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1 esent in an acidic compartment rich in Ca2+ (acidocalcisome).
2 and possessing a high calcium content (i.e., acidocalcisomes).
3 g site being an acidic vacuole, known as the acidocalcisome.
4 polyP hydrolysis and Ca(2+) release from the acidocalcisome.
5 torage in the endoplasmic reticulum (ER) and acidocalcisomes.
6 t of the polyphosphate granules localized in acidocalcisomes.
7 proteins (VSPs), which are localized to its acidocalcisomes.
8 a short chain polyP kinase that localizes to acidocalcisomes.
9 in acidic, calcium-rich organelles known as acidocalcisomes.
10 vacuolar proton pyrophosphatase, a marker of acidocalcisomes.
11 ls of inorganic polyphosphate (polyP) within acidocalcisomes.
12 n, and high density, are similar to those of acidocalcisomes.
13 by driving Mn relocation from the cytosol to acidocalcisomes.
14 imalarial chloroquine to deplete Ca(2+) from acidocalcisomes.
15 xoplasma gondii tachyzoites is stored within acidocalcisomes.
16 phore membranes, is predominantly located in acidocalcisomes.
17 pyrophosphatase (V-H(+)-PPase), a marker of acidocalcisomes.
18 umefaciens possess properties similar to the acidocalcisomes.
19 ane, endoplasmic reticulum, mitochondria and acidocalcisomes.
20 polyphosphatase activities characteristic of acidocalcisomes.
21 calcium, and magnesium, as found before for acidocalcisomes.
22 reduced levels of polyphosphate and altered acidocalcisomes.
23 ata, a link between these organelles and the acidocalcisomes.
24 ologically and by X-ray microanalysis as the acidocalcisomes.
25 -localization with antibodies against VP1 to acidocalcisomes.
26 )-ATPase activity was detectable in isolated acidocalcisomes.
27 disappearance of the electron density of the acidocalcisomes.
29 of the spt2- promastigotes involving 'empty' acidocalcisomes (ACs), which may point to the origin of
31 TgVP1), a membrane proton pump, localizes to acidocalcisomes and a novel lysosome-like compartment te
34 that AP-3 is essential for the biogenesis of acidocalcisomes and for growth and virulence of T. bruce
36 from permeabilized trypanosomes or isolated acidocalcisomes and photolytic release of IP(3) in intac
37 flagellar pocket, that was distinct from the acidocalcisomes and that was identified by immunogold el
38 r, these results strongly support a role for acidocalcisomes and the contractile vacuole complex in o
39 ng together, the presence of an aquaporin in acidocalcisomes and the contractile vacuole complex of T
40 pathway to the synthesis of polyphosphate in acidocalcisomes, and may lead to better understanding of
41 an platelet dense granules strongly resemble acidocalcisomes, and we recently showed that they contai
42 nic phosphate (Pi) from the cytosol into the acidocalcisome- and lysosome-related vacuoles of yeast,
50 The combined results provide evidence that acidocalcisomes are organelles different from lysosomes
52 on acting as an intracellular proton pump in acidocalcisomes but in PPi synthesis in the chromatophor
53 ase) activity was detectable in the isolated acidocalcisome, but ionophore experiments indicated that
56 f purified T. brucei, T. cruzi, and L. major acidocalcisomes, calcium and phosphorus storage organell
57 s and identified two distinct populations of acidocalcisomes, defined by their unique trace elemental
58 nules of D. discoideum are homologous to the acidocalcisomes described in protozoan parasites and are
61 the ars76 phenotypes, suggesting that normal acidocalcisome formation in cells deprived of S requires
62 of virulence was associated with a defect in acidocalcisome formation, as this unique organelle was g
63 les generally indicated no enrichment in the acidocalcisome fraction; glycosomes were concentrated 5-
64 ol density gradients for purification of the acidocalcisome from Trypanosoma cruzi epimastigotes.
65 rference (RNAi) resulted in disappearance of acidocalcisomes from both procyclic and bloodstream form
66 Our data also indicate that a deficiency in acidocalcisome function impacts trafficking of periplasm
68 ellar rod; d) special organelles such as the acidocalcisome, hydrogenosome, and glycosome; and e) the
69 respond to what were described previously as acidocalcisomes, i.e. acidic compartments rich in Ca2+.
70 dation processes suggest a major role of the acidocalcisome in reshaping the cell during acclimation
71 de further evidence for the unique nature of acidocalcisomes in comparison with other, previously des
73 scribe organelles with properties similar to acidocalcisomes in the green alga Chlamydomonas reinhard
74 the cellular Cu and 80% of Fe sequestered in acidocalcisomes in these conditions and identified two d
75 e we present evidence that the biogenesis of acidocalcisomes in Trypanosoma brucei is linked to the e
81 hat a Ca(2+) signaling pathway that involves acidocalcisomes is required for growth and establishment
82 density gradient method previously used for acidocalcisome isolation from Trypanosoma cruzi epimasti
87 In this work we demonstrate that swelling of acidocalcisomes mediated by an aquaporin and microtubule
88 ic polyphosphate is an abundant component of acidocalcisomes of bacteria and unicellular eukaryotes.
90 PPase was located in the plasma membrane and acidocalcisomes of the three different forms of the para
91 ports on the localization of this channel to acidocalcisomes of Trypanosoma brucei and suggest that c
92 tional IP(3)R as a Ca(2+) release channel in acidocalcisomes of trypanosomes and suggest that a Ca(2+
93 notion that polyP hydrolysis products within acidocalcisomes or alkalinization of their luminal pH ac
94 analysis to be particularly associated with acidocalcisomes, organelles shown previously to contain
95 we present evidence that Trypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate
98 od for the isolation and characterization of acidocalcisomes, showing that they are distinct from oth
99 crotubule- and cyclic AMP-mediated fusion of acidocalcisomes to the contractile vacuole complex with
100 confirmed by visualization of polyPs in the acidocalcisomes using 4',6-diamidino-2-phenylindole.
102 lectron microscopy), are similar to those of acidocalcisomes (volutin granules, polyP bodies) of bact
105 lysosomes, and lysosome-related organelles (acidocalcisomes) were unaffected, indicating that in try
106 xistence of elemental nanodomains within the acidocalcisomes, where cationic elements display a self-
107 l electron-dense granules of some parasites (acidocalcisomes) whereby H+-coupled Ca2+ transport is in
108 y located in an acidic compartment named the acidocalcisome, which among other pumps and exchangers p
109 ated Fe was intracellularly sequestered into acidocalcisomes, which are localized towards the periphe
110 ith the vacuolar H(+)-pyrophosphatase to the acidocalcisomes while TbPMC2 localized to the plasma mem
111 cuoles of C. reinhardtii are very similar to acidocalcisomes with regard to their chemical compositio
112 vacuolar proton pyrophosphatase, a marker of acidocalcisomes, with the Golgi marker Golgi reassembly