade bodies as compared with the monomeric form

30 vWF behavior and suggested exocytosis of the Weibel-Palade body by the endothelium.

31 The results indicate that vWF released from Weibel-Palade bodies can dramatically increase the conce

32 Weibel-Palade bodies contain mediators that promote thro

33 Weibel-Palade bodies could not be identified in the cani

34 hat VWF multimerization is not necessary for Weibel-Palade body creation.

35 reductase inhibitors decrease exocytosis of Weibel-Palade bodies, endothelial cell granules whose co

36 We show that NO inhibits exocytosis of Weibel-Palade bodies, endothelial granules that mediate

37 next studied NO effects on ceramide-induced Weibel-Palade body exocytosis because NO can inhibit vas

38 Simvastatin decreased thrombin-stimulated Weibel-Palade body exocytosis by 89%.

39 o human aortic endothelial cells and assayed Weibel-Palade body exocytosis by measuring the concentra

40 CHGA led to the release of endothelin-1 and Weibel-Palade body exocytosis in cultured human umbilica

41 dings show that endogenous ceramide triggers Weibel-Palade body exocytosis, and that endogenous NO in

42 mmation and thrombosis in part by triggering Weibel-Palade body exocytosis.

43 , or tumor necrosis factor-alpha also induce Weibel-Palade body exocytosis.

44 sterone stimulates endothelial exocytosis of Weibel-Palade bodies, externalizing P-selectin and relea

45 von Willebrand disease, leads to a defect in Weibel--Palade body formation.

46 We determined that loss of Weibel-Palade body formation is associated with markedly

47 w that P-selectin deficiency does not affect Weibel-Palade body formation or their release in respons

48 s to study intracellular VWF trafficking and Weibel-Palade body formation.

49 Activated endothelial cells release Weibel-Palade bodies, granules containing von Willebrand

50 were used to evaluate the role of VWF and/or Weibel-Palade bodies in Bordetella pertussis toxin-induc

51 the result of stimulated release of VWF from Weibel-Palade bodies in certain beds of endothelial cell

52 que opportunity to examine the biogenesis of Weibel-Palade bodies in endothelium from a canine model

53 P-selectin is constitutively expressed in Weibel-Palade bodies in the endothelium, which moved to

54 hagfish tissues demonstrated the presence of Weibel-Palade bodies in the endothelium.

55 osodium urate (MSU) results in exocytosis of Weibel-Palade bodies in vitro and in vivo, leading to th

56 um ionophore A23187, a known secretagogue of Weibel-Palade bodies, induced immediate platelet adhesio

57 e of NOS2 is correlated with the presence of Weibel-Palade bodies inside endothelial cells, whereas t

58 eleased from endothelial storage organelles (Weibel-Palade bodies) into the lumen of the blood vascul

59 found that the typical rodlike shape of the Weibel--Palade body is missing in vWf -/- endothelial ce

60 strated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric

61 propeptide is required for the formation of Weibel-Palade bodies, it cannot independently induce the

62 ry, these results suggest that exocytosis of Weibel-Palade bodies links postischemic repair with infl

63 Angiopoietin 2 alone induced exocytosis of Weibel-Palade bodies, mobilized hematopoietic stem cells

64 ogether, these data indicate that VWF and/or Weibel-Palade bodies negatively regulate BBB permeabilit

65 aped organelles similar in appearance to the Weibel-Palade bodies of endothelial cells in which vWF i

66 ECE-1beta) in the perinuclear region and in Weibel-Palade bodies of the human umbilical vein endothe

67 The release of Weibel-Palade bodies on infusion of activated platelets

68 ls, some ARHGAP18 puncta also colocalized to Weibel-Palade bodies on the microtubules.

69 ned within the ER, producing only few pseudo Weibel-Palade bodies over longer time periods compared w

70 They have been transfected into Weibel-Palade body-positive endothelial cells isolated f

71 Coexpression experiments show that the Weibel-Palade body proteins P-selectin and CD63, as well

72 Prevention of Weibel-Palade body release might be a mechanism by which

73 anisms by which endothelial cell activation, Weibel-Palade body release, hypoxia, reactive oxygen spe

74 VT likely through endothelial activation and Weibel-Palade body release, which is, at least in part,

75 , increased adhesion molecule expression, or Weibel-Palade body release.

76 actin cytoskeleton, cell-cell junctions, and Weibel-Palade body release.

77 ared to Prdx1(+/+) mice, indicating elevated Weibel-Palade body release.

78 S1P activates endothelial cell exocytosis of Weibel-Palade bodies, releasing vasoactive substances ca

79 EGF activates endothelial cell exocytosis of Weibel-Palade bodies, releasing vasoactive substances ca

80 d 48/80, an MC secretagogue, or histamine, a Weibel-Palade body secretagogue from MCs, potentiated DV

81 ADAMTS13 in preventing excessive spontaneous Weibel-Palade body secretion, and in the regulation of l

82 fusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a co

83 timulation with histamine, a secretagogue of Weibel-Palade bodies, slowed down leukocyte rolling in A

84 othelin (ET)-like immunoreactive staining in Weibel-Palade bodies, storage granules that are an integ

85 regulated VWF release from endothelial cell Weibel-Palade bodies, suggesting defective storage also

86 We demonstrate the reestablishment of Weibel-Palade bodies that recruit endogenous P-selectin

87 on, P-selectin is transiently mobilized from Weibel-Palade bodies to the surface of histamine-activat

88 ing vesicles in HUVECs are distinct from the Weibel-Palade bodies, which contain von Willebrand facto

89 Finally, heme promoted a rapid exocytosis of Weibel-Palade bodies, with membrane expression of P-sele

90 Weibel-Palade bodies within endothelial cells are secret

91 Cells were characterized for their Weibel Palade body (WPB) content and VWF release.

92 Weibel-Palade bodies (WPB) are secretory organelles of e

93 Weibel-Palade bodies (WPB) are unique secretory organell

94 g-2 that is presynthesized and stored in the Weibel-Palade bodies (WPB) of endothelial cells upon bin

95 Activation induces the fusion of Weibel-Palade Bodies (WPB) with the plasma membrane, thu

96 lated secretory pathways, the latter two via Weibel-Palade bodies (WPB).

97 Weibel-Palade body (WPB) exocytosis underlies hormone-ev

98 on dependence and extent of histamine-evoked Weibel-Palade body (WPB) exocytosis were investigated wi

99 The Weibel-Palade body (WPB) is a well-described secretory g

100 Endothelial exocytosis of Weibel-Palade body (WPB) is one of the first lines of de

101 Heme rapidly (5 minutes) mobilized Weibel-Palade body (WPB) P-selectin and VWF onto EC and

102 endothelial characteristics and responded to Weibel-Palade body (WPB) secretagogues except desmopress

103 Serotonin releases Weibel-Palade bodies (WPBs) and we asked whether absence

104 Weibel-Palade bodies (WPBs) are secretory granules that

105 Weibel-Palade bodies (WPBs) are specific cigar-shaped gr

106 F) glycoprotein is stored in tubular form in Weibel-Palade bodies (WPBs) before secretion from endoth

107 Weibel-Palade bodies (WPBs) comprise an on-demand storag

108 The exocytosis of Weibel-Palade bodies (WPBs) containing von Willebrand fa

109 roregion) following exocytosis of individual Weibel-Palade bodies (WPBs) from single human endothelia

110 ecretion of von Willebrand factor (VWF) from Weibel-Palade bodies (WPBs) in endothelial cells is fund

111 ns of complement, on the release of vWF from Weibel-Palade bodies (WPBs) in human umbilical vein ECs

112 The formation of Weibel-Palade bodies (WPBs) is also cargo driven, but th

113 (VWF) from intracellular organelles known as Weibel-Palade bodies (WPBs) is required for platelet adh

114 Indeed, although the storage of vWF in Weibel-Palade bodies (WPBs) of endothelial cells has bee

115 om platelets, it inhibits secretion from the Weibel-Palade bodies (WPBs) of endothelial cells.

116 ontain specialized storage organelles called Weibel-Palade bodies (WPBs) that release their content i

117 al cells selectively release cargo stored in Weibel-Palade bodies (WPBs) to regulate vascular functio

118 granules of vascular endothelial cells, the Weibel-Palade bodies (WPBs), and is released following s

119 At the acidic pH of the trans-Golgi and Weibel-Palade bodies (WPBs), but not at the alkaline pH

120 VWF is stored in EC Weibel-Palade bodies (WPBs), but the intracellular locat

121 , a glycoprotein essential to haemostasis in Weibel-Palade bodies (WPBs), cigar-shaped secretory gran

122 Weibel-Palade bodies (WPBs), endothelial-specific secret

123 lized endothelial cell secretory organelles, Weibel-Palade bodies (WPBs), is thought to play an impor

124 of regulated secretory organelles, including Weibel-Palade bodies (WPBs), the tissue plasminogen acti

125 lease of endothelial storage organelles, the Weibel-Palade bodies (WPBs), whereas VWF is also a key d

126 ique rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs), which contain the hemostati

127 nthesized in endothelial cells and stored in Weibel-Palade bodies (WPBs).

128 s stored in unique secretory granules called Weibel-Palade bodies (WPBs).

129 is: fusion of individual secretory granules (Weibel-Palade bodies [WPBs]) and subsequent expulsion of