ライフサイエンスコーパス: acinar

1 f 0.91 (solid), 0.76 (micropapillary), 0.74 (acinar), 0.6 (cribriform), and 0.96 (non-tumor) respecti

2 Sustained intra-acinar activation of nuclear factor kappaB pathway seems

3 histological features of well-differentiated acinar adenocarcinoma, with strong androgen receptor (AR

4 geneity (Sacin) is thought to be a marker of acinar airway involvement but has not been validated by

5 (CT) densitometry to determine the nature of acinar airway involvement in asthmatic patients.

6 decrease likely caused by relief of an intra-acinar airway obstruction that we propose reflects ampli

7 the lowest prevalence of SAD associated with acinar airway ventilation heterogeneity (S(acin)), an ou

8 eneity in the most peripheral, pre-acinar or acinar airways.

9 y repeated caerulein injections and isolated acinar and bone marrow cells for ex vivo studies.

10 t, mathematical modeling has been limited to acinar and branching morphogenesis and breast cancer, wi

11 ressed by progenitors that give rise to both acinar and duct cells, genetic ablation of SOX2 results

12 EpiSCs were capable to differentiate into SG acinar and duct cells.

13 the comparative ability of adult pancreatic acinar and ductal cells to respond to oncogenic Kras and

14 imal luminal cells are most similar to human acinar and ductal populations, that a PrU-like populatio

15 ling promotes progenitor survival as well as acinar and endocrine specification.

16 during paligenosis in both mouse pancreatic acinar and gastric chief cells.

17 In summary, CTSD is expressed in pancreatic acinar and inflammatory cells, undergoes subcellular red

18 appeared evenly distributed in postjuvenile acinar and islet cells in donors without diabetes, LDs w

19 re found in normal human juvenile pancreatic acinar and islet cells, with numbers subsequently increa

20 (I:C)) widely, but transiently, depleted the acinar and progenitor cells, 24 hours post poly (I:C) in

21 function to recognize solid, micropapillary, acinar, and cribriform growth patterns, and non-tumor ar

22 ct tumor phenotypes in vivo, including solid acinar, and solid nodular malignancies as well as cystic

23 Pancreatic Bap1 deficiency causes acinar atrophy but combines with oncogenic Ras to produc

24 Histologically, MG acinar atrophy was observed with ductal enlargement and

25 results support a contribution of the islet-acinar axis in pancreatic development and underscore a p

26 c genes and is essential for the survival of acinar but not ductal cells.

27 initially cause injury to organelles of the acinar cell (endoplasmic reticulum, mitochondria, and en

28 ere inflammation in the salivary glands with acinar cell atrophy, fibrosis, and dilation of the ducts

29 Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tu

30 developed various subtypes of PC, including acinar cell carcinoma, ductal adenocarcinoma, sarcomatoi

31 Lesions with histological features mimicking Acinar Cell Carcinomas are also observed in some tumors.

32 pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.

33 ng proximity of PTF1 and MIST1 in pancreatic acinar cell chromatin implies extensive collaboration, a

34 a was also suppressed in ex vivo cultures of acinar cell clusters isolated from mouse pancreas bearin

35 and thus transforms our understanding of the acinar cell compartment as a pool of equipotent secretor

36 risk factors, such as chronic pancreatitis, acinar cell damage, and/or defective autophagy increase

37 s of CM4620 on SOCE, trypsinogen activation, acinar cell death, activation of NFAT and NF-kappaB, and

38 1, die perinatally due to massive pancreatic acinar cell death, precluding investigation of the effec

39 e of cathepsin B into the cytosol leading to acinar cell death.

40 so activates ER stress pathways that promote acinar cell death.

41 trypsin activity, cell death signalling and acinar cell death.

42 s expressed in response to caerulein-induced acinar cell dedifferentiation, early neoplasia, and thro

43 is associated with chronic pancreatitis and acinar cell dedifferentiation.

44 Immunohistochemical stains demonstrate an acinar cell defect but normal islet cells.

45 s to form but are accelerated by deletion of acinar cell differentiation factors such as Ptf1a, sugge

46 cell line to study underlying mechanisms of acinar cell differentiation in culture has not been desc

47 ression of transcription factors that affect acinar cell differentiation suggested that acinar cells

48 tis, with pathways involved in inflammation, acinar cell differentiation, and cell junctions being sp

49 ith controls, Ddr1(-/-) models had increased acinar cell dropout and reduced proliferation with no di

50 -regulation of genes that promote the mature acinar cell fate is required to reduce injury associated

51 x of pancreatic acinar cells and critical to acinar cell fate specification and differentiation.

52 pression of proteins critically relevant for acinar cell function.

53 orm crucial functions in food digestion, and acinar cell homeostasis required for secretion of digest

54 The loss of acinar cell homeostasis, differentiation, and identity i

55 se in the number of acini without individual acinar cell hyperplasia.

56 tify a critical role for PDX1 in maintaining acinar cell identity, thus resisting the formation of pa

57 pecialized phenotype of the adult pancreatic acinar cell in vivo Transcriptome sequencing and chromat

58 re selected based on those found to decrease acinar cell injury.

59 In conclusion, Hes1 plays a key role in acinar cell integrity and plasticity on cellular insults

60 rmeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced panc

61 ses in mouse and human primary acini and the acinar cell line AR42J.

62 To date, a pure pro-acinar cell line to study underlying mechanisms of acina

63 Thus, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a

64 te that FGF2 regulates specific steps during acinar cell maturation.

65 addition, Slug attenuated TGF-alpha-induced acinar cell metaplasia to ductal structures and TGF-alph

66 nnabinoid receptor subtype 2 (CB2R) prevents acinar cell pathogenesis in animal models of acute pancr

67 olecule 1 (STIM1)/Orai complexes, attenuates acinar cell pathology and acute pancreatitis in mouse ex

68 ying this Ca(2+)-dependent generation of the acinar cell phenotype.

69 ction of cellular plasticity in multiple non-acinar cell populations.

70 enhancer landscape, activates differentiated acinar cell programs, and indirectly suppresses oncogeni

71 ppear to be excellent lectins for pancreatic acinar cell purification.

72 Acinar cell responses to the muscarinic agonist carbacho

73 Perturbation of pancreatic acinar cell state can lead to acinar-to-ductal metaplasi

74 identified the presence of a progenitor-like acinar cell subpopulation.

75 ical role for ATF3 as a key regulator of the acinar cell transcriptional response during injury and m

76 lder model) without directly affecting intra-acinar cell trypsin activation in vitro The absence of C

77 elial constituents, and uncovered 3 distinct acinar cell types, with possible implications for homeos

78 atitis features including pancreatic oedema, acinar cell vacuolization, intrapancreatic trypsin activ

79 verity of pancreatitis not by reducing intra-acinar cell zymogen activation but by reducing infiltrat

80 However, in the acinar cell, Munc18c's functions in exocytosis and homeo

81 cal samples from 1795 volunteers, pancreatic acinar cell, rather than duct cell, function is presentl

82 is only minimal and transient in the early, acinar cell-dependent phase of pancreatitis and much gre

83 Mice with acinar cell-specific expression of Kras(G12D) were cross

84 )) via Cre(ERTM) recombinase regulated by an acinar cell-specific promoter (Ptf1a).

85 ed mice with tamoxifen-inducible, pancreatic acinar cell-specific Sec23b deletion.

86 erentiated phenotype of the adult pancreatic acinar cell.

87 ense variants in genes related to pancreatic acinar cells (GP2) and insulin secretion (GLP1R).

88 old in tears (p = 0.0116) and 1.4-fold in LG acinar cells (LGAC)(p = 0.0026) from male NOD mice, a mo

89 bipotent progenitors (BPs) and unipotent pro-acinar cells (PACs).

90 mbination strategy in adult mouse pancreatic acinar cells (Yap1fl/fl;Tazfl/fl;Ela1-CreERT2).

91 s constituted approximately 2% of the normal acinar cells and 5% of dacryoadenotic acinar cells.

92 ymogen-containing subcellular compartment of acinar cells and activation of CTSD, CTSB, and trypsinog

93 A possible link between progenitor-like acinar cells and cancer initiators is proposed.

94 x transcription factor complex of pancreatic acinar cells and critical to acinar cell fate specificat

95 Ectopic pancreatic tissue included acinar cells and cystically dilated secretory ducts with

96 , leading to activation of EGFR signaling in acinar cells and increased ADM.

97 tin cytoskeleton and autophagy in pancreatic acinar cells and is potently protective against cerulein

98 Moreover, Arg-II is mainly expressed in acinar cells and is upregulated with aging, which enhanc

99 scribed in considerable detail in pancreatic acinar cells and oocytes.

100 ression, repressed renewal of Mist1-positive acinar cells and prevented recovery of salivary secretio

101 ing E-cadherin in adherens junctions between acinar cells and reduced the activity of neutrophil seri

102 re to cigarette smoke increased ER stress in acinar cells and sensitized the pancreas to LPS-induced

103 ) that induce saliva secretion from residual acinar cells and the use of saliva substitutes.

104 Despite this requirement, how acinar cells are generated during organogenesis is uncle

105 ophagy, and mitochondrial dysfunction in the acinar cells are now recognized to be important in drivi

106 We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells.

107 This involves not only signalling in acinar cells but also in stellate cells.

108 and CK 7-positive tonofilaments in the pale acinar cells by myriad mucus granules.

109 features of pancreatitis in EtOH-sensitized acinar cells by suppressing the adaptive unfolded protei

110 r TP53(f/f) specifically in adult pancreatic acinar cells by using a full-length pancreatic elastase

111 terations in calcium signaling in pancreatic acinar cells can result in pancreatitis.

112 nstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellul

113 In vitro studies using Par-C10 acinar cells demonstrated that when compared with L(1p)M

114 iduals >2 years of age contained clusters of acinar cells devoid of amylase (AMY(-)).

115 te and expand at 72 hours, the Mist1-positve acinar cells did not re-appear until 96 hours post poly

116 However, whether acinar cells directly contribute to PSC activation is un

117 e with beta1 syntrophin deletion in exocrine acinar cells exhibit increased severity of cerulein-indu

118 Zymogen secretory granules in pancreatic acinar cells express two vesicle-associated membrane pro

119 ce KLF5 activity might reduce progression of acinar cells from ADM to PanIN and pancreatic tumorigene

120 ells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1.

121 Accordingly, conditioned medium of isolated acinar cells from old WT (not Arg-II(-/-)) mice contains

122 I) lectin has been used to label and isolate acinar cells from the pancreas.

123 generation and maintenance of exocrine gland acinar cells have not yet been established.

124 s required for normal function of pancreatic acinar cells in adult mice.

125 ovel strategy for generating and maintaining acinar cells in culture.

126 Granular, zymogen-rich pyramidal acinar cells in normal glands predominated over a previo

127 arate lineages of myoepithelial, ductal, and acinar cells in postnatal glands.

128 SHP expression is induced in acinar cells in response to ER stress and regulates the

129 genesis, and a lack of differentiated mucous acinar cells in submandibular and sublingual glands.

130 at Lfng is uniquely expressed in a subset of acinar cells in the adult pancreas.

131 gglutinin (PNA) have a specific affinity for acinar cells in the mouse pancreas, with minimal affinit

132 activation of KRAS in normal, untransformed acinar cells in the pancreatic tissues of mice resulted

133 established PanINs reverts them to quiescent acinar cells in vivo.

134 The addition of IL22 to cultured acinar cells increased their expression of markers of du

135 Hippo inactivation in acinar cells induced yes-associated protein 1 (YAP1)/tra

136 substrate p62/SQSTM1 in stressed Kras(G12D) acinar cells is associated with PDAC development and mai

137 e intracellular Ca(2+) signals in pancreatic acinar cells is largely unknown.

138 the fibroinflammatory program in pancreatic acinar cells is suppressed under normal physiological co

139 t acinar cell differentiation suggested that acinar cells lacking ATF3 maintain a mature cell phenoty

140 tion of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall

141 in the developing ductal, serous, and mucous acinar cells of salivary glands.

142 netic recombination predominantly within the acinar cells of the glands.

143 secretion of bicarbonate-rich fluid from the acinar cells of the pancreas that accumulates within the

144 directly via G protein-coupled receptors on acinar cells or through inflammatory cells.

145 Epithelial pancreatic acinar cells perform crucial functions in food digestion

146 Damaged acinar cells play a passive role in activating pancreati

147 Acinar cells play an essential role in the secretory fun

148 Acinar cells prepared from the pancreas of rats or mice

149 approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB1R-knockout (KO)

150 Kras activation in Mist1(+) adult acinar cells resulted in brisk PanIN formation, whereas

151 in rats and in vitro in rat pancreatic AR42J acinar cells stimulated with taurocholate or TNF-alpha.

152 educed caspase-3 activation and apoptosis in acinar cells stimulated with the intestinal hormone chol

153 more extensive necrosis in both stellate and acinar cells than TLC-S alone.

154 the pancreas primarily comprises long-lived acinar cells that are not considered a bona fide source

155 pathway; this could be a mechanism by which acinar cells that express activated KRAS become suscepti

156 -22 acts directly at the level of pancreatic acinar cells to decrease expression of the pancreas asso

157 trast, TGF-beta1 efficiently converted human acinar cells to duct-like cells (AD) in a SMAD-dependent

158 tor Snail (Snai1) can cooperate with Kras in acinar cells to enhance ADM development, the contributio

159 uce cell-autonomous proliferation but primed acinar cells to exogenous pro-proliferative stimuli, imp

160 ound shifts in PDX1 chromatin occupancy from acinar cells to PDA.

161 ts that prevent conversion of differentiated acinar cells to proliferative ductal progenitors.

162 Hippo disruption promotes acinar cells to secrete fibroinflammatory factors and in

163 lls connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for the

164 Notably, these effects were recapitulated in acinar cells treated with a pharmacological inhibitor of

165 of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in aci

166 hat GRP78 could exert a protective effect on acinar cells under stress, as during PDAC development.

167 st-induced Ca(2+) oscillations in pancreatic acinar cells using multiple experimental approaches with

168 While amylase-positive (AMY(+)) acinar cells were detectable in pancreata from all study

169 transgenic mice expressing Slug and Kras in acinar cells were generated.

170 ncubation of AR42J or primary mouse or human acinar cells with MKC-3946 reduced expression of XBP1s,

171 Better methods for purifying human or mouse acinar cells without the need for genetic modification a

172 y reduced CTSB and trypsinogen activation in acinar cells, and CTSD directly activated CTSB but not t

173 tabolism were measured in pancreatic tissue, acinar cells, and isolated mitochondria.

174 omplexes expressed in adipocytes, pancreatic acinar cells, and the nervous system in mice.

175 bone marrow chimeras, expression of BCL3 by acinar cells, but not myeloid cells, was required for re

176 In acinar cells, cooling decreased the lipolysis induced by

177 ature activation of digestive enzymes within acinar cells, followed by necrosis and inflammation.

178 C-S), known to induce Ca(2+) oscillations in acinar cells, had only minor effects on stellate cells i

179 In acinar cells, our study demonstrates an age-associated A

180 xes contributes to the disease in pancreatic acinar cells, supporting a role for endoplasmic reticulu

181 in the ductal cell layer and/or in surviving acinar cells, to drive transcellular flux of interstitia

182 naliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur.

183 ment of Ca(2+) signaling in mouse pancreatic acinar cells, which suggests a potential cellular mechan

184 ocess involves activation of YAP1 and TAZ in acinar cells, which up-regulate JAK-STAT3 signaling to p

185 ve Orai1 inhibitor, prevents Ca(2+) entry in acinar cells.

186 ntumor pancreatic tissues, such as islet and acinar cells.

187 CCK cellular actions directly affected human acinar cells.

188 or-like state before re-differentiation into acinar cells.

189 r potential vanilloid subfamily 4 (TRPV4) in acinar cells.

190 ccelerates disorders of the ER in pancreatic acinar cells.

191 xygen species generation in mouse pancreatic acinar cells.

192 r acinar cells are terminally differentiated acinar cells.

193 pathological Ca(2+) signals and necrosis in acinar cells.

194 cholate-induced necrosis in mouse pancreatic acinar cells.

195 elicited simultaneously in the neighbouring acinar cells.

196 e pathogenesis of pancreatitis in pancreatic acinar cells.

197 normal acinar cells and 5% of dacryoadenotic acinar cells.

198 KDM6A to genomic binding sites in pancreatic acinar cells.

199 ibrosis-associated genes in adult pancreatic acinar cells.

200 initiated by cerulein and GTL was studied in acinar cells.

201 fic D1-like dopamine receptor (InvD1L), with acinar cells.

202 ial neoplasia (PanINs) when induced in mouse acinar cells.

203 d quantitative assessment of microstructural acinar changes in the lungs.

204 in permanent damage to the saliva producing acinar compartment of the salivary gland.

205 ng to more severe damage, loss of the normal acinar compartment, and increased cytokeratin 19-positiv

206 h), indicating an important effect of extra-acinar CTSD on course of the disease.

207 tigates third-phase secretory inhibition and acinar damage caused by the accumulation of prematurely

208 from intracellular trypsin accumulation and acinar damage.

209 Also at the PanIN2 stage, pancreas acinar-derived cells frequently invade along sensory neu

210 lico simulations predict a transient wave of acinar differentiation around E11.5, while endocrine dif

211 perturbed on the deletion of Hes1, terminal acinar differentiation in the adult pancreas is compromi

212 Expression and localization of the acinar differentiation marker MIST1 were altered in Irf6

213 H (L(1p)T-FH) can increase the expression of acinar differentiation markers and elevate saliva secret

214 ility of L(1p)M-FH and L(1p)T-FH to increase acinar differentiation markers and restore saliva flow r

215 significantly improved the expression of the acinar differentiation markers and saliva secretion when

216 r, L(1p)M-FH produce only weak expression of acinar differentiation markers in vivo (e.g., aquaporin-

217 al cell in close proximity to the either the acinar duct or its valve, respectively.

218 tigate possible phenotypes during pancreatic acinar ductal metaplasia (ADM), pancreatic acini from wi

219 ed, giving rise to three important lineages: acinar, ductal and endocrine.

220 several differentiated cell types, including acinar, ductal and myoepithelial cells, that are maintai

221 l states to become terminally differentiated acinar, ductal and myoepithelial cells.

222 population that will differentiate into the acinar, ductal or endocrine lineages.

223 re to differentiate key pancreatic lineages: acinar, ductal, and endocrine.

224 ATDC is required for KRAS-driven acinar-ductal metaplasia (ADM) and its progression to pa

225 Cells in the pancreas that have undergone acinar-ductal metaplasia (ADM) can transform into premal

226 mutant Kras, Mst1r overexpression increased acinar-ductal metaplasia (ADM), accelerated the progress

227 Intra-acinar ductular cells and the scattered loss of myoepith

228 ion of myoepithelial cells and ectopic intra-acinar ductular cells were also observed in dacryoadenos

229 gnosed interstitial neonatal lung disorders: acinar dysplasia (n = 14), congenital alveolar dysplasia

230 In contrast, the molecular bases of acinar dysplasia and congenital alveolar dysplasia have

231 ia with misalignment of the pulmonary veins, acinar dysplasia, congenital alveolar dysplasia, and oth

232 This remodels the acinar enhancer landscape, activates differentiated acin

233 The pancreatic acinar-enriched miR-216a, miR-216b and miR-217 are encod

234 uced expression of ductal markers in ex vivo acinar explant cultures.

235 peripheral tip domain, where they acquire an acinar fate.

236 Acinar flow heterogeneity was assessed by the coefficien

237 ated an increase in Krt19 and a reduction in acinar genes (Carboxypeptidase A1, Amylase2a) on day 4 o

238 ure of the lacrimal gland is the presence of acinar goblet cells that had been long overlooked; they

239 In order to recapitulate disruption of acinar homeostasis, we induced epithelial-to-mesenchymal

240 temperature dependence paralleled pancreatic acinar injury induced by monomeric STC.

241 protected from adipocyte-induced pancreatic acinar injury without affecting NEFA signaling or acute

242 was to describe recruitment/derecruitment at acinar length scales over short-time frames and test the

243 1p)M-FH, L(1p)T-FH induced similar levels of acinar-like cell clustering, polarization, lumen formati

244 cells, which gradually re-differentiate into acinar-like cells, partially restoring pancreatic parenc

245 ed switch of salivary epithelial cells to an acinar-like phenotype involves remodeling of SOCE and NF

246 ed from salivary gland biopsies, acquired an acinar-like phenotype when the [Ca(2+)] in the serum-fre

247 Development towards the acinar lineage is paralleled by an increase in GP2 expre

248 and parasympathetic nerves in generating the acinar lineage that has broad implications for epithelia

249 rise in a spatially distinct domain from the acinar lineage.

250 H activity can commit to either endocrine or acinar lineages, and can be divided into four sub-popula

251 differentiate into the endocrine, ductal and acinar lineages.

252 mbrane conductance regulator and dilation of acinar lumen are potential predisposition factors.

253 revealed positive axons radiating along the acinar lumen.

254 mSG-PAC1 cells express the pro-acinar markers SOX10 and aquaporin-5.

255 Similarly, although acinar markers, such as Cpa1 and CelA, were upregulated,

256 e UPR, induces cellular injury, and provokes acinar metaplasia.

257 res of glandular epithelium in vivo, such as acinar morphogenesis and apical expression patterns of E

258 sue-culture plastic better recapitulates the acinar morphology observed in mammary epithelium in vivo

259 Here, we report the establishment of a pro-acinar (mSG-PAC1) and ductal (mSG-DUC1) cell line, from

260 on heterogeneity in the most peripheral, pre-acinar or acinar airways.

261 nd exocrine pancreas, whereas hepatocyte and acinar pancreas development is not affected.

262 Induction of acinar pancreatitis by supramaximal cholecystokinin (CCK

263 Because data on these human acinar preparations are sparse, we assessed their functi

264 nd induce stromal activation, which precedes acinar proliferation and metaplasia.

265 Chymotrypsin, another acinar protease, has recently been shown be play critica

266 atitis biopsy samples showed the presence of acinar-REG(+) cells, a reciprocal association between ma

267 kappaB-Ras proteins are also required for acinar regeneration after pancreatitis, demonstrating a

268 ey do not make a significant contribution to acinar regeneration.

269 Acinar Sec23b deletion results in induction of ER stress

270 Furthermore, we show that SOX2 targets acinar-specific genes and is essential for the survival

271 n the pancreas that was missing in mice with acinar-specific p53 activation, suggesting non-cell-auto

272 Importantly, AQP5, an acinar-specific protein critical for function, is up-reg

273 In several cell types, including pancreatic acinar, stellate cells (PaSCs) and immune cells, SOCE is

274 ation, which was initiated by Hippo-mediated acinar-stromal communications and ameliorated by blockin

275 stologically more aggressive, with a loss of acinar structures and low/absent AR and PSA expression.

276 The tool segments normal acinar structures, the ductal phenotype of acinar-to-duc

277 fies a functionally and molecularly distinct acinar subpopulation and thus transforms our understandi

278 However, certain acinar subpopulations have a repopulating capacity durin

279 hat support the existence of progenitor-like acinar subpopulations, including active progenitor-like

280 ing stromal expansion, a reduction of normal acinar tissue, and an increase in both ADM and dysplasia

281 ng cells with transitional phenotypes toward acinar tissue.

282 reatic epithelial cells, led to formation of acinar to ductal metaplasia, and induced focal inflammat

283 IL22 promotes acinar to ductal metaplasia, stem cell features, and inc

284 ling halt their differentiation and leads to acinar to ductal metaplasia.

285 pecific study of certain mechanisms, such as acinar-to-beta-cell reprogramming and pancreatitis.

286 ry but, at later time points, showed reduced acinar-to-duct cell metaplasia.

287 kappaB-Ras deficiency promotes acinar-to-ductal metaplasia (ADM) during tumour initiati

288 Acinar-to-ductal metaplasia (ADM) has been identified as

289 al studies suggest that pancreatitis-induced acinar-to-ductal metaplasia (ADM) is a key event for pan

290 of pancreatic acinar cell state can lead to acinar-to-ductal metaplasia (ADM), a precursor lesion to

291 l acinar structures, the ductal phenotype of acinar-to-ductal metaplasia (ADM), and dysplasia with Di

292 OX9) is required for oncogenic Kras-mediated acinar-to-ductal metaplasia (ADM), pancreatic intraepith

293 s in mice that express KrasG12D by promoting acinar-to-ductal metaplasia (ADM).

294 , when ductal remodeling fails, and signs of acinar-to-ductal metaplasia appear.

295 d secretory phenotype (SASP) that attenuates acinar-to-ductal metaplasia, pancreatic intraepithelial

296 multiple-breath inert gas washout parameter acinar ventilation heterogeneity (Sacin) is thought to b

297 the highest level of discrimination of both acinar VH (measured by using phase 3 slope analysis of m

298 with decreasing ratio of deadspace to total acinar volume, and with increasing frequency above lung

299 rway opening, to a greater extent than overt acinar wall destruction.

300 (2/2, 50%) or rare (2/2, 50%) ducts and rare acinar zymogen granules (3/4, 75%).