ライフサイエンスコーパス: aboral

1 ontrols the homeobox gene patterning of oral/aboral and proximal/distal domains within the first bran

2 ub-networks, including endomesodermal, oral, aboral, and apical.

3 showed that, by postgastrulation, cells from aboral areas of the preingression embryo developed lower

4 also come from lateral, aboral-lateral, and aboral areas.

5 The oral/aboral asymmetry in veg1 allocations was also demonstrat

6 fates along both the animal-vegetal and oral-aboral axes of sea urchin embryos.

7 with respect to the animal/vegetal and oral/aboral axes of the embryo.

8 pulations along the proximal-distal and oral-aboral axes.

9 irst known molecular determinant of the oral-aboral axis (the embryonic dorsoventral axis), and is cr

10 cell polarity and patterning along the oral-aboral axis are disrupted.

11 ion of ectoderm and polarization of the oral-aboral axis in Lytechinus pictus depends on cellular int

12 ed in a complementary pattern along the oral-aboral axis in mouse embryonic mandibular arch.

13 yonic regions and the patterning of the oral-aboral axis in Nematostella We also show functionally th

14 ere founder cells are specified and the oral-aboral axis is determined, and to activate the CyIIIa ge

15 is established during oogenesis and the oral-aboral axis is specified sometime after fertilization.

16 e planar polarized perpendicular to the oral-aboral axis of the animal.

17 MP signaling activity to throughout the oral-aboral axis of the distal mandibular arch and subsequent

18 o specify the oral fate and pattern the oral-aboral axis of the mandibular mesenchyme.

19 in concert to pattern tissues along the oral-aboral axis of the polyp.

20 The oral-aboral axis of the sea urchin embryo is specified condit

21 on resulted in embryoids that displayed oral-aboral axis patterning in the absence of endoderm.

22 Effective entrainment of the oral-aboral axis requires that the embryos remain immobilized

23 with reference to earlier work on both oral-aboral axis specification and P3A2 and used to develop a

24 op a testable model of the mechanism of oral-aboral axis specification in the sea urchin embryo.

25 viously established interactions on the oral/aboral axis to generate a GRN model encompassing the 2D

26 iotemporal patterning process along the oral-aboral axis, our results propose a model in which the de

27 lly along the axis perpendicular to the oral-aboral axis, the directive axis.

28 identical quadrants organized along the oral-aboral axis.

29 ng biradial symmetry organized along an oral-aboral axis.

30 formation and differentiation along the oral-aboral axis.

31 external comb rows, which run along the oral-aboral axis.

32 meres as well as interactions along the oral-aboral axis.

33 polarization of the ectoderm along the oral-aboral axis.

34 ommitment and differentiation along the oral-aboral axis.

35 (PCP) to direct morphogenesis along the oral-aboral axis.

36 opment of radialized embryos lacking an oral-aboral axis.

37 ents control axial patterning along the oral-aboral axis.

38 and foot along a single axis called the oral-aboral axis.

39 regarding the mechanisms patterning the oral-aboral axis.

40 tivity is spatially modulated along the oral-aboral axis.

41 mbryos, specification of the secondary (oral-aboral) axis occurs via nodal, expression of which is en

42 symmetrical around their longitudinal (oral-aboral) axis.

43 alterations in the specification of the oral/aboral boundary of the jaw.

44 propose that ectoderm is first specified as aboral by broadly expressed activators, including SpOtx,

45 e mesoglea and connect the outer wall to the aboral canal.

46 t role in gastrulation: during gastrulation, aboral cells become more columnar and oral cells less co

47 regulator of morphogenetic movements in the aboral compartments of the ectoderm, endoderm and mesode

48 d- to late-gastrula stage, PMCs utilize oral-aboral cues from the ectoderm for the first time.

49 ic cues that distinguish the future oral and aboral domains of the early embryo.

50 henceforth expressed exclusively, in oral or aboral domains, presaging the mesodermal cell types that

51 , a positive inductive signal to specify the aboral ectoderm and a negative suppressive signal to ina

52 tomeres and is critical for specification of aboral ectoderm and for ectoderm patterning, presumably

53 the CyIIIa gene, expressed in the embryonic aboral ectoderm and on the Endo16 gene, expressed in the

54 ry studies to be expressed in either oral or aboral ectoderm by 24 h are included, though universally

55 formation is a prerequisite for induction of aboral ectoderm by lithium and for normal ectoderm patte

56 and inhibited the formation of endoderm and aboral ectoderm cell types.

57 pressor activity at the proximal G-string in aboral ectoderm cells.

58 ne and more generally the differentiation of aboral ectoderm cells.

59 by repressing LpS1 gene transcription in non-aboral ectoderm cells.

60 ur results suggest that SpOtx is involved in aboral ectoderm differentiation by activating aboral ect

61 uitous transcription activator that promotes aboral ectoderm differentiation.

62 xists for spec genes despite their conserved aboral ectoderm expression.

63 ded together with Otx sites for specifically aboral ectoderm expression.

64 w that SpGsc is a repressor that antagonizes aboral ectoderm fate specification and promotes oral ect

65 tx redirected nonaboral ectoderm cells to an aboral ectoderm fate.

66 on factor SpOtx is required for endoderm and aboral ectoderm formation during sea urchin embryogenesi

67 not overcome the inhibition of endoderm and aboral ectoderm formation, suggesting that SpOtx functio

68 of beta-catenin's functions in endoderm and aboral ectoderm formation.

69 f beta-catenin, have defects in endoderm and aboral ectoderm formation.

70 e early embryo and in all tissues except the aboral ectoderm in later embryos.

71 fic features disappear and expression of the aboral ectoderm marker spec1 encompasses the whole of th

72 aboral ectoderm-specific gene expression and aboral ectoderm morphology, but with C-cadherin present,

73 e CyIIIa cytoskeletal actin gene outside the aboral ectoderm of the embryo.

74 nism underlying the known dependence of oral-aboral ectoderm polarity on intercellular signaling.

75 cohorts of independently activated oral and aboral ectoderm regulatory genes, and we predict yet uni

76 in the sea urchin embryo, and indirectly, of aboral ectoderm specification as well.

77 pOtx mRNA developed into epithelial balls of aboral ectoderm suggesting that SpOtx redirected nonabor

78 ry network analysis to the adjacent oral and aboral ectoderm territories over the same period.

79 ole is to establish CyIIIa expression in the aboral ectoderm territory as the blastomere founder cell

80 l ectoderm-specific genes in the prospective aboral ectoderm territory, are needed for correct spatia

81 ion which accompanies differentiation of the aboral ectoderm, and that a negative regulatory region n

82 s), which are fated to give rise to oral and aboral ectoderm, developed into polarized embryoids that

83 showed that in addition to expression in the aboral ectoderm, the proximal G-string mutation caused e

84 is transcribed exclusively in the embryonic aboral ectoderm, under the control of 2.3 kb cis-regulat

85 SpOtx plays a key role in the activation of aboral ectoderm- and endoderm-specific gene expression a

86 Strongylocentrotus purpuratus embryogenesis, aboral ectoderm-specific expression of spec2a relies on

87 Coexpressing SpOtx with C-cadherin restored aboral ectoderm-specific gene expression and aboral ecto

88 tein reduced the expression of endoderm- and aboral ectoderm-specific genes and inhibited the formati

89 boral ectoderm differentiation by activating aboral ectoderm-specific genes and that modulating its e

90 markers, although we previously showed that aboral ectoderm-specific genes can be induced by 25 mM l

91 The truncated PDGF receptor-beta caused the aboral ectoderm-specific genes LpS1 and LpC2 to be repre

92 d for correct spatial expression of oral and aboral ectoderm-specific genes.

93 Expression of the aboral ectoderm-specific LpS1 gene in Lytechinus was use

94 erm, resulted in polarized expression of the aboral ectoderm-specific LpS1 protein, but global expres

95 The aboral ectoderm-specific LpS1-alpha and -beta genes of L

96 somere-derived embryoids did not express any aboral ectoderm-specific markers, although we previously

97 controlling the expression of the sea urchin aboral ectoderm-specific spec genes.

98 is believed to direct the activation of the aboral ectoderm-specific Spec2a gene and more generally

99 icated as a transcriptional activator of the aboral ectoderm-specific Spec2a gene.

100 rogressive confinement of hyalin mRNA to the aboral ectoderm.

101 purpuratus is expressed specifically in the aboral ectoderm.

102 e constructs were expressed primarily in the aboral ectoderm.

103 ween TGFbeta-expressing endodermal cells and aboral ectoderm.

104 o cause expression of the spec2a gene in the aboral ectoderm.

105 late and for the activation of spec2a in the aboral ectoderm.

106 B, which bilaterally separates the oral from aboral ectoderm; (3) the vegetal lateral CB, which bilat

107 rovide new information on development of the aboral end in buds.

108 rical, expression of both genes in the bud's aboral end is initially asymmetrical, appearing first on

109 Axial patterning of the aboral end of the hydra body column was examined using e

110 During regeneration of the aboral end, expression of manacle precedes that of shin

111 ined to its position by the formation of the aboral epithelium anteriorly and the non-dental oral epi

112 To determine if the aboral expression of LvTbx2/3 is linked between germ lay

113 ve, and the initial polarization of oral vs. aboral fate is manifested in a redox differential, the b

114 Lewis rat small bowel xenotransplants (n=7), aboral free ends of Thierry-Vella loops constructed from

115 affect survival of lipolytic activity during aboral gastrointestinal transit.

116 The other two INCs, paired aboral INCs, also extend proximally beyond the arm's bas

117 ly developing echinoids, the secondary (oral-aboral) larval axis is established after fertilization b

118 oral area, but a few also come from lateral, aboral-lateral, and aboral areas.

119 nist drug treatments result in an absence of aboral markers, a shift in the expression boundaries of

120 nic mesoderm and is downstream of Gcm in the aboral NSM gene regulatory network.

121 analyzed the regulatory linkages within the aboral NSM gene regulatory network.

122 egulatory genes that later contribute to the aboral NSM regulatory state.

123 age, is asymmetrically inactivated in future aboral nuclei.

124 ian Nematostella vectensis, the primary oral-aboral (O-Ab) axis first develops during the early embry

125 indicated that asymmetry was about the oral/aboral (O/A) axis.

126 The oral-aboral (OA) axis in the sea urchin is specified by the T

127 he initial asymmetry that specifies the oral-aboral (OA) axis of the sea urchin embryo has long been

128 Previous studies have shown that oral-aboral (OA) polarity correlates with a mitochondrial gra

129 ry (animal-vegetal) (AV) and secondary (oral-aboral) (OA) axes of sea urchin embryos are established

130 tic variation in E along the length (oral to aboral) of each element that largely mirrors the spatial

131 , subsequently, became refined solely to the aboral ones during skeletogenesis.

132 reased cell apoptosis, especially within the aboral (or caudal) domain of the BA1, resulting in hypop

133 ulation of neural fiber tracts projecting in aboral, oral, and circumferential directions activated d

134 o the subepithelial nerve net (SNN), sensory aboral organ (AO), and epithelial sensory cells (ESCs),

135 on of the embryonic mouth, tentacles, combs, aboral organ, and putative sensory cells.

136 s, such as coloration, length, and number of aboral papillae, which are highly variable and can be af

137 regulatory genes involved in euechinoid oral-aboral patterning of nonskeletogenic mesodermal and ecto

138 At this time, some aboral PMCs migrate into the adjacent oral quadrant to a

139 Surprisingly, no blastema developed at the aboral pole after stolon removal.

140 equently, micromeres are formed first at the aboral pole and later at the oral pole.

141 l processes, was initially recognized at the aboral pole during the third day of development.

142 ession boundaries of oral markers toward the aboral pole, and changes in the position of differential

143 NvecGrl1 transcripts are detected around the aboral pole, considered the equivalent to the head-formi

144 rthologues of genes patterning the anthozoan aboral pole, secondary axis and endomesoderm support sim

145 neages, respectively) followed a strict oral/aboral profile.

146 late-gastrula stages, when some PMCs from an aboral quadrant migrate to the adjacent oral quadrant.

147 ion of the oral ectoderm begins with an oral-aboral redox gradient, which is interpreted by the cis-r

148 and chromatin accessibility during oral and aboral regeneration in the cnidarian Hydra vulgaris.

149 ssion of Gsc and other genes in the proximal aboral region of the developing mandible.

150 distinct networks of neurons in the oral and aboral regions of the animal.

151 and part of a feedback loop locking down the aboral regulatory state.

152 e central integrative structure known as the aboral sensory organ.

153 e side facing the inside tends to become the aboral side.

154 her rate of respiration than the prospective aboral side.

155 IP3 concentration in the ICCs can guide the aboral slow-wave propagation essential for peristalsis,

156 Nodal and its target Gsc each rescue oral-aboral specification and patterning when expressed asymm

157 essed in the oral territory, is required for aboral specification.

158 majority of glia responded to both oral and aboral stimulation and circumferential pathways, while s

159 distribution of LvTbx2/3 was observed in the aboral territories of all three germ layers.

160 indicates that expression of LvTbx2/3 in the aboral territories of each germ layer is a common aspect

161 fied signaling interactions between oral and aboral territories.

162 These defects were not observed aboral to the obstruction.

163 cells differentiate while migrating from the aboral to the oral end of the animal, but it is unclear

164 tivity of the ileal muscles, 0-5 cm oral and aboral to the site of resection, were examined at 5 and

165 cells of Cajal (ICC) decreased oral, but not aboral, to the site of obstruction.

166 We found different patterns of aboral-to-oral Cnox-2 expression among polyp polymorphs,

167 archenteron up to the foregut region, while aboral veg1 clones contributed only small numbers of hin

168 ntly contributed more cells to endoderm than aboral veg1 clones.

169 l-vegetal and at 45 degree angle to the oral-aboral (ventral-dorsal) axis.

170 ion of nodal and entrains OA polarity toward aboral when confined to half of the embryo via 2-cell st