ライフサイエンスコーパス: a previously unknown

1 ge and cyclize geranylated indolenine (2) to a previously unknown 12-epi-hapalindole U (3), raised th

2 namine intermediate-bound DrDXPS reveals how a previously unknown 17- angstrom conformational change

3 we resolved the structure of VPg, revealing a previously unknown 3-dimensional (3D) fold, and charac

4 ich converts geranylgeranyl diphosphate into a previously unknown 5,7-fused bicyclic diterpene, coine

5 Thus, we report identification of a previously unknown ability for spine actin dynamics to

6 which is unable to ring-open DOL, possesses a previously unknown ability to coordinate with and stra

7 At the top of the crypts, we find a previously unknown absorptive cell, expressing the pro

8 Our structure contains a previously unknown accessory subunit CydH, the L-subfa

9 In conclusion, we report a previously unknown accumulation of CD11b(+) macrophage

10 Our results uncover a previously unknown adaptive dimension of the well-stud

11 ito-nuclear transcription factor ATFS-1, and a previously unknown and highly conserved repressor of A

12 eal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1

13 Here, we describe a previously unknown and potentially useful property of

14 We have identified Emc10 as a previously unknown angiogenic growth factor that is pr

15 Here we describe a previously unknown archaeal phylum, Helarchaeota, belo

16 Our work reveals a previously unknown ARF6-PI3K-AKT proinvasive pathway,

17 ire input for longer duration, demonstrating a previously unknown aspect of Bicoid decoding.

18 Our findings indicate a previously unknown assembly pathway and inspire a sugg

19 Here, we identified a previously unknown association between KIF11 and prima

20 esses on an unprecedented scale and discover a previously unknown association between the type and co

21 anuscript, Michelassi et al. (2017) identify a previously unknown autoinhibited state for Unc13 media

22 POLD1 or POLD2 as the underlying etiology of a previously unknown autosomal-recessive syndrome that c

23 chniques, we discovered Clostridium immunis, a previously unknown bacterial species from this family,

24 arium carbonate (ABC), which transforms into a previously unknown barium carbonate hydrate (herewith

25 cessing of the 3' extension, and we identify a previously unknown base-pairing interaction between th

26 size and morphology of this species suggest a previously unknown bauplan, and a previously undetecte

27 tructure of a USP11-peptide complex revealed a previously unknown binding site in USP11's noncatalyti

28 promiscuous flavoenzymes has thus furnished a previously unknown biocatalytic reaction.

29 aling, but they also expose the existence of a previously unknown branch of signaling events that can

30 identify aerobic respiration by bacteria as a previously unknown but essential process for mosquito

31 Findings from this study point to a previously unknown but important pathway of Cr(VI) for

32 (2019) report a previously unknown Ca(2+)-CaMKK2-AMPK signaling cascad

33 They constitute a previously unknown category of large dinosaurian trace

34 ilitated the identification and treatment of a previously unknown cause of human SCID.

35 In addition, a previously unknown CBZ phototransformation product, 3-

36 Macrophages were identified as a previously unknown cellular source of CXADR in human p

37 We identify endothelial FTO as a previously unknown central regulator of both obesity-i

38 re we identify host cell factor 1 (HCF-1) as a previously unknown ChREBP-interacting protein that is

39 Our results reveal a previously unknown circuit mechanism for fear learning

40 les into a superlattice lamellar morphology, a previously unknown class of diblock nanostructures, bu

41 and sporulation) family have now emerged as a previously unknown class of essential glycosyltranfera

42 osine phosphorylation of EphBs may represent a previously unknown class of mechanism mediating protei

43 intestinal epithelial dysfunction, revealing a previously unknown class of mediators of radiosensitiv

44 re we report on the endogenous production of a previously unknown class of omega-3 PUFA-derived lipid

45 We describe here a previously unknown class of potential PLP enzyme inact

46 In summary, our study reveals a previously unknown confounding effect of PPG, widely u

47 In vitro analyses revealed R371Q:ALK6 is a previously unknown constitutively active receptor.

48 ressive feedback between regions and reveals a previously unknown cortical network alteration in auti

49 l roles for yeast CAF-1 subunits and uncover a previously unknown critical function of the middle sub

50 PHF11 (plant homeodomain finger 11) encodes a previously unknown DDR factor involved in 5' end resec

51 s was unaffected, indicating the presence of a previously unknown degree of functional compensation a

52 kely to increase, indicating the presence of a previously unknown degree of functional compensation i

53 Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by

54 a-producing gammadelta populations, implying a previously unknown differential role of STAT5 gene pro

55 Our work reveals a previously unknown divergence in ejaculate component a

56 Gpr126 ECR and reveal five domains including a previously unknown domain.

57 sed control of the cell surface proteome, is a previously unknown driver of metastatic adaptation and

58 Our results have uncovered a previously unknown dysfunction (achalasia and impaired

59 Here, we decode a previously unknown E. coli metabolic pathway that prod

60 the human K326X mutation in vivo and reveal a previously unknown effect of Arhgap29 in murine cranio

61 Plexin-B1 for CIL in osteoblasts and reveals a previously unknown effect of Semaphorin signalling on

62 alpha-Syn PFF endocytosis, but also reveals a previously unknown endocytosis mechanism for HSPG-bind

63 sensory neurons, and we identify LPC 18:1 as a previously unknown endogenous activator of the ligand-

64 d-liquid extracts to propose an identity for a previously unknown endogenous TSPO ligand.

65 Thus, we have identified a previously unknown enterovirus protein that facilitate

66 icornavirus host factor that is required for a previously unknown event in the viral life cycle.

67 suggests that alpha-syn arginylation can be a previously unknown factor that facilitates normal alph

68 ue hydrophobic anchor mechanism that defines a previously unknown family of protein deacetylases.

69 ull-length enzymes, a C-terminal domain with a previously unknown fold has no impact on oligomerizati

70 The enzyme uses a previously unknown fold to bind cA(4) specifically, an

71 findings indicate that ATG proteins mediate a previously unknown form of defence in response to infe

72 new mouse model of COPA syndrome to identify a previously unknown function for Copa in thymocyte sele

73 These findings underscore a previously unknown function for GCN2 phosphorylation o

74 Our findings uncovered a previously unknown function for LYVE-1 and show that t

75 These data suggest a previously unknown function for p190BRhoGAP in control

76 Finally, we defined a previously unknown function for SHCA in the formation

77 This study reveals a previously unknown function for the DNA damage checkpo

78 Our work reveals a previously unknown function of Ccr4-Not and identifies

79 ophagy receptor/adaptor, thereby identifying a previously unknown function of gasdermin family protei

80 Together, we uncover a previously unknown function of pyruvate in regulating

81 Thus, this study identified a previously unknown function of STIM2beta in myogenesis

82 Collectively, our findings reveal a previously unknown function of STRAP in mediating the

83 These findings provide evidence for a previously unknown function of stromal Scrib in PDZ fo

84 Overall, we identify a previously unknown function of the antiviral factor ZA

85 In this work, we discovered a previously unknown function of the HPV16 E5 oncoprotei

86 that BRCA1 is transcriptionally activated by a previously unknown function of ZC3H18.

87 ontaining protein 2 (MOSPD2), a protein with a previously unknown function, regulates monocyte migrat

88 Taken together, our data identify a previously unknown functional link between miR-181a an

89 These findings reveal a previously unknown functional relationship between mem

90 hievable goal.IMPORTANCE This work describes a previously unknown genetic mechanism that allows neona

91 Our results revealed a previously unknown GLIS3-to-CD133-to-WNT signaling axi

92 to previous findings there and suggestive of a previously unknown He isotopic fractionation.

93 We also identify a previously unknown heterodimer interface between trans

94 IP-exo) method allowed the identification of a previously unknown high-affinity AICE2 motif at a huma

95 EA) undergo subsequent reactions to generate a previously unknown, highly reducing species (2).

96 Our results identify TRC8 as a previously unknown Hsp70-independent quality control E

97 Here we report the identification of a previously unknown human prenyltransferase complex con

98 ps were determined on the basis of NOEs, and a previously unknown hydrogen-bonding network between Ma

99 wth media in a compound screen that unmasked a previously unknown hyperactivity of the old antibiotic

100 ults identified a VGLL3-regulated network as a previously unknown inflammatory pathway that promotes

101 and patterning, leading to identification of a previously unknown interaction between ankyrin-B and b

102 With our system, we identified a previously unknown interaction between ESCRT proteins

103 eased detection power, we are also unveiling a previously unknown interaction with Nucleolin, a prote

104 We report the formation of a previously unknown intermediate in the Mg-V-S composit

105 the GMP hierarchy led us to further identify a previously unknown intermediate proNeu2 population.

106 Together, these data suggest a previously unknown interplay between SOD1 acylation, m

107 Taken together, we present a previously unknown kinase-independent role for MASTL a

108 CDK9 enhanced MYC protein stability through a previously unknown, KRAS-independent mechanism involvi

109 The discovery of microRNAs revealed a previously unknown layer of regulation for several bio

110 structure of ACMSD with diflunisal revealed a previously unknown ligand-binding mode and was consist

111 eature is associated with photoconversion of a previously unknown light-sensitive, blue-shifted photo

112 Altogether, these data unraveled a previously unknown link between an imbalanced stoichio

113 is issue of the JCI, Kraakman et al. uncover a previously unknown link between hyperglycemia and enha

114 These findings establish a previously unknown link between KIF11 and the dynamics

115 Our results reveal a previously unknown link between Pro metabolism and pho

116 This study reveals a previously unknown link between rRNA processing and mi

117 These observations highlight a previously unknown link between SphK1 activity, NPC1,

118 These findings suggest that a previously unknown link exists between ChREBP and the

119 uclear actin pool is regulated and uncovered a previously unknown link of RASSF1A and MRTF-A/SRF in t

120 he identification and validation of PSMD9 as a previously unknown lipid regulatory protein.

121 in a 3-m-deep stratified sequence, revealing a previously unknown lithic industry that underwent only

122 re we describe and functionally characterize a previously unknown liver-specific enhancer-promoter el

123 e have identified and successfully validated a previously unknown locus with a powerful protective ef

124 bly into spherical micelles, which pack into a previously unknown, low-symmetry lyotropic liquid crys

125 Here, we describe a previously unknown lymphocyte that is a dual expresser

126 Vpr counteracts a previously unknown macrophage-specific restriction fac

127 isode has consequently been deemed to reveal a previously unknown major tropical eruption in 1108 CE.

128 we show that thermogenic adipocytes express a previously unknown, mammal-specific protein of the end

129 esent evidence that suggests Bermuda sampled a previously unknown mantle domain, characterized by sil

130 These findings provide novel insights into a previously unknown mechanism by which oxytocin may act

131 ginosa Taken together, our findings identify a previously unknown mechanism by which P. aeruginosa Ex

132 Here we report a previously unknown mechanism by which rain disperses s

133 endogenous proteolytic activity and defines a previously unknown mechanism by which S. aureus may in

134 Taken together, we have identified a previously unknown mechanism by which the nuclear acti

135 This study presents a previously unknown mechanism controlling the rate of m

136 Taken together, these results reveal a previously unknown mechanism for perceiving the afford

137 cers via chromatin looping, which identifies a previously unknown mechanism for regulating the T cell

138 Overall, our study highlights a previously unknown mechanism for RIPK1 kinase activity

139 of human osteogenesis imperfecta, and reveal a previously unknown mechanism for splicing "rescue."

140 of phosphorene cut upon oxidation represents a previously unknown mechanism for the formation of vari

141 protective role for NEAT1 in PD and suggest a previously unknown mechanism for the neuroprotective t

142 of resting membrane potential, demonstrating a previously unknown mechanism for the regulation of exc

143 hese proteomic and functional studies reveal a previously unknown mechanism important for excitatory

144 In sum, our study uncovers a previously unknown mechanism in which RBF and E2F1 mod

145 aneptine is an effective antidepressant with a previously unknown mechanism of action.

146 port through quantum fluctuations represents a previously unknown mechanism of heat transfer in addit

147 ication in response to stress and identifies a previously unknown mechanism of SG regulation.

148 Our results suggest a previously unknown mechanism of temporal orchestration

149 Overall our data uncover a previously unknown mechanism of tumour growth by peric

150 study establishes lysine fatty acylation as a previously unknown mechanism that regulates the Ras fa

151 emodeling via the LiaR response regulator by a previously unknown mechanism.

152 Our results define a previously unknown mechanistic link between filamentou

153 l data on one of the orphan pathways suggest a previously unknown member of the rare polytheonamide-t

154 These results reveal a previously unknown metabolic component to postthymic T

155 freshwater bacteria are directly produced by a previously unknown methionine biosynthesis pathway.

156 ch carbamazepine resists biodegradation, and a previously unknown microbial biodegradation was predic

157 We identified a previously unknown mitochondrial fission arrest phenot

158 oing de novo genome methylation and identify a previously unknown MIWI2-associated factor, SPOCD1, th

159 salts 3H(+)BF(4)(-)-6H(+)BF(4)(-) represents a previously unknown mixed NH...N(n,pai) interaction.

160 A previously unknown MmpL3 ligand, phosphatidylethanolam

161 These natural materials provide a previously-unknown model for bioinspired humidity-stab

162 This study identifies TRIM21 as a previously unknown modulator of Toxoplasma gondii resi

163 o Aalpha-chain frameshift variants, yielding a previously unknown molecular basis for the pathogenesi

164 cking, function, and pharmacology and reveal a previously unknown molecular interaction that modulate

165 We have identified a previously unknown molecular link between folate avail

166 We report a previously unknown molecular mechanism by which folate

167 Together, our study uncovered a previously unknown molecular mechanism of salt toleran

168 control over SIRT1 functions by constituting a previously unknown molecular relay.

169 d adenine nucleotide translocase 3 (ANT3) as a previously unknown mortalin substrate and cell surviva

170 Here, we report that blur differences cause a previously unknown motion illusion that makes people d

171 Our work provides insight into a previously unknown mumps virus-host interaction.

172 Abundant pollination by a previously unknown native moth in experimental and res

173 e bacterial infections likely resulting from a previously unknown negative interference between dieta

174 Here we identify a previously unknown neuron type in the songbird brain t

175 otivated behaviors through identification of a previously unknown neuropeptide-containing pnVTA nucle

176 lized hydridosilylenes 3 was accomplished by a previously unknown NHC-induced fragmentation of silano

177 cal modelling to quantitatively characterise a previously unknown OFG system near Canterbury, New Zea

178 These results highlight a previously unknown oncogenic function of Mdm2 during t

179 jor migration events: an initial peopling by a previously unknown Palaeolithic population of 'Ancient

180 re tumorigenic processes/pathways and reveal a previously unknown pan-cancer miRNA signature with pat

181 (18)F-FLT biodistribution over time revealed a previously unknown path of cellular recovery of haemop

182 tes proliferate in situ during AH, providing a previously unknown pathogenic mechanism and new avenue

183 each other's relative abundance, identifying a previously unknown pathological link between TGF-beta1

184 Together, this study defines a previously unknown pathway by which S. aureus epicutan

185 c DSBs through CSB-RAD52-POLD3-mediated BIR, a previously unknown pathway protecting telomeres from R

186 Cs prior to postnatal day 10 (P10), and from a previously unknown Pax7(-)/MyoD(-)/Prrx1(+)/NG2(-) mus

187 We have discovered that GAS uses a previously unknown peptide-mediated intercellular sign

188 ing integrin (alpha(IIb)beta(3)) activation, a previously unknown phenomenon.

189 he presumably uniformly fluidic ER membrane, a previously unknown phenomenon.

190 These data identify a previously unknown phosphorylation-dependent KCC2 regu

191 Importantly, our results reveal a previously unknown physiological function of allergic

192 Our results uncover a previously unknown physiological role of NCOA5 in the

193 This work identifies a previously unknown player in cancer heterogeneity and

194 and adaptive antitumor immune responses, as a previously unknown player in the Hh signaling pathway.

195 We report the identification in mouse of a previously unknown population of multipotent stem/prog

196 ncode RNA-binding proteins, thus delineating a previously unknown post-transcriptional regulatory sub

197 cytoplasm to the apoplast of host cells via a previously unknown post-translational mechanism of end

198 Overall, our results define a previously unknown principle in neuroscience; thalamic

199 These results illuminate a previously unknown program of liver regeneration after

200 Our results define a previously unknown protective role for NK cells during

201 In conclusion, our study identifies a previously unknown protective SMA modifier in humans,

202 In this study, we have identified a previously unknown protumorigenic role for the RUNX ge

203 ns in parallel to Gli induction, identifying a previously unknown Ptch2-specific signal pathway.

204 Here, we provide evidence for a previously unknown quality control mechanism in which

205 We report that a previously unknown, quorum-sensing-controlled LysR-typ

206 tes on the surface of zinc metal establishes a previously unknown reactivity correlation that predict

207 These data identify endothelial FTO as a previously unknown regulator in the development of obe

208 We conclude that Krtap5-5 is a previously unknown regulator of cytoskeletal function

209 is bioactive collagen fragment may represent a previously unknown regulator of the hippo effector kin

210 These results identify SMAD4 as a previously unknown regulator that restricts non-canoni

211 ish OTUD3 as a repressor of MAVS and uncover a previously unknown regulatory mechanism by which the c

212 brane domains of LptB(2)FG, which represents a previously unknown regulatory mechanism for ATP-bindin

213 r study identifies lysine fatty acylation as a previously unknown regulatory mechanism for the Ras fa

214 of the activation of IRF3 but also identify a previously unknown regulatory mechanism independent of

215 a phosphosite in its N-peptide, representing a previously unknown regulatory step in mammalian autoph

216 d with GSL and AA concentrations, suggesting a previously unknown relationship between plants and end

217 Our work describes a previously unknown requirement for Sfxn3 in retinal fu

218 This report identifies a previously unknown requirement for tetrodotoxin-sensit

219 lls in the genesis of RA-ILD, which exist in a previously unknown, reversible, prefibrotic stage of t

220 ts revealed that JUND mRNA is a component of a previously unknown ribonucleoprotein complex.

221 P) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP), a previously unknown ribonucleotide.

222 findings indicate that preterm birth may be a previously unknown risk factor for HF.

223 In essence, these studies highlight a previously unknown role for A20 in the restriction of

224 This study uncovers a previously unknown role for acyl-carnitines in this tr

225 These data demonstrate a previously unknown role for BAs in intestinal control

226 These results elucidate a previously unknown role for blood-derived non-classica

227 Altogether, we uncovered a previously unknown role for CDK4 in lysosomal biology

228 These findings support a previously unknown role for CNS astrocytes in energy b

229 Here, we identify a previously unknown role for cohesin.

230 ication of the abdominal aorta and describes a previously unknown role for HDAC9 in the development o

231 We also reveal a previously unknown role for MET at inhibitory synapses

232 ese studies identified what we believe to be a previously unknown role for miR181ab1 as a potential t

233 These findings suggest a previously unknown role for myocardial trabeculae in t

234 These studies reveal a previously unknown role for PDGFB-to-PDGFRbeta paracri

235 Here, we reveal a previously unknown role for Pif1 in replication barrie

236 These findings establish a previously unknown role for platelet-derived PDGFB, wh

237 This evidence supports a previously unknown role for PPAR-alpha in behavior reg

238 ial cues for NK cell organization and reveal a previously unknown role for S1P in positioning cells w

239 These results reveal a previously unknown role for the cation channel Trpc5 i

240 These findings highlight a previously unknown role for the CTD of SREBPs in regul

241 Our findings reveal a previously unknown role for the epigenetic mark 5hmC i

242 Our data reveal a previously unknown role for the gut microbiota in infl

243 We describe a previously unknown role for the Hippo pathway in myeli

244 This suggests a previously unknown role for the LEC in processing of h

245 These data demonstrate a previously unknown role for the MCH system in the dyna

246 Our findings highlight a previously unknown role for the PVT in heroin seeking

247 Our work highlights a previously unknown role for the reovirus outer capsid

248 Our work highlights a previously unknown role for the reovirus outer capsid

249 ssion and the splicing of PTC7 and establish a previously unknown role for the SWI/SNF complex in the

250 uating a ctpD disruption mutant demonstrated a previously unknown role for this gene in INH susceptib

251 Together, these results reveal a previously unknown role for transcription factor IIH i

252 nserved across phyla, and this study reports a previously unknown role for VGLUT as an acid-extruding

253 This heterogeneity is believed to play a previously unknown role in cellular processes.

254 ctivate NFkappaB signaling thereby revealing a previously unknown role of 2-12(S)-HETE-lysophospholip

255 Our study reveals a previously unknown role of ARF6 in neutrophil polariza

256 Therefore, these findings reveal a previously unknown role of Cav1.2 channels within the

257 In summary, we reveal a previously unknown role of Chrna5 as well as an effect

258 This underscores a previously unknown role of DNA damage repair in the pa

259 Taken together, these data demonstrate a previously unknown role of HDAC11 as a negative epigen

260 These findings uncover a previously unknown role of IL-27 in regulating Treg fu

261 Our results uncover a previously unknown role of nuclear pores in heterochro

262 Together, these results indicate a previously unknown role of the centrosome in regulatin

263 n this issue of the JCI, Casas et al. define a previously unknown role of the NADPH oxidase catalytic

264 Our findings have uncovered a previously unknown role of U1 snRNP beyond the process

265 tutions in Ubc13-deficient strains uncovered a previously unknown role of Ubc13 in controlling the ac

266 These data uncover a previously unknown signal transduction pathway by whic

267 Therefore, this study identifies a previously unknown signaling pathway by which GP78 sti

268 of sea ice and sea ice-influenced ocean are a previously unknown significant source of atmospheric o

269 G6P was found to bind to a previously unknown site adjacent to the canonical site

270 Our studies reveal a previously unknown Slit-independent function and regul

271 solution LC-MS/MS analysis of PSA identified a previously unknown small molecular-weight, covalently

272 Here we show that the midbrain, a previously unknown source of acetylcholine in the stri

273 nimal is subjected to sickness or exposed to a previously unknown source of food.

274 The results demonstrate a previously unknown specificity of calcineurin isoforms

275 These epithelial changes accompany a previously unknown spheroid to lentoid shape transitio

276 yR2 interaction, suggesting the existence of a previously unknown SR nanodomain composed of both RyR2

277 to prior studies, we find that CcdA samples a previously unknown state where only one of the disorde

278 sence of cytoskeletal tension generation, as a previously unknown strategy to maintain stemness in 3D

279 13 interaction, and suggest the existence of a previously unknown stress-response pathway.

280 The stic2 locus identified a previously unknown stromal protein that interacts phys

281 These results hint at a previously unknown stromal role of Nkx2.3 as driver of

282 We identify clinoforms as a previously unknown structural control on the lateral e

283 Furthermore, Brn3c(+) neurons highlight a previously unknown subdivision of the deep mesencephal

284 of intracellular lipid droplets to identify a previously unknown susceptibility of lipid mono-unsatu

285 Our data demonstrate a previously unknown synergy between AngII and BAFF in i

286 Furthermore, we uncovered a previously unknown "synthetic-sick" interaction betwee

287 We also discovered a previously unknown T. pallidum lineage recovered as a

288 Our work reveals a previously unknown target for treatment of age-related

289 ammalian cell lysates, including histone H3, a previously unknown target of phospholyases.

290 ctive states via phase transition represents a previously unknown thermosensory mechanism.

291 Collectively, our study uncovers a previously unknown tightly coupled positive feedback s

292 We describe a previously unknown tool-use behavior for wild birds, s

293 intensity, migrating songbirds can negotiate a previously unknown trade-off between sleep-mediated en

294 We therefore interpret the Bermuda source as a previously unknown, transient mantle reservoir that re

295 Our experimental results reveal a previously unknown transition state that we tentativel

296 a low-luminosity active galactic nucleus or a previously unknown type of extragalactic source.

297 Ten infants sharing a previously unknown variant in troponin I (TnI) were id

298 The cardiac phenotype consists of a previously unknown vasculogenesis defect that affects

299 nd ground survey had indicated, and revealed a previously unknown wetland field complex that is even

300 Importantly, these studies reveal a previously unknown zinc-binding site on the surface of