ライフサイエンスコーパス: aberration

1 essing tumours without apparent FGFR genetic aberration.

2 rom controls (P > .05), except for wavefront aberrations.

3 detected diagnostically informative genetic aberrations.

4 ting in extensive DNA damage and chromosomal aberrations.

5 s enriched in DNA damage response (DDR) gene aberrations.

6 ntained in culture do not present centrosome aberrations.

7 an accumulation of mutations and chromosomal aberrations.

8 ependent induction of apoptosis upon mitotic aberrations.

9 groups with distinct combinations of pathway aberrations.

10 s characterized by a wide variety of genetic aberrations.

11 of the back-ward imaging by reducing motion aberrations.

12 ploidy, translocations, and other chromosome aberrations.

13 characteristic histopathological and genomic aberrations.

14 effect of misalignment on the correction of aberrations.

15 me (Xi) is inherently susceptible to genomic aberrations.

16 d included patients who had del(17p) or TP53 aberrations.

17 ability, that are characterized by dendritic aberrations.

18 with clinical characteristics and lymphocyte aberrations.

19 y trajectories for SCNAs and DNA methylation aberrations.

20 subclones that arise by random (epi)genetic aberrations.

21 f CPCS group vs. FLACS group regarding total aberrations (0.563 +/- 0.386 vs. 0.91 +/- 1.20) (p = 0.0

22 ew, high resolution and sensitivity with low aberration(1).

23 ncer, we identified 968 reportable molecular aberrations (39.9% in WGS and RNAseq, 35.1% in WGS only

24 , 93.7% had at least one germline or somatic aberration, 71.4% had therapeutic targets and 5.2% had a

25 161 patients had DDR gene aberrations, 98 of whom were randomly assigned and treat

26 D) enriched with genomic deletions and BRCA2 aberrations, a tandem duplication genotype associated wi

27 We characterize the aberrations across a 30-um field-of-view, demonstrating

28 bit one of the highest burdens of structural aberrations across human cancer.

29 designed to eliminate the positive spherical aberration added by traditional IOLs to the pseudophakic

30 had prognostic impact, but only TP53 and MYC aberrations added value independently of genomic complex

31 ells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential.

32 However, metalenses that correct chromatic aberration also suffer from markedly reduced focusing ef

33 Significantly higher somatic copy number aberration and allelic imbalance burdens are identified

34 berration but no del17p), and high risk (MYC aberration and del17p) (P = .0006).

35 data are represented by the ocular wavefront aberration and pupil diameter, both either coming from i

36 b/AZD6738 treatment induces more chromosomal aberrations and achieves this at lower concentrations an

37 Aiming to characterize gene aberrations and assess their effects on cancer, we desig

38 TERT aberrations and ATRX mutations are associated with alter

39 a strong link between developmental sensory aberrations and behavioral abnormalities relevant for Ta

40 of a point scanning instrument with minimal aberrations and capable of diffraction-limited performan

41 l sources of errors resulting from chromatic aberrations and detector cross talk.

42 HGSC exhibits high rates of chromosomal aberrations and knowledge of causative mechanisms would

43 x, we removed both high-order sample-induced aberrations and multiple scattering noise with the effec

44 our GBM cohort, finding similar copy number aberrations and mutated genes based on coding mutations

45 ly validate the association between DDR gene aberrations and response to olaparib in metastatic castr

46 mechanistic links between cellular-molecular aberrations and specific manifestations of psychosis as

47 plex disease that is associated with genetic aberrations and subsequent cellular and noncellular host

48 at can reveal the timing of specific genomic aberrations and the changing influence of mutational pro

49 orrelation and predictability between ocular aberrations and the postoperative visual outcome were ev

50 The optical model takes account of ocular aberrations and their variation across the visual field,

51 anterior corneal surface, Q-value, spherical aberration, and ecentricity at 6.0 and 8.0 mm were measu

52 otential cooperation of multiple driver gene aberrations, and diverse resistant mechanisms.

53 chain (IGHV) mutation status, common genomic aberrations, and gene mutations in 421 untreated patient

54 y enzymes underlie a number of developmental aberrations, and in flies and worms, their loss-of-funct

55 egulators, anti-apoptotic stimuli, metabolic aberrations, and their interactions, are discussed.

56 tumors are characterized by specific driver aberrations, and this has expanded the therapeutic optio

57 Centrosome aberrations are commonly observed in human tumors and co

58 vice thickness is only 10 mum, and chromatic aberrations are corrected over the entire LWIR band with

59 The consequences of these chromosomal aberrations are difficult to study in cancer, and theref

60 RB1/TP53/AR aberrations are enriched in later stages, but the preval

61 These aberrations are particularly prevalent in sarcomas and h

62 Tumor-specific genomic aberrations are routinely determined by high-throughput

63 Although molecular aberrations are routinely used to stratify AML patients

64 Epigenetic aberrations are widespread in cancer, yet the underlying

65 tructure are common in tumors, yet how these aberrations arise is unknown.

66 es that have shed light on the role of IKZF1 aberration as prognostic factor in pediatric ALL and sum

67 platforms to profile genetic and epigenetic aberrations as well as the tumor microenvironment.

68 plasticity, sustained by a range of somatic aberrations, as well as epigenetic and metabolic adaptat

69 us replication fork stalling and chromosomal aberrations, as well as fewer camptothecin (CPT)-induced

70 The most frequent chromosomal aberrations associated with HSTCL are isochromosome 7q a

71 CDVA, contrast sensitivity, and higher-order aberrations at 12 months.

72 Because PMBCL is associated with genetic aberrations at 9p24 and overexpression of programmed cel

73 In conclusion, assessing genomic aberrations at FL diagnosis with CGAT improves risk stra

74 Cytogenetic aberrations at the single-cell level represent an import

75 blastomas, which have a 14% frequency of ALK aberrations at the time of diagnosis and show increasing

76 phenotype and a de novo balanced chromosomal aberration (BCA).

77 ed the development of THC-induced behavioral aberrations, blocked cortical downregulation of local GS

78 High copy number aberration burden is associated with worse prognosis in

79 Adaptive focusing can compensate for such aberration but is only effective over a restricted field

80 (no MYC aberration), intermediate risk (MYC aberration but no del17p), and high risk (MYC aberration

81 e have been proposed to circumvent chromatic aberration but their throughput efficiency is still limi

82 bypass the effects of longitudinal chromatic aberration by placing a spectral filter behind the optic

83 genomic complexity (ie, the total number of aberration calls) was associated with poor outcome in FL

84 However, centrosome aberrations can also disrupt tissue architecture and con

85 Phase aberrations can then be unscrambled for any point, provi

86 , mainly by studying (classical) chromosomal aberrations (CAs) or micronuclei (MN) as markers of DNA

87 Leading-strand template aberrations cause helicase-polymerase uncoupling and imp

88 ther structural chromosomal rearrangement or aberrations caused by splicing or transcriptional readth

89 ad an IKZF1 deletion plus additional genetic aberrations (CDKN2A or CDKN2B, PAX5, or both [i.e., IKZF

90 Copy-number aberration (CNA) analysis identified recurrent alteratio

91 5P) mutation and the genome-wide copy number aberration (CNA) profiles of individual vitreous-isolate

92 DNA copy number aberrations (CNA) are frequently observed in colorectal

93 s the prognostic significance of copy-number aberrations (CNAs) and copy-neutral loss of heterozygosi

94 or which genome-wide chromosomal copy number aberrations (CNAs) and mutational profiles for a subset

95 Copy-number aberrations (CNAs) and whole-genome duplications (WGDs)

96 Somatic copy number aberrations (CNAs) have been implicated in the developme

97 eir use to the analysis of large copy-number aberrations (CNAs) in individual cells.

98 onable mutations and copy number alterations/aberrations (CNAs) in the two most common breast cancer

99 tified extensive allele-specific copy-number aberrations (CNAs) in these samples, including copy-neut

100 Copy number aberrations (CNAs), which are pathogenic copy number var

101 Copy number aberrations (CNAs), which delete or amplify large contig

102 e nucleotide variants (SNVs) and copy number aberrations (CNAs), while MutSigCV (SNVs) and GISTIC (CN

103 quantitation, highlighting the need for the "aberration compensated" aspect of AC-LSCM.

104 We develop aberration-compensated laser scanning confocal microscop

105 homa category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (

106 The incidences of genomic aberrations considering the hierarchical model were del(

107 nown about how the majority of these genetic aberrations contribute functionally to disease.

108 films, using an in situ heating stage in the aberration corrected scanning transmission electron micr

109 dispersion promoter and characterized using aberration corrected scanning transmission electron micr

110 ossible using spherical and chromatic double aberration-corrected electron microscopy combined with e

111 Aberration-corrected electron microscopy revealed that i

112 Aberration-corrected electron microscopy reveals that th

113 By using in situ aberration-corrected environmental transmission electron

114 tiple characterization techniques, including aberration-corrected high-resolution scanning transmissi

115 of MIL-101 is reported by low-dose spherical aberration-corrected high-resolution transmission electr

116 nd epitaxial growth are revealed by low-dose aberration-corrected high-resolution transmission electr

117 in the carbon matrix is clearly disclosed by aberration-corrected scanning transmission electron micr

118 his study, postsynthesis nanocrystal fusion, aberration-corrected scanning transmission electron micr

119 Here we describe the use of aberration-corrected scanning transmission electron micr

120 Here, by using an aberration-corrected transmission electron microscope, w

121 tubes, and an 'atomic injector' coupled with aberration-corrected transmission electron microscopy, t

122 Whilst aberration correction may be used, this is difficult to

123 multiple scattering noise with the effective aberration correction speed of 10,000 modes/s.

124 l tomography pattern could benefit more from aberration correction with custom intraocular lenses (IO

125 These results suggest that molecular aberrations could be critical for future differentially

126 ponse heterogeneity and the specific genetic aberrations could improve current practice.

127 explored, and the prognostic significance of aberration count, and TP53 and CDKN2A/B deletion were fu

128 These systems rely on aberration detection algorithms to identify potential th

129 hich selectively eliminates gross chromosome aberrations during mitosis.

130 High-CK with >=5 chromosomal aberrations emerges as prognostically adverse, independe

131 ing with clarified specimens to overcome the aberrations encountered in imaging thick tissues.

132 ost deleterious substitution in structure as aberrations extensively compromised the active site.

133 The spherical aberration for 6.0 and 8.0 mm diameter was 1.16 +/- 0.39

134 The spherical aberration for 8.0 mm cornea diameter showed the highest

135 ified Haigis-L formula considering spherical aberration for 8.0 mm produced smaller values in standar

136 ing into consideration the corneal spherical aberration for the 8.0 mm zone at pre-cataract surgery s

137 y-one normal eyes were randomized to receive aberration-free (n = 30) or negative-spherical aberratio

138 Higher positive SA in the aberration-free group potentially led to better DCNVA th

139 The aberration-free IOL group showed significantly better DC

140 ze (P = .05) than normal eyes implanted with aberration-free IOLs.

141 nty post-hyperopic femto-LASIK eyes received aberration-free IOLs.

142 In liver, respiratory motion and aberrations from subcutaneous fat affected the treatment

143 Motion aberrations from the forward dynamic imaging link impede

144 e of the interplay between different somatic aberrations, from point mutations to whole-genome duplic

145 DNA repair gene aberrations (GAs) occur in several cancers, may be progn

146 We posit that different genomic aberrations generally exhibit a temporal order, shaped b

147 Higher-order aberrations (HOA's) are exaggerated in eyes with keratoc

148 cies on GBAF in malignancies without SWI/SNF aberrations, however, are less defined.

149 The most direct approach to reduce aberrations, improve the contrast and achieve an optimal

150 Hottip aberration in mice abnormally promotes HSC self-renewal

151 Aberrations in 3D chromatin conformation have been impli

152 Furthermore, the combination of pathway aberrations in a tumour defines its disease mechanism, a

153 1q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML).

154 be used as a foundation for models relating aberrations in amygdala connectivity to psychiatric symp

155 contributes to subsequent neurodevelopmental aberrations in ASD.

156 tifying genes with more frequent copy-number aberrations in BM-LUAD compared to 503 primary LUADs.

157 also associated with suppressing centrosomal aberrations in breast cancer; however, the role of p15 i

158 Instead, our results suggest that aberrations in Ca(2+) signalling may be a synergistic re

159 nd (CGI) hypermethylation are key epigenomic aberrations in cancer.

160 gnant rhabdoid tumors, both of which possess aberrations in canonical BAF (cBAF) and Polybromo-BAF (P

161 Aberrations in centriole structure are common in tumors,

162 Our pilot study points towards aberrations in complement activation and oxidative damag

163 sociations among MTHFR c.677C > T, tHcy, and aberrations in DNA methylation, we investigated whether

164 Most hereditary tumors show aberrations in DNA repair genes or their regulators.

165 these mice do not survive post birth due to aberrations in erythropoiesis resulting from an arrest i

166 mising option for the correction of advanced aberrations in eyes with non-progressive keratoconic cor

167 subtypes are linked to specific copy number aberrations in genes such as mutant KRAS and GATA6.

168 We achieved this goal by correcting optical aberrations in gradient index lens-based ultrathin (<=50

169 hese findings provide novel evidence linking aberrations in homeostatic signaling pathways within dep

170 to study the origins of centriole structural aberrations in large populations of human cells.

171 erebral hypoxia ischemia to promote ASD-like aberrations in mice using a novel two-hit model.

172 py recalcitrant disease characterized by the aberrations in multiple genes that drive pathogenesis an

173 ner myelin of large diameter axons and gross aberrations in myelin organization affecting the nodes o

174 tcomes and are often associated with genomic aberrations in neurofibromin 1 (NF1) and phosphoinositid

175 ure of the endosomal system and suggest that aberrations in NMDAR-regulated membrane trafficking may

176 s, with nearly 25% of all cancers harbouring aberrations in one or more of these genes.

177 etic donor cell memory or disease-associated aberrations in patient-specific hiPSC.

178 alth of evidence has accrued indicating that aberrations in phase transitions are early events in the

179 In HNSCC, genetic aberrations in phosphatidylinositol 3-kinase (PI3K) and

180 We studied genomic aberrations in primary prostate cancer biopsies from pat

181 ent data suggest that the distinct metabolic aberrations in prostate adenocarcinoma are driven by the

182 Invasive tumors exhibit aberrations in recruitment and activity of immune cells,

183 L3 disease-associated gene variations showed aberrations in size and a reduction of a "CC" end motif

184 However, whether such aberrations in somatosensory processing extend and/or pr

185 actor-kappaB pathway signaling, resulting in aberrations in T- and B-cell maturation and function.

186 Aberrations in the anterior portion of the right CB may

187 ed by multiple mechanisms, including genomic aberrations in the DNA regulatory regions.

188 op in the presence of wild-type p53, acquire aberrations in the p53 pathway to bypass p53-mediated tu

189 he premise that the constellation of genomic aberrations in the tumor gives rise to the molecular sub

190 tive optics to compensate for tissue-induced aberrations in the wavefront.

191 Pathologies can also arise from aberrations in these gene-gene interactions.

192 opment across childhood and adolescence, and aberrations in these trajectories are relevant for a ran

193 Aberrations in time-varying engagement of the SN with th

194 A role for such aberrations in tumorigenesis is evidenced by cancer pred

195 oint for the onset of genome-wide epigenetic aberrations in urothelial carcinogenesis.

196 The aberrations included 10 missense mutations, 1 deletion,

197 Interestingly, archetypal CLL genomic aberrations including HIST1H1B and TP53 mutations and de

198 static colorectal cancer harboring molecular aberrations, including ATM loss and an ARID1A mutation,

199 ne recurrent driver gene alteration and most aberrations, including MYCN, ATRX, and TERT alterations,

200 contrast, most cancer cells have centrosome aberrations, including supernumerary centrosomes, and th

201 eloping seven major categories of structural aberrations, including translocations, insertions, delet

202 terized by biallelic BUBR1, CEP57, or TRIP13 aberrations; increased chromosome missegregation; and a

203 ) will reduce the positive corneal spherical aberration induced in eyes by myopic LASIK or PRK or by

204 xtures of subclones, accumulation of somatic aberrations, infiltration of immune and stromal cells in

205 the possibility of electrically controlling aberrations inherent to these smart lenses holds promise

206 ct cytogenetic risk groups: low risk (no MYC aberration), intermediate risk (MYC aberration but no de

207 One of the most common aberrations, inversion of chromosome 16 [inv(16)], gener

208 but the cause or mechanism of this metabolic aberration is not clear.

209 The measured field variation of aberrations is consistent with system geometry and agree

210 patial heterogeneity in neoplastic metabolic aberrations is critical for tumor treatment.

211 However, chromatic aberration, limiting broadband operation, has remained a

212 the Zeiss i.Profiler(plus) gathers of ocular aberrations (low and high order).

213 s, they contrasted with CK cases with 3 or 4 aberrations (low-CK and intermediate-CK, respectively) w

214 30-um field-of-view, demonstrating a minimum aberration magnitude of smaller than [Formula: see text]

215 Spherical aberration may be a consideration with patient selection

216 ecular events, including somatic copy number aberration, may be a common characteristic of tumors wit

217 garding these mechanisms by which intestinal aberrations might drive the development of PSC.

218 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy-number analysis an

219 Novel therapies targeting certain aberrations, most notably BRCA1/2 mutations, mismatch re

220 he virtual fovea was evaluated for cIOLs and aberration-neutral IOLs (nIOLs) in a simulated clinical

221 bute to striking morphological and molecular aberrations observed upon DXO1 knockout in plants, which

222 remodeling complex, is the hallmark genetic aberration of atypical teratoid rhabdoid tumors (ATRT).

223 es might be the result of a subtle transient aberration of salicylic acid-jasmonic acid homeostasis d

224 The mathematical aberration of the Gregorian chronology's missing "year z

225 ng the function of a cell signaling pathway, aberration of which often leads to fatal diseases, inclu

226 ethod for characterizing the field-dependent aberrations of a full-field synchrotron-based extreme ul

227 Genomic aberrations of resectable non-MYCN-amplified stage 2 neu

228 S) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to various developm

229 ore specifically, we discuss several genetic aberrations of these factors as mechanisms for the devel

230 Aberrations of Tregs correlate with pathogenesis of infl

231 lar, cellular, and clinical impact of ARID1A aberrations on cancer immunity.

232 on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status

233 nomenclature is used to describe chromosomal aberrations (or lack thereof) in a collection of cells,

234 92% of the patients had unmutated IGHV, TP53 aberration, or chromosome 11q deletion.

235 s to computationally correct the objectives' aberrations out of the rendered images, and provides us

236 These data implicate cell-intrinsic aberrations outside of the immune system and suggest new

237 isition of somatic mutations and copy number aberrations over time.

238 The chromosomal aberration patterns of the parental tumors were largely

239 tative biomarkers for early pancreatic islet aberrations preceding T2D.

240 th inferior PFS and OS were as follows: TP53 aberration, prior treatment, beta-2 microglobulin >= 5 m

241 , and chip-to-chip communications as well as aberration-proof light focusing with multiple lenses for

242 wed permeability abnormalities and metabolic aberrations regarding the production of natural moisturi

243 sed at Public Health England, and the 'Early Aberration Reporting System' (EARS) method used at the U

244 ion and the severity and progression of lung aberrations require a method of radiological evaluation

245 We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility

246 ves identifying and targeting tumor-specific aberrations resulting from causative SGAs.

247 ix (76%) of the 34 patients exhibited an MYC aberration, resulting from mutually exclusive translocat

248 Analysis of copy number aberrations revealed genomic changes characteristic of h

249 Patients with tumors harboring actionable aberration(s) in fibroblast growth factor receptor (FGFR

250 erration-free (n = 30) or negative-spherical aberration (SA) IOLs (n = 61).

251 Spherical aberration (SA) occurs when light rays entering at diffe

252 Intraocular lenses with negative spherical aberration (SA) will reduce the positive corneal spheric

253 Corneal higher-order aberrations (SA, coma, trefoil, and corneal asphericity)

254 occurred independent of segmental chromosome aberrations (SCAs); only 1p loss decreased EFS (5-year E

255 Both APITH indexes for SCNAs and methylation aberrations show significant associations with poor prog

256 lluminated biology downstream of copy number aberrations, somatic mutations, and fusions and identifi

257 cient cells accumulate extensive chromosomal aberrations stemming from dysfunctions in homologous rec

258 ) defined by the presence of >=3 chromosomal aberrations (structural and/or numerical) identified by

259 ation of DHT and insulin exhibited endocrine aberrations such as hyperandrogenism and insulin resista

260 ion calling and analysis of large structural aberrations such as pathogenic macrosatellite arrays not

261 mplexity of CRC, and include a wide range of aberrations such as point mutations, amplifications, fus

262 utations in DICER1 or other microRNA-related aberrations such as somatic amplification of miR-17-92 (

263 The detection of DNA repair aberrations, such as mutation of BRCA2, could help selec

264 toration of this pathway improves behavioral aberrations, suggesting that altered neurotransmission a

265 tion-resistant prostate cancer with DDR gene aberrations, supporting the implementation of genomic st

266 the 17q23 amplicon, a recurrent copy number aberration that defines about 9% of all primary breast c

267 SARC is associated with a variety of genomic aberrations that contribute to higher risk for metastasi

268 eal AGRs as a class of underexplored genetic aberrations that could be pathological in breast cancer,

269 ntifies and quantifies depth-dependent axial aberrations that could confound quantitation, highlighti

270 ons between driver mutations and chromosomal aberrations that define two tumor clusters, with distinc

271 Genomic aberrations that disrupt chromosome spatial domains can

272 pes, and results from epigenetic and genetic aberrations that give rise to distinct transcriptional p

273 ents with CACNA1C mutations or other genetic aberrations that impair calcium signaling or disrupt the

274 prevalence and persistence of large genetic aberrations that probably arose from IVF-related CIN.

275 roved for clinical use to restore epigenetic aberrations that result in silencing of tumor-suppressor

276 derstanding of the interplay between genetic aberrations, the microenvironment, and epigenetic and me

277 vation is selective against gross chromosome aberrations through causing defects in telomere cohesion

278 SC and LAM lesions have additional signaling aberrations, thus possess the potential to become resist

279 analysis can be applied to other chromosomal aberrations to further our etiological understanding of

280 ngly, although the immune system revealed no aberrations under steady-state conditions, FlgHrnr(-/-)

281 uggest a potential gene regulatory mechanism aberration underlying the increased frequency of autoimm

282 mpanied by extensive accumulation of somatic aberrations, varying cell type admixtures, and different

283 RMS high order aberration was higher in FLACS group vs. CPCS group but

284 The impact of genomic aberrations was assessed for early progression (progress

285 In patients with adverse-risk chromosomal aberrations, we found no significant influence of the NP

286 uare (RMS) postoperative ocular higher-order aberrations were 1.07 +/- 0.34, 0.67 +/- 0.25, and 0.70

287 hinnest pachymetry, and corneal higher-order aberrations were 60.89 +/- 10.9 D, 396.05 +/- 95.03 mum,

288 Furthermore, the majority of ocular aberrations were also associated with certain postoperat

289 induced astigmatism) as well as higher-order aberrations were analyzed.

290 Most aberrations were apparent in both sexes, though more pro

291 tability, cylinder vectors, and higher-order aberrations were evaluated, together with subjective QoV

292 Several chromosomal aberrations were examined as proof of concept for study

293 Patients with DDR gene aberrations were randomly assigned (1:1) by a computer-g

294 . 0.91 +/- 1.20) (p = 0.03), while low order aberrations were significantly less in FLACS group vs. C

295 The most frequent chromosomal aberrations were translocations involving MYC [t(MYC)] (

296 ssociations of NF1 and non-canonical RAS/RAF aberrations with primary resistance and validated transc

297 nstability emerges first, followed by larger aberrations, with compensatory effects leading to robust

298 e device that could dynamically tune optical aberrations within a range of about 2-5 wavelengths.

299 tomography (SD-OCT) revealed hyperreflective aberrations within photoreceptor-associated bands.

300 erexpression of MYC lacking additional focal aberrations, yet it remains unclear whether MYC overexpr