1 malformations resembling chondrodysplasia or achondrogenesis.

2 yseal dysplasia, atelosteogenesis type 2 and achondrogenesis 1B (ACG-1B).

3 tified, we find that individuals with severe achondrogenesis 1B phenotype have null mutations on both

4 skeletal dysplasia in humans, suggested that achondrogenesis type 1A may be caused by GMAP-210 defici

5  mutations in the 10 unrelated patients with achondrogenesis type 1A whom we studied.

6 pes in these mice and those in patients with achondrogenesis type 1A, a neonatal lethal form of skele

7 t a third even more severe chondrodysplasia, achondrogenesis type IB, is also caused by mutations in

8                                 They include achondrogenesis type II, hypochondrogenesis, spondyloepi