ライフサイエンスコーパス: acid-base

1 ydroxide and likely functions as the general acid-base.

2 is balanced out by paracellular shunting of acid/base.

3 ign, synthesis, and evaluation of carboxylic acid-based ACC inhibitors with organic anion transportin

4 que to the conventional template based Lewis acid/base activation methods, herein, we report on a sim

5 Recent advances in designing hyaluronic acid-based, actively targeted, hyaluronidase- or reactiv

6 -Cas loci provide prokaryotes with a nucleic-acid-based adaptive immunity against foreign DNA.

7 rough introduction of stoichiometric boronic acid-based additives.

8 ystallization has been embodied as the Lewis acid-base adduct formed by metal halides (serve as Lewis

9 it is proposed to constitute efficient Lewis acid-base adduct in the SnI2 deposition step to modulate

10 the photophysical behavior between the Lewis acid-base adducts and free acid-base pairs is examined.

11 ns involving the use of both classical Lewis acid-base adducts and frustrated Lewis pair systems are

12 opharmacology, not previously seen for amino acid-based AMPA receptor antagonists, X-ray crystal stru

13 ns of DNA at the level of individual nucleic acid bases and base pairs is important for elucidating m

14 orescence to examine the effects of multiple acid-base and electrolyte disturbances on expression of

15 ays (hypoxia tolerance, oxygen uptake rates, acid-base and haematological status) were conducted upon

16 anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in

17 ts have long known that CO2 directly affects acid-base and ion regulation, respiratory function and a

18 that the reaction is regulated by off-cycle acid-base and ligand exchange processes.

19 Here, we report hydroxamic acid-based and benzoic acid-based inhibitors (SH5-07 and

20 ntified Glu-294 and Glu-361 as the catalytic acid/base and nucleophile, respectively, and we observed

21 and CRS and may restore normal electrolyte, acid-base, and fluid balance before renal recovery.

22 tubule is critical for blood pressure (BP), acid-base, and potassium homeostasis.

23 iloring particle size, morphology, porosity, acid-base, and redox properties of solid catalysts are e

24 ing mode not previously identified for amino acid-based antagonists.

25 nments and exceptional chemical stability in acid/base aqueous solutions.

26 allenges faced by current methods of nucleic acid-based assays and symptom-based diagnosis, which hav

27 Among them immunoassays and Nucleic acid-based assays provide results within 24h, but they a

28 point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain reaction,

29 Nucleic acids-based assays, particularly aptamers, have a great

30 Nucleic acid-based assemblies that interact with each other and

31 nd very low affinity was found for picolinic acid-based auxins (picloram) and quinolinecarboxylic aci

32 tidic foldamers, consisting of various amino acid based backbones, have been the most studied from a

33 The optimal approach to managing acid-base balance is less well defined for patients rece

34 Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connex

35 ammonia toxicity and aid in osmoregulation, acid-base balance, and excretion have been well document

36 metabolic alkalosis in the regulation of the acid-base balance.

37 scades are intimately linked to the cellular acid-base balance.

38 tion and is involved in Na(+) absorption and acid-base balance.

39 urine output, osmolality, salt excretion, or acid-base balance.

40 intravenously, have fewer adverse effects on acid-base balance.

41 nergy to maintain their calcified shells and acid/base balance with ocean acidification.

42 age of narrow HOMO-LUMO energy gap and Lewis acid-base bifunctionality of divalent Si centres.

43 The use of poly-l-lactide acid-based bioresorbable scaffolds is limited in daily c

44 The Absorb everolimus-eluting poly-L-lactic acid-based bioresorbable vascular scaffold (BVS) provide

45 ased pharmaceutical development, and nucleic acid based biosensor device design.

46 Functional nucleic acid-based biosensors are emerging tools that are capabl

47 Nucleic-acid-based biosensors have enabled rapid and sensitive d

48 To inhibit GBMs more effectively, polymalic acid-based blood-brain barrier crossing nanobioconjugate

49 gh-molecular-weight, amorphous poly-l-lactic acid-based BRS (Amaranth BRS).

50 igh molecular weight amorphous poly-l-lactic acid-based BRS (APTITUDE, Amaranth Medical [AMA]) to Abs

51 the quantification and modification of amino acid-based cargo stability.

52 The acid/base-catalysed Kemp elimination of 5-nitro-benzisox

53 tent with its likely role as acid in general acid base catalysis (delta and beta catalysis).

54 s, charge storing materials, and homogeneous acid-base catalysis among others.

55 te, thus suggesting a direct role in general acid-base catalysis, the function of A32 is less clear.

56 the distinction between general and specific acid-base catalysis.

57 One outcome of the acid-based catalysis is that 1-phenylalkanes cannot be p

58 Acid-based catalysis of procyanidin B2 and B3 produced f

59 selectivity that is opposite to traditional acid-based catalysis.

60 the rational design of selective and robust acid-base catalyst for C-C coupling via aldolization rea

61 The mechanism involves a histidine as acid/base catalyst, which is unique for glycosidases.

62 s to transcript backtracking, rather than as acid-base catalysts.

63 tive catalytic activity of such bifunctional acid-base catalysts.

64 The acid/base catalysts also promote the dedeuteration of ac

65 Instead of a Bronsted acid-based catalytic activation, the chiral phosphate ac

66 lishes enzyme activity, thus identifying the acid/base catalytic machinery.

67 functions by means of the synthetic nucleic-acid-based CDNs, the systems introduce versatile perspec

68 and indirect photolysis on citric and malic acid-based CDs.

69 capable of plasticity in response to extreme acid-base challenges.

70 by metal ion-loaded nickel-nitrilotriacetic acid-based chelator heads conjugated to fluorophores, wh

71 We also assessed blood acid-base chemistry and haemoglobin-O(2) binding affinit

72 In aqueous environments, acid-base chemistry and, by extension, aqueous-phase pH,

73 Oxygen is an essential participant in the acid-base chemistry that takes place within many enzyme

74 erve polar interactions but are incapable of acid-base chemistry, had little effect on either phospho

75 ent with a variety of experiments concerning acid-base chemistry, ion distributions near hydrophobic

76 Besides their obvious importance in acid-base chemistry, these ions play an important role i

77 le of the conserved glutamate on active site acid-base chemistry, we mutated the putative proton dono

78 profile strongly influenced by the redox and acid-base chemistry.

79 of cleaving H(2) outside of the usual Lewis acid/base chemistry described by the concept of frustrat

80 nal modes change in the presence of possible acid/base chemistry.

81 llustrates an approach for designing boronic acid-based chemoreceptors for the recognition and quanti

82 We find that atmospheric ions and small acid-base clusters, which are not generally accounted fo

83 , we determined that the preclusion of Lewis acid-base complexation between the Ni catalyst and the b

84 The Lewis acid-base complexes involving CO and Xe can be cleaved p

85 kable ability to form intermediate-stability acid-base complexes with a wide number of metal chloride

86 A betulinic acid-based compound, bevirimat (BVM), inhibits HIV-1 mat

87 Acid-base conditions modify artery tone and tissue perfu

88 auto-inductive protocol employs a Meldrum's-acid-based conjugate acceptor (1) as a latent source of

89 e specifically functionalized by a myriad of acid-base conjugation strategies for applications rangin

90 ed/translated proteins, we introduce nucleic acid-based constitutional dynamic networks (CDNs) as fun

91 ities, we introduce the evolution of nucleic-acid-based constitutional dynamic networks (CDNs) that f

92 The emergence of nucleic acid-based constitutional dynamic networks, CDNs, from a

93 An alpha-amino acid-based core structure, derived from a hydantoin core

94 In contrast with the common acid-base coupling pathway, the HNO is not voluntarily y

95 The in situ switching upon several acid/base cycles is also demonstrated.

96 redox-robust thorium compounds engage in an acid-base/dehydrocoupling route.

97 Nucleic acid-based detection methods are widely accepted as the

98 as a bio-specimen for non-invasive, nucleic acid-based detection of GI diseases.

99 on-site testing, there is a need for nucleic acid based diagnostic tools combining the sensitivity, s

100 A typical nucleic acid-based diagnostic test consists of three major steps

101 is of tularemia by blood culture and nucleic acid-based diagnostic tests is insufficiently sensitive.

102 d target amplification-free tool for nucleic acid based diagnostics.

103 atform for rapid field deployment of nucleic acid-based diagnostics using consumer-class quadcopter d

104 bolic acidosis with that of patients without acid-base disorders.

105 rolling living systems, we introduce nucleic acid-based dissipative constitutional dynamic networks (

106 ascular perfusion, and blood pressure during acid-base disturbances and altered tissue metabolism.

107 ickly compensate to environmentally relevant acid-base disturbances using baseline cellular machinery

108 eview, we discuss recent progress in nucleic acid-based drug delivery strategies, their potential, un

109 logies for large-scale production of nucleic acid-based drugs have been exploited for various therape

110 nhancing the drug-like properties of nucleic acid-based drugs, including antisense oligonucleotides (

111 The acid-base dynamics of these acylated anthocyanins was ev

112 hesis affects energetic budgets and internal acid-base dynamics, changes in it due to OA or light cou

113 For a nucleic acid-based electrochemical sensor with signal-off behavi

114 catalyzing the oxygen evolution reaction in acid-based electrolyzers must be guided by the proper ba

115 s employed identical LC settings with formic-acid-based eluents in the last dimension.

116 Herein, an acid-base engineered foam is employed for separation of

117 de antibodies, lectins, aptamers and boronic acid-based entities.

118 rent pH values in order to determine its (i) acid-base equilibria, (ii) coordination equilibria, (iii

119 based on a conceptually different outlook on acid-base equilibria.

120 We additionally identified the internal acid-base equilibrium as a key determinant of the GCaMP

121 An acid-base equilibrium between 3 and 2 was achieved throu

122 ling constant observed at the midpoint of an acid-base equilibrium.

123 erating CO(2) / HCO3- -mediated buffering of acid-base equivalents, they could not appreciably affect

124 alkyne dehydrocarbation with a carbon Lewis acid based FLP to form the new C-C bond.

125 has been devoted to the development of amino acid-based fluorophores that do not require a specific e

126 ew era was marked by the recent isolation of acid-base free main group carbonyl analogues, ranging fr

127 A new one-pot, transition-metal, acid/base-free domino process is developed for the regio

128 Attributed to the redox neutral and strong acid/base-free reaction conditions, high chemoselectivit

129 a strained active site geometry, with Lewis acid/base frustration enforced by the protein secondary

130 ode extension and the development of nucleic acid-based functional nanodevices, DNA duplexes containi

131 37 very polar model chemicals with different acid/base functionalities.

132 organic backbone polymers, discuss how Lewis acid/base functionalization of polymers results in unpre

133 Streptomyces plicatus in which the catalytic acid/base glutamate has been mutated to an alanine (SpHe

134 ed: variation in surface complexation, Lewis acid/base hardness, steric hindrance, and electrostatic

135 An acetic acid-based homemade lure, prepared by impregnating the a

136 Oxygenation and acid-base homeostasis are maintained by matching ventila

137 ear fluid and regulation of electrolytes and acid-base homeostasis in the collecting duct system of t

138 Acid-base homeostasis is critical for normal growth, dev

139 These sensors can be used to manage of acid-base homeostasis, diabetes, and liver failure in po

140 e (V-ATPase) and are extensively involved in acid-base homeostasis.

141 where it functions to maintain normal bodily acid-base homeostasis.

142 molecular orbital analyses and the hard-soft acid-base (HSAB) theory is advanced to explain the obser

143 structed a ROS sensor comprising an ascorbic-acid-based hydrogel encapsulating luminescent amphiphili

144 ethod to assemble stimuli-responsive nucleic acid-based hydrogel-stabilized microcapsule-in-microcaps

145 A phenylboronic acid-based, hydrogel-interlayer Radio-Frequency (RF) res

146 nature of both RF read-out and phenylboronic acid-based hydrogels will enable biosensors capable of l

147 eurological symptoms that accompany systemic acid/base imbalances.

148 A magnetic graphene nanoribbon-boronic-acid-based immunosensor was developed and tested for the

149 retion might be a better and perhaps earlier acid-base indicator of risk than serum bicarbonate, part

150 we report hydroxamic acid-based and benzoic acid-based inhibitors (SH5-07 and SH4-54, respectively)

151 n, and biological activity of new hydroxamic acid-based inhibitors with nanomolar affinity for human

152 onal monomers preventing the favorable Lewis acid base interaction.

153 e unique host-guest interaction (e.g., Lewis acid-base interaction), between F(-) and MOF host, a hig

154 a bridging oxygen of the support via a Lewis acid-base interaction.

155 ems that possess no obvious frustrated Lewis acid-base interaction.

156 tatic attraction, ligand exchange, and Lewis acid-base interactions.

157 ubstrate selectivity is achieved by means of acid-base interactions.

158 Application of a new 1-naphthyllactic acid-based iodine(III)-catalyst allows the control of te

159 ghly potent 3-azabicyclo[3.1.0]hexane acetic acid-based KHK inhibitors by combined use of parallel me

160 g the last universal ancestor of all nucleic-acid-based life.

161 approach to other reaction types, including acid-base, ligand exchange, and redox, as well as to col

162 Aptamers are nucleic acid-based ligands that exhibit promising features inclu

163 Nucleic acid-based materials enable sub-nanometer precision in s

164 oups to degrade lippopolysaccharide using an acid/base mechanism.

165 up identifications were confirmed by nucleic acid-based methods and included nine group A and 12 grou

166 nsatory adaptation that can confound nucleic-acid-based methods that involve slow depletion or perman

167 obes to target cells is critical for nucleic acid-based methods to successfully image low-abundance T

168 Other nucleic acid-based methods were expensive and required trained p

169 ed manufacturing expertise for these nucleic-acid-based modalities, especially in the developing worl

170 We used a physical-chemical acid-base model to understand the factors influencing bl

171 ion events in RNA nanotechnology and nucleic-acid-based molecular computation.

172 Nucleic acid-based molecular diagnosis reveals valuable informat

173 Nucleic acid-based molecular diagnostics are particularly well s

174 of the major obstacles to implement nucleic acid-based molecular diagnostics at the point-of-care (P

175 s technology has opened a new era of nucleic acid-based molecular diagnostics.

176 able polymers chitosan-sodium alginate-oleic acid based nano-carrier loaded with lutein (LNCs) was pr

177 creation of a stunning diversity of nucleic acid-based nanodevices.

178 switches into more complex synthetic nucleic acid-based nanostructures and functionalized smart mater

179 y describes the use of tailored poly(acrylic acid)-based (NaPAA) hydrogels as effective sorbents for

180 ary groups (e.g., hydrogen bonding, Bronsted acid/base) near the active site of metal-containing cata

181 Aqueous proton transport plays a key role in acid-base neutralization and energy transport through bi

182 ive evidence for the hydrolysis/methanolysis acid-base neutralization pathway, as formulated by Manfr

183 orrosion, ash hydration and carbonation, and acid-base neutralization.

184 vibrational frequencies for the monoboronic acid base of our bisboronic acids, glucose and fructose.

185 compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.

186 To circumvent this problem, several nucleic acids based on amino-sugar nucleotides have been studied

187 one correspondences between subsets of amino acids based on atomic coordinates).

188 o from sulfonamides and aliphatic carboxylic acids based on reactions with TMMS and one or two CAD ex

189 .g. proteins, dyes, drugs, biomarkers, amino acids) based on application of the alternating electric

190 transformation does not require an exogenous acid, base, or transition metal catalyst; instead the ad

191 uptake by ASBT, and the development of bile acid-based oral drug delivery for ASBT-targeting, includ

192 Previously, we found that an amino acid-based oral rehydration solution (AA-ORS) improved g

193 Chiral phosphoric acid based organocatalysis and visible-light photocataly

194 um by a linear molecular pump are induced by acid-base oscillations.

195 erse CNTs rely on tedious and time-consuming acid-based oxidation.

196 uded that the catalytic cooperativity of the acid-base pair can be affected by two factors: (1) the c

197 work not only demonstrates a balanced Lewis acid-base pair for the highly active and selective casca

198 This Lewis acid-base pair is initiated and preserved by disrupting

199 regions are widely buffered by the conjugate acid-base pair NH(4) (+)/NH(3) (ammonium/ammonia).

200 single-cell technique that harnesses nucleic acid base pairing to detect the abundance and positionin

201 With these main-group element Lewis acid base pairs, it is not only possible to polymerize s

202 alently connected linear sequence of nucleic acid base pairs.

203 A class of intramolecular Lewis acid-base pairs containing Lewis acidic dimesitylboranes

204 between the Lewis acid-base adducts and free acid-base pairs is examined.

205 a result, ZnxZryOz catalysts with only Lewis acid-base pairs were discovered, on which nearly a theor

206 of relevant intracellular and extracellular acid-base parameters in a coral reef fish exposed to ele

207 on toward downstream applications in nucleic acid based pathogen detection.

208 s we will argue, future endeavors in nucleic acid-based pattern generation will be most greatly advan

209 Nucleic acid-based pattern recognition receptor agonists are eff

210 ical insights into nuclear crowding, nucleic acid based pharmaceutical development, and nucleic acid

211 Acid-base physiology was measured with arterial blood ga

212 r, an important requirement toward a nucleic-acid-based point-of-care diagnostic system.

213 study, structurally different ionic phthalic acid based polyesters (the number-average molecular weig

214 the early application and success of hydroxy acid based polyesters as degradable sutures and controll

215 rs classified as polyacids (e.g., carboxylic acid based polymers, sulfonamides, anionic polysaccharid

216 In acidic or basic environments, acid-base polymers acquire surface charge due to protona

217 locondensation reactions using the hard-soft acid-base principle, quantum chemical calculations (dens

218 o-aminophenoxy)ethane-N,N,-N',N'-tetraacetic-acid-based probe allows Ca(2+) ion sensing with 0.02-0.0

219 Recently, nucleic-acid-based probes have emerged as a promising platform f

220 onstructing cell membrane-anchorable nucleic acid-based probes.

221 tional effect in an o-hydroxydihydrocinnamic acid based prodrug design.

222 delivery for ASBT-targeting, including bile acid-based prodrugs, bile acid/drug electrostatic comple

223 We propose a general acid base-promoted catalytic mechanism, invoking direct

224 can be controlled to greatly tune catalytic acid/base properties and consequently the reaction selec

225 dicate correlation between dual polarity and acid-base property.

226 mer (Slow Off-rate Modified Aptamer) nucleic acid-based protein-binding reagents allows for biomarker

227 on of miRNA was determined by locked nucleic acid-based quantitative real-time polymerase chain react

228 Existing fluorine-18-labeled amino acid-based radiotracers predominantly visualize amino ac

229 ed to monitor minuscule heat evolution in an acid-base reaction and the decomposition of H(2)O(2) by

230 2)O) and ethanol (C(2)H(5)OH), conducting an acid-base reaction between aqueous droplets of sodium hy

231 sign CO2 resistant membranes using the Lewis acid-base reaction concept and thermodynamics perspectiv

232 eport a functionalization method via a Lewis acid-base reaction that does not alter the host structur

233 co-workers have implicated an excited-state acid/base reaction as the source of the nonradiative dec

234 ,4-diyl)dinitramidate anion were prepared by acid-base reactions and fully characterized by infrared,

235 Acid-base reactions are ubiquitous in nature.

236 Our findings on the distinctly different acid-base reactivities for aromatic hydroxyl and aromati

237 function as a major source for fast in vivo acid-base reactivity in the blood plasma, possibly penet

238 the proton-transfer reactions underlying the acid/base reactivity at the interface.

239 the PP-chip and undergoes a reaction with an acid-based reagent.

240 ortho-Aminomethylphenylboronic acid-based receptors with appended fluorophores are comm

241 old electrodes were generated using an amino acid based recognition element, N-methacryloyl-L-histidi

242 Apart from Lewis acid-base recognition, hydrogen bonding recognition is a

243 we present a mechanism comprising a coupled acid-base/redox reaction that leads to a proton-induced

244 sessing the energetic demand associated with acid-base regulation by examining ion movement and O2 co

245 alated cells of the collecting duct impaired acid-base regulation by the kidney.

246 Energetic costs associated with ion and acid-base regulation in response to ocean acidification

247 es crucial for normal inner ear function and acid-base regulation in the kidney.

248 chins than mussels, suggesting that internal acid-base regulation in urchins may substantially modera

249 may be compromised, while genes involved in acid-base regulation were up-regulated.

250 rbonic anhydrase IX (CAIX), one of the major acid/base regulators in cancer cells, forms a protein co

251 Nucleic acid-based replication has been pondered during cycles o

252 ding the catalytic nucleophile (Glu-297) and acid/base residue (Glu-160).

253 several mutants with mutation at the general acid/base residue E274 of the Lactobacillus casei alpha1

254 tein sequence using non-coordinating and non-acid base residues in the helical core can perturb metal

255 e-based mechanism involves the two invariant acid/base residues, Glu499 and Tyr578, poised on each si

256 ith limited capacity for specialized nucleic acid-based reverse transcription polymerase chain reacti

257 r-His-Asp triad, proposed to serve a general acid-base role, minimally affect catalytic activity.

258 Using a well-known boronic acid-based saccharide sensor (3), this work reveals a ne

259 Also included is a section on Lewis acid-base secondary coordination sphere interactions, wh

260 While previously reported nucleic acid-based self-replicating systems rely on presynthesis

261 We propose that a sialic acid-based "self-associated molecular pattern" on erythr

262 ated in other ortho-aminomethylphenylboronic acid-based sensors.

263 lypeptide chain primary sequence and nucleic acid base sequence, control the two-phase coexistence re

264 rted binding site for synthetic, non-nucleic-acid-based, sequence-specific DNA-binding molecules.

265 opurity and are prone to undergo deleterious acid-base side-reactions under the reaction conditions f

266 orrelations between the catalytically active acid-base sites and reactants, it is concluded that the

267 dimethenamid (DM), a model compound lacking acid-base speciation.

268 1 exhibits high solvent and acid/base stability, and resistance to 400 kGy beta irra

269 and ammonia can nucleate directly through an acid-base stabilization mechanism to form ammonium nitra

270 hock, we measured hemodynamics, blood gases, acid-base status, metabolism, organ function, cytokine p

271 Herein, we developed hyaluronic acid-based substrates capable of sequential photodegrada

272 tter's high-melting fraction, with the oleic acid-based surfactants and canola oil showing little inf

273 cocoa butter crystal size whereas the oleic acid-based surfactants and canola showed no notable effe

274 lized RNA-binding protein is a novel nucleic-acid-based surveillance mechanism of RQC.

275 The acid-base switching of complexes formed from anti-electr

276 Nucleic acid based techniques, such as quantitative PCR (qPCR) a

277 es, such as immunological assays and nucleic acid-based techniques, Raman spectroscopy (RS) is a nond

278 Control of protein levels by nucleic-acid-based technologies has proven to be a useful resear

279 apacity lies at the heart of several nucleic acid-based technologies that are finding applications in

280 tics, which could be integrated with nucleic acid-based tests and isothermal amplification experiment

281 erase chain reaction tests and rapid nucleic acid-based tests offer good performance in most circumst

282 Nucleic acid-based tests were assumed to perform at 100% specifi

283 n; however, without its input as a catalytic acid-base, the oxidative half-reaction where carboxylati

284 OH(-)-(H(2)O) (x)-AM(+) as per the hard-soft acid-base theory, thereby selectively promoting the HER.

285 ability was developed based on the hard/soft acid-base theory.

286 we find can be explained using the hard/soft acid-base theory.

287 s represent a promising new class of nucleic acid-based therapeutics in cancer.

288 However, their compatibility with nucleic-acid-based therapeutics is not fully explored.

289 afe and sustained release of various nucleic acid-based therapeutics with applications in both fundam

290 g, and remains a desirable route for nucleic-acid-based therapeutics.

291 onomers in the polyester bulk in contrast to acid-base titrations where those monomers severely disto

292 ntified via diffuse layer modeling of the GO acid/base titrations.

293 BITs) are two powerful activators of certain acid-base transporters.

294 ic anhydrases form transport metabolons with acid/base transporters in human tumor tissue and that th

295 rks can also be readily regenerated via mild acid/base treatment and maintain constant boron adsorpti

296 We exploit a reversible acid-base triggered molecular shuttling process to switc

297 tigated safety and efficacy of a novel boric acid-based vaginal anti-infective with enhanced antibiof

298 ia for metabolic acidosis and 145 had normal acid-base values.

299 tau biosensor cells, indicating that nucleic acid-based vectors can be used for inhibitor delivery.

300 CE was utilized for the detection of nucleic acid bases with a well resolved oxidation peak for the i