ライフサイエンスコーパス: acidification

1 cidification) or discretely (~3 months after acidification).

2 ves under impending global warming and ocean acidification.

3 t protonation, which occurs upon muscle cell acidification.

4 gulation of V-ATPase trafficking and urinary acidification.

5 educed coral calcification rates under ocean acidification.

6 ubcellular location, or changes in endosomal acidification.

7 equestration but delayed lysosomal fusion or acidification.

8 e-mediated processes, microbial activity and acidification.

9 quaculture leases differing in environmental acidification.

10 plies the potential for acclimation to ocean acidification.

11 tive autophagic flux due to reduced lysosome acidification.

12 f this species to contemporary environmental acidification.

13 dy reduces atherosclerosis and blocks lesion acidification.

14 red: de novo protein synthesis and endocytic acidification.

15 ain fatty acid (SCFA)-mediated intracellular acidification.

16 a job-sharing role with V-ATPase in vacuolar acidification.

17 ction as well as by a reduction in lysosomal acidification.

18 tand future climate-driven change to habitat acidification.

19 uires Src phosphorylation and endo/lysosomal acidification.

20 nge effects-in particular, ocean warming and acidification.

21 that are not as plant-available as prior to acidification.

22 elevated seawater CO(2) levels due to ocean acidification.

23 a consequence of recovery from anthropogenic acidification.

24 vations that NCOA7 is required for lysosomal acidification.

25 docytosis, protein maturation, and lysosomal acidification.

26 matter supporting excess respiration driving acidification.

27 greater than atmospheric CO(2)-driven ocean acidification.

28 ting against eutrophication and global water acidification.

29 ing, MVB fusion, exosome uptake and endosome acidification.

30 rete sample analysis at least 3 months after acidification.

31 ceptor, respectively, and impaired lysosomal acidification.

32 oteasome activity but dependent on lysosomal acidification.

33 ure to contemporary and future environmental acidification.

34 ulated via chronic exposure to extracellular acidification.

35 l biomineralization, promoting resilience to acidification.

36 tion of high-latitude populations from ocean acidification.

37 This untimely egress depends on host cell acidification.

38 ncing browning associated with recovery from acidification.

39 global change, particularly increasing ocean acidification.

40 a second mutation in lysosomal biogenesis or acidification.

41 tated further H(+)-ATPase-mediated endosomal acidification.

42 ch as light exposure, temperature, and ocean acidification.

43 ted to end-Triassic global warming and ocean acidification.

44 ied in semiarid grasslands experiencing soil acidification.

45 s to the protection of the brain milieu from acidification.

46 CO(2) can cause intracellular acidification.

47 fied shells and acid/base balance with ocean acidification.

48 C(6) F(5) )(3) ], which releases N(2) O upon acidification.

49 TM3, SLC15A3, and CNP contribute to lysosome acidification.

50 with the complete decay of ECD signals upon acidification.

51 ls reduced autophagic flux and autophagosome acidification.

52 nhibited, so long as cells undergo cytosolic acidification.

53 contrast to the uniform trends of open-ocean acidification (-0.0004 to -0.0026 pH units yr(-1)) drive

54 ed food and soil security, and reduced ocean acidification(2-4).

55 d a significant reduction in urine pH (i.e., acidification) accompanied by an increase in blood pH an

56 Ocean warming and acidification act concurrently on marine ectotherms with

57 Extracellular acidification activated two types of currents in a conce

58 Its cytoplasm acidifies to pH 5.6; acidification activates pathogenicity island 2 (SPI-2).

59 lobal warming (GWP), eutrophication (EU) and acidification (AD) impacts of soybean production in near

60 er increasing pCO(2) , suggesting that ocean acidification alleviates oxidative stress in kelp, which

61 Environmental acidification also increased extracellular vesicle produ

62 Acidification also increased mammary carcinoma cell moti

63 Physiological heat-triggered acidification also increases population fitness and prom

64 of gold nanostar morphology is induced upon acidification, an effect that depends on both pH and aci

65 emission was positively correlated with soil acidification and an increase in the relative abundances

66 cell-mediated inflammation through impairing acidification and cathepsin K secretion.

67 ) exchanger (Nhe1) and induces extracellular acidification and cell apoptosis.

68 After acidification and centrifugation of pressure-treated sol

69 ce extent, increase in riverine input, ocean acidification and changes in primary productivity are cr

70 nthase beyond its canonical role in vacuolar acidification and cytosolic PP(i) scavenging.

71 As a consequence, lysosomal acidification and degradation of phagocytosed materials

72 ver, this regulating service causes warming, acidification and deoxygenation of deep waters, leading

73 stically, Hvcn1 deficiency delayed endosomal acidification and enhanced intracellular reactive oxygen

74 2) and DO cycles in severity and duration of acidification and hypoxia.

75 subunit VMA5 expression, impairing lysosome acidification and inhibiting autophagic protein degradat

76 ar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro

77 smegmatis Polyphosphate inhibited phagosome acidification and lysosome activity in D. discoideum and

78 doption of an ecosystem perspective to ocean acidification and multiple stressors in productive aquat

79 ), which is responsible for proper lysosomal acidification and protein degradation.

80 nduced aggregation and co-precipitation upon acidification and significantly reduced purity (~71%).

81 P132 overexpression include reduced apoplast acidification and suppressed vegetative growth.

82 o the cell cytosol, which leads to cytosolic acidification and the generation of action potentials.

83 r long-term culture in predicted end-century acidification and warming conditions.

84 Here we show that ocean acidification and warming, alone and in combination have

85 re measured both continuously (4.5 min after acidification) and discretely (repeatedly from 1 to 151

86 tems, such as climate change (warming, ocean acidification) and pollution, with irreversible ramifica

87 paired cellular acidification, extracellular acidification, and bone resorption.

88 an, through warming, oxygen loss, increasing acidification, and changing particulate organic carbon f

89 enario in terms of global warming potential, acidification, and eutrophication in ~63, ~77, and ~100%

90 ssors: rising sea surface temperature, ocean acidification, and increased prevalence of infectious di

91 uman health, air pollution, ozone depletion, acidification, and land transformation.

92 gh TRPML1 channels is vital for trafficking, acidification, and other basic functions of these organe

93 hat local ecosystem processes modulate ocean acidification, and support the adoption of an ecosystem

94 Climate change and ocean acidification are altering marine ecosystems and, from a

95 Thus, the deleterious effects of ocean acidification are modulated by resource availability in

96 ulub impact, supporting impact-induced ocean acidification as a mechanism for ecological collapse in

97 adults were significantly more vulnerable to acidification as well as the additional stressors.

98 s of soil food webs, and highlight that soil acidification, as an anthropogenic stressor, reduced the

99 nt that can be effectively removed following acidification at the end of sample digestion.

100 itat suitability, but larvae are tolerant to acidification at this scale.

101 redicts that pH fluctuations decrease during acidification, but noise analysis of single-vesicle data

102 quired to ensure surface water recovery from acidification by 2050.

103 ts suggest that kelp will benefit from ocean acidification by a reduction in environmental stress how

104 ominance of woody vegetation as well as soil acidification by EM fungi, which are associated with gre

105 erns worldwide, nutrient enrichment and soil acidification can lead to substantial changes in the div

106 c analysis, taking into account growth rate, acidification capacity, proteolytic activity, cell envel

107 uricemia with UA crystalluria due to urinary acidification caused tubular obstruction, inflammation,

108 hat many tumors have increased extracellular acidification compared to healthy tissues.

109 Island, Australia, we simulated future ocean acidification conditions, and found reduced pH led to a

110 s how species may survive under future ocean acidification conditions, and help to reveal the traits

111 lic costs when exposed to experimental ocean acidification conditions, potentially limiting the energ

112 exity of responses within Crustacea to ocean acidification conditions.

113 of impaired PLGA degradation and intestinal acidification confirming an important enterohepatic axis

114 Results showed that strain growth and acidification correlate with peptide production and that

115 oupled during H(+)-ATPase-mediated endosomal acidification, crucial for ClC-5 activation by depolariz

116 nisms collected on the 2016 West Coast Ocean Acidification cruise in the California Current System.

117 ores with a calcite exoskeleton dissolved by acidification (decalcified).

118 of the histidine 98 residue, which is, after acidification, decoupled from the resting position and i

119 Acidification decreased overall mammary carcinoma cell v

120 sting a therapeutic approach to overcome the acidification defect.

121 ulture is vulnerable to the impacts of ocean acidification driven by increasing carbon dioxide (CO(2)

122 ermined that Acetobacter species counter the acidification driven by L. plantarum production of lacta

123 bsorption by the ocean as well as to coastal acidification driven by land run off and rising sea leve

124 ults extend evidence that impaired lysosomal acidification drives progressive lysosomal failure in mu

125 For instance, acidification due to carbohydrate fermentation or inflam

126 cifiers are particularly vulnerable to ocean acidification due to dissolution and a reduction in shel

127 ries and is particularly vulnerable to ocean acidification, due to its natural upwelling of carbon-en

128 suggest that shifts in plant cover and soil acidification during ecosystem development are associate

129 systems (i.e., wetter and warmer), increased acidification during pedogenesis was associated with dec

130 ell-known antiautophagy property of impeding acidification during the late stage of autophagic flux.

131 tic demands of pinto abalone caused by ocean acidification during winter will be exacerbated by seaso

132 r oxygen consumption (OCR) and extracellular acidification (ECAR) are widely used proxies for mitocho

133 ipneustes ventricosus) submitted to a 5 week acidification experiment (pHT of 8.1, 7.7, and 7.4).

134 rgeting Ac45 (AAV-sh-Ac45) impaired cellular acidification, extracellular acidification, and bone res

135 ene inactivations of lysosomal biogenesis or acidification factors causes vitamin B12 deficiency.

136 ycling of ESS is shown to reduce terrestrial acidification, freshwater eutrophication, and particulat

137 er membrane in most impact categories (e.g., acidification, global warming potential, and carcinogeni

138 d as an imminent threat to our oceans, ocean acidification has been documented in all oceanic basins.

139 onoamine transporter function and on vesicle acidification has been reported, a role of CAPS in vesic

140 lution and mechanical chip removal and ocean acidification has been shown to accelerate bioerosion ra

141 These drivers of environmental acidification have deleterious effects on biomineralizat

142 en (N) and phosphorus (P) contents, and soil acidification have greatly increased in grassland ecosys

143 mbined result of projected ocean warming and acidification, highlighting the susceptibility of coral

144 ave catastrophic biotic effects due to ocean acidification hindering biogenic carbonate production, w

145 re further suggested by media and apoplastic acidification, hygromycin B tolerance and changes in rel

146 patterns are important for predicting ocean acidification impacts, but are lacking in coastal oceans

147 , revealed specific requirements for luminal acidification in apical, but not basolateral, membrane p

148 -ATF4 hyperactivation and impaired lysosomal acidification in beta-cells lacking Furin, causing beta-

149 on, whereas increasing productivity enhances acidification in bottom waters of stratified coastal eco

150 observation, the importance of extracellular acidification in cancer is now considered a hallmark of

151 nitude over time, especially because of soil acidification in low diversity communities and especiall

152 iate acid extrusion to counter intracellular acidification in melanoma cells.

153 osomal-delivered MPO also disrupts lysosomal acidification in RPE cells, which coincides with nuclear

154 Using 30 mm propionate, we found that acidification in the absence of a change in PCO2 caused

155 obably due to TrkB reduction, caused by over acidification in the absence of NHE6.

156 PLGA nanoparticles accumulate and cause gut acidification in the cecum, accompanied by significant c

157 The responses of S. glomerata to acidification in their estuarine habitat provide key ins

158 of hypoxia are stronger than the effects of acidification in weakening these grazing interactions ov

159 melanoma cells, in response to intracellular acidification induced by ammonium chloride prepulse.

160 Soil acidification induced by N addition decreased available

161 abolished lysosome enlargement and lysosome acidification induced by wild-type TMEM106B overexpressi

162 s from this study suggest that environmental acidification induces drug resistance and extracellular

163 Environmental acidification induces protonation of His144 and reorgani

164 through lantibiotic expression or intestinal acidification, influence host mucosal immune cells and e

165 Lysosomal acidification is a key feature of healthy cells.

166 Ocean acidification is expected to negatively impact calcifyin

167 O(3) biominerals but their response to ocean acidification is poorly understood.

168 We demonstrate that acidification is required for heat shock response induct

169 s phenomenon, commonly referred to as "Ocean Acidification", is endangering coral reefs and the broad

170 zation during neurotransmission, rather than acidification, is a generalizable phenomenon across conv

171 le in the sugar metabolism and environmental acidification (key virulence traits associated with cari

172 The results showed different gastric acidification kinetics implying an effect of the gel str

173 Dough acidification led to softer breads and enhanced the anti

174 proportional to light-driven thylakoid lumen acidification, manipulating thylakoid ion and proton flu

175 a novel mechanism linking impaired lysosomal acidification, mitochondrial malfunction and inflammatio

176 ced dormant model-organism cultures using an acidification model and characterized those by a multila

177 l skeletons' resilience to ocean warming and acidification must take into account the dual formation

178 tigated how predicted ocean warming (OW) and acidification (OA) affect key ecological behaviours (loc

179 investigated the cumulative effects of ocean acidification (OA) and hypoxia on the organic carbon fat

180 test of coral parental conditioning to ocean acidification (OA) and tracking of offspring for 6 month

181 Ocean Acidification (OA) has become one of the most studied gl

182 -fixing cyanobacteria Trichodesmium to ocean acidification (OA) is critical to understanding future o

183 Ocean acidification (OA) is predicted to enhance photosynthesi

184 The near-term progression of ocean acidification (OA) is projected to bring about sharp cha

185 assessing and predicting the impact of ocean acidification (OA) on marine ecosystems.

186 Yet, the impact of ocean acidification (OA) on several abundant and ecologically

187 Ocean acidification (OA) poses a major threat to marine ecosys

188 Ocean acidification (OA), a consequence of anthropogenic carbo

189 ng global climate change (warming) and ocean acidification (OA, a reduction in oceanic pH).

190 However, it is unclear whether acidification occurs at non-ribbon-type synapses.

191 ial pH, suggesting a possible involvement of acidification of airway fluid and/or tissue generated by

192 equired for cell migration and extracellular acidification of breast cancer cells in response to HER2

193 iphosphatase is not only responsible for the acidification of CG, but also contributes to the maturat

194 Our results suggest that episodic acidification of coastal waters might limit the ability

195 trafficking required microtubular transport, acidification of endosomes, and a functional redox envir

196 onium chloride and monensin, which block the acidification of endosomes.

197 n bronchopulmonary C-fibres was generated by acidification of fluid and/or tissue in the lung and air

198 olysis by salivary amylase via a preliminary acidification of gastric contents.

199 ng Trypanosoma brucei brucei Endocytosis and acidification of high-density lipoprotein-associated APO

200 a multisubunit protein complex required for acidification of intracellular compartments.

201 , electrolyte movement across epithelia, and acidification of intracellular organelles.

202 They play important roles in acidification of intracellular vesicles, organelles, and

203 e again use the reduced DS model explore the acidification of large, lysosome-like vesicles to determ

204 e attributed to a deficiency in autophagy or acidification of lysosomes.

205 osensors for evaluation of the extracellular acidification of microorganisms in various biotechnologi

206 esults of this study show that the impact of acidification of natural waters on Fe availability will

207 of dissolution of iron oxyhydroxides on the acidification of natural waters will also have implicati

208 The resulting in-line acidification of natural waters with millimolar sodium c

209 es to marine ecosystems globally, with ocean acidification of particular concern for coral reefs.

210 Acidification of skim milk powder (SMP) dispersions to p

211 Site-directed acidification of the basic residues within the polybasic

212 , starter cultures are needed for successful acidification of the cheese and proteolytic strains like

213 cid-activated proton channel responsible for acidification of the inside of the virus, a critical ste

214 and is part of a feedback loop that ensures acidification of the luminal compartment These results h

215 al complex I during acute hypoxia(11) drives acidification of the matrix and the release of free Ca(2

216 porated into solid medium, with accompanying acidification of the media, and extensive precipitation

217 The acidification of the microcapsule-in-microcapsule system

218 he bacteria, but cannot be explained through acidification of the phagosome or calcium limitation.

219 This was followed by acidification of the PV and elimination of the parasite.

220 c aspects of frustule biosynthesis involving acidification of the silica deposition vesicle (SDV) by

221 cers, mammary carcinoma progression involves acidification of the tumor microenvironment, which is an

222 lar ATPases as the likely mechanisms driving acidification of the venom gland lumen during venom prod

223 eviously underappreciated role for localized acidification of tumor microenvironment in the expressio

224 taste of Citrus fruits is due to the extreme acidification of vacuoles in juice vesicle cells via a m

225 Deletion of CAPS does not alter acidification of vesicles.

226 ., sediment, low salinity, anoxia, and ocean acidification), offering an alternative approach for der

227 We conclude that the effect of ocean acidification on algae (primary producers) can have a st

228 em nucleus that mediates the effect of brain acidification on breathing, also contributes to arousal

229 re currently no data on the effects of ocean acidification on iodine metabolism in kelp.

230 SMs to provide skillful predictions of ocean acidification on large scales in the CCS.

231 aluated fundamental effects of environmental acidification on mammary carcinoma cells in standard two

232 nic activities, and the consequences of this acidification on marine fauna and ecosystems are the sub

233 previous attempts to quantify the effect of acidification on planktonic calcifying organisms has rel

234 ogically limited in their tolerance to ocean acidification on shorter time scales.

235 is study aims to determine the role of dough acidification on the nutritional pattern of Chlorella vu

236 ations that did not interfere with lysosomal acidification or degradation and were nontoxic in primar

237 cally is analyzed continuously (<5 min after acidification) or discretely (~3 months after acidificat

238 Thus, luminal acidification plays distinct and specific roles in apica

239 Ocean acidification poses serious threats to coastal ecosystem

240 nd 25-64% in eutrophication potential, while acidification potential ranged between a 24% decrease to

241 s generated in vitro either using the common acidification procedure or primed by limited selective c

242 ion of how the phagocytic cell optimizes the acidification process to prevail.

243 dinal patterns, implying that the phagosomal acidification process was a stochastic dynamical system.

244 Phagolysosomal acidification produced a range of pH values that approxi

245 , IFN-I signaling modified the localization, acidification, protease activity, and proteomic profile

246 In response to extracellular acidification, proton activation of GPR65 stimulates cAM

247 oxygen consumption rate (OCR), extracellular acidification rate (ECAR) and proton production rate (PP

248 oxygen consumption rate (OCR), extracellular acidification rate (ECAR), and fatty acid beta-oxidation

249 onse, as evidenced by elevated extracellular acidification rate and increased expression of key glyco

250 se in oxygen consumption rate, extracellular acidification rate and spare respiratory capacity, chang

251 we prospectively screened the extracellular acidification rate as a measure of glycolysis and the ox

252 en consumption, and glycolysis extracellular acidification rate assays.

253 CBCs had a very low glycolytic extracellular acidification rate but consumed oxygen in response to FA

254 s in the parasite nor impaired extracellular acidification rate, but resulted in specific defects in

255 colytic function with enhanced extracellular acidification rate, glycolytic metabolites, and lactate

256 ndrial oxygen consumption, and extracellular acidification rates.

257 th of which work in concert with IRT1 in the acidification-reduction-transport strategy of iron uptak

258 he mechanisms elicited by impaired lysosomal acidification remain poorly understood.

259 e dataset that could be used in future ocean acidification response studies.

260 ss-inducing mechanisms behind pteropod ocean acidification responses.

261 Remarkably, re-acidification restores citrate synthase activity and ATP

262 n collections as a tool to investigate ocean acidification since the early Industrial Revolution.

263 Thermal and acidification stress significantly reduced skeletal stif

264 shellfish varieties exhibiting resilience to acidification stress.

265 they routinely experience temperature and/or acidification stress.

266 an be induced to perforate membranes through acidification, such as would occur within maturing phago

267 knockout HeLa cells increased autophagosome acidification, suggesting a therapeutic approach to over

268 to characterize the extent of surface-ocean acidification that occurred during the event.

269 radients of temperature, salinity, and ocean acidification, then model growth rate and duration of Ol

270 ecursor protein (APP) gene impairs lysosomal acidification, thereby depressing lysosomal hydrolytic a

271 alyses indicate that increased use of slurry acidification, thermal drying, incineration and pyrolysi

272 ydroxybilobalide is found to rely on lactone acidification through lone-pair delocalization, which le

273 A two-component system CpxRA directly senses acidification through protonation of CpxA periplasmic hi

274 The reduced acidification time during continuous analysis may result

275 discrete, stochastic (DS) model of vesicular acidification to answer this question.

276 re (HHP) in order to separate alpha-la after acidification to pH 4.6.

277 nsequences of eutrophication versus those of acidification, to maintain biodiversity and ecosystem se

278 lucose and linoleic acid, restored lysosomal acidification, TOR activation, and survival with refeedi

279 anion currents are detectable, whereas upon acidification transport of the neutral, protonated monoa

280 tCLCa loss of function mutant, the cytosolic acidification triggered by extracellular NO(3) (-) and t

281 We show here that inhibition of lysosomal acidification triggers cellular iron deficiency, which r

282 four common grazers under hypoxia and ocean acidification using short-term laboratory experiments an

283 a, resident in habitats subjected to coastal acidification, using high-resolution electron backscatte

284 enilin-1 (PSEN1) function causing AD impedes acidification via defective vacuolar ATPase (vATPase) V0

285 IFN-I-dependent lysosome acidification was associated with elevated intracellular

286 Phagosomal acidification was crucial for O(2) (*-) permeation, beca

287 The defect in acidification was rescued by reexpression of wild type (

288 Using a mouse model of impaired lysosomal acidification, we observed a robust iron deficiency resp

289 Short-term exposure to low oxygen, not acidification, weakened interaction strengths across the

290 us K(m) estimates based on substrate-induced acidification were severely biased by confounding pH-reg

291 e antioxidant defence system and rhizosphere acidification were up-regulated in Si and SA treatments

292 productivity can improve resistance to ocean acidification, whereas increasing productivity enhances

293 been known to cause transient intracellular acidification which, for reasons which have remained unc

294 and then accelerated with ocean warming and acidification (which increased per capita lethal grazing

295 2) is absorbed by oceans, resulting in ocean acidification, which is a threat to calcifying algae.

296 otency of MSA-2 increased upon extracellular acidification, which mimics the tumor microenvironment.

297 ing, increased dissolved carbon dioxide, and acidification will affect the distribution and relative

298 Because of findings that endolysosome de-acidification with, for example, the weak-base anti-mala

299 NaC is profoundly activated by extracellular acidification within biologically relevant ranges (pH 8.

300 Our findings of alkalinization, rather than acidification, within the cleft of two different neurona