ライフサイエンスコーパス: absolute configuration

1 rrelation allows for the assignment of their absolute configuration.

2 s also established the previously unassigned absolute configuration.

3 total synthesis, which also established its absolute configuration.

4 tion which enables an accurate assignment of absolute configuration.

5 alkyltin nucleophile, and with retention of absolute configuration.

6 al center featuring either a Lambda or Delta absolute configuration.

7 lic ring systems having defined relative and absolute configuration.

8 the natural products and establishing their absolute configuration.

9 metal center adopts either a Lambda or Delta absolute configuration.

10 lpha/beta-peptides the beta(3)-residue has S absolute configuration.

11 e of 5 solidified its (3R,6S,7R,10S,11R,14R) absolute configuration.

12 nal stereofidelity and with net retention of absolute configuration.

13 sing the sulfinyl group with the appropriate absolute configuration.

14 ntum-chemical ECD calculations to assign the absolute configuration.

15 d is a quick and reliable means to determine absolute configuration.

16 ichroism (ECD) spectra for the corresponding absolute configuration.

17 c separation and aid in the determination of absolute configuration.

18 e use of ECD spectral correlations to assign absolute configurations.

19 viding their chiral pyrrolines with opposite absolute configurations.

20 es that embed stereogenic axes of controlled absolute configurations.

21 nd (iii) two rhamnose residues with opposite absolute configurations.

22 h TDDFT ECD calculations for determining the absolute configurations.

23 yclic cores in enantiopure form with correct absolute configurations.

24 to the CHDA-Gly unit with either of the two absolute configurations.

25 o using the transition rates between various absolute configurations.

26 Its absolute configuration (3R,5S,6S,7R,11S,14R) is enantiom

27 y functional theory (TDDFT) to determine the absolute configuration (AC) of cryptophane derivatives.

28 powerful techniques for the determination of absolute configurations (AC), as it does not require any

29 s not possible to unambiguously assign their absolute configurations, although given the absolute (2S

30 In an attempt to rationalize this switch in absolute configuration an investigation of the ambiguous

31 re or si face to solvent, respectively; (2) absolute configuration analysis using vibrational circul

32 trisubstituted olefins with control of both absolute configuration and alkene geometry.

33 A correlation between the absolute configuration and chiroptical properties of non

34 The absolute configuration and conformations of (-)-tert-but

35 o acids with stereodivergent control of both absolute configuration and double bond geometry.

36 can be used for in situ ICD analysis of the absolute configuration and ee of a wide range of amines.

37 t can be used for in situ CD analysis of the absolute configuration and ee of cyclic and acyclic subs

38 stereodynamic probe for determination of the absolute configuration and enantiomeric composition of c

39 ften provides accurate information about the absolute configuration and enantiomeric composition of t

40 conventional methods for the analysis of the absolute configuration and enantiopurity.

41 od allows for simultaneously determining the absolute configuration and quantity of stereoisomers of

42 ate salts is described, and determination of absolute configuration and racemization barrier is also

43 rates, were used to assess the impact of the absolute configuration and the stereospecific hydrogen b

44 ed the first unambiguous confirmation of its absolute configuration and therefore that of natural (-)

45 lysis, leading to reassignment/assignment of absolute configurations and characterization of a remark

46 troscopy have been utilized to determine the absolute configurations and geometries of two Frater-See

47 quinone antibiotic, the determination of its absolute configuration, and the biological evaluation of

48 e]-1,1'-diol (VANOL) are used to confirm its absolute configuration as (+)(589)-(aR) or (-)(589)-(aS)

49 erimental data led to the elucidation of the absolute configuration as (-)-(R)-tert-butylphenylphosph

50 Its structure including absolute configuration as 8R,9R,10S,13S was established

51 e stereocenters, SynOxC, results in the same absolute configuration as for SynOxA.

52 the cis-cyclopropane diastereomer of 1 R,2 S absolute configuration, as experimentally observed.

53 chiral chemistry, including determination of absolute configuration, as well as in influencing the un

54 b and 12a/12b were separated by HPLC and the absolute configuration assigned by VCD technique in comb

55 However, there exist conflicting absolute configuration assignments arising from electron

56 cts leading to the first total syntheses and absolute configuration assignments of the aglain natural

57 previously reported asymmetric syntheses and absolute configuration assignments of the aglains (+)-po

58 ese new insights provide a fresh look at the absolute configuration assignments of the dSp diastereom

59 cin aglycone, proceeds with the inversion of absolute configuration at C(5) stereogenic center.

60 DP4+/DIP calculations demonstrated that the absolute configuration at C-9 had been incorrectly assig

61 ition of a novel "0.2 ppm rule" allowing the absolute configuration at tetralin C-2 to be determined.

62 te the best antiviral activity with the ( R) absolute configuration at the alpha-methoxy stereogenic

63 Thus, eight more analogues with different absolute configuration at the chiral center of the aroma

64 The absolute configuration at the new chiral centers was ass

65 the relationship between chemical shift and absolute configuration at the phosphorus center of H-pho

66 obtained by asymmetric synthesis, and their absolute configurations at both phosphorus and C-5 carbo

67 The absolute configurations at C24 and its influence on the

68 ts convincingly prove that the assignment of absolute configuration based on vibrational chiroptical

69 he case of an optically pure enantiomer, its absolute configuration can be determined.

70 xample of using VCD carbonyl multiplets, the absolute configuration could be reliably predicted, stre

71 e material, the MChD spectra exhibit intense absolute configuration dependent MChD signals reaching r

72 d method for the complete identification and absolute configuration determination of all 12 pentose i

73 NP-inspired fragment absolute configuration determines the conformation of th

74 VCD is the more reliable technique to assign absolute configuration due to the larger functional and

75 can be used for in situ determination of the absolute configuration, ee, and total concentration of m

76 P)- or (M)-, of this helical folding and the absolute configuration, either (R)- or (S)-, of the chir

77 assay for simultaneous determination of the absolute configuration, enantiomeric composition and con

78 r instantaneous in situ determination of the absolute configuration, enantiomeric composition and tot

79 lutions and allows fast determination of the absolute configuration, enantiomeric composition, and ov

80 hat allow instantaneous determination of the absolute configuration, enantiomeric excess and concentr

81 The comprehensive determination of the absolute configuration, enantiomeric ratio, and total am

82 re isolated by enantioselective HPLC and the absolute configuration established by DFT simulation of

83 ESI, or CDESI and QTOF-MS/MS experiments and absolute configurations established by quantum mechanica

84 idues and in which all residues are of the d-absolute configuration, except for fucose and rhamnose w

85 , however, most of them were unknown for the absolute configurations, except that of ustilaginoidin D

86 A compound with a shorter tether and (3R,4S) absolute configuration exhibited high activity with a K(

87 n natural products was used to determine the absolute configuration for both thiaplakortones C and D

88 ly crystallized racemic jasmonic acid, whose absolute configuration had only been inferred from deriv

89 e of heterocyclic scaffold but with opposite absolute configuration has also been accomplished by mak

90 The absolute configuration has been assigned by comparison o

91 e araiosamines has been developed, and their absolute configuration has been assigned.

92 streptophenazine G has been revised, and its absolute configuration has been determined to be 1'S,2'R

93 lactomycin (1), as well as assignment of the absolute configuration, has been achieved exploiting a c

94 to the enantiopure molecular cages of which absolute configurations have been assigned by ECD spectr

95 containing amino acid residues with opposite absolute configurations have long been a source of inter

96 key construction was the installation of (S) absolute configuration in m-hydroxyphenylalanine using a

97 In addition, the absolute configuration inferred from CD spectra of the t

98 ly attributable to either conformation or to absolute configuration is identified.

99 which is a semiconserved element because its absolute configuration is virus-dependent.

100 olecule-including assigning its relative and absolute configurations-is paramount, enabling one to un

101 that the natural levo-isomer possesses the R absolute configuration, not S.

102 The absolute configuration of (+)-2 was also determined to (

103 The absolute configuration of (+)-2 was determined to be (R,

104 The absolute configuration of (-)-2 was determined by compar

105 The absolute configuration of (-)-illisimonin A was revised

106 Inversion of the absolute configuration of (S)-2,3,4,9-tetrahydro-1H-carb

107 The absolute configuration of 1 was established by single-cr

108 on C(1) allows for easy determination of the absolute configuration of 1,6,7-trisubstituted 2,3-dihyd

109 A (1), B (2), and D (4) was executed and the absolute configuration of 2 and 4 was determined.

110 The absolute configuration of 2 was assigned by (1)H NMR ana

111 The (-)-(1R,5R)/(+)-(1S,5S) absolute configuration of 4b inferred from the TDDFT cal

112 The absolute configuration of 6 was confirmed via spectrosco

113 The absolute configuration of 9-epixylogranatin A (1) was de

114 pies are evaluated for the assignment of the absolute configuration of a highly flexible natural comp

115 The absolute configuration of a key intermediate and that of

116 rst ever case study of the assignment of the absolute configuration of a molecule based on the isoneo

117 Additionally, we report the first proof of absolute configuration of a natural ladderane.

118 Determination of the absolute configuration of all obtained sugars was feasib

119 rivatization agent for the assignment of the absolute configuration of beta-chiral primary alcohols.

120 olution for an unambiguous assignment of the absolute configuration of bound molecules.

121 products with full retention of stereo- and absolute configuration of chiral centers.

122 are increasingly employed for assigning the absolute configuration of chiral molecules through compa

123 rometers, allow for the determination of the absolute configuration of chiral secondary alcohols by d

124 the isoneoamphilectane carbon skeleton, the absolute configuration of compound 5 was established as

125 The absolute configuration of compounds obtained is opposite

126 This synthesis confirms the absolute configuration of crocagin A and provides access

127 is was explored to tentatively elucidate the absolute configuration of cryptomoscatone E3, a polyketi

128 rrect structure and the determination of the absolute configuration of cystobactamid 919-2.

129 Further determination of the absolute configuration of each product helped rebuild th

130 The absolute configuration of embellicine A (1) was determin

131 was developed to qualitatively determine the absolute configuration of enantioenriched secondary alco

132 sidual dipolar couplings or to determine the absolute configuration of enantiotopic NMR signals is di

133 or rules cannot be safely used to assign the absolute configuration of even these simple derivatives.

134 d structure necessitated the revision of the absolute configuration of greensporone F and dechlorogre

135 The absolute configuration of haliclamide thus is 2S, 9S, 14

136 total synthesis enabled us to establish the absolute configuration of malacidin A, which is in agree

137 d the ability of this methodology to set the absolute configuration of multiple stereocenters in a si

138 The absolute configuration of namalide was established, and

139 The absolute configuration of natural (+)-cladoacetal A was

140 m sector and helicity rules to determine the absolute configuration of optically active alpha,beta-un

141 pectra data analysis were used to define the absolute configuration of phaeophytins 12 (13(2)R, 17R,

142 The planar structure and (3R,6S,7R) absolute configuration of pustulosaisonitrile-1 were ded

143 The absolute configuration of rearrangement products was ini

144 determination of enantiomeric purity and/or absolute configuration of remotely chiral primary alcoho

145 ient utilization in the determination of the absolute configuration of secondary alcohols.

146 The absolute configuration of sphenostylisin C (3) was estab

147 The absolute configuration of stable atropisomers (compound

148 The relative and absolute configuration of stagonolide D was established

149 sulfur atoms enables reliable assignment of absolute configuration of stereogenic centers.

150 The absolute configuration of stereogenic sulfoxide acceptor

151 ted by chiral column chromatography, and the absolute configuration of the 2-position was assigned by

152 that of analogues in order to determine the absolute configuration of the active natural flavonoidal

153 of the desymmetrization process, whereas the absolute configuration of the alpha-amino stereocenter g

154 ective total synthesis and assignment of the absolute configuration of the architecturally challengin

155 The absolute configuration of the asymmetric C(alpha)-atom o

156 s enantiospecific, hence correlated with the absolute configuration of the bile steroid rather than i

157 Here, we report the full structure and absolute configuration of the borolithochromes, enigmati

158 It establishes the correct absolute configuration of the C-6 hydroxyl function in e

159 nd amides showed strong consistency with the absolute configuration of the carbinol and amine moietie

160 The absolute configuration of the carbon stereogenic center

161 The absolute configuration of the cardamom peroxide is repor

162 ty, its central double bond geometry and the absolute configuration of the chiral centers were not de

163 The absolute configuration of the chlorocyclopropane ring in

164 allows the unambiguous determination of the absolute configuration of the conformationally flexible

165 The absolute configuration of the corresponding cyclocarbony

166 ectra to computationally simulated ones, the absolute configuration of the enantiomeric pair (6R, 12a

167 e biocatalytic transamination and assign the absolute configuration of the enantiomeric products.

168 The absolute configuration of the enantiomers of these fire

169 ve coupling is demonstrated to depend on the absolute configuration of the Evans chiral auxiliary emp

170 ies also support the experimentally obtained absolute configuration of the final adducts.

171 The absolute configuration of the imino-aldol adducts has be

172 reporter systems might be correlated with an absolute configuration of the inductor, whereas the line

173 ace is reported and analyzed in terms of the absolute configuration of the lipid tail carbinols at pH

174 The absolute configuration of the major (-)-(R) enantiomer o

175 and tetrahydrofuran and also to predict the absolute configuration of the major stereoisomers derive

176 The resultant absolute configuration of the mandelalide A macrolide wa

177 resolved on a semipreparative scale, and the absolute configuration of the more slowly eluting enanti

178 hesis of garcibracteatone, which allowed the absolute configuration of the natural compound to be det

179 Structural revision and absolute configuration of the natural compounds were car

180 This allowed to determine the absolute configuration of the natural product and to pla

181 ed to enable access to both enantiomers, the absolute configuration of the natural product could be a

182 The absolute configuration of the natural product was determ

183 ynthetic results unambiguously confirmed the absolute configuration of the natural products mucorisoc

184 The stereochemistry and absolute configuration of the natural sesterterpenolide

185 of these conjugates allowed determining the absolute configuration of the new fulleropyrrolidines.

186 CD spectra that have been used to assign the absolute configuration of the new fulleropyrrolidines.

187 acterize and determine the assignment of the absolute configuration of the new isolated chiral alcoho

188 The absolute configuration of the new spiro stereocenter was

189 The absolute configuration of the newly created chiral cente

190 The absolute configuration of the nonacylated enantiomer of

191 acid acylation before peptide assembly, the absolute configuration of the ornibactin side chain, and

192 The absolute configuration of the primary amines was unambig

193 the dienophile can control the relative and absolute configuration of the product.

194 itio theoretical investigation explained the absolute configuration of the products and different ste

195 stereochemical model explaining the observed absolute configuration of the products based on DFT calc

196 g modes for one substrate but give different absolute configuration of the products by binding the al

197 The absolute configuration of the products has been assigned

198 The absolute configuration of the products makes the sulfena

199 The absolute configuration of the products that are predicte

200 dichroism should in principle establish the absolute configuration of the propeller-shaped molecules

201 The absolute configuration of the resulting olefinated produ

202 It has also enabled the absolute configuration of the side chain hydroxy group o

203 d transition state of the cycloaddition, the absolute configuration of the starting lactone controlle

204 Variation of the absolute configuration of the starting segments 5a and 9

205 tching/mismatching effect depending upon the absolute configuration of the stereocenter in the starti

206 ediction of the CD spectrum to determine the absolute configuration of the stereogenic carbon C-9 as

207 ture needed to be revised with regard to the absolute configuration of the stereogenic center bearing

208 The identical absolute configuration of the stereogenic center of the

209 her and amide functional groups and constant absolute configuration of the stereogenic centers at all

210 epared with equal efficiency by changing the absolute configuration of the sulfinyl chiral auxiliary.

211 d with the same good results by changing the absolute configuration of the sulfur atom of the sulfiny

212 The absolute configuration of the synthetic material was con

213 ic field and the light wavevector and on the absolute configuration of the system.

214 idation approach and securely determines the absolute configuration of the targeted natural product,

215 The absolute configuration of the THF cores was secured by a

216 The absolute configuration of the tungsten stereocenter in T

217 characterized with the aim to attribute the absolute configuration of the two adjacent stereocenters

218 The absolute configuration of these enantiomers was assigned

219 toxins B, and thus allowed assignment of the absolute configuration of this naturally occurring antib

220 h establishes unequivocally the relative and absolute configuration of this oxopolyene macrolide.

221 -teucladiol enabled the determination of the absolute configuration of this terpene natural product.

222 -valencene, leading to a reassignment of the absolute configuration of this unusual cyclopropenone-co

223 c aminoxylation step ultimately controls the absolute configuration of three adjacent stereogenic cen

224 tioenriched material for reassignment of the absolute configuration of trichoflectin and deflectin-1a

225 ponding enantiomerically pure diones 4b, the absolute configuration of which was determined by compar

226 The absolute configurations of 1,n-glycols (n = 2-12, 16) be

227 The structures and absolute configurations of 1-3 were determined by spectr

228 The absolute configurations of 2-4 were established for the

229 The absolute configurations of all of the isolated MBCHs wer

230 The absolute configurations of all the HPLC separated enanti

231 Structures and absolute configurations of analogues 3 and 5 were confir

232 The C23 absolute configurations of both 20S,23S/R-dihydroxyvitam

233 ridine) complexes were used to determine the absolute configurations of chiral mono-ols.

234 d us to suggest that the originally assigned absolute configurations of chiral polyacetylenes from At

235 otal synthesis reported herein confirmed the absolute configurations of curvularides A-E and supporte

236 s confirmed that the proposed structures and absolute configurations of hyacinthacines B3, B4, and B5

237 een on the market as Lariam for decades, the absolute configurations of its enantiomers have not been

238 The relative and absolute configurations of KmTx2 were determined using J

239 A macrolide was extrapolated to propose the absolute configurations of mandelalides B-D.

240 ave a stable pyramidal conformation, and the absolute configurations of new chiral centers were assig

241 -performance liquid chromatography), and the absolute configurations of obtained enantiomers were mai

242 The absolute configurations of phosphorothioate diesters, H-

243 The absolute configurations of primary amines were assigned

244 In addition, the absolute configurations of the bicyclo[2.2.2]oct-5-en-2-

245 ng, for the first time, an assignment of the absolute configurations of the chromophores.

246 he basis of these simplified approaches, the absolute configurations of the compounds have been unamb

247 The absolute configurations of the diastereomers were determ

248 Structures and absolute configurations of the diols 21a, 21b, and 22a a

249 ta)-CHX-P(gamma) carbons on the basis of the absolute configurations of the individual diastereomers

250 mic compounds via chiral HPLC and assign the absolute configurations of the isolated enantiomers by X

251 as well as the difficulty in determining the absolute configurations of the isolated MBCHs.

252 f the halogen substituents, and relative and absolute configurations of the known natural products.

253 The relative and absolute configurations of the meroterpenoids were deter

254 eoselective fashion by proper control of the absolute configurations of the methoxy groups in the bis

255 The absolute configurations of the natural products were una

256 The absolute configurations of the novel atropisomers has be

257 ography on chiral stationary phases, and the absolute configurations of the separated enantiomers wer

258 cally observed structural changes (e.g., the absolute configurations of the three PP binding sites sw

259 lysis based on Flack parameters assigned the absolute configurations of the two enantiomers.

260 mpounds to be resolved into enantiomers, the absolute configurations of which are denoted Lambda (lef

261 al benzene compounds is often used to assign absolute configurations on the basis of sector rules.

262 wed the determination of the product aldols' absolute configuration (S).

263 ng to unambiguously assign the atropisomers' absolute configuration, something, to the best of our kn

264 odel reaction and systematic analysis of the absolute configuration support the suggested mechanism.

265 faster and more reliable VCD assignments of absolute configuration, the ability to rapidly explore c

266 become invaluable for the assignment of the absolute configuration, the study of conformational isom

267 ic stereoisomers led to determination of its absolute configuration, thus correcting the original ass

268 tiviral activity well correlating with the R absolute configuration to the stereogenic center of the

269 Preparation and assignment of absolute configurations to both enantiomers of the sex p

270 omalous X-ray diffraction, we determined the absolute configuration using a combination of NMR, optic

271 atic methods that speed-up the assignment of absolute configuration using vibrational circular dichro

272 Its absolute configuration was again assigned by ECD investi

273 Its absolute configuration was assigned by the known configu

274 The absolute configuration was assigned for mandelalide A af

275 Sinister absolute configuration was assigned to (+)-subincanadine

276 microsyringe as the reaction vessel, and the absolute configuration was assigned via qualitative dete

277 The relative and absolute configuration was determined by a combination o

278 The absolute configuration was determined by chemical reacti

279 ed by means of enantioselective HPLC and the absolute configuration was determined by TD-DFT simulati

280 its two enantiomers by chiral HPLC, and the absolute configuration was established by circular dichr

281 ncluding 1D and 2D NMR spectroscopy, and the absolute configuration was established by comparison of

282 The absolute configuration was established by comparison of

283 The assigned absolute configuration was further supported by the resu

284 The (+)-PP absolute configuration was thus established for the anti

285 l 3-spirotetramic acid of hitherto uncertain absolute configuration, was synthesized for the first ti

286 The structure and absolute configuration were established by X-ray diffrac

287 tereomers were isolated by HPLC (4, 5) whose absolute configurations were assigned according to the h

288 isolated by enantioselective HPLC and their absolute configurations were assigned by TD-DFT simulati

289 Absolute configurations were assigned by X-ray crystallo

290 tions (DFT-D3, TD DFT, and sTD DFT), and the absolute configurations were assigned for all chiral rep

291 NMR chemical shifts measurements, while the absolute configurations were determined by comparison be

292 The absolute configurations were determined by comparison of

293 were resolved into their enantiomers, whose absolute configurations were determined by comparison of

294 e readily resolved by chiral HPLC, and their absolute configurations were determined by X-ray crystal

295 nternal probe to unequivocally determine the absolute configuration, which was also supported by opti

296 ish molecular conformation and correlate the absolute configuration with the observed NMR shift.

297 both gave the trans-aziridines with the same absolute configuration with the same catalyst; however,

298 isolated from the natural source enabled the absolute configurations within these alkaloids to be con

299 he determination of the correct relative and absolute configuration without additional information fr

300 both the E and Z isomers to provide the same absolute configuration without showing E-Z isomerization