ライフサイエンスコーパス: Werner syndrome

1 one of the clinical findings associated with Werner syndrome.

2 te telomere attrition in the pathogenesis of Werner syndrome.

3 ularly nonepithelial malignancies typical of Werner syndrome.

4 nuclease, causes the premature aging disease Werner syndrome.

5 the genomic instability progeroid syndrome, Werner syndrome.

6 teristic of cells derived from patients with Werner syndrome.

7 encodes a RecQ helicase, which is mutated in Werner syndrome.

8 remature ageing phenotypes that characterize Werner syndrome.

9 e premature aging and cancer-prone disorder, Werner syndrome.

10 , which is compromised by the loss of WRN in Werner syndrome.

11 RN), mutated in the premature aging disorder Werner syndrome.

12 iation of WRN, the factor that is mutated in Werner syndrome.

13 manifest as a rare premature aging disorder, Werner syndrome.

14 ilford Progeria Syndrome (HGPS) and Atypical Werner Syndrome.

15 f rapidly dividing cells is not a feature of Werner syndrome.

16 4 complex), and WRN the protein deficient in Werner syndrome.

17 in Hutchinson-Gilford progeria and atypical Werner syndromes.

18 The prototypic example of the former is the Werner syndrome, a condition caused by mutations of the

19 s with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many char

20 3'-->5' exonuclease and helicase mutated in Werner syndrome, a disorder characterized by aberrant te

21 Mutations in the WRN gene cause Werner syndrome, a genetic disorder characterized by pre

22 the recent gene-driven phase of research on Werner syndrome, a heritable adult progeroid syndrome wi

23 structures that resemble defects observed in Werner syndrome, a premature ageing disorder.

24 ion mutations in the WRN helicase gene cause Werner syndrome- a progeroid syndrome with an elevated r

25 tational inactivation of the gene WRN causes Werner syndrome, an autosomal recessive disease characte

26 Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which

27 Research on the Werner syndrome and a surprising number of other progero

28 Werner syndrome and Bloom syndrome result from defects i

29 Cellular phenotypes of Werner syndrome and Bloom syndrome, including genomic in

30 ns of the WRN and BLM helicases defective in Werner syndrome and Bloom syndrome, respectively, have b

31 Terc mutants but similar to that observed in Werner syndrome and Bloom syndrome, such as bone loss, w

32 nction may contribute to the pathogenesis of Werner syndrome and Bloom syndrome.

33 instability/cancer predisposition syndromes Werner syndrome and Bloom syndrome.

34 e responsible for the cancer-prone disorders Werner syndrome and Bloom syndrome.

35 n profiles occur in cells from patients with Werner syndrome and from normally aged individuals.

36 ns that cause the accelerated aging diseases Werner syndrome and Hutchinson-Gilford progeria syndrome

37 ive human genetic disorders (Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectiv

38 ence of cultured cells from individuals with Werner syndrome and the lack of a disease phenotype in W

39 The Werner syndrome and the Nijmegen breakage syndrome are r

40 function, such as Rothmund-Thomson syndrome, Werner syndrome, and Cockayne syndrome, also exhibit ski

41 Bloom syndrome and Werner syndrome are genome instability disorders, which

42 he varied and complex cellular phenotypes of Werner syndrome are precipitated by exhaustion of telome

43 Werner syndrome arises through mutations in the WRN gene

44 f BLM, or another G4-unwinding helicase, the Werner syndrome-associated helicase WRN, resulted in inc

45 one of our most promising dependencies, the Werner syndrome ATP-dependent helicase, as a synthetic l

46 at three RecQ members (WRN, deficient in the Werner syndrome; BLM, deficient in the Bloom syndrome; a

47 number of human genetic disorders, including Werner Syndrome, Bloom Syndrome and Rothmund-Thomson Syn

48 ated incidence of cancer or premature aging: Werner syndrome, Bloom syndrome, and Rothmund-Thomson sy

49 Hutchinson-Gilford progeria syndrome (HGPS), Werner syndrome, Bloom syndrome, Cockayne syndrome, tric

50 Werner syndrome, caused by mutations of the WRN gene, mi

51 solve these structures in Bloom syndrome and Werner syndrome cells may contribute to genome instabili

52 the replication and recombination defects in Werner syndrome cells may reflect abnormal processing of

53 asmids with noncompatible ends introduced to Werner syndrome cells underwent extensive deletions at n

54 utations that occur at elevated frequency in Werner syndrome cells.

55 mic instability and cancer predisposition in Werner syndrome cells.

56 VX-745 against p38alpha MAPK is confirmed in Werner syndrome dermal fibroblasts at 1.0 microM concent

57 Persons with Werner syndrome displays premature aging of the skin, va

58 bility, perhaps in concert with the Bloom or Werner syndrome DNA helicases.

59 WRN protein involved in the premature aging Werner syndrome, do not exhibit the gene cluster instabi

60 The gene mutated in Werner syndrome encodes both a 3' --> 5' DNA helicase an

61 mature aging and genome instability disorder Werner syndrome, encodes a protein with DNA helicase and

62 The Werner syndrome gene (WRN) has recently been cloned.

63 The Werner syndrome gene (WRN) has recently been identified

64 from a 1.4-Mb genomic region containing the Werner syndrome gene (WRN).

65 FFA-1 is the orthologue of the Werner syndrome gene product (WRN), a member of the RecQ

66 Moreover, it is a homologue of the human Werner syndrome gene product WRN, a protein associated w

67 during S phase when it colocalizes with the Werner syndrome gene product, WRN, in the nucleolus.

68 xonuclease domain of DNA polymerase I in the Werner syndrome gene product.

69 thods and present a transcription map of the Werner syndrome gene region.

70 rectly stimulates transcription of the human Werner syndrome gene, WRN, which encodes a conserved Rec

71 stability of the multicopy transgene and the Werner Syndrome gene.

72 ecQ-like DNA helicases such as the Bloom and Werner syndrome genes, BLM and WRN, have been suggested

73 eening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulne

74 Werner syndrome helicase (WRN) has emerged as a compelli

75 The Werner syndrome helicase (WRN) participates in DNA repli

76 To map regions of Werner syndrome helicase (WRN) that interact with RPA, y

77 ify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature

78 tability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-s

79 In particular, Werner syndrome helicase and related genes are different

80 f, and contrapodal to, the gene encoding the Werner syndrome helicase, Wrn, at human chromosome band

81 The Werner Syndrome helicase, WRN, is a promising therapeuti

82 pounds against a 50 kDa-sized target protein-Werner syndrome helicase.

83 of the RecQ DNA helicase WRN protein causes Werner syndrome, in which patients exhibit features of p

84 Werner syndrome is a disorder characterized by genomic i

85 Werner syndrome is a genetic condition of young adults c

86 Werner syndrome is a genetic disorder characterized by g

87 Werner syndrome is a hereditary disorder characterized b

88 Werner syndrome is a hereditary premature aging disorder

89 Werner syndrome is a hereditary premature aging disorder

90 Werner syndrome is a human disorder characterized by pre

91 Werner syndrome is a human premature aging disorder disp

92 Werner syndrome is a Mendelian disorder of man that prod

93 Werner syndrome is a premature aging and cancer-prone he

94 Werner Syndrome is a premature aging disorder characteri

95 Werner Syndrome is a premature aging disorder characteri

96 Werner syndrome is a rare autosomal recessive disease ch

97 Werner syndrome is a rare human disease characterized by

98 Werner syndrome is an autosomal recessive disorder assoc

99 Werner syndrome is an inherited disease characterized by

100 Werner syndrome is an inherited disease displaying a pre

101 Werner syndrome is associated with mutations in the DNA

102 Werner syndrome is associated with premature aging and i

103 The premature aging and cancer-prone disease Werner syndrome is caused by loss of function of the Rec

104 Human Werner Syndrome is characterized by early onset of aging

105 in the premature aging disease known as the Werner syndrome is designated WRN and is a member of the

106 The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function.

107 Werner syndrome is genetically linked to mutations in WR

108 WRN, which is absent in the human progeroid Werner syndrome, is thought to counteract this genomic i

109 Thus, manifestations of Werner syndrome may reflect an impaired ability of slowl

110 The WRN helicase/exonuclease is mutated in Werner syndrome of genomic instability and premature agi

111 Cells from Werner syndrome patients are characterized by slow growt

112 We recently discovered that cells from Werner syndrome patients displayed a deficiency in p53-m

113 In addition to its DNA helicase activity, Werner syndrome protein (WRN) also possesses an exonucle

114 lta processivity was enhanced by full length Werner Syndrome protein (WRN) and by WRN fragments conta

115 in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrov

116 Ku70/80 interacts with the Werner syndrome protein (WRN) and stimulates WRN exonucl

117 DNA2 acts with RecQ helicases such as the Werner syndrome protein (WRN) and the heterotrimeric euk

118 rovide evidence for an indispensable role of Werner syndrome protein (WRN) and WRN-interacting protei

119 Evidence suggests that the Werner syndrome protein (WRN) contributes to the mainten

120 The wild type Werner syndrome protein (WRN) has been demonstrated to e

121 Our previous studies indicated that the Werner syndrome protein (WRN) interacts with Ku, a heter

122 The Werner syndrome protein (WRN) is a caretaker of the huma

123 The Werner syndrome protein (WRN) is a RecQ family helicase

124 Werner syndrome protein (WRN) is a RecQ-type DNA helicas

125 The Werner syndrome protein (WRN) is the only known member o

126 A defect in the Werner syndrome protein (WRN) leads to the premature agi

127 Cells deficient in the Werner syndrome protein (WRN) or BRCA1 are hypersensitiv

128 Caenorhabditis elegans expresses human Werner syndrome protein (WRN) orthologs as two distinct

129 In this study, we provide evidence that the Werner syndrome protein (WRN) physically interacts with

130 Werner syndrome protein (WRN) plays critical roles in DN

131 In addition, the Werner syndrome protein (WRN) possesses an exonuclease a

132 The Werner syndrome protein (WRN) suppresses the loss of tel

133 We show here that the Werner syndrome protein (WRN), a member of the RecQ fami

134 hich hpol kappa activity is modulated by the Werner syndrome protein (WRN), a RecQ helicase known to

135 FEN1, abolished the interaction of FEN1 with Werner syndrome protein (WRN), an interaction that is cr

136 human DNA polymerase eta (hpol eta) and the Werner syndrome protein (WRN).

137 te here that the stimulating activity is the Werner syndrome protein (WRN).

138 function of the RecQ helicase family member Werner syndrome protein (WRN).

139 der Werner syndrome results from loss of the Werner syndrome protein (WRN).

140 Mechanistically, Xenopus Werner syndrome protein (xWRN) is required for the unwin

141 cases, the major one of which is the Xenopus Werner syndrome protein (xWRN), a member of the RecQ hel

142 acts on ssDNA unwound mainly by the Xenopus Werner syndrome protein (xWRN), xEXO1 acts directly on d

143 s (ss-tails) by stimulating both the Xenopus Werner syndrome protein (xWRN)-mediated unwinding of DNA

144 gest that the RNase D family, which includes Werner syndrome protein and the 100 kDa antigenic compon

145 We also found that the Xenopus Werner syndrome protein, a member of the RecQ helicase f

146 ogy with the FEN-1 interaction domain of the Werner syndrome protein, a RecQ helicase family member h

147 DNA Polymerase delta (Pol delta) and the Werner syndrome protein, WRN, are involved in maintainin

148 The Werner syndrome protein, WRN, is a member of the RecQ fa

149 The human Werner syndrome protein, WRN, is a member of the RecQ he

150 Q DNA helicase family that also includes the Werner syndrome protein, WRN.

151 rma overlap syndrome 100 kDa autoantigen and Werner syndrome protein.

152 One in particular, Werner syndrome, provides evidence to support the hypoth

153 The Werner syndrome RecQ helicase WRN was identified as a sy

154 rived B cells that contained variants in the Werner syndrome, RecQ helicase-like gene (WRN, encoding

155 the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging.

156 line mutations are responsible for Bloom and Werner syndromes, respectively.

157 The segmental, progeroid disorder Werner syndrome results from loss of the Werner syndrome

158 The premature aging and cancer-prone disease Werner syndrome stems from loss of WRN protein function.

159 Analysis of these markers in Werner syndrome subjects demonstrates that the candidate

160 ease nuclear localization of WRN (mutated in Werner syndrome), which is required for processing DSB e

161 are mutated, respectively, in the Bloom and Werner syndromes, whose manifestations include predispos

162 The chromosome 8p11-12 Werner syndrome (WRN ) locus encodes a RecQ helicase pro

163 ses result in Bloom Syndrome (BLM mutation), Werner Syndrome (WRN mutation), Rothmund-Thomson Syndrom

164 useful in association studies involving the Werner syndrome (WRN) gene.

165 The clinical phenotype of Werner Syndrome (WRN) includes features reminiscent of a

166 Werner syndrome (WRN) is an uncommon autosomal recessive

167 Werner syndrome (WRN) is an uncommon autosomal recessive

168 d DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts phy

169 cosmid clone contig was constructed for the Werner syndrome (WRN) region of chromosome 8p12-p21 and

170 e genes involved in Bloom syndrome (BLM) and Werner syndrome (WRN) show that both are DNA and RNA hel

171 utations in the chromosome 8p WRN gene cause Werner syndrome (WRN), a human autosomal recessive disea

172 ligase IIIalpha, and the protein deleted in Werner syndrome, WRN, are up-regulated.

173 Werner protein (WRN), which is defective in Werner syndrome ( WS) patients, belongs to the RecQ fami

174 Werner Syndrome (WS) and Bloom Syndrome (BS) are disorde

175 e accelerated replicative senescence seen in Werner syndrome (WS) fibroblasts is due to accelerated t

176 Werner syndrome (WS) is a genetic premature aging disord

177 Werner syndrome (WS) is a human genetic disorder charact

178 Werner Syndrome (WS) is a human genetic disorder with ma

179 Werner syndrome (WS) is a human premature aging disorder

180 Werner syndrome (WS) is a human premature aging disorder

181 Werner Syndrome (WS) is a human progeroid disorder chara

182 Werner syndrome (WS) is a human progeroid syndrome chara

183 Werner syndrome (WS) is a premature aging disorder cause

184 Werner syndrome (WS) is a premature aging disorder where

185 Werner syndrome (WS) is a premature aging disorder, disp

186 Werner syndrome (WS) is a premature aging syndrome cause

187 Werner syndrome (WS) is a progeroid-like syndrome caused

188 The Werner syndrome (WS) is a prototypic adult Mendelian pro

189 Werner syndrome (WS) is a rare autosomal recessive disor

190 The Werner syndrome (WS) is a rare autosomal recessive proge

191 Werner syndrome (WS) is a rare disease caused by the lac

192 Werner syndrome (WS) is a rare human premature aging dis

193 Werner syndrome (WS) is a rare progeroid disorder charac

194 Werner syndrome (WS) is a recessive disorder characteriz

195 Werner syndrome (WS) is an accelerated ageing disorder w

196 Werner syndrome (WS) is an autosomal recessive disease c

197 Werner syndrome (WS) is an autosomal recessive disease c

198 Werner syndrome (WS) is an autosomal recessive disease t

199 Werner syndrome (WS) is an autosomal recessive disease w

200 Werner syndrome (WS) is an autosomal recessive disease,

201 Werner syndrome (WS) is an autosomal recessive disorder

202 Werner syndrome (WS) is an autosomal recessive disorder

203 Werner syndrome (WS) is an autosomal recessive genetic d

204 The Werner syndrome (WS) is an autosomal recessive segmental

205 Werner syndrome (WS) is an inherited disease characteriz

206 Werner Syndrome (WS) is an inherited disease characteriz

207 Werner syndrome (WS) is an inherited disorder characteri

208 Werner syndrome (WS) is an uncommon autosomal recessive

209 The human premature aging disorder Werner syndrome (WS) is associated with a large number o

210 Werner syndrome (WS) is characterized by features of pre

211 Werner Syndrome (WS) is characterized by premature aging

212 Werner syndrome (WS) is characterized by premature onset

213 Werner syndrome (WS) is characterized by the early onset

214 Werner syndrome (WS) is marked by early onset of feature

215 Werner syndrome (WS) is the canonical adult human proger

216 Werner syndrome (WS) is the hallmark premature aging dis

217 sis, the second leading cause of death among Werner syndrome (WS) patients, are not fully understood.

218 from normal (young and old) donors and from Werner syndrome (WS) patients.

219 etabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease ca

220 roposed to contribute to the pathogenesis of Werner syndrome (WS), a premature-aging disorder.

221 g and old individuals and from patients with Werner syndrome (WS), a segmental progeroid condition wi

222 Mutations of wrn cause Werner syndrome (WS), an autosomal recessive premature a

223 Werner syndrome (WS), caused by loss of function of the

224 Werner syndrome (WS), caused by mutations of the WRN gen

225 associated with a rare, recessive disorder, Werner syndrome (WS), distinguished by premature aging a

226 WRN protein loss causes Werner syndrome (WS), which is characterized by prematur

227 n (WRN) leads to the premature aging disease Werner syndrome (WS).

228 e (BS), Rothmund-Thomson syndrome (RTS), and Werner syndrome (WS).

229 helicase locus (WRN) are responsible for the Werner syndrome (WS).

230 and cancer susceptibility syndrome known as Werner syndrome (WS).

231 n causes the cancer-prone progeroid disorder Werner syndrome (WS).

232 s a hallmark of the premature aging disorder Werner syndrome (WS).