ライフサイエンスコーパス: X-ray crystallography

1 e not fully entering the cavity of the host (X-ray crystallography).

2 (Hpz=pyrazole) and further characterized by X-ray crystallography.

3 ed allosteric regulation of isolated GCH1 by X-ray crystallography.

4 high-resolution cryo-electron tomography and X-ray crystallography.

5 ent, variable binding modes were observed by X-ray crystallography.

6 wo different DHHC-PATs were determined using X-ray crystallography.

7 nvestigated their binding modalities through X-ray crystallography.

8 y site by means of enzymatic assays, MS, and X-ray crystallography.

9 variety of NMR spectroscopic experiments and X-ray crystallography.

10 , cyclic voltammetry, mass spectrometry, and X-ray crystallography.

11 sly used to improve maps from macromolecular X-ray crystallography.

12 ion transfer difference NMR spectroscopy and X-ray crystallography.

13 yzed structures of the inhibited protease by X-ray crystallography.

14 ired for anticoagulant activity) as shown by X-ray crystallography.

15 (OD) of P at 1.4- angstrom resolution using X-ray crystallography.

16 assay followed by structure determination by X-ray crystallography.

17 ecursor, and its structure was determined by X-ray crystallography.

18 in complex with the EGFR kinase domain with X-ray crystallography.

19 ramagnetic resonance (EPR) spectroscopy, and X-ray crystallography.

20 characterized by NMR, mass spectroscopy, and X-ray crystallography.

21 previously reported homodimer identified by X-ray crystallography.

22 1 was characterized by multinuclear NMR and X-ray crystallography.

23 m catalyst was prepared and characterized by X-ray crystallography.

24 vis, and cyclic voltammetry measurements and X-ray crystallography.

25 nsion, making it unsuitable for conventional X-ray crystallography.

26 kinetic studies, H/D isotopic labelling, and X-ray crystallography.

27 d 2) meshing a protein with a structure from x-ray crystallography.

28 ucts were identified by NMR spectroscopy and X-ray crystallography.

29 tures are fully elucidated by single-crystal X-ray crystallography.

30 l suited for samples that are intractable by X-ray crystallography.

31 cale focused screen of proline analogs using X-ray crystallography.

32 otentially used for structure elucidation by X-ray crystallography.

33 ohydrate models have been studied by NMR and X-ray crystallography.

34 s characterized by (1)H NMR spectroscopy and X-ray crystallography.

35 r NMR, microanalysis, mass spectrometry, and X-ray crystallography.

36 esolution mass spectrometry (HRMS), NMR, and X-ray crystallography.

37 ne-II riboswitch ligand binding domain using X-ray crystallography.

38 ained, which was confirmed by single-crystal X-ray crystallography.

39 the exo C=C bond) has been confirmed through X-ray crystallography.

40 underlying the approach was corroborated by X-ray crystallography.

41 id-state structure, as confirmed by previous X-ray crystallography.

42 a based on optical rotation, CD spectra, and X-ray crystallography.

43 oses were determined for select compounds by X-ray crystallography.

44 t synthetic carbon nanocone was confirmed by X-ray crystallography.

45 omplex with protospacer DNAs, were solved by X-ray crystallography.

46 g conclusions mostly based on single-crystal X-ray crystallography.

47 n paramagnetic resonance spectroscopy and by X-ray crystallography.

48 ced current density calculations, as well as X-ray crystallography.

49 h TMOP-PH(2) (3a) have been characterized by X-ray crystallography.

50 al hexasubstituted ring was investigated via X-ray crystallography.

51 emental analysis, spectroscopic methods, and X-ray crystallography.

52 slowly eluting enantiomer was established by X-ray crystallography.

53 tion mass spectroscopies, and in many cases, X-ray crystallography.

54 the pyrG promoter using soak-trigger-freeze X-ray crystallography.

55 have now been structurally characterized by X-ray crystallography.

56 lly and, in many cases, using single-crystal X-ray crystallography.

57 a with P11 and defined their interactions by X-ray crystallography.

58 c resolution by cryo-electron microscopy and X-ray crystallography.

59 vity mechanisms using molecular dynamics and X-ray crystallography.

60 indolenine was isolated and characterized by X-ray crystallography.

61 )Pb), electronic, and IR spectroscopy and by X-ray crystallography.

62 ment:protein co-structures are determined by X-ray crystallography.

63 osuberone structure was further confirmed by X-ray crystallography.

64 nd fully characterized by NMR techniques and X-ray crystallography.

65 analysis, UV-vis spectrum measurements, and X-ray crystallography.

66 elucidation of its structure and assembly by X-ray crystallography.

67 the accuracy of macromolecular structures in X-ray crystallography.

68 two cis-ethylene linkers was explored using X-ray crystallography.

69 beta-amino-alpha-ketone group was secured by X-ray crystallography.

70 ask that has previously been accomplished by X-ray crystallography.

71 investigated by electron microscopy(4,5) and X-ray crystallography(6-8).

72 Here, we demonstrate via X-ray crystallography a nanobody-targeted allosteric bin

73 conformations of MdfA have been captured by X-ray crystallography: An outward open (O(o)) conformati

74 lorimetry, small-angle X-ray scattering, and X-ray crystallography analyses, we have pinpointed a cri

75 Finally, X-ray crystallography analysis showed that the switching

76 ochemistry of two products were confirmed by X-ray crystallography analysis.

77 of the products is discussed on the basis of X-ray crystallography analysis.

78 We used x-ray crystallography and biochemical approaches to show

79 s that is both structurally characterized by X-ray crystallography and capable of activating strong C

80 structural studies using techniques such as x-ray crystallography and cryo-electron microscopy (cryo

81 X-ray crystallography and cryo-electron microscopy have

82 Structure determination by X-ray crystallography and cryo-electron microscopy not o

83 has emerged as a complementary technique to X-ray crystallography and cryo-electron microscopy.

84 le-isoform self-recognition complexes, using X-ray crystallography and cryo-electron tomography.

85 y to the SOSIP structures determined by both x-ray crystallography and cryo-EM.

86 ge-sensor domain II (VSD2) from Nav1.7 using X-ray crystallography and cryoelectron microscopy.

87 support of NMR spectroscopy, single-crystal X-ray crystallography and density functional theory calc

88 ll four compounds have been characterized by X-ray crystallography and density-functional theory, ena

89 While X-ray crystallography and electron microscopy have revea

90 l species were structurally characterized by X-ray crystallography and electronic absorption spectros

91 exchange mass spectrometry, room-temperature X-ray crystallography and EPR spectroscopy on four SLO v

92 Nowadays, it is possible to combine X-ray crystallography and fragment screening in a medium

93 A structural study was undertaken by X-ray crystallography and in silico tools to assess the

94 NMR spectrometry, X-ray crystallography and mass spectrometry confirm the

95 via endoperoxide generation was confirmed by X-ray crystallography and mass spectrometry.

96 X-ray crystallography and molecular docking analysis of

97 X-ray crystallography and molecular dynamics simulations

98 Using X-ray crystallography and molecular dynamics simulations

99 X-ray crystallography and molecular dynamics simulations

100 Detailed structural analysis by x-ray crystallography and molecular simulations suggest

101 X-ray crystallography and mutagenesis confirmed a struct

102 Single-crystal X-ray crystallography and NMR reveal a folding pattern b

103 integrated structural biology approach using X-ray crystallography and NMR spectroscopy and evaluate

104 the reaction products were characterized by X-ray crystallography and NMR spectroscopy.

105 f these trapped, off-pathway oligomers using X-ray crystallography and NMR, providing insight into wh

106 ect to the anti/syn-ratio of the products by X-ray crystallography and nuclear Overhauser effect spec

107 erized using a combination of single-crystal X-ray crystallography and paramagnetic (1)H NMR spectros

108 Here we used a combination of X-ray crystallography and protein engineering to define

109 e scenario emerged from previous findings of X-ray crystallography and rapid kinetics supporting a pr

110 Integrating x-ray crystallography and SAXS, we also describe the str

111 rait of AChE extracted exclusively from 100K X-ray crystallography and scarcity of structural knowled

112 X-ray crystallography and SDS-PAGE further show that tri

113 of forming hexamers that can be observed by X-ray crystallography and SDS-PAGE.

114 X-ray crystallography and SEC-MALS revealed inhibitor in

115 Here, we use X-ray crystallography and single-particle cryo-electron

116 mechanism, we determined eight structures by X-ray crystallography and single-particle cryo-electron

117 X-ray crystallography and small-angle X-ray scattering s

118 catalysis, we have used ultrahigh-resolution X-ray crystallography and the recently approved beta-lac

119 ha3 is the only system where high-resolution X-ray crystallography and toxicity data are available.

120 We solve its 3D structure by NMR and x-ray crystallography and validate leads with 3 differen

121 of compounds with binding modes confirmed by X-ray crystallography and yielded unexpectedly accurate

122 ation of cryo-electron microscopy (cryo-EM), x-ray crystallography, and computational predictions wer

123 PbCSP) using molecular dynamics simulations, X-ray crystallography, and cryoEM.

124 h the method of continuous variations (MCV), x-ray crystallography, and density functional theory (DF

125 zed by EPR spectroscopy, elemental analysis, X-ray crystallography, and DFT calculations.

126 oretic mobility macromolecular analysis, EM, X-ray crystallography, and enzyme assays.

127 sing kinetic analyses, fluorescence binding, X-ray crystallography, and gel filtration experiments wi

128 diate has been isolated and characterized by X-ray crystallography, and its reactivity was studied.

129 terial and membrane permeabilization assays, X-ray crystallography, and molecular dynamics simulation

130 Functional analysis, x-ray crystallography, and molecular dynamics simulation

131 y combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well a

132 Here, we employ enzymatic assays, X-ray crystallography, and molecular simulations to reso

133 ctures found using cryo-electron microscopy, x-ray crystallography, and other methods.

134 he structure of the hItln-1.KO complex using X-ray crystallography, and our 1.59 angstrom resolution

135 ma- or pai-dimer) by UV-vis spectroscopy and X-ray crystallography, and performing computational anal

136 rgeted selectively by stopped-flow kinetics, X-ray crystallography, and solution-state NMR.

137 s limitation, we combined virtual screening, x-ray crystallography, and structure-guided design to de

138 ructures of 1-Tb and 2-Tb were determined by X-ray crystallography, and the presence of Tb(4+) was un

139 porated into an RNA octamer were analysed by X-ray crystallography, and the structure explains the lo

140 of VCBC-Cullin5 has recently been solved by X-ray crystallography, and, using molecular dynamics sim

141 Data from X-ray crystallography at 2.85 angstrom, as well as kinet

142 re of the C5_MG4-CirpT complex was solved by X-ray crystallography (at 2.7 angstrom).

143 solution NMR-, isothermal calorimetry-, and X-ray crystallography-based analyses of the p12-PCNA int

144 ates of metal centers derived from zero dose X-ray crystallography can advance our mechanistic unders

145 Isolated and fully characterized (X-ray crystallography) Co(I)-complexes, (dppp)(3)Co(2)Cl

146 Fe Mossbauer spectroscopy and single-crystal X-ray crystallography combined with reactivity studies a

147 Besides X-ray crystallography, complete spectroscopic and electr

148 the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting b

149 ectron microscopy, cryo-electron tomography, X-ray crystallography, computation, and functional assay

150 hange in assembly strength, revealed through X-ray crystallography, computational analysis, and solut

151 e electron laser (XFEL), ambient-temperature X-ray crystallography, computer simulations, and enzyme

152 X-ray crystallography confirmed that these discrete pept

153 TR that have not previously been detected by X-ray crystallography, consistently with the inhibition

154 We employed NMR spectroscopy and X-ray crystallography coupled with ensemble refinement t

155 X-ray crystallography, cryo-electron microscopy, and hyd

156 nsive investigations in vitro, which include x-ray crystallography, cryoelectron microscopy, and NMR

157 P-powered molybdate pumping process based on X-ray crystallography, cryoelectron microscopy, hydrogen

158 c proposals, we collected "room temperature" X-ray crystallography data for Pseudomonas putida ketost

159 uer spectroscopy, reaction product analysis, X-ray crystallography, density functional theory calcula

160 X-ray crystallography depicted the binding mode of phosp

161 This X-ray crystallography driven study shows that the rim of

162 icult to resolve in DNA:protein complexes by X-ray crystallography due to ambiguous electron density

163 loops, which previously was not detected by X-ray crystallography due to crystal packing effects.

164 Here, using a combination of X-ray crystallography, electron microscopy, and function

165 Using X-ray crystallography, electron microscopy, and mass spe

166 tical spectroscopy, global kinetic modeling, X-ray crystallography, electron paramagnetic resonance s

167 Experimental evidence (e.g., X-ray crystallography, electron paramagnetic resonance,

168 Compounds 1 and 2 were characterized by X-ray crystallography, electronic and NMR spectroscopy,

169 X-ray crystallography enabled structure-guided design, l

170 Through X-ray crystallography, engagement of both the catalytic

171 d 1.1/2MeOH were confirmed by single crystal X-ray crystallography, EPR spectroscopy, and DFT calcula

172 X-ray crystallography experiments allowed structural ass

173 nding have been precisely identified through x-ray crystallography experiments.

174 identified sensitively and unambiguously by X-ray crystallography, exploiting the anomalous scatteri

175 We conducted x-ray crystallography, F-actin binding and bundling assa

176 and virus-induced gene silencing (VIGS), and X-ray crystallography for structure-guided mutagenesis,

177 Detailed experimental studies (X-ray crystallography, gas sorption, and quartz-crystal

178 A long-standing goal of X-ray crystallography has been to combine structural inf

179 X-ray crystallography has facilitated the majority of pr

180 nalysis of a tubular structure determined by X-ray crystallography has revealed a hierarchical assemb

181 odeling, diffusion-ordered NMR spectroscopy, X-ray crystallography, highly correlated coupled-cluster

182 Using X-ray crystallography, identical conductive MthK structu

183 ingle JMS-053 binding site was identified by X-ray crystallography in human serum albumin at drug sit

184 helical conformations were characterized by X-ray crystallography in the solid state, by NMR spectro

185 description, achieved using a combination of X-ray crystallography, in vitro enzyme assays and site-d

186 PC) continues to be refined with cryo-EM and x-ray crystallography, in vivo conformational changes of

187 X-ray crystallography indicates that intermolecular pai-

188 X-ray crystallography indicates that the amino groups of

189 in solid state and solution, as revealed by X-ray crystallography, IR, and NMR spectroscopy.

190 Further, using a combination of X-ray crystallography, kinetics, and in vitro motility a

191 ploying ligand-protease structures solved by X-ray crystallography led to the identification of 3 and

192 use of mass spectrometry and single-crystal X-ray crystallography, led to the assignment of the loca

193 ometry, electrochemistry, and single-crystal X-ray crystallography, led us to confirm that noble meta

194 EPR, NMR and X-ray absorption spectroscopy, X-ray crystallography, mass spectrometry, chromatography

195 In this work, the serial X-ray crystallography method was successfully adopted to

196 vel, we employed a combination of time-lapse X-ray crystallography, molecular dynamics simulations, a

197 , [Fe(tpyPY2Me)](0), and characterization by X-ray crystallography, Mossbauer spectroscopy, X-ray abs

198 rrhiza pumila (OpSTR) using a combination of X-ray crystallography, mutational, and molecular dynamic

199 Here we use a combination of X-ray crystallography, NMR and Microscale Thermophoresis

200 that are not amenable to characterization by x-ray crystallography, NMR or EM.

201 bine multiple biophysical methods, including x-ray crystallography, NMR spectroscopy, and small angle

202 Here, we use a combination of X-ray crystallography, NMR spectroscopy, functional anal

203 of single-particle cryoelectron microscopy, X-ray crystallography, NMR, and other biophysical method

204 vestigate by conventional techniques such as X-ray crystallography, NMR, or cryo-EM.

205 e mainstay structural biology techniques are X-ray crystallography, nuclear magnetic resonance (NMR)

206 X-ray crystallography of 11s and related thieno[3,2-d]py

207 Herein, we describe an analysis using X-ray crystallography of a diverse library of compounds

208 Using X-ray crystallography of four apo- and cofactor-bound Mt

209 ined by NMR analysis of free peptides and by X-ray crystallography of peptides in complex with antibo

210 Subsequent X-ray crystallography of the A(2A) AR with a low and a h

211 X-ray crystallography often requires non-native construc

212 High-resolution X-ray crystallography on selected derivatives in the add

213 can be seen experimentally, for example with x-ray crystallography or cryo-electron microscopy.

214 in the N terminus insertion and, as shown by X-ray crystallography, partly by Tyr-172 inserting into

215 e mechanistic docking, machine learning, and X-ray crystallography, pointing the way for future terpe

216 Using MS, X-ray crystallography, protein engineering, and immunobl

217 selective synthesis, molecular modeling, and X-ray crystallography, providing experimental evidence t

218 analogues using single-particle cryo-EM and x-ray crystallography, respectively.

219 NMR and X-ray crystallography reveal that Leishmania has a uniqu

220 X-ray crystallography revealed a slightly twisted geomet

221 mutagenesis of a Der p 2 epitope defined by x-ray crystallography revealed an IgE Ab binding site th

222 X-ray crystallography revealed key amino acids potential

223 tide/protein complex by NMR spectroscopy and X-ray crystallography revealed multiple modes of binding

224 X-ray crystallography revealed that a potent, reversible

225 X-ray crystallography revealed that Aequorea CPs contain

226 nation of the three-dimensional structure by X-ray crystallography revealed that CopG consists of a t

227 e near the solvent-binding site of iron, and X-ray crystallography revealed that the substitution alt

228 X-ray crystallography revealed the structure of Bs164, t

229 propylphenyl) structural characterization by X-ray crystallography reveals a short Al-N distance, whi

230 X-ray crystallography reveals distinctly different posit

231 X-ray crystallography reveals face-to-face alignment of

232 X-ray crystallography reveals that 34 occupies the class

233 X-ray crystallography reveals that peptide N+1 assembles

234 X-ray crystallography reveals that these CNT mimics exhi

235 X-ray crystallography reveals that they bind in the enzy

236 While X-ray crystallography routinely provides structural char

237 pyrroles, which we further analyzed by ITC, X-ray crystallography, selectivity studies, the NCI60 ce

238 Using serial femtosecond X-ray crystallography (SFX), we have determined the pris

239 Single crystal X-ray crystallography showed that in some cases, fulvene

240 X-ray crystallography showed that the glycosylation site

241 X-ray crystallography showed that this Tudor domain chem

242 X-ray crystallography showed the inhibitors to bind to a

243 2 was structurally characterized by X-ray crystallography, showing a square pyramidal geomet

244 X-ray crystallography shows that peptide 3(F20Cha) forms

245 While structural analysis by X-ray crystallography shows that the majority of these c

246 Single crystal X-ray crystallography shows that the mononuclear [CuOH](

247 s structure, determined using single-crystal X-ray crystallography, shows that quantum dots (QDs) of

248 y enhanced in the last decade by advances in X-ray crystallography, single-molecular imaging, and the

249 My lab has focused on CYP2B enzymes using X-ray crystallography, site-directed mutagenesis, deuter

250 basic dimethylamino unit by a combination of X-ray crystallography, solution NMR studies, and computa

251 We have combined X-ray crystallography, solution NMR, and pre-steady-stat

252 Herein we use X-ray crystallography, solution-state NMR, and solid-sta

253 udies, and maltosides are frequently used in x-ray crystallography structure determination.

254 y comparing 20 recently obtained cryo-EM and X-ray crystallography structures of the ribosome from al

255 X-ray crystallography studies combined with functional a

256 Additionally, x-ray crystallography studies identified key amino acid

257 X-ray crystallography studies identify subtle changes in

258 X-ray crystallography studies reveal that FxxP motifs bi

259 ast the binding of B2 versus DDM in tubulin, X-ray crystallography studies revealed a shift in the po

260 Our thermostability and X-ray crystallography studies, together with the molecul

261 (mu-O)(mu-NO)](2+) complex with IR, EPR, and X-ray crystallography suggests a localized mixed-valent

262 ays, quantitative ribosome footprinting, and X-ray crystallography support a model in which propylamy

263 X-ray crystallography supports a role for the selectivit

264 bauer, near-infrared (NIR) spectroscopy, and X-ray crystallography techniques.

265 We show, by means of X-ray crystallography, that the two target nitrogen atom

266 ctural water sites can be easily detected by X-ray crystallography, the dynamics within functional wa

267 As revealed by X-ray crystallography, the highly contorted tetra-anion

268 We used X-ray crystallography, thermostability assessments, and

269 ructure of recombinant BcelPL6 was solved by X-ray crystallography to 1.3 angstrom resolution, reveal

270 erimentally solved its apo-structure through X-ray crystallography to a resolution of 2.60 angstrom.

271 This study used high-resolution X-ray crystallography to demonstrate the detailed nature

272 Here, we use X-ray crystallography to identify a conserved site on th

273 Here, we used X-ray crystallography to investigate these Dsl1-SNARE in

274 Here, we combine NMR spectroscopy and X-ray crystallography to provide dynamic and static char

275 chemical synthesis, biophysical mapping and X-ray crystallography to reveal the binding mode of an a

276 Here, we use room-temperature X-ray crystallography to study changes in the conformati

277 cell sequencing, biolayer interferometry and X-ray crystallography to trace mutation selection pathwa

278 e saturation (SILCS), and experimentally, by X-ray crystallography, to map potential interaction site

279 ion of Pv-M17 by cryoelectron microscopy and X-ray crystallography together with solution studies rev

280 l approaches, site-directed mutagenesis, and X-ray crystallography uncovered an additional nickel-bin

281 terized by mass spectrometry, single-crystal X-ray crystallography, UV-vis-NIR, nuclear magnetic reso

282 X-ray crystallography validated the dimeric mechanism of

283 An analysis of the selected products by X-ray crystallography was carried out to obtain a better

284 ifficult targets for structural biology when X-ray crystallography was the mainstream approach.

285 With X-ray crystallography, we detected an unexpected photoch

286 ation optimized (TROSY) NMR spectroscopy and X-ray crystallography, we established that the DcpS subs

287 Using X-ray crystallography, we have discovered a domain-swap

288 Using X-ray crystallography, we here show how Drosophila CAL1,

289 Using cryo-electron microscopy and x-ray crystallography, we reveal the assembly principles

290 Using x-ray crystallography, we show how a preTCR applies the

291 Here using X-ray crystallography, we show that human HC1 has a stru

292 By using X-ray crystallography, we show that the complexes Lambda

293 surements, steady-state enzyme kinetics, and X-ray crystallography, we show that the P167S/D240G doub

294 Here, using electrophysiology and X-ray crystallography, we show that UBP791 ((2S*,3R*)-1-

295 ds were investigated by NMR spectroscopy and X-ray crystallography, which revealed the occurrence of

296 ibed in the context of recent progress using X-ray crystallography with free-electron lasers on these

297 By combining X-ray crystallography with molecular dynamics simulation

298 EPR spectroscopy ((1,2)H HYSCORE, ENDOR) and X-ray crystallography, with corresponding DFT studies, c

299 uccessfully synthesized and fully studied by X-ray crystallography, X-ray photoelectron spectroscopy,

300 ance (SPR), antigen presentation assays, and X-ray crystallography (yielding crystal structures of 19