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1 oxide ring opening and carboxylation to form acetoacetate.
2 to epoxypropane followed by carboxylation to acetoacetate.
3 of the carbon nucleophilic lipid metabolite acetoacetate.
4 evels ( approximately 10% yield) relative to acetoacetate.
5 ates acetone and HCO3(-) to form the product acetoacetate.
6 secondary product formed by the reduction of acetoacetate.
7 and a ketone/enolate nucleophile to generate acetoacetate.
8 inhibition pattern, partially alleviated by acetoacetate.
9 hydrolysis via acetoacetamide-N-sulfonate to acetoacetate.
10 ardial oxidation of beta-hydroxybutyrate and acetoacetate.
11 d inhibiting protonation in the formation of acetoacetate.
12 tabolically preferred carboxylation product, acetoacetate.
13 were identified as beta-hydroxybutyrate and acetoacetate.
14 of the enamine or an imine tautomer produces acetoacetate.
15 ding an allene (2,3-butadienoate) to produce acetoacetate.
16 similarly to rat islets but formed much more acetoacetate.
17 uctive cleavage and carboxylation to produce acetoacetate.
18 results in the conversion of epoxypropane to acetoacetate.
19 leavage of HMG-CoA to produce acetyl-CoA and acetoacetate.
20 e is dependent on the presence of Mg(2+) and acetoacetate.
21 ading capacity in the presence or absence of acetoacetate.
22 t cleavage of HMG-CoA to form acetyl-CoA and acetoacetate.
23 he condensation of acetone and CO(2) to form acetoacetate.
25 oxylation to form acetone and CO(2); and (4) acetoacetate/(14)CO(2) exchange to form (14)C(1)-acetoac
26 ated increased acetate, adenosine, xanthine, acetoacetate, 3-hydroxybutyrate and betaine in alcohol-f
28 emonstrated that high glucose (25 mm) and/or acetoacetate (4 mm) increased reactive oxygen species, d
29 se plus insulin (40 microU/ml), glucose plus acetoacetate (5 mM), or glucose plus insulin and acetoac
30 tate 4a, N-tosyl carbamate 5a, TBDMS 6a, and acetoacetate 7a) undergo metathesis without competing si
31 cells, AMPK-deficient cells required instead acetoacetate, a product of fatty acid catabolism indicat
32 counter elevated levels of the ketone bodies acetoacetate (AA), beta-hydroxybutyrate (BHB), and aceto
34 U937 cells were cultured with ketone bodies (acetoacetate [AA] and beta-hydroxybutyrate [BHB]) in the
38 strip displays high selectivity for HB over acetoacetate (AcAc) and other interferences (i.e., aceta
39 ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during st
41 ticular interest, as ketone bodies (acetone, acetoacetate (AcAc), and beta-hydroxybutyrate (BHB)) ser
42 including beta-hydroxybutyrate (betaOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8(+)
45 biotinylated capture probe, the Friedlander-acetoacetate adduct can be trapped and purified directly
47 d the labeling of the ketone bodies [1-(13)C]acetoacetate and [1-(13)C]beta-hydroxybutyryate, without
48 erized and demonstrated to cleave HMG-CoA to acetoacetate and acetyl-CoA with catalytic and affinity
49 oduction from glycine and conversion between acetoacetate and B-OH-butyrate, were assigned higher wei
51 T1D is associated with both hyperketonemia (acetoacetate and beta-hydroxybutyrate) and hyperglycemia
53 esis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky react
55 topropylthio)ethanesulfonate; 2-KPC] to form acetoacetate and coenzyme M (CoM) in the bacterial pathw
57 nd carboxylation of 2-ketopropyl-CoM to form acetoacetate and CoM according to the reaction: 2-ketopr
60 zation in vivo using hyperpolarized [3-(13)C]acetoacetate and investigated the alterations in myocard
61 oacetyl-CoA synthetase to synthesize and use acetoacetate and suggests human islets may use this path
62 least two redundant pathways, one involving acetoacetate and the other citrate, for the synthesis SC
63 er a longer fast and with severer ketonemia, acetoacetate and total ketone-body production and oxidat
65 ld ketonemia and minimal ketonuria, rates of acetoacetate and total ketone-body production and oxidat
66 ed of three compounds (beta-hydroxybutyrate, acetoacetate, and acetone) that circulate during starvat
67 ma concentrations of KBs (B-hydroxybutyrate, acetoacetate, and acetone) were measured by nuclear magn
69 output of 13C-labeled beta-hydroxybutyrate, acetoacetate, and CO2, indicating stimulated fatty acid
70 gen content in hearts perfused with glucose, acetoacetate, and insulin suggests increased glycogen tu
71 for a series of ketones (2-butanone, methyl acetoacetate, and N,N-dimethylacetoacetamide) and alkyl
73 The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced metabolites catabo
76 in fumarylacetoacetate to yield fumarate and acetoacetate as the final step of Phe and Tyr degradatio
79 networks and signals through the Oct-1-HMGCL-acetoacetate axis to selectively promote BRAF V600E-depe
80 d between dietary intakes of whole grain and acetoacetate (B: -0.50, P < 0.001) and B-hydroxybutyrate
81 01), as well as intakes of saturated fat and acetoacetate (B: 0.47, P < 0.001) and B-hydroxybutyrate
82 sured using NMR, reveals intact oxidation to acetoacetate but no contribution of ketone bodies to the
83 DNL, PUFA elongation required activation of acetoacetate by cytosolic acetoacetyl-coenzyme A synthet
84 ding on the medium, and was not derived from acetoacetate by nonenzymatic decarboxylation in the medi
85 enesis (production of beta-hydroxybutyrate + acetoacetate), C(5) ketogenesis (production of beta-hydr
86 t metabolites (3-D-hydroxybutyrate, acetone, acetoacetate, citrate, lactate, creatine, creatinine, an
87 the physiological products of the reaction, acetoacetate, coenzyme M, and NADP, and reduction of the
88 tructure demonstrates reduced coenzyme A and acetoacetate covalently bound to the active site cystein
90 e include the upregulated adc gene, encoding acetoacetate decarboxylase (EC 4.1.1.4), and the downreg
91 of enzymes in the acetone-formation pathway (acetoacetate decarboxylase [AADC] and coenzyme A-transfe
93 a high degree of structural similarity with acetoacetate decarboxylase, though the respective quater
94 previously uncharacterized family within the acetoacetate decarboxylase-like superfamily (ADCSF) and
95 mologues, identify a novel family within the acetoacetate decarboxylase-like superfamily with diverge
98 sing 2-ketopropyl-CoM but did not inactivate acetoacetate decarboxylation or (14)CO(2) exchange react
99 siologically important forward reaction; (3) acetoacetate decarboxylation to form acetone and CO(2);
103 m a diverse range of benzyl alcohols, methyl acetoacetate/ethyl benzoylacetate and hydroxylamine hydr
105 phosphono allylic carbonates with tert-butyl acetoacetate followed by hydrolysis and decarboxylation,
106 for acetone carboxylation of 0.225 micromol acetoacetate formed min-1.mg-1 at 30 degrees C and pH 7.
109 exosamine pathway including glucose, GlcNAc, acetoacetate, glutamine, ammonia, or uridine but not by
110 issues, starch was first functionalized with acetoacetate groups and subsequently blended with chitos
111 Dynamic cross-linking occurred between the acetoacetate groups and the primary amine groups of chit
116 ient mice (specifically mice lacking fumaryl acetoacetate hydrolase [Fah], recombination activating g
117 ed the carboxylation of epoxypropane to form acetoacetate in a reaction that was dependent on the add
120 release indicating formation of SC-CoAs from acetoacetate in the cytosol is important for insulin sec
121 toacid-CoA transferase, an enzyme that forms acetoacetate in the mitochondria, and acetoacetyl-CoA sy
124 uction in the absence of acetoacetate, while acetoacetate inhibited the uptake of glucose and the oxi
127 beta-hydroxybutyrate formaton indicate that acetoacetate is the primary product of propylene oxide c
128 ruvate) and mitochondrial (3-hydroxybutyrate/acetoacetate) NADH redox states were elevated by at leas
130 media with serum and without serum; however, acetoacetate only induced proteolysis in cells maintaine
134 tion with the metabolic substrates pyruvate, acetoacetate, or hydroxybutyrate also prevented mitochon
135 earrangement of nonracemic phosphono allylic acetoacetates, or the intermolecular allylic substitutio
137 HMG-CoA reductase reaction and/or cleaved to acetoacetate plus acetyl-CoA by HMG cleavage enzyme.
138 elds a markedly reduced beta-hydroxybutyrate:acetoacetate ratio of 1:3, compared with 3:1 in Oxct1(+)
139 ns of ketone bodies (beta-hydroxybutyrate or acetoacetate) reduced the spontaneous firing rate of neu
143 the active enzyme catalyzing acetyl-CoA and acetoacetate synthesis when incubated with (S)-HMG-CoA.
144 Within a minute upon injection of [3-(13)C]acetoacetate, the production of [5-(13)C]glutamate and [
145 t synthesis of 2-ketopropyl-CoM from CoM and acetoacetate, the reverse of the physiologically importa
146 observed in condensations of 16 with benzyl acetoacetate to afford Biginelli adduct 29 supports the
148 which is subjected to nucleophilic attack by acetoacetate to form the new C(gamma)-C(delta) bond in 3
149 generated succinyl-CoA initially reacts with acetoacetate to yield acetoacetyl-CoA plus succinate in
150 nary complex with NAD(+) and 3-ketobutyrate (acetoacetate) to 1.4 A resolution, and as a ternary comp
151 uccinate esters or generated by succinyl-CoA-acetoacetate transferase is metabolized to malate follow
153 oacetate (5 mM), or glucose plus insulin and acetoacetate, using a three tracer (3H, 14C, and 13C) te
159 reated with high glucose alone or along with acetoacetate, was prevented by vitamin D supplementation
160 the product of reductive decarboxylation of acetoacetate, was revealed in this structure in addition
162 P, Krebs cycle intermediates, glutamate, and acetoacetate were investigated as candidate stimulus-cou
164 not alter the stereochemistry at C-2 of [2-D]acetoacetate when the reaction is conducted in D2O.
165 s-CaaD and the T34 mutant generate (2R)-[2-D]acetoacetate, whereas Cg10062 generates mostly the 2S is
166 he developing charge during the formation of acetoacetate, which acts as a product inhibitor in the W
167 n release caused large relative increases in acetoacetate, which is a precursor of pathways to short
168 the conversion of 2-ketopropyl-coenzyme M to acetoacetate, which is used as a carbon source, in a con
169 eased intracellular levels of HMGCL product, acetoacetate, which selectively enhances binding of BRAF
170 nd promotes the formation of the ketone body acetoacetate, which subsequently enhances BRAF(V600E)/ME
171 ake and lactate production in the absence of acetoacetate, while acetoacetate inhibited the uptake of
172 ghest yields are observed upon reaction with acetoacetates, while neutral and electron-rich substrate
173 ensation of 2-hydroxybenzaldehydes and ethyl acetoacetate with 1:1 acetylenecarboxylate-isocyanides i
174 se catalyzes the carboxylation of acetone to acetoacetate with concomitant hydrolysis of ATP to AMP a
175 he ATP-dependent carboxylation of acetone to acetoacetate with the concomitant production of AMP and