ライフサイエンスコーパス: X-linked agammaglobulinemia

1 ongenital asplenia, and 2 of Bruton disease (X-linked agammaglobulinemia).

2 cally normal in BTK, the gene that underlies X-linked agammaglobulinemia.

3 ptor signaling culminate in X-linked and non-X-linked agammaglobulinemia.

4 l blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia.

5 ction and results in a clinical phenotype of X-linked agammaglobulinemia.

6 hy donors versus BTK-deficient patients with X-linked agammaglobulinemia.

7 witzerland was 1.3:100,000, almost double of X-linked agammaglobulinemia.

8 B-cell levels; prior anti-CD20 therapy, and X-linked agammaglobulinemia.

9 tions in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency di

10 owest response was detected in patients with X-linked agammaglobulinemia and in patients with CVID wi

11 nase defective in the human immunodeficiency X-linked agammaglobulinemia and in xid mice.

12 Bruton's tyrosine kinase (Btk) causes human X-linked agammaglobulinemia and murine X-linked immunode

13 ain pathological conditions such as myeloma, X-linked agammaglobulinemia, and HIV infection may provi

14 mmune Deficiency, leukocyte adhesion defect, X-linked agammaglobulinemia, Ataxia Telangiectasia, Hype

15 such as common variable immunodeficiency and X-linked agammaglobulinemia, bacterial organisms are the

16 isolated or undefined antibody deficiencies, X-linked agammaglobulinemia, combined B- and T-cell immu

17 e present the case of a 34-year-old man with X-linked agammaglobulinemia from Australia suffering fro

18 (Btk), which is mutated in the human disease X-linked agammaglobulinemia, has been shown to interact

19 utation in the PH-TH domain (R28H) linked to X-linked agammaglobulinemia impairs BTK activation at th

20 hat results in the immunodeficiency diseases X-linked agammaglobulinemia in humans and X-linked immun

21 illustrated by the primary immune disorder, X-linked agammaglobulinemia in which patients are prone

22 sine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which there is a profoun

23 X-linked agammaglobulinemia is caused by mutations in Bt

24 other BCR signaling deficiencies, including X-linked agammaglobulinemia, our findings suggest that C

25 Bruton's tyrosine kinase (Btk) is mutated in X-linked agammaglobulinemia patients and plays an essent

26 X-linked agammaglobulinemia patients and X-linked immuno

27 rs, patients who were treated with BTKi, and X-linked agammaglobulinemia patients.

28 dicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men t

29 Here, we describe a case of X-linked agammaglobulinemia resulting from a GC 5'ss act

30 X-linked agammaglobulinemia syndrome was excluded geneti

31 e development of gene therapy strategies for X-linked agammaglobulinemia, the immunodeficiency associ

32 tor activation was reported in patients with X-linked agammaglobulinemia, underscoring the important

33 sine kinase (BTK) mutations as the cause for X-linked agammaglobulinemia was a milestone in understan

34 dition, a patient previously thought to have X-linked agammaglobulinemia was found to have an amino a

35 mutation of the Btk PH domain, which causes X-linked agammaglobulinemia, was introduced into the flu

36 Seven individuals with the diagnosis of X-linked agammaglobulinemia were analyzed for mutations

37 obulinemia and absent B cells are males with X-linked agammaglobulinemia, which is caused by mutation

38 Control of N addition appears aberrant in X-linked agammaglobulinemia, which may exacerbate the bl

39 -cell development and patients with presumed X-linked agammaglobulinemia who did not have mutations i

40 Severe combined immunodeficiency (SCID) and X-linked agammaglobulinemia (XLA) are inborn errors of i

41 Late-onset complications in X-linked agammaglobulinemia (XLA) are increasingly recog

42 h an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly funct

43 The gene defective in X-linked agammaglobulinemia (XLA) encodes a novel protei

44 ficient mice or monocytes from patients with X-linked agammaglobulinemia (XLA) exhibited increased NL

45 Mutation detection for X-linked agammaglobulinemia (XLA) has revealed the heter

46 ed in SLP-76-deficient mice or Btk-deficient X-linked agammaglobulinemia (XLA) human platelets.

47 because mutations in Btk are responsible for X-linked agammaglobulinemia (XLA) in humans and X-linked

48 ion of Bruton's tyrosine kinase (Btk) causes X-linked agammaglobulinemia (XLA) in humans and X-linked

49 in Bruton's tyrosine kinase (Btk) result in X-linked agammaglobulinemia (XLA) in humans and X-linked

50 e (btk) cause the B cell deficiency diseases X-linked agammaglobulinemia (XLA) in humans and X-linked

51 Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked

52 Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked

53 he Bruton's tyrosine kinase (btk) gene cause X-linked agammaglobulinemia (XLA) in humans and X-linked

54 Mutations in BTK lead to X-linked agammaglobulinemia (XLA) in humans.

55 X-linked immunodeficiency (xid) in mice and X-linked agammaglobulinemia (XLA) in humans.

56 X-linked agammaglobulinemia (XLA) is a congenital humora

57 X-linked agammaglobulinemia (XLA) is a human immunodefic

58 X-linked agammaglobulinemia (XLA) is a primary immunodef

59 X-linked agammaglobulinemia (XLA) is an inborn error of

60 X-linked agammaglobulinemia (XLA) is an inherited immuno

61 X-linked agammaglobulinemia (XLA) is the prototype of pr

62 phoblastoid lines derived from patients with X-linked agammaglobulinemia (XLA) lacking Btk expression

63 lines, and cultured cells from patients with X-linked agammaglobulinemia (XLA) suggested defective TL

64 In 1993, two groups showed that X-linked agammaglobulinemia (XLA) was due to mutations i

65 eatment with wortmannin and in patients with X-linked agammaglobulinemia (XLA), a condition caused by

66 The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutation

67 light key issues in gene therapy strategies: X-linked agammaglobulinemia (XLA), X-linked chronic gran

68 amily kinase linked to the B-cell deficiency X-linked agammaglobulinemia (XLA).

69 cells isolated from patients suffering from X-linked agammaglobulinemia (XLA).

70 mutations cause the genetic immunodeficiency X-linked agammaglobulinemia (XLA).

71 s associated with the immunological disorder X-linked agammaglobulinemia (XLA).

72 tyrosine kinase (Btk) result in the disorder X-linked agammaglobulinemia (XLA).

73 common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA).

74 nked immunodeficiency (XID)-a model of human X-linked agammaglobulinemia (XLA).

75 severe combined immune deficiency (SCID) and X-linked agammaglobulinemia (XLA); however, gain-of-func