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1 Meta-analyses of real-world data suggested a doubling of 2- and 3-year survival in glioblastoma pat
4 ed that instantaneous radiative forcing from a doubling of a given CO(2) concentration (IRF(2xCO2)) i
5 was therefore prepared and found to exhibit a doubling of affinity (Ki = 94 microM) relative to pare
6 1.06, 1.55) for cardiovascular mortality and a doubling of albuminuria was associated with an IRR of
7 mRNA and soluble protein levels demonstrate a doubling of alpha-synuclein expression, consistent wit
8 t from organic to inorganic forms and led to a doubling of annual NH(4)(+) export from a 440 hectare
10 ith SLR (+ 74 cm), results suggest more than a doubling of areal flood extent for Irene and more than
11 In single-exposure linear regression models, a doubling of arsenic (As) and mercury (Hg) (mug/g) were
13 y function for the sensitivity of climate to a doubling of atmospheric carbon dioxide levels, and obt
15 r-surface air-temperature increase following a doubling of atmospheric CO(2) concentration, leaves us
16 a high-resolution global climate model under a doubling of atmospheric CO(2) to project loggerhead pr
18 er cent to a 60 per cent increase in GPP for a doubling of atmospheric CO2 concentrations in model st
19 per cent for extratropical ecosystems under a doubling of atmospheric CO2 concentrations on the basi
21 global mean surface temperature response to a doubling of atmospheric CO2, measured by the equilibri
25 Progression of kidney disease was defined as a doubling of baseline serum creatinine level or onset o
28 by a median of only 14% was associated with a doubling of behavioral contrast detection threshold.
29 Preplanned subgroup analysis demonstrated a doubling of benefit compared with sham injections in p
30 ericytes led to sustained local dilation and a doubling of blood cell flux selectively in capillaries
32 ETATION: Concomitant DMPA-IM use resulted in a doubling of BMD loss in women living with HIV initiati
36 and contractile force in trabeculae revealed a doubling of Ca2+ transient amplitude, with a concomita
37 lic Access Defibrillation trial demonstrated a doubling of cardiac arrest survival in community units
40 ize for each outcome that is associated with a doubling of cash transfers while controlling for a wid
41 ed pits (CCPs) to "necked"/"closed" CCVs and a doubling of CCP/CCV diameter, whereas AP2 depletion ha
44 during and after drug exposure, resulting in a doubling of cell number by 48 h after drug washout.
46 on of its initial architecture, resulting in a doubling of cellular population over a single hour of
47 Nepal, upwind from this site, is recorded by a doubling of chloride concentrations and a fourfold inc
48 ng with meals, was associated with more than a doubling of cirrhosis incidence (adjusted RR 2.47, 1.9
50 defined as the global temperature change for a doubling of CO(2) once the whole Earth system has reac
51 redict a natural BNF increase in response to a doubling of CO(2) that aligns with a meta-analysis of
53 of global warming projections in response to a doubling of CO2-from 1.5 degrees C to 4.5 degrees C or
55 Idiopathic dilated cardiomyopathy showed a doubling of collagen concentration and a quadrupling o
57 d seabird-derived nutrients, in turn, caused a doubling of coral growth rates both within individuals
59 expired, and expiration was associated with a doubling of COVID-19 incidence (incidence rate ratio =
61 nine (n=407, 36%), and severe AKI was either a doubling of creatinine or the requirement of acute ren
62 s common before day 100; 63% of patients had a doubling of creatinine, and 52% had a peak creatinine
68 rate striatal co-grafts were associated with a doubling of DA neuron survival compared with solo mese
69 greater than 1 y delay being associated with a doubling of defect size (adjusted odds ratio (OR) 2.0;
70 erature from 20 to 12 C results typically in a doubling of DegT(50) values and can lead to a stricter
71 vy chain (MHC) promoter led to approximately a doubling of DGAT activity and TG content and reduction
72 e higher maternal choline intake also led to a doubling of dimethylglycine in cord plasma (P = 0.002)
73 ersal evolution and their interaction led to a doubling of distance spread by cane toads in our model
74 W m(-2) per 100% percent cloud fraction for a doubling of droplet concentrations and associated incr
76 ing holographic optical tweezers and achieve a doubling of escape rates compared to unhindered Browni
77 nt of the nuclear fallout from the tests and a doubling of estimates of the mean thyroid radiation do
80 between prenatal PFHxS and TGs z-score [for a doubling of exposure, beta=0.11; 95% confidence interv
82 in bFGF mRNA during this period, followed by a doubling of expression by 48 hours, at which time bFGF
84 the range of 50 to 400 mug/d indicated that a doubling of folic acid intake resulted in an increase
86 ude a reduction in connections between MSNs, a doubling of FSI inhibition to D2 MSNs, an increase in
87 net emissions by 0.16 Pg of carbon per year, a doubling of fuel efficiency for cars and light trucks
88 Moreover, the engineered enzymes enabled a doubling of GalOA yields when glucose was used as a co
90 ssion of Nkx6.1 in class 3 cells resulted in a doubling of glucagon mRNA, with no effect on Pdx1 leve
91 tivated brown adipose tissue as evidenced by a doubling of glucose uptake, and increased beta-oxidati
92 intermediate, and mobile RRDs, we found that a doubling of head movement (angular velocity) correlate
93 opulation has doubled in size, necessitating a doubling of health and social services to maintain cov
94 Granulocytic differentiation resulted in a doubling of HGE binding and enhanced infection consist
98 ed a threefold increase of GIP-R protein and a doubling of insulin secretion to 16.7 mmol/l glucose/1
100 Myocardial infarction was associated with a doubling of intensive care unit time (3.5 days among p
103 ession of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adip
104 of Sox9(+) Neurog3(TA.LO) progenitors, with a doubling of its mitotic index relative to normal Neuro
106 ment [adjusted hazard ratio; 95% CI 1.27 for a doubling of leucocyte telomere length at baseline; 1.0
107 satory elevation of caspase-9 expression and a doubling of levels of direct IAP binding protein with
108 vity and/or reproduction are associated with a doubling of life expectancy in the long-lived rodent g
111 ork) cohort, COPD status was associated with a doubling of lung cancer incidence, no apparent overdia
112 ng would be disrupted by hyperoxia, we found a doubling of lung EC-SOD protein in newborn rats expose
114 ically in nude mice resulting in a more than a doubling of median life extension compared to RT alone
115 addition of elesclomol to paclitaxel yielded a doubling of median PFS (112 v 56 days) and a 41.7% ris
116 atients younger than 70 years can now expect a doubling of median survival to 5 years, a 20% chance o
119 2-yl]-2,5-diphenyl tetrazolium bromide), and a doubling of mitotic activity combined with the presenc
121 e 6 months following ACS predicted more than a doubling of mortality over 6.7 years of follow-up.
122 a species if it was associated with at least a doubling of mortality rate in univariate analyses.
124 LTF (P = 0.005, hazard ratio [HR] = 2.4 for a doubling of MTV), DM and OS (P < 0.001 for both, HR =
125 dependent kinase 2, which was accompanied by a doubling of myocytes in the S and G(2) phases of the c
126 nematodes is developing rapidly with almost a doubling of newly described species in the past five y
130 also associated with a delay in onset, with a doubling of onset time observed in the WAP-TGFalpha/Mu
131 s (1971 to 1994), the past 6 years have seen a doubling of overall activity for the whole basin, a 2.
133 from 45% to 84% (p = 0.001) and resulted in a doubling of participants providing compressions of bot
134 ial database has expanded considerably, with a doubling of patients exposed in the clinical trial env
135 certain PFAS and ASD-related symptoms, with a doubling of perfluorononanoic acid (PFNA), perfluorode
139 -specific adiponectin overexpression induces a doubling of phosphoenolpyruvate carboxylase expression
141 or women; the relative risks associated with a doubling of plasma 25-hydroxyvitamin D were 1.15 (95%
143 layer counting uncertainty, our record shows a doubling of precipitation since 1840 CE, with recent v
145 and diminishing land resources forecast that a doubling of productivity is critical in meeting agricu
146 15-PGDH null colons and is concomitant with a doubling of prostaglandin E(2) in 15-PGDH null colonic
147 repared during the day show more robust LTP (a doubling of PS amplitude), a difference persisting in
148 preoperative serum PSA level (odds ratio for a doubling of PSA levels, 1.9; 95% confidence interval,
150 rts of pregnant individuals have experienced a doubling of rates of hypertensive disorders of pregnan
154 scenarios assessed: 33-48%), implying up to a doubling of residential cooling electricity consumptio
155 ned regularly with increasing Hb levels from a doubling of risk at Hb <10 g/dl to a 61% decrease at 1
157 lysis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a h
159 m reproductive rate of bacteria doubles with a doubling of rrn copy number, and the efficiency of car
160 ment of ascites, encephalopathy, or varices; a doubling of serum bilirubin to 2.5 mg/dL or greater; a
162 filtration rate from baseline [approximately a doubling of serum creatinine], or kidney disease death
165 h 10 muM intracellular concentration) led to a doubling of Shigella intracellular migration velocity
168 5.25 h, turbidity spikes exceeding 1000 FNU, a doubling of specific conductance from 175 to 415 uS/cm
169 AED in communities is associated with nearly a doubling of survival after out-of-hospital cardiac arr
170 ally limited tumor progression, resulting in a doubling of survival in the p48-Cre;LSL-Kras(G12D);Trp
173 s include that the "new normal" will feature a doubling of telecommuting, reduced air travel, and imp
174 s associated with improved overall survival, a doubling of the 2-year survival rate, maintenance of q
177 given the twenty-first century will witness a doubling of the aging population and an increased freq
178 iNOS inhibitor 1400W (1 microM) resulted in a doubling of the amiloride-sensitive Na+ current in GFP
179 etic field with the flowing ions, leading to a doubling of the ascorbic acid oxidation rate, compared
180 obal-mean surface temperature in response to a doubling of the atmospheric carbon dioxide concentrati
181 lobal mean temperature change in response to a doubling of the atmospheric carbon dioxide concentrati
182 disease have evolved in recent decades with a doubling of the average patient age and an increased p
183 ular alterations were associated with nearly a doubling of the average survival time in the RAD-treat
184 for a path as short as 2 km - this is nearly a doubling of the band averaged extinction coefficient.
186 e time to the primary composite end point of a doubling of the base-line serum creatinine concentrati
187 The primary outcome was the composite of a doubling of the base-line serum creatinine concentrati
188 for those with normal ALT at the baseline or a doubling of the baseline ALT for those with elevated A
189 Among the four racial and ethnic groups, a doubling of the calcium score increased the risk of a
192 15 patients, 46.7% had equal to or more than a doubling of the central scotoma area in response to a
193 uring the period of kinocilium migration was a doubling of the centrioles' confinement area taking pl
194 dSe aerogels exhibit twice the surface area, a doubling of the complex viscosity for 5 wt % aerogel-P
195 cific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal
196 ower than expected without an epidemic), and a doubling of the crude death rate because of HIV/AIDS,
198 he introduction of the fall armyworm induced a doubling of the deforestation rate in Zambia in the 3
200 for obesity, the past few decades have seen a doubling of the diabetes mellitus incidence with an in
202 a superior primary outcome, as compared with a doubling of the dose of an inhaled glucocorticoid, as
203 an inhaled glucocorticoid, as compared with a doubling of the dose of the inhaled glucocorticoid (pr
204 ns continue, the subcontinent may experience a doubling of the drought frequency in the coming decade
207 e local field size on age at diagnosis, with a doubling of the expected field diameter between ages a
209 o fluorophores for transduction resulting in a doubling of the extinction coefficient and improving t
212 ytes, at 2-yr follow-up there was on average a doubling of the frequency of naive CD4(+) T cells at t
213 The faster growth rates are accompanied by a doubling of the frequency of transport of short microt
216 romotional language is associated with up to a doubling of the grant's probability of being funded.
217 Waquoit Bay, MA, USA), we observed more than a doubling of the groundwater-associated nitrogen flux t
220 on and that CK flux does not increase during a doubling of the heart rate-blood pressure product by d
221 epresentative data from 1980 to 2012 suggest a doubling of the incidence and prevalence of diabetes d
222 duce a significant decrease in lifespan, and a doubling of the incidence of premature coronary artery
225 nitrogen and phosphorus fertilization rates, a doubling of the irrigated land area, and an 18% increa
227 ct whereas use of CTLA4-Ig alone resulted in a doubling of the median graft survival compared with co
228 h relapsed and then newly diagnosed MM, with a doubling of the median survival as a direct result.
229 Irrespective of duration of breast-feeding, a doubling of the mercury concentration in cord blood wa
230 om single to double valency, consistent with a doubling of the molecular brightness of mCherry-tagged
231 nimum hospital caseloads necessary to detect a doubling of the mortality rate were 64 cases for crani
232 ilic diseases is increasing, as reflected in a doubling of the number of annual articles focused on t
234 first 9 months of the scheme, there has been a doubling of the number of HLA-000 mismatched kidneys t
237 glucagon, and growth hormone concentrations, a doubling of the plasma glucose levels inhibited EGP by
239 s C incidence by 80% is estimated to require a doubling of the primary screening rate, increasing ref
241 hreshold at approximately 20% bone loss with a doubling of the probability ratios of CHD compared to
242 ldren had significant cognitive deficits and a doubling of the rate of developmental delay during the
244 d with increased serum creatinine levels and a doubling of the rate of hyperkalemia (18.7%, vs. 9.1%
249 allele in the PS-1 gene was associated with a doubling of the risk for late-onset Alzheimer's diseas
251 Surprisingly, CHIP is also associated with a doubling of the risk of atherosclerotic cardiovascular
252 /neonatal complications were associated with a doubling of the risk of developing a psychotic disorde
254 obese subjects, high levels of pro-NT denote a doubling of the risk of developing obesity later in li
261 chronic kidney disease, which was defined as a doubling of the serum creatinine level, a diagnosis of
262 ted GFR of <15 ml per minute per 1.73 m(2)), a doubling of the serum creatinine level, or death from
264 of muscle stem cell turnover, accounting for a doubling of the signal from satellite cell and progeny
265 HR) = 1.74 (95% CI 1.25-2.41; P = 0.002) for a doubling of the sRAGE level; HR = 1.45 (1.11-1.89; P =
267 of a metalloproteinase inhibitor results in a doubling of the time required for human monocytes to c
268 tion, increases in each nIF mRNA resulted in a doubling of the total amount of nIF mRNA, as well as a
269 integrated nutrition curriculum resulted in a doubling of the total hours of required instruction in
270 oli lysate revealed improved peptide scores, a doubling of the total number of peptides, and a 30% in
271 duction in fishing mortality has resulted in a doubling of the total population biomass compared with
272 ed by the P2(1)/c space group which involves a doubling of the unit cell along the [0 1 0] direction.
274 itamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin
275 induces an increase in L-Asp transport with a doubling of the Vmax and no change in Km (4.5 micronM)
277 eenland show a strong seasonality as well as a doubling of their rate of occurrence over the past 5 y
279 ease in 15-F2t-IsoP (95% CI: 3.2, 14.7), and a doubling of toenail As was associated with a 1.7% incr
280 However, in contrast with expectations, a doubling of toenail As was associated with a 2.3% decr
284 iate-adjusted estimates of associations with a doubling of urinary As suggested an 8.8% increase in 1
287 ciated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible
288 bited no significant change in Km but showed a doubling of Vmax to 87 +/- 6 pmol TC/mg protein/min (P
289 marked reductions in fertility, resulted in a doubling of world population between 1960 and 2000.
291 e in the price of conventional vehicles, and a doubling of ZEV-related Research & Development (R&D) i
292 Such band structure engineering results in a doubling of zT in p-type PbTe to above 1.5 at 773 kelv