ライフサイエンスコーパス: acetoxy

1 e most useful for asymmetric alkylation of 3-acetoxy-1,3-diphenylpropene and less suitable/effective

2 reoselectivity applied to the reactions of 4-acetoxy-1-(N-hydroxyphenyacetamido)cyclopentene (8).

3 onding succinimide analog of N-5-maleimido-2-acetoxy-1-benzoic acid did not inhibit either enzyme act

4 The reduction of the 2-acetoxy-1-C-oxacarbenium ion intermediates proceeds with

5 enyl-1,3-propanediol providing exclusively 3-acetoxy-1-phenyl-propan-1-ol in good yield.

6 4-Acetoxy-1-phenylacetamidocyclopentene (9), however, affo

7 Taxa-4(20),11(12)-dien-5 alpha-acetoxy-10 beta-ol 6 has been identified as an early sta

8 droxylation at C10 to yield taxadien-5 alpha-acetoxy-10 beta-ol.

9 by X-ray crystallography, crystals of 3beta-acetoxy-16,17-seco-17,20-dioxopregn-5-ene-16-nitrile are

10 elimination" substitution reaction of 3 beta-acetoxy-17-chloro-16-formylandrosta-5,16-diene (2) and a

11 -elimination" substitution reaction of 3beta-acetoxy-17-chloro-16-formylandrosta-5,16-diene (2) and b

12 alogous thioesters, S-tert-butyl (2R*,3R*)-3-acetoxy-2,3-2H2-butanethioate (3) and its (2R*,3S*) dias

13 ospecifically labeled tert-butyl (2R*,3R*)-3-acetoxy-2,3-2H2-butanoate (1) and its (2R*,3S*) diastere

14 sh vacuum pyrolysis studies of substituted 6-acetoxy-2,4-cyclohexadienones (3 and 10) from 300 to 500

15 are generated during hydrolysis of 4-aryl-4-acetoxy-2,5-cyclohexadienones, 2c and 2d, and O-(4-aryl)

16 rranged spongian diterpenes (8-substituted 6-acetoxy-2,7-dioxabicyclo[3.2.1]octan-3-one and 6-substit

17 Details of the first synthesis of the 6-acetoxy-2,7-dioxabicyclo[3.2.1]octan-3-one ring system,

18 icyclo[3.2.1]octan-3-one and 6-substituted 7-acetoxy-2,8-dioxabicyclo[3.3.0]octan-3-one) are reported

19 In addition, the first synthesis of 7-acetoxy-2,8-dioxabicyclo[3.3.0]octanones containing quat

20 Compound 2, 1-(2(R)-[1(S)-acetoxy-2-[2(S)-(2,4-difluoro-benzoylamino)-3-phenyl-pro

21 A model system using the carcinogen, N-acetoxy-2-acetylaminofluorene (AAAF), was used to synthe

22 on-cycling cultured human cells exposed to N-acetoxy-2-acetylaminofluorene (NA-AAF), which generates

23 mid DNA containing bulky adducts formed by N-acetoxy-2-acetylaminofluorene or benzo(a)pyrene diol epo

24 iol epoxide, aflatoxin B1 8,9-epoxide, and N-acetoxy-2-acetylaminofluorene.

25 pyrimidine dimers,(6-4) photoproducts, and N-acetoxy-2-aminofluorene (AAF) adducts by an excision rep

26 Pd(0)/InI-mediated allylation of 4-acetoxy-2-azetidinone is used to install the beta-amino

27 eleutherobin, the steroid derivative 17beta-acetoxy-2-ethoxy-6-oxo-B-homo-estra-1,3,5(10)-trien-3-ol

28 ,2,5,5-tetramethylpyrrolidine (AMCPy), and 1-acetoxy-3-(acetoxymethoxy)carbonyl-2,2,5,5-tetramethylpy

29 nyl-2,2,6,6-tetramethylpiperidine (AMCPe), 1-acetoxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine

30 d 3 were obtained in five steps from ethyl 4-acetoxy-3-oxobutanoate and 6-iodo-3-methyl-1,3-hexadiene

31 4-Acetoxy-4-(benzothiazol-2-yl)-2,5-cyclohexadien-1-one, 1

32 e Lewis acid-promoted cyanation of (5R,6S)-2-acetoxy-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetra

33 d that 1-N-chrysenyl and 1-N-phenanthrenyl 3-acetoxy-4-aryl-2-azetidinones have potent anticancer act

34 The enantioselective total syntheses of 11-acetoxy-4-deoxyasbestinin D and asbestinin-12 have been

35 thesized the acyl-protected hydroxylamines 1-acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine

36 acid- and base-catalyzed decomposition of 4-acetoxy-4-methyl-2,5-cyclohexadienone, 2b, in (18)O-H(2)

37 alyzed and acid-catalyzed decomposition of 4-acetoxy-4-phenyl-2,5-cyclohexadienone, 2a, generates the

38 an N-Boc-2-phenylacrylamide to generate a 5-acetoxy-5-benzyloxazolidine-2,4-dione.

39 bound to an oviposition pheromone (5R,6S)-6-acetoxy-5-hexadecanolide (MOP).

40 n hydride-mediated cyclizations of 1-nitro-2-acetoxy-5-hexenes 7a-g having multiple substitutions on

41 The steroid SC17599 (17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna -

42 reactions of salicylic aldehydes with (-)-8-acetoxy-6-hydroxymethyllimonene, readily accessible from

43 nance measurements identified NX-2 as 3alpha-acetoxy-7alpha,15-dihydroxy-12,13-epoxytrichothec-9-ene.

44 The cAMP-elevating agent 7B-acetoxy-8,13-epoxy-1a,6B,9a-trihydroxylabd-14-en-11-one

45 N-Acetoxy-AalphaC also formed an adduct at Tyr(332).

46 -acetyloxy-2-amino-9H-pyrido[2,3-b]indole (N-acetoxy-AalphaC), and their [(13)C6]AalphaC-labeled homo

47 ious omega-[bis(acetoxy)]alkyl or omega-[bis(acetoxy)]alkoxyalkyl groups are substituted at the 3'-am

48 elated compounds in which various omega-[bis(acetoxy)]alkyl or omega-[bis(acetoxy)]alkoxyalkyl groups

49 on and lactonization strategy in which delta-acetoxy allenoate functions as a 5C-synthon in its react

50 In contrast, with B'-acetoxy allenoate, 2-sulfonamidoindole acts only as a ca

51 emperature-controlled [3 + 3] annulations, d-acetoxy allenoates afforded dihydrocarboline and carboli

52 The same delta-acetoxy allenoates and thioamides, under DABCO, pyridine

53 red benzothiazole bisnucleophiles with beta'-acetoxy allenoates by switching the Lewis base is develo

54 Under metal-free conditions, delta-acetoxy allenoates react with cyclic N-sulfonyl imines (

55 The reactivity of 2-sulfonamidoindoles with acetoxy allenoates under phosphine catalysis depends on

56 -catalyzed regioselective hydration of gamma-acetoxy-alpha,beta-acetylinic ester by the assistance of

57 imple primary, secondary, and tertiary gamma-acetoxy-alpha,beta-acetylinic esters, even those bearing

58 8) s(-1)) in all solvents studied, and the 2-acetoxy analogue (3b) reacted much faster than related r

59 C-4 acetoxy and acetylsalicyloxy derivatives were also studi

60 The use of acetoxy and diphenoxyphosphatoxy as leaving groups provi

61 ur base-initiated alpha,beta-eliminations of acetoxy and mesyloxy esters and their analogous thioeste

62 ubstrates in EtOH/H(2)O, with beta-tosyloxy, acetoxy, and 3-trifluoromethylphenoxy nucleofuges.

63 pyridinium, sulfonium, thiol, carbonitrile, acetoxy, and amino derivatives.

64 this method is introduced that employs alpha-acetoxy- and alpha-lactone-substituted tryptamides.

65 4-dihydro-1-benzazepine-2,5-dione-N-prenyl-N-acetoxy-anthranilamide scaffold, was isolated from a nov

66 d via hydrosilylation of the corresponding o-acetoxy arylacetylenes.

67 ective conversion to the corresponding alpha-acetoxy-beta-chloro derivative.

68 inversion of one alpha-d-glucose into a 5-C-acetoxy-beta-l-idose unit possessing a (1)C4 conformatio

69 oliferation; however, the 4-pyridinyloxy and acetoxy compounds were also potent inhibitors of NQO1 ac

70 of t-Bu-MacE and a structurally related des-acetoxy congener to substituted pyrroles in the presence

71 The iodocyclization of acetoxy-containing 2-(1-alkynyl)anisoles and subsequent

72 ] and -[5.3.0] skeletons possessing an alpha-acetoxy cyclopentadienone.

73 teria: N-acetylglycine, D-lactic acid, and 2-acetoxy-D-propanoic acid.

74 Among other derivatives tested, the alpha-acetoxy derivative 7 affords the highest enantioselectiv

75 and subsequent Pummerer rearrangement to the acetoxy derivative of the tetrahydrothiophenocucurbit[5]

76 elective C-C coupling of silyloxyfurans with acetoxy-dihydropyranones, affording a hindered C(sp(3))-

77 Herein, we report a 3-acetoxy directing group for the regioselective C2 alkeny

78 ylated glycals by a new, mild anomeric S(N)'-acetoxy displacement with Hg(CN)(2)/HgBr(2)/TMSCN.

79 resent the first evidence that a compound (3-acetoxy ecgonine methyl ester) exists that prevents inhi

80 acetate is trans to palladium and with beta-acetoxy elimination when acetate is cis.

81 2-Ir-C migratory insertion followed by syn-B-acetoxy elimination, which is different from that of pre

82 se-catalyzed hydrolysis of a mixture of C-35 acetoxy epimers indicated a 35R absolute configuration f

83 om a conjugate base (E1cB(I)) mechanism with acetoxy ester 3, acetoxy thioester 4, and mesyloxy thioe

84 steps, 3.7% global yield), via a nor-labdane acetoxy ester, has been achieved starting from commercia

85 creased formation of ethyl esters, acetates, acetoxy esters and alcohols, thus allowing the authentic

86 in the elimination of acetic acid from beta-acetoxy esters and thioesters.

87 (1), reductive acetylation to give the alpha-acetoxy ether (3), and cyclization on treatment with a L

88 at, under mild acidic conditions, many alpha-acetoxy ethers can be further reduced to the correspondi

89 to be converted into the corresponding alpha-acetoxy ethers in good to excellent yields.

90 yl (8), 4-methoxyphenoxycarbonyl (9), and (1-acetoxy)ethoxycarbonyl (10) and a bis-carbonate ethoxyca

91 in A have demonstrated the importance of the acetoxy functionality on the A-ring in its activity as a

92 ccessful route involved the reaction of beta-acetoxy-gamma-thianyl carbonyl compounds with dimethyl(m

93 The presence of the acetoxy group at C(3) of the beta-lactams has proven to

94 i-PrOH without a promoter revealed that the acetoxy group at C-5 in a molecule of a sialic acid glyc

95 nsporter binding potency, while a hydroxy or acetoxy group at the 2'-position exhibited increased bin

96 tution of the 5-acetamido group and of the 4-acetoxy group from neuraminic acid.

97 substitution reaction of the bay-region C10 acetoxy group in four stereoisomeric 7,8,9,10-tetraaceto

98 (S)-Acetoxy group in the succinimide precursor was initially

99 Mass spectrometry and NMR indicate that an acetoxy group is covalently bound to the delta-meso-carb

100 eria and plants, the replacement of the beta-acetoxy group of O-acetyl-L-serine (OAS) by a thiol to g

101 beta-replacement reaction in which the beta-acetoxy group of O-acetyl-L-serine (OAS) is replaced by

102 acteria and plants, substitution of the beta-acetoxy group of O-acetyl-l-serine (OAS) with inorganic

103 eria and plants, the replacement of the beta-acetoxy group of O-acetyl-l-serine by a thiol to give l-

104 vity to give beta-C-arylglucosides without 2-acetoxy group participation.

105 g with the beta14, beta15-epoxide and beta16-acetoxy group was found to be challenging due to the ins

106 hiral auxiliary with a good alignment of the acetoxy group with the other biaryl ring, and places the

107 ic attack at the carbonyl carbon of the beta-acetoxy group.

108 Acetoxy groups are labile and thus not suitable protecti

109 nic acid donor compared to the corresponding acetoxy groups in the KDO series, resulting in a reactio

110 R6 and R7 hydroxyl groups by alkoxy groups, acetoxy groups, or benzyloxy groups could yield compound

111 sterase-mediated hydrolysis of the omega-bis(acetoxy) groups and give rise to 5- or 6-membered ring c

112 rtiary carbon atom adjacent to the omega-bis(acetoxy) groups, was also substantially less active than

113 precursors to the 1-azaallyl cations, alpha-acetoxy hydrazones were employed and ionized with a stro

114 yclo[2.1.1]hexanes containing bromo, fluoro, acetoxy, hydroxy, azido, imidazole, thiophenyl, and iodo

115 Newly identified acetoxy/hydroxybutyrate was present only in LAM from EAI

116 ramethyl-piperidin-1-yl)oxyl (TEMPO) and bis(acetoxy)iodobenzene (BAIB).

117 lization of amido-urea precursors, using bis(acetoxy)iodobenzene.

118 tion was used to generate end-functionalized acetoxy ionizable oligomers for the structural decipheri

119 d that a trans relationship of palladium and acetoxy is essential for acetate elimination.

120 ase, Fasp; aldo-keto reductase, Ypr1p; alpha-acetoxy ketone reductase, Gre2p).

121 chloroaldehyde or an alpha-phenoxy- or alpha-acetoxy ketone with a substituted benzyl hydroxylamine t

122 In addition, we have also synthesized alpha-acetoxy ketones in the case of absence of sulfonamide.

123 incubation of the cells with 50 microM BAPTA acetoxy methyl ester (AM) or thapsigargin also blocked a

124 aminoethyl ether)-N,N,N',N'-tetraacetic acid-acetoxy-methyl ester also reduces gadd153 induction by 2

125 erin for the ATP assay or loaded with Fluo-3-acetoxy methylester for intracellular calcium measuremen

126 is(carboxyethyl)-S-(and 6)carboxyfluorescein acetoxy methylester/fluorometry.

127 Organic molecules bearing acetoxy moieties are important functionalities in natura

128 generated from hydrolysis or photolysis of O-acetoxy-N-(4-(benzothiazol-2-yl)phenyl)hydroxylamine 8,

129 tly modified using the model carcinogen 2-(N-acetoxy-N-acetylamino)fluorene.

130 )-stemoamide was achieved in 11 steps from 5-acetoxy-N-crotyl pyrrolidinone.

131 ): atropine (nonselective, 9.0) > 4-diphenyl-acetoxy-N-methyl piperidine methiodide (M3/M1, 8.6) > pa

132 Furthermore, pirenzepine, diphenyl-acetoxy-N-methyl-piperidine and mecamylamine had no meas

133 y M1- (pirezenpine; 2 mum) and M3- (diphenyl-acetoxy-N-methyl-piperidine; 100 nm) receptor blockers,

134 c substrates such as acetylthiocholine and 7-acetoxy-N-methylquinolinium (M7A) bind to the peripheral

135 [reaction: see text] Alpha-acetoxy-N-nitrosomorpholine (7) has been synthesized sta

136 pH compared with its carbon analogue, alpha-acetoxy-N-nitrosopiperidine, is also consistent with the

137 in the stimulation of repair synthesis by N:-acetoxy-N:- acetylaminofluorene, but are proficient in t

138 catalysis depends on the disposition of the acetoxy (OAc) group on the allenoate.

139 s, alkyl sulfenyl thiocarbonate (AST-2), and acetoxy perthiocarbamate (APT-1), together with their mi

140 a tetra-acetylated inhibitor (2E)-3-[3,4-bis(acetoxy)phenyl]-2-propenoate-N-[(2E)-3-[3,4-bis(acetylox

141 polar adducts are found after reaction of N-acetoxy-PhIP with the oligonucleotide.

142 hyl-6-phenylimidazo[4,5-b]pyridine (PhIP), N-acetoxy-PhIP, with a single-stranded 11mer oligodeoxyrib

143 g the C8-dG adduct formed by reaction with N-acetoxy-PhIP.

144 CCTXGCCTCTC, where X = C, A, G, or T) with N-acetoxy-PhIP.

145 ration and polymerization of Pro and trans-4-acetoxy-Pro N-carboxyanhdrides (NCAs).

146 cridinium iodides bearing bulky saturated (3-acetoxy)propyl or (E)-3-(morpholin-4-yl)-3-oxopropenyl s

147 to TAB, predicted that modifications to the acetoxy residue of the lead inhibitor could exploit bind

148 isons, namely 11-saxitoxinethanoic acid, C13-acetoxy saxitoxin, decarbamoyl saxitoxin, and saxitoxin.

149 temperature employing PIDA as a nonmetallic acetoxy source.

150 nes with 4-nitrophenoxy, 4-pyridinyloxy, and acetoxy substituents at the (indol-3-yl)methyl position

151 e leads to ring opening and formation of a 5-acetoxy-substituted 2(1H)-pyridone.

152 [Chemical reaction: see text] A series of acetoxy-substituted enyne-allenes, fused to cyclopentene

153 Well-defined acetoxy telechelic structures were obtained and analyzed

154 se (E1cB(I)) mechanism with acetoxy ester 3, acetoxy thioester 4, and mesyloxy thioester 6.

155 With moderately electron-withdrawing groups (acetoxy), we observe >90% of the perfectly folded confor