ライフサイエンスコーパス: abscission

1 ects the speed of both furrow ingression and abscission.

2 itotic time because of delayed and/or failed abscission.

3 mechanism explaining drought-triggered leaf abscission.

4 anistic role of water and turgor pressure in abscission.

5 equency of cytokinetic failure and a delayed abscission.

6 s maturation of the intercellular bridge and abscission.

7 eration of the ultimate step of cytokinesis, abscission.

8 5 are all necessary for drought-induced leaf abscission.

9 nserved in regulating drought-triggered leaf abscission.

10 ll events necessary for membrane budding and abscission.

11 on between daughter cells during cytokinetic abscission.

12 te a MAP kinase cascade that is required for abscission.

13 signaling pathway that controls floral organ abscission.

14 and IST1, an ESCRT-III subunit required for abscission.

15 how reduced ethylene sensitivity and delayed abscission.

16 encystment of the germline in promoting GSC abscission.

17 tmitotic genome surveillance and cytokinetic abscission.

18 g, nuclear envelope closure, and cytokinetic abscission.

19 growth by way of salt ion dilution and organ abscission.

20 naling system known to regulate floral organ abscission.

21 ing relative to Tsg101 and CHMP4B upon virus abscission.

22 ole for ESCRT-II and CHMP6 in ESCRT-mediated abscission.

23 al development, senescence, and floral organ abscission.

24 anonical ESCRT players ESCRT-II and CHMP6 in abscission.

25 rog2, determine cilium disassembly and final abscission.

26 cting the two daughters immediately prior to abscission.

27 mation, which appeared to be responsible for abscission.

28 to the acquisition of DT, longevity, and pod abscission.

29 mbrane and the midbody microtubules prior to abscission.

30 y distinct RhoGEF required for completion of abscission.

31 plants withdraw nutrients from leaves before abscission.

32 CEP55-Alix and CEP55-Tsg101 complexes during abscission.

33 ude fruit formation, expansion, ripening and abscission.

34 -3-3 but not ARF6 frequently collapse before abscission.

35 cell separation step of cell division called abscission.

36 rchestrates the biochemical preparations for abscission.

37 ehind the forming package, and apparent self-abscission.

38 ational model for ESCRT-mediated cytokinetic abscission.

39 cessing and remodeling of ESCRT filaments in abscission.

40 egulator required for the completion of cell abscission.

41 brane-modeling events necessary for particle abscission.

42 s ESCRT-III to the midbody (MB), the site of abscission.

43 ecifically the final stage of mitosis termed abscission.

44 beyond its primary function of orchestrating abscission.

45 1 or RhERF4 was observed to accelerate petal abscission.

46 ontrol of the ESCRT machinery of cytokinetic abscission.

47 d for transport III filaments at the site of abscission.

48 reduced expression of RhBGLA1 delayed petal abscission.

49 of NSC midbodies, which mediate cytokinetic abscission.

50 bridges indicating abnormal cytokinesis and abscission.

51 and isolation of the two daughter cells via abscission.

52 ors require Cep55 and ESCRT for survival and abscission.

53 RhERF1 and RhERF4 which play a role in petal abscission.

54 into the cone-shaped helices and spirals of abscission.

55 ms, while ethephone application led to berry abscission.

56 ve months elapse from fertilization to fruit abscission.

57 of potential models for ESCRT-mediated virus abscission.

58 actin coordination are necessary for proper abscission.

59 of membrane tension as a mechanism to drive abscission.

60 ls that narrow down to the incipient site of abscission [6-8].

61 pluripotency exit, and artificially inducing abscission accelerates it.

62 Apical abscission also dismantles the primary cilium, known to

63 Checkpoint failure leads to incomplete abscission and a binucleate outcome.

64 ntegrity pathway (CIP), leading to premature abscission and a multi-septated phenotype.

65 ms during cytokinesis, is a key regulator of abscission and appears to function as a signaling platfo

66 orphisms in this region associated with leaf abscission and cellulose content are suggested to repres

67 is Aurora B kinase activity, which inhibits abscission and forms the major activity of the abscissio

68 hese results delineate distinct steps during abscission and highlight the central role of the midbody

69 ation of internal biological (leaf-flush and abscission and increased Pc) and environmental (incoming

70 Knockdown of WDR5 impairs abscission and increases the incidence of multinucleated

71 ted ovary patterning as well as floral organ abscission and lateral organ lamina outgrowth.

72 Floral organ abscission and lateral root emergence are both accompani

73 conserved abscission/NoCut checkpoint delays abscission and prevents formation of binucleated cells b

74 d addiction; and novel proteins for membrane abscission and protein turnover.IMPORTANCE We extended t

75 required for ALIX to function in cytokinetic abscission and retroviral budding, but not in multivesic

76 must be disassembled to allow for the final abscission and separation of the daughter cells.

77 ively regulates SERK-SOBIR1 signaling during abscission and that the identified SERK1 mutations likel

78 was long thought that immediately following abscission and the conclusion of cell division, the midb

79 y of riparian vegetation, the timing of leaf abscission and the establishment of invasive riparian sp

80 on, as well as leaf and petal senescence and abscission and, hence, plays a role in virtually every p

81 the midbody in SCCRO-deficient cells during abscission, and its inactivation resulted in phenotypic

82 ssing plants displayed abnormal floral organ abscission, and produced leaves, sepals and petals with

83 Depletion of CDK11 inhibits abscission, and rescue of this phenotype requires CDK11(

84 ong gain-of-function brassinosteroid, floral abscission, and stomatal patterning phenotypes, respecti

85 arrives at the intercellular bridge, blocks abscission, and subsequently leads to cell death.

86 enabled us to uncover new genes involved in abscission, and their possible contribution to the proce

87 esses including multivesicular body sorting, abscission, and viral budding.

88 ne and that affect pectin degradation during abscission are not well understood.

89 Our study identifies abscission as a key cellular process coupling cell divis

90 y known to control plant immunoresponses and abscission, as a regulator of secondary growth.

91 ptor KLHL21 mediates the effects of SCCRO on abscission, as it fails to localize to the midbody in SC

92 ail the role of the midbody in orchestrating abscission, as well as discuss the relatively new field

93 ne can promote flowering, fruit ripening and abscission, as well as leaf and petal senescence and abs

94 multinucleation, multipolar mitoses, failed abscission, asymmetric segregation of daughter nuclei, f

95 otein is regarded as the master regulator of abscission, because it recruits ESCRT-III to the midbody

96 re redundant in function during floral organ abscission, but during lateral root emergence they are d

97 s postmitotic process and delays cytokinetic abscission by keeping the abscission checkpoint active.

98 The midbody mediates abscission by recruiting many factors, including the Kin

99 ion that the ESCRT machinery initiates virus abscission by scaffolding early-acting ESCRT-I within th

100 ponent and Aurora B substrate CHMP4C enables abscission, bypassing the PKCvarepsilon-Aurora B exit pa

101 delays cytokinetic abscission by keeping the abscission checkpoint active.

102 epsilon signals through Aurora B to exit the abscission checkpoint and complete cell division.

103 an essential signal required to sustain the abscission checkpoint and that ULK3 and CHMP4C are funct

104 on directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at S22

105 The 'NoCut', or Aurora B abscission checkpoint can be activated if DNA is retaine

106 s in the proposed mechanistic pathway of the abscission checkpoint concern factors involved in (1) re

107 The Aurora B abscission checkpoint delays cytokinesis until resolutio

108 This switch is essential for abscission checkpoint exit.

109 The abscission checkpoint in mammalian cells stabilizes the

110 the spindle midzone, which is needed for the abscission checkpoint in other systems.

111 omosome bridges, a phenotype associated with abscission checkpoint signaling failure.

112 he cytokinetic bridge and implicates ALIX in abscission checkpoint signaling.

113 its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chrom

114 reduction by MsrB2 is a key component of the abscission checkpoint that favors F-actin polymerization

115 New work identifies components of the abscission checkpoint that prevent premature severing of

116 CHMP4C functioned in the Aurora B-dependent abscission checkpoint to prevent both premature resoluti

117 This process is regulated by the abscission checkpoint, a genome protection mechanism tha

118 nesis timing and plays a central role in the abscission checkpoint.

119 by coordinating midbody resolution with the abscission checkpoint.

120 scission and forms the major activity of the abscission checkpoint.

121 response to chromosome bridges via the NoCut abscission checkpoint.

122 Abscission completes cytokinesis to form the two daughte

123 Although abscission could be organized from the inside out by the

124 s that require high wind velocities for seed abscission could experience threshold-like reductions in

125 p27(CK-) expression caused a cytokinesis and abscission defect in mouse embryonic fibroblasts.

126 ity can rescue or exacerbate the age-induced abscission defect, respectively.

127 Further investigation revealed that the abscission delay is primarily due to slower formation of

128 point components Aurora B and ANCHR, and the abscission delay upon checkpoint activation by nuclear p

129 Correction of abscission delays in SCCRO-deficient cells with addition

130 Before the final step of cytokinesis, termed abscission, dividing cells need to ensure that the cleav

131 Interestingly, the disruption of abscission does not appear to result in binucleate cells

132 In mammalian cells, efficient abscission during cytokinesis requires proper function o

133 for multivesicular body biogenesis, membrane abscission during cytokinesis, and retroviral budding.

134 esses including multivesicular body sorting, abscission during cytokinesis, budding of enveloped viru

135 In addition to its role in membrane abscission during cytokinesis, viral budding, endosomal

136 siRNA strategies reduced cell retraction and abscission during late-stage cytokinesis, causing multin

137 unction disassembly and acto-myosin-mediated abscission, during which the centrosome is retained whil

138 erval between cleavage furrow ingression and abscission, during which the midbody microtubule bundle

139 sure model (IP-CELC) was used to investigate abscission effects on seed dispersal kernels and plant p

140 h as benzyladenine and metamitron, acting as abscission enhancers.

141 its the midbody ring (MR) upon completion of abscission even in apparently symmetrically dividing cel

142 defect in late cytokinesis, just before the abscission event.

143 live imaging and genetic analyses show that abscission failure is due to inappropriate retention of

144 r bridge but almost completely abolishes the abscission failure phenotype.

145 Abscission failure significantly disrupts both self-rene

146 ing the phosphorylation of Borealin leads to abscission failure, as does expression of a non-phosphor

147 exhibited midbody formation consistent with abscission failure.

148 nt to precociously age young GSCs and induce abscission failure.

149 Moreover, studies of abscission frequently involve the examination of events

150 ess-related developmental processes, such as abscission, fruit ripening, and senescence.

151 owever, how ESCRT-III is activated to set on abscission has not been resolved.

152 bscission mutants inflorescence deficient in abscission (ida) and blade-on-petiole1 (bop1)/bop2 and a

153 f HAESA (HAE) and INFLORESCENCE DEFICIENT IN ABSCISSION (IDA) is induced in cauline leaf abscission z

154 ed by the peptide INFLORESCENCE DEFICIENT IN ABSCISSION (IDA), which signals through the leucine-rich

155 hich involves the INFLORESCENCE DEFICIENT IN ABSCISSION (IDA)-derived peptide and its receptors, HAES

156 Finally, interfering with abscission impairs naive pluripotency exit, and artifici

157 septin 9 (SEPT9) depletion, which abrogates abscission, impairs recruitment of VPS25 (ESCRT-II) and

158 acetic acid (IAA) in regulating floral organ abscission in Arabidopsis (Arabidopsis thaliana).

159 Flower organ abscission in Arabidopsis is regulated by a peptide horm

160 Furthermore, the ability to study leaf abscission in Arabidopsis opens up a new avenue to tease

161 e the steps required for the first embryonic abscission in Caenorhabditis elegans Our findings indica

162 e evolution and ovary senescence and pedicel abscission in fruits that were not pollinated under cont

163 in early dry season, and is followed by net abscission in late dry season that coincides with increa

164 investigate whether polarized furrowing and abscission in mouse NSCs are regulated differently at ea

165 linked components of the timer that controls abscission in multiple physiological situations.

166 to live image furrow ingression and midbody abscission in NSCs within cortical explants.

167 port a key role for IAA in the regulation of abscission in planta and reveal, to our knowledge for th

168 required for proper midbody organization and abscission in polarized cortical stem cells and has a cr

169 B and the ESCRT-III subunit CHMP4C to delay abscission in response to chromosome missegregation.

170 via tandem MIT domains, and thereby, delays abscission in response to lagging chromosomes, nuclear p

171 important information on regulation of petal abscission in roses.

172 w study describes how drought-induced flower abscission in tomato is regulated similarly, but distinc

173 reveals greatly delayed fission kinetics in abscission in which a population of cells with persisten

174 int that delays progression from anaphase to abscission in yeast was activated by both UFBs and chrom

175 The results confirm that nonrandom seed abscission increased dispersal distances, particularly f

176 o physical feedbacks: (i) although nonrandom abscission increased the initial acceleration of seeds f

177 nd speed increased; and (ii) while nonrandom abscission increased the mean dispersal length, it reduc

178 of ethylene during the very early stages of abscission induction was investigated in fruitlet popula

179 tification of isoprene as an early marker of abscission induction.

180 contrast, Boi2 is specifically required for abscission inhibition in cells with chromatin bridges.

181 abscission, is necessary and sufficient for abscission inhibition.

182 at sites of polarized growth, and acts as an abscission inhibitor during cytokinesis in response to c

183 The effects of SCCRO on abscission involve its role in neddylation and localizat

184 Abscission is a process in which plants shed their parts

185 Drought-triggered abscission is a strategy used by plants to avoid the ful

186 Surprisingly, abscission is accelerated in the Kif20b mutant NSCs.

187 egulating developmentally timed floral organ abscission is conserved in regulating drought-triggered

188 Floral abscission is controlled by the leucine-rich repeat rece

189 of ESCRT function in C. elegans, cytokinetic abscission is delayed but can be completed, suggesting t

190 We propose that cytokinetic abscission is driven by an ESCRT-III fission complex, wh

191 e specific molecular changes associated with abscission is hampered by contamination from neighboring

192 The timing of plant organ abscission is modulated by the balance of two hormones,

193 f any, during cleavage-furrow ingression and abscission is poorly understood.

194 Abscission is the final step of cytokinesis and results

195 Abscission is the process by which plants shed unwanted

196 Abscission is the terminal step of cytokinesis leading t

197 Abscission is the terminal step of mitosis that physical

198 SCRT machinery necessary for mediating viral abscission is unclear.

199 Abscission is usually observed on both sides of the midb

200 ivision, when the cells physically separate (abscission), is tightly regulated to ensure that it occu

201 r bud growth and targets Boi2 to the site of abscission, is necessary and sufficient for abscission i

202 in CSA or CSB result in perturbation of the abscission leading to the formation of long intercellula

203 idzone/cleavage furrow and prevents cellular abscission, leading to the generation of cells with poly

204 d cleavage furrow and guides the assembly of abscission machinery.

205 sumed that midbody microtubules scaffold the abscission machinery.

206 h an extremely relevant phenomenon, fruitlet abscission, may occur as a response to both endogenous a

207 Here, we show that extracellular post-abscission MBs can be internalized by interphase cells,

208 Despite the emerging roles of post-abscission MBs, how MBs accumulate in the cytoplasm and

209 surface wind environment, independent of the abscission mechanism.

210 This work elucidates both NSC apoptosis and abscission mechanisms that could underlie human microcep

211 ed further by crossing reporter lines to the abscission mutants inflorescence deficient in abscission

212 dividing cells, an evolutionarily conserved abscission/NoCut checkpoint delays abscission and preven

213 We show that abscission occurs in two stages.

214 In Arabidopsis (Arabidopsis thaliana), the abscission of floral organs is regulated by two related

215 mber of the genetic components that regulate abscission of floral organs, including a pair of related

216 ion of multinucleated cells caused by failed abscission of the cleavage furrow after telophase.

217 Motility is required for the final cell abscission of the procyclic form in the insect vector, b

218 s suggest that SEPT9 plays multiple roles in abscission, one of which is regulated by the action of C

219 or SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of

220 he absence of chromatin and that it promotes abscission, perhaps by facilitating midbody microtubule

221 membrane fusion event that occurs during the abscission phase of cytokinesis.

222 e midbody and that MITD1 participates in the abscission phase of cytokinesis.

223 eased expression of HAE as well as a delayed abscission phenotype.

224 els supporting the fruitlets with the lowest abscission potential (central fruitlet), indicating that

225 gated in fruitlet populations with different abscission potentials due either to the natural correlat

226 In this study, different abscission potentials were obtained within the apple fru

227 ate in the leaf abscission zones through the abscission process.

228 plex drives membrane fission, completing the abscission process.

229 ncrease in HAE) observed in flowers when the abscission program is initiated.

230 tructures at the intercellular bridge during abscission progression.

231 bridges long after division, and that bridge abscission progressively accelerates as cells exit naive

232 The midbody directs the final membrane abscission reaction and has been proposed to attach the

233 in the division machinery leading to faster abscission regulates pluripotency exit.

234 Our work defines Cep55 as an abscission regulator only in specific tissue contexts an

235 Transcriptomic evidence indicated that abscission-related ABA is biologically active, and its i

236 Seven novel abscission-related genes were identified, four of which

237 d to probe a microarray, and a population of abscission-related transcripts was studied in detail.

238 Apple (Malus domestica) fruitlet abscission represents an interesting model system to stu

239 Control of abscission requires Eph kinase activity, and Src and cit

240 Abscission requires membrane traffic and microtubule dis

241 Abscission requires the endocytic sorting complex requir

242 nner to bring about secondary ingression and abscission, respectively.

243 We conclude that during petal abscission, RhERF1 and RhERF4 integrate and coordinate e

244 ar development, programmed cell death, organ abscission, senescence, and plant responses to their bio

245 Abscission shares several features with cell polarizatio

246 is gaseous hormone and the generation of the abscission signal within the fruit.

247 aturation to date and may help elucidate how abscission sites are positioned and regulated.

248 mutants, hws loses its delayed floral organ abscission ("skirt") phenotype, suggesting epistasis.

249 abidopsis thaliana) where the promoter of an abscission-specific polygalacturonase gene (At2g41850/AR

250 ous membrane fission events required for the abscission stage of cytokinesis and for a series of "rev

251 s during multivesicular body biogenesis, the abscission stage of cytokinesis, and enveloped virus bud

252 rovesicles, enveloped virus budding, and the abscission stage of cytokinesis.

253 membrane of infected cells; and the membrane abscission step in cytokinesis.

254 avenue to tease apart mechanisms involved in abscission that have been difficult to separate from flo

255 late changes occurring between anaphase and abscission that potentially involve differential cortica

256 ed proplatelets in vitro to undergo repeated abscissions that yield circulating platelets.

257 ated as the driving force for mammalian cell abscission, that is, fission of the intercellular membra

258 During cytokinetic abscission, the endosomal sorting complex required for t

259 (ESCRT) proteins have a critical function in abscission, the final separation of the daughter cells d

260 Cytokinetic abscission, the final stage of cell division where the t

261 Abscission, the final stage of cell division, requires w

262 a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the

263 evolutionarily conserved role in cytokinetic abscission, the final step of cell division where daught

264 required for transport (ESCRT)-III mediates abscission, the process that physically separates daught

265 er, these results suggest that regulation of abscission timing and midbody remnants in embryonic NSCs

266 lls links postmitotic genome surveillance to abscission timing and that Chk1 integrates this and othe

267 A key regulator of abscission timing is Aurora B kinase activity, which inh

268 ), a human ESCRT-III subunit, is involved in abscission timing.

269 activity opposes Aurora B activity to enable abscission to proceed and result in successful completio

270 ent in the abscission checkpoint that delays abscission until chromatin is cleared from the intercell

271 This checkpoint prevents abscission until chromosomes have been cleared from the

272 ch suggested a model whereby CHMP4C inhibits abscission upon phosphorylation by Aurora B.

273 leavage through laser ablation or inhibiting abscission using optogenetic clustering of Rab11 result

274 Abscission was associated with large scale up-regulation

275 Nonrandom abscission was investigated using models of three seed r

276 ivision, particularly during cytokinesis and abscission, when 2 daughter cells partition through coor

277 SCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a componen

278 midbody formation consistent with successful abscission, whereas those from 3 day-old cardiomyocytes

279 final step of cytokinesis in animal cells is abscission, which is a process leading to the physical s

280 cipal function being to localize the site of abscission, which physically separates two daughter cell

281 e ethylene-sensitive and undergo rapid petal abscission while hybrid roses show reduced ethylene sens

282 tive imaging of ESCRT-III during cytokinetic abscission with biophysical properties of ESCRT-III comp

283 follow apical mitoses of NSCs; coordinating abscission with delamination from the apical membrane; t

284 ctivity specifically within the floral organ abscission zone (AZ).

285 s mediated by a particular set of cells, the abscission zone (AZ).

286 on the loss of middle lamella pectin in the abscission zone (AZ).

287 nfirmed the expression of these genes in the abscission zone and revealed other places of expression

288 a variety of cell types, such as trichomes, abscission zone cells, peripheral root cap cells, and xy

289 ata permitted a detailed characterization of abscission zone development and the identification of ke

290 , auxin, and cell wall-remodeling enzymes in abscission zone formation.

291 llow deposition of lignin that initiates the abscission zone in the seed-pedicel junction.

292 transcriptionally up-regulated in the floral abscission zone just before cell separation.

293 It is unknown how expression of IDA in the abscission zone leads to HAESA activation.

294 The other mutation eliminated the flower abscission zone, providing "jointless" fruit stems that

295 leading to the downstream activation of the abscission zone.

296 rences, a comparative transcriptome of petal abscission zones (AZ) of 0 h and 8 h ethylene-treated fl

297 They are found in heartwood, sapwood, and in abscission zones and can be induced by various stresses,

298 and HAE continues to accumulate in the leaf abscission zones through the abscission process.

299 ABSCISSION (IDA) is induced in cauline leaf abscission zones when the leaves become wilted in respon

300 xtension or remodeling, such as young stems, abscission zones, or developing vasculature, showing goo