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1 relationships (e.g. distances ligand - amino acid).
2 propose C15:0 as a potential essential fatty acid.
3 laying improved kinetics towards 2-oxoadipic acid.
4 e of a primary ammonium salt or a carboxylic acid.
5 t, which removes cell surface anionic sialic acid.
6 aldehydes to their corresponding carboxylic acids.
7 to increased production of unsaturated fatty acids.
8 I IFNs (IFN-I) in response to viral nucleic acids.
9 reductase toward noncognate omega-hydroxylic acids.
10 isms towards cysteine thiols and other amino acids.
11 resulted in high levels of total free amino acids.
12 tected level of human and SARS-CoV-2 nucleic acids.
15 ministered intravenously over 2 h, l-folinic acid (175 mg flat dose administered intravenously over 2
16 tered intravenously over 2 h) or d,l-folinic acid (350 mg flat dose administered intravenously over 2
17 r experiments revealed PLD3 as the principal acid 5' exonuclease in HeLa cells, where it showed a mar
19 quent structure elucidation of chloroxanthic acid A as the founding member of a novel secondary metab
20 itized photodegradation of cysteine sulfinic acid, a (photo)degradation product of cysteine, to sulfa
21 ORC1 signaling is also a target for decanoic acid, a key component of the medium-chain triglyceride (
22 he colonic epithelium with 5-amino salicylic acid, a PPAR-gamma (peroxisome proliferator-activated re
23 e composition of beer wort in terms of amino acid (AA) content affects the final product quality, onc
25 r, including linoleic acid (LA), arachidonic acid (AA), docosahexaenoic acid (DHA), or eicosapentaeno
26 spectra of aromatic amino acids and nucleic acids (AAA + NA), tryptophan residues, nicotinamide aden
29 as a highly efficient candidate for hexanoic acid activation (Taxol C side chain), and TmAAE4 as suit
31 ch are tags of minimal size (ca. 15-20 amino acids) affording high-affinity lanthanide ion binding, a
32 helpers") to minimize lipid oxidation during acid/alkaline pH-shift protein isolation was evaluated.
33 hydrocarbon resin), including alkanes, fatty acids, amides, and tackifying terpenoids embedded in a f
34 mino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in vitro after exposure to patient
36 to attach the well-known anthracene-boronic acid (An-BA) probe to a biomimetic DNA scaffold and cons
40 yer was formed via polymerization of silicic acid and gelation of silica particles, which were less i
42 es the effect of ethanol, glycerol, tartaric acid and glucose/fructose on the refractive index in mod
43 ent combinations of deuterated and proteated acid and hydride reagents, the deuterated positions on t
46 the other hand, the levels of eicosadienoic acid and octadecanoic acid were significantly higher in
47 ng-chain insulating surface ligands of oleic acid and oleylamine, even for unpurified PQDs with high
49 ologies have been limited to natural nucleic acids and are often incompatible with polymerase-generat
50 igher concentrations of non-esterified fatty acids and beta-hydroxybutyrate than mid-postpartum anima
51 ent media for on-line separation of phenolic acids and flavonoids, which were subsequently detected b
52 s indicate that sequential inputs from amino acids and growth factors trigger PA production required
53 ntities of the protein-ligand complex (amino acids and ligands) and the edges represent structural re
54 s and fluorescence spectra of aromatic amino acids and nucleic acids (AAA + NA), tryptophan residues,
55 ides not only amino acids, but sugars, fatty acids and nucleotides for biosynthesis, conferring resis
56 Among cutin compounds, omega-hydroxy fatty acids and polyhydroxy-fatty acids were specifically affe
57 tophagy and promoted beta-oxidation of fatty acids and stimulated gene expression of acyl-CoA dehydro
58 ne/vitamin B6, taurine, some essential amino acids, and a conditionally essential amino acid and its
59 ry potentials of food originated 34 phenolic acids, and flavonoid compounds were screened against ace
60 ed 230 metabolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid co
61 metabolism by suppressing oxidation of fatty acids, and thus adapts the cells to an avascular life.
64 w how more challenging variants of rubazonic acid are efficiently prepared using an alternative two-s
65 hown, the previously unreported dicarboxylic acids are easily turned into corresponding delta-lactone
67 pecifically, exogenous polyunsaturated fatty acids are rapidly incorporated into membrane lipids, ind
70 300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITE
71 ight into the properties of molecular nitric acid at the surface of liquid water (the air-water inter
73 ed teams including (1) auxin/indole-3-acetic acid (AUX/IAA)-histone deacetylase (HDA) and (2) auxin r
77 erating CO(2) / HCO3- -mediated buffering of acid-base equivalents, they could not appreciably affect
78 e unique host-guest interaction (e.g., Lewis acid-base interaction), between F(-) and MOF host, a hig
80 ary groups (e.g., hydrogen bonding, Bronsted acid/base) near the active site of metal-containing cata
81 y describes the use of tailored poly(acrylic acid)-based (NaPAA) hydrogels as effective sorbents for
84 0.04; eta2p = 0.31] and branched-chain amino acids (BCAAs) [between-group difference (95% CI): 266 (7
85 otein regulates lipid mobilization and fatty acid beta-oxidation during seed germination and seedling
86 However, current CRISPR-Cas-based nucleic acid biosensing has a lack of the quantitative detection
87 e (DAH7PS), at the gateway to aromatic amino acid biosynthesis in Mycobacterium tuberculosis, which s
88 ts through quantitative exploration of fatty acid biosynthesis processes for optimal biofuels, renewa
90 ipic semialdehyde (alpha-AASA) and pipecolic acid both in brain and liver tissues, similar to the bio
91 ls that necrocytosis provides not only amino acids, but sugars, fatty acids and nucleotides for biosy
97 fter preconcentration by the help of stearic acid coated magnetic nanoparticle (SAC-MNPs) based sonic
98 show that MVs isolated from the human lactic acid commensal bacteria Pediococcus pentosaceus suppress
99 RSA), oxidative stability index (OSI), fatty acid composition and Maillard reaction products (MRPs).
100 s to gain insights on the interplay of amino acid composition, structure, self-association, and adhes
101 terpenoids embedded in a fluid matrix (fatty acids) comprising nonpolar and polar portions serving th
103 H, saturation state and approximate aspartic acid concentrations inferred to occur at the coral calci
105 hemoselectively N-oxidized using an aspartic acid containing peptide catalyst to afford stable, helic
106 MmpL11 as a conserved transporter of mycolic acid-containing lipids including monomeromycolyl diacylg
108 ive oils (OOs) with high and low triterpenic acid contents, and specifically the effect of triterpene
109 YC(3), 2) its functional dependence on amino acids critical for OGT activity, and 3) its ability to O
110 lycolysis/gluconeogenesis, the tricarboxylic acid cycle, and monosaccharide and disaccharide metaboli
111 impaired growth in the absence of the amino acid cysteine and that gigC regulates the expression of
113 mic reticulum omega-oxidation, a minor fatty acid degradation pathway known to be stimulated by C(12)
114 ough our discovery that human aminolevulinic acid dehydratase (ALAD), which catalyzes the second step
115 , the reduced charging of tRNA(Gln) in amino-acid-deprived cells also leads to specific depletion of
118 (LA), arachidonic acid (AA), docosahexaenoic acid (DHA), or eicosapentaenoic acid (EPA), and (2) the
120 non-polar molecule, while for the VP4, amino acid differences at position D195G was radical in nature
122 fficacy by prolonging the release of nucleic acid drug payload for sustained, long-term gene expressi
123 ethod, including enantiomerically pure amino acids, enabling us to explore structural diversity.
125 l liver imaging score derived from gadoxetic acid-enhanced MRI identified patients with advanced chro
127 osahexaenoic acid (DHA), or eicosapentaenoic acid (EPA), and (2) the enzyme group, including cyclooxy
129 n, a total phenolic content of 0.72 g gallic acid equivalents per 100 g of soybean hull was obtained
130 PDEs) and 2-monochloropropane-1,3-diol fatty acid esters (2-MCPDEs), and semi-quantification of glyci
131 cation of 3-monochloropropane-1,2-diol fatty acid esters (3-MCPDEs) and 2-monochloropropane-1,3-diol
134 This study assessed the impact of fatty acid (FA) type, phospholipid concentration on MM formati
136 cally active hexamers to generate free amino acids from human hemoglobin and are drug targets for the
137 that the increase of length chain of sinapic acid, from C4 to C12, reduced the secondary products of
139 The need for an ester versus carboxylic acid-functionalized coupling partner is also explored, a
140 an interfacial phenomena standpoint, gallic acid (GA), methyl gallate (MG), and their combination al
143 , a critical actor of the gamma-aminobutyric acid (GABA) metabolism as it catalyses the decarboxylati
146 visual analog scale (-11.5 in the zoledronic acid group vs -16.8 in the placebo group; between-group
152 hich 27.4% was melezitose, and 2.5% gluconic acid (higher than typical honeydew honeys); 41.2% monosa
155 tRNAs retain charging of their cognate amino acids in a manner that is dependent upon intact lysosoma
157 rganic acids, water soluble sugars and amino acids in three onion varieties ('Shallot', 'Chata' and '
161 mine rather than an alpha,beta-dehydro-amino acid intermediate during C(alpha)-thioether bridge LC-MS
162 able incorporation of the rare cognate amino acids into the growing peptide chain at a rate of ~20 aa
165 the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhibit several mesenchymal-like p
166 dihydroxyphenyl)prop-2-enoyl]amino]propanoic acid) is a naturally occurring caffeoyl conjugate and a
167 arbene (1cc) by means of pyrolysis of oxalic acid, isolation of the lower-energy s-trans,s-trans (1tt
168 mic allostery: three distinct aromatic amino acids jointly communicate occupancy to the active site v
169 an auxiliary site capable of binding a Lewis acid (LA(II)); we used this unique feature to further mo
170 the fatty acid precursor, including linoleic acid (LA), arachidonic acid (AA), docosahexaenoic acid (
171 nces in wheat protein chemistry and shikimic acid levels, especially when applied earlier than recomm
172 cally disordered proteins (IDPs) and nucleic acids like RNA and other polynucleotides play a key role
173 nd that the cleavage site in this 1192-amino-acid-long fragment is located between amino acids 961-97
175 , increasing production of short chain fatty acids (mainly acetate and lactate) and favoring growth o
180 ening of stomata in plants with crassulacean acid metabolism (CAM) is mainly shifted to the night per
182 letal muscle may contribute to reduced amino acid metabolism and insulin resistance in MHD patients.
183 connected to intracellular pathways of fatty acid metabolism and therefore uniquely poised to communi
184 o-toxic factors, such as endotoxins and bile acids, might mediate parenchymal renal injury in patient
185 r modulators, which often feature carboxylic acid motifs for target engagement, have emerged as a cla
186 t and safe delivery to cancer cells, nucleic acids must generally be packaged into a vehicle, such as
187 itable for the activation of 4-methylbutyric acid (N-debenzoyl-N-(2-methylbutyryl)taxol side chain),
188 ulin protein 1 (NRG1) is a large (> 60-amino-acid) natural peptide ligand for the ErbB protein family
189 mes unstable when fused to the last 10 amino acids of SpxA2 but remained stable when fused to the C-t
190 by the brain, D-serine, an endogenous amino acid, offers new hope as a therapeutic agent for refract
191 g the catalytic reaction parameters, benzoic acid or benzaldehyde can be selectively optimized as the
192 ny organic and main-group compounds, usually acids or bases, can accelerate chemical reactions when u
193 , incubated with fluorescently labeled fatty acids or glucose analog, and analyzed by confocal micros
194 tor CD36, accumulated lipids, and used fatty acid oxidation (FAO) instead of glycolysis for energy.
195 nvolving oxidative phosphorylation and fatty acid oxidation (FAO) with substantial accumulation of ac
198 es including Delta1-piperideine-6-carboxylic acid (P6C), alpha-aminoadipic semialdehyde (alpha-AASA)
200 myelins with fully saturated sphingoid-fatty acid pairs (RR Q4 versus Q1 = 3.15; 95% CI: 1.75, 5.67;
204 rom maize using pyrrolidinyl peptide nucleic acid (PNA) immobilized on a magnetic solid support as a
205 a pro-drug that is converted into pyrazinoic acid (POA) by pyrazinamidase, however, the exact target
206 ructural analyses to identify key ACE2 amino acid positions including 30, 83, 90, 322, and 354 that d
207 es, we show that depletion of the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhi
208 osynthetic pathway, defined by (1) the fatty acid precursor, including linoleic acid (LA), arachidoni
212 3)C and Delta(13)C values of the major fatty acids, provides chemical evidence for milk, meat, and pl
213 nstrate a homogeneous and isothermal nucleic acid quantification strategy based on C2CA and optomagne
216 sensors for detection of two putative fatty acid receptors, G protein-coupled receptor 120 (GPR120)
217 anding the substrate scope of the carboxylic acid reductase toward noncognate omega-hydroxylic acids.
218 tually all analyzed strains had single amino acid replacements in penicillin-binding protein 2X (PBP2
220 reactive and footprint broadly several amino acid residue side chains on the time scale of submillise
221 vity, we propose that those C-terminal amino acid residues are a potentially targetable motif of TIMP
222 y for cleavage after asparagine and aspartic acid residues during in-solution digestions of proteomes
223 te-specific replacement of active-site amino acids revealed the presence of a water-coordinating aspa
224 an breast cancer cells that express a sialic-acid rich glycocalyx also induced protease release, and
225 g transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a criti
231 A novel bis-pillar[5]arene dicarboxylic acid self-assembles in the presence of 1,12-diaminododec
232 regulated by the Ssy1-Ptr3-Ssy5 (SPS) amino acid sensing system and have been proposed to have disti
235 peptide peaks with their corresponding amino acid sequence by database search and subsequent MALDI-TO
236 eost Sws2 photopigments for which both amino acid sequence information and experimentally measured la
237 w natural interstrain variation in the amino acid sequence of gO influences the biology of HCMV.
239 ed with cuprizone and treated with anacardic acid showed lower g-ratio scores when compared to contro
240 ning GABA(A) receptors, the derivative SH53d-acid shows superior (>40-fold) affinity selectivity and
242 ith radiation and polyinosinic-polycytidylic acid significantly expands the proportion of proliferati
243 crystallinity, micro-/mesoporosity, Bronsted acid site density and distribution (in micro- vs. mesopo
245 the use of amino acid quantitation and amino-acid-specific isotope ratio analysis of scalp hair of Am
246 p inhibited growth, and induced a GCN4 amino acid starvation response, indicative of uncharged tRNA a
248 viability assays, we report that point amino acid substitutions in the trigger loop, a flexible eleme
250 sucrose and increases in ethanol and lactic acid, suggesting that resource competition shapes organi
253 elating with this, administration of a fatty acid synthase inhibitor, cerulenin, also alleviated the
254 l-CoA, the rate-limiting substrate for fatty acid synthesis (FAS), is produced in the soma and delive
255 ociated with oil synthesis (27 genes), amino acid synthesis (four genes) and the tricarboxylic acid (
257 rylation facilitates the increase in nucleic acid synthesis required for anabolic cell growth and pro
258 s to the germline; there it is used in fatty acid synthesis to critically support embryonic developme
260 s conjugation is interrupted in a GCC acetic acid system, providing an explanation for the absence of
261 ticle biosensor enables detection of nucleic acid targets using a smartphone coupled to an appropriat
262 ndidate for generating a CoA ester of tiglic acid (Taxol B side chain), TmAAE3 and TmAAE13 as suitabl
263 icient enzymes for the activation of butyric acid (Taxol D side chain), TmAAE13 as the best candidate
264 synthesis (four genes) and the tricarboxylic acid (TCA) cycle (five genes), and four genes (GmFATB1a,
265 ty acid oxidation activity and tricarboxylic acid (TCA) cycle metabolites were measured in cells coll
266 ycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, and amino acid synthesis/catabolism.
268 donic acid (Scia) is a Delta5-olefinic fatty acid that is particularly abundant in edible pine seeds
269 synthetic single-stranded chains of nucleic acids that target specific RNA transcripts through sever
270 nonenzymatically cyclize to form quinolinic acid, the precursor for de novo biosynthesis of nicotina
276 method is based on conversion of carboxylic acids to the corresponding organic halides via selective
277 er-mediated histidine uptake, system L amino acid transporter activity and Na(+) K(+) -ATPase activit
278 ethodology developed involves two sequential acid treatments followed by stepwise ethanol precipitati
279 s its activity is independent of the nucleic acid type (RNA or DNA), its strandedness (single or doub
280 alpha5 subunit-containing gamma-aminobutyric acid type A receptors would improve cognitive performanc
283 4 single codon changes encoding 14,160 amino acid variants in Hsp90 and quantified growth effects und
284 datasets probing the effects of single amino acid variation on enzyme activity and steady-state cellu
285 ro restoration of TET expression by ascorbic acid was accomplished in cultured human keratinocyte ste
286 yimides with ketones, esters, and carboxylic acids was achieved employing the di-tert-butyl peroxide
287 rue ileal digestibility (TID) of their amino acids was determined in minipigs, to calculate the diges
288 enic, neochlorogenic, p-coumaric and caffeic acids was measured in most of the fruit beers in respect
289 flavonoids, organosulfur compounds, organic acids, water soluble sugars and amino acids in three oni
290 evels of eicosadienoic acid and octadecanoic acid were significantly higher in SCH in the third trime
294 ga-hydroxy fatty acids and polyhydroxy-fatty acids were specifically affected, while the reduction of
295 reviously, Bode's chiral acylated hydroxamic acids were used to determine the stereochemistry of prim
296 intensity for polar molecules such as amino acids, which has important implications for SIMS imaging
298 ines the natural catabolism of charged amino acids with a catalytically efficient and thermodynamical
299 g the transvinylation reaction of carboxylic acids without losing their original metathetic activity.
300 visualization of processes involving nucleic acids without perturbing their natural properties and be