ライフサイエンスコーパス: actin-binding protein

1 n cytoskeletal dynamics (e.g. RhoGTPases and actin binding proteins).

2 recruitment of vinculin, a tension-sensitive actin binding protein.

3 g domains, is a novel ER membrane-associated actin-binding protein.

4 in increased levels of profilin1 (Pfn1), an actin-binding protein.

5 ruited through an interaction with Filamin A actin-binding protein.

6 ed Ig binding to cofilin, a highly conserved actin-binding protein.

7 ene, is a large sarcolemmal myosin II- and F-actin-binding protein.

8 present in a complex with cofilin and other actin binding proteins.

9 common than previously considered for other actin binding proteins.

10 llular cues, is regulated by an abundance of actin binding proteins.

11 xoplasma gondii contains a limited subset of actin binding proteins.

12 ns that are specifically recognized by other actin-binding proteins.

13 oskeleton are controlled by a large array of actin-binding proteins.

14 the coordinated action of different sets of actin-binding proteins.

15 he calcium-regulated gelsolin superfamily of actin-binding proteins.

16 act as gatekeepers for the binding of other actin-binding proteins.

17 Precise control of actin dynamics requires actin-binding proteins.

18 a region involved in the binding of several actin-binding proteins.

19 zation and the interaction between actin and actin-binding proteins.

20 tr family of protein phosphatase 1 (PP1)-and actin-binding proteins.

21 e can be modulated by cooperative binding of actin-binding proteins.

22 less this aging effect is overcompensated by actin-binding proteins.

23 polymerization are regulated by a variety of actin-binding proteins.

24 led by a vast array of intricately regulated actin-binding proteins.

25 cific member of the NETWORKED superfamily of actin-binding proteins.

26 ytoskeleton, via transmembrane integrins and actin-binding proteins.

27 cess, requiring the activity of more than 75 actin-binding proteins.

28 This study reveals that actin-binding protein 1 (Abp1/HIP-55/SH3P7) is a negativ

29 nteract with the SH3 domain of Dictyostelium actin-binding protein 1 (dAbp1).

30 Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an imp

31 Recently, the mammalian actin-binding protein 1 (mAbp1; Hip-55, SH3P7, debrin-li

32 Mammalian actin-binding protein-1 (mAbp1) is an adaptor protein th

33 s the F-actin cross-linking protein filamin (actin-binding protein 120, abp120) in vivo.

34 ngs to a plant-specific superfamily (NET) of actin-binding proteins, (2) VAP27, a plant homolog of th

35 t to an association between cytoskeletal and actin-binding proteins, a mesenchymal or hybrid EMT phen

36 l lines was upregulation of cytoskeletal and actin-binding proteins, a signature shared with mesenchy

37 were exactly mirrored by knockdown of the F-actin-binding protein Abp1.

38 tes WH2 domain functions with those of the F-actin-binding protein Abp1.

39 vered that competition between fission yeast actin binding proteins (ABPs) for binding F-actin facili

40 Even though cells have multiple actin binding proteins (ABPs) that exist simultaneously

41 fect(s) of Ca(2+)-sensitive and -insensitive actin-binding proteins (ABPs) on PC2(iv) channel functio

42 In cells, actin-binding proteins (ABPs) sort to different regions

43 Through interactions with various actin-binding proteins (ABPs), actin plays an active rol

44 [PI(4,5)P2], regulate the activities of many actin-binding proteins (ABPs), including profilin, cofil

45 cellular processes at discrete locations by actin-binding proteins (ABPs), including the formins and

46 are connected to the actin cytoskeleton via actin-binding proteins (ABPs).

47 first eukaryote known to lack all canonical actin-binding proteins (ABPs).

48 Furthermore, we show that a related actin-binding protein, advillin which shares 75% homolog

49 We recently found that the F-actin-binding protein afadin is required for lumen conti

50 l dynamics, in part, by interacting with the actin-binding protein alpha-actinin 4 during tumor cell

51 We show that the actin-binding protein alpha-actinin binds to the C-termi

52 Here we show that the F-actin-binding protein alpha-actinin targets CaMKIIalpha

53 s-linking induced complex formation with the actin-binding protein alpha-actinin, linking membrane-bo

54 Mutations in the ACTN4 gene, encoding the actin-binding protein alpha-actinin-4, are a rare cause

55 d the specific association of EWI-2 with the actin-binding protein alpha-actinin; this association wa

56 plasmic tail of classical cadherins to the F-actin-binding protein alpha-catenin.

57 e Wnt-signaling protein beta-catenin and the actin-binding protein alpha-catenin.

58 Decreases in actin-binding proteins alpha-actinin-1 and alpha-actinin

59 N-termini of SK2 channels interact with the actin-binding proteins alpha-actinin2 and filamin A, res

60 Here, we reported that an actin-binding protein, alpha-actinin (ACTN)4, was dysreg

61 Mutations in the actin-binding protein, alpha-actinin 4 (ACTN4), are link

62 Here we identify a Ca(2+)-sensitive actin-binding protein, alpha-actinin-4, as a novel group

63 herin, beta-catenin, and the filamentous (F)-actin binding protein alphaE-catenin form a minimal cadh

64 ctin cytoskeleton via beta-catenin and the F-actin binding protein alphaE-catenin.

65 The actin-binding protein alphaE-catenin may contribute to t

66 ement in these processes is mediated by many actin-binding proteins, among which the cofilin family p

67 an alteration of filament interactions with actin binding proteins and myosin motors, consistent wit

68 Cofilin is an actin-binding protein and a major actin depolymerization

69 Cofilin-2, a small actin-binding protein and member of the AC protein famil

70 Additionally, we found that PMD1 is an actin-binding protein and that a functioning actin cytos

71 he band 3 macrocomplex, CD47 associates with actin-binding proteins and we confirm that CD47 membrane

72 atory proteins, caldesmon (a calmodulin- and actin-binding protein) and calpain 1 and 2 (calcium-depe

73 which have reversible knockdown of anillin, actin binding protein (ANLN).

74 viously observed that a membrane-associated, actin binding protein, annexin A2 (AnxA2), is up-regulat

75 The formin family of actin binding proteins are involved in nucleating MFs in

76 Actin's interactions with myosin and other actin-binding proteins are essential for cellular viabil

77 Actin and actin-binding proteins are incorporated into HIV-1 parti

78 These observations support the idea that actin-binding proteins are key elements of the molecular

79 Whereas several actin-binding proteins are known to be regulated by chan

80 and how the dozens of PI(4,5)P(2)-sensitive actin-binding proteins are selectively recruited to memb

81 Many actin-binding proteins are thought to be stimulus-respon

82 regulator of ubiquitin ligases) and LCP1 (an actin-binding protein), are completely repressed in 2-KO

83 RhoA stabilization by structurally unrelated actin-binding proteins as a conserved mechanism for regu

84 These genes encode numerous actin-binding proteins as well as actin.

85 alphaE-catenin is an actin-binding protein associated with the E-cadherin-bas

86 tion resulted in reduced Cdc12, F-actin, and actin-binding proteins at the CR, which in turn led to a

87 hemical and functional properties of diverse actin-binding proteins, both alone and in combination, h

88 Profilin 1 is a well studied actin-binding protein but how PFN1 mutations cause ALS i

89 ic events are choreographed by a plethora of actin-binding proteins, but the exact mechanisms are poo

90 Filaments are regulated by actin-binding proteins, but the nucleotide state of acti

91 We selected two vital Plasmodium berghei G-actin-binding proteins, C-CAP and profilin, in combinati

92 ng and binding assays that a fragment of the actin-binding protein caldesmon added to polymerizing ac

93 The actin-binding protein calponin has been previously impli

94 We identify the endothelial actin-binding protein CD2-associated protein (CD2AP) as

95 example, through compromised function of the actin-binding protein Cdc3-profilin.

96 Through the coordinated action of diverse actin-binding proteins, cells simultaneously assemble ac

97 adhesion kinase (FAK) and phosphorylate the actin binding protein cofilin.

98 In this study, we have determined that the actin-binding protein cofilin is O-GlcNAcylated by OGT a

99 is known to initiate changes to the cortical actin-binding protein cofilin to stimulate the depolymer

100 Surprisingly, the actin-binding protein cofilin was excluded from some reg

101 We have also defined in the actin-binding protein cofilin-1 a link between PP2A, act

102 ccumulation of the inactive, phosphorylated, actin-binding protein cofilin.

103 ments were hypersensitive to severing by the actin-binding protein cofilin.

104 horylation levels of inhibitory sites of the actin-binding proteins cofilin and VASP, which are upstr

105 increased levels of inhibitory sites of the actin-binding protein, cofilin, and vasodilator-stimulat

106 e filamins (FLNs), which are multifunctional actin-binding proteins, consist of 24 Ig domains.

107 Michael and colleagues (2016) show that the actin binding protein Coronin plays a critical role in a

108 Further, we show that the F-actin binding protein cortactin binds the PLS and is req

109 RSV induced phosphorylation of the actin binding protein cortactin in a PKD-dependent manne

110 rylation of Y573 influences association of F-actin binding protein cortactin to MT1-MMP-positive endo

111 osome transport in vivo also depend on the F-actin-binding protein cortactin.

112 The actin-binding protein, cortactin, in endothelial cells i

113 anism linking a signaling intermediate to an actin-binding protein critical to T cell migration.

114 Importantly, the actin binding proteins Cyclase-Associated Protein and Ac

115 or binding to F-actin and represents a novel actin-binding protein domain.

116 self-administration negatively regulates the actin-binding protein drebrin in the NAc.

117 nhanced green fluorescent protein (EGFP) and actin-binding protein-EGFP (Abp1-EGFP) fluorescence.

118 resistant form of one of these proteins, the actin-binding protein elongation factor 1 alpha 1 (EF1al

119 These actin-binding proteins enhance the disassembly of actin

120 polarized actomyosin network, and the Shroom actin-binding protein enhances myosin contractility loca

121 Vinculin is filamentous (F)-actin-binding protein enriched in integrin-based adhesio

122 We show that the actin-binding protein epidermal growth factor receptor p

123 Overexpression of the actin-binding protein espin causes elongation of stereoc

124 Cortactin is an actin-binding protein expressed in virtually all cell ty

125 Furthermore, the actin binding protein ezrin relocated from the plasma me

126 egy was used to knock down expression of the actin binding protein ezrin, which is expressed almost e

127 29 differentially expressed spots, including actin-binding protein ezrin and its interaction partner,

128 The actin-binding protein Ezrin and the activator protein 1

129 lasting clusters that are enriched with the actin-binding protein ezrin and with clathrin.

130 cently that Ras activation also requires the actin-binding proteins ezrin, radixin, and moesin.

131 In double mutants the muscle-specific actin binding protein Filamin Ca is up-regulated.

132 Here we identify the actin-binding protein filamin A (FLNA) as a central mech

133 Here, we report that the actin-binding protein filamin A (FlnA) physically intera

134 The actin-binding protein filamin A (FLNa) regulates neurona

135 ain (C-tail) also has a binding site for the actin-binding protein filamin A (FLNA); it is not known

136 main of meckelin directly interacts with the actin-binding protein filamin A, potentially at the apic

137 using RNAi techniques that knockdown of the actin-binding protein filamin-A (FLNa) severely impaired

138 s only 40 years ago that the first nonmuscle actin-binding protein, filamin, was identified and chara

139 The actin-binding protein filamins (FLNs) are major organize

140 i14 (retinoic acid induced protein 14) is an actin binding protein first identified in the liver, hig

141 The actin-binding protein FLNA (filamin A) regulates signal

142 In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and prof

143 tyostelium) and the Cdc42-GEF FGD1-related F-actin binding protein (Frabin) (in human cells).

144 own that villin, an epithelial cell-specific actin-binding protein functions as an anti-apoptotic pro

145 ving to modulate cell migration and named it actin-binding protein G (AbpG); this 971-amino acid (aa)

146 The decreases in expression of ACTB, and the actin-binding protein gene TB10, suggest changes in cyto

147 Profilin1 (Pfn1), a ubiquitously expressed actin-binding protein, has an indispensable role in migr

148 he ezrin, radixin and moesin (ERM) family of actin-binding proteins have been implicated in several a

149 Nuclear actin and actin-binding proteins have been shown to contribute to

150 etitive and cooperative interactions between actin binding proteins help define their associations wi

151 es of actin filaments is finely regulated by actin-binding proteins; however, the underlying mechanis

152 , PC3 cells do not express alpha-catenin, an actin binding protein in the cadherin complex.

153 gnaling, a function for afadin and adducin-1 actin binding proteins in thrombin-induced endothelial b

154 t instability, leaving uncertain the role of actin-binding proteins in controlling dynamics.

155 nical cues control the activities of various actin-binding proteins in different cellular, developmen

156 n-interacting proteins, actin filaments, and actin binding proteins, in a highly ordered and regulate

157 ing that its role, and perhaps that of other actin binding proteins, in growth cone motility is subst

158 Actin binding proteins, including spectrin and alpha-act

159 s of afadin (Afdn) - an obligate nectin- and actin-binding protein - induces a high penetrance of CP,

160 y reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibres by blocking

161 which beta-III-spectrin, and likely similar actin-binding proteins, interact with actin, and how thi

162 ied profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and neurot

163 Villin is a tissue-specific, actin-binding protein involved in the assembly and maint

164 Drebrin A, an actin-binding protein, is a key regulatory element in sy

165 Vinculin, an actin-binding protein, is emerging as an important regul

166 Cortactin, an actin-binding protein, is essential for cell growth and

167 LSP1, a F-actin-binding protein, is expressed in hematopoietic cel

168 ebulette), a member of the nebulin family of actin-binding proteins, is a newly identified component

169 network of actin filaments and associated F-actin-binding proteins, is fundamentally important in eu

170 Tropomyosin is a coiled-coil actin binding protein key to the stability of actin fila

171 F-actin) and regulates its interactions with actin-binding proteins like myosin by moving between thr

172 Targeting the actin-binding proteins LIMK1 and LIMK2 significantly dim

173 a missense mutation in FLNA (Filamin A), an actin-binding protein located at Xq28, mutations in whic

174 tide hydrolysis, ions, and a large number of actin-binding proteins, make actin a critical player in

175 process requiring the involvement of several actin-binding proteins, many of which are still unidenti

176 uniform, as neither vinculin nor LIM-domain actin-binding proteins match the boundaries of cadherin

177 ural plasticity of actin, suggest that other actin-binding proteins may also induce large but differe

178 Gelsolin, a multifunctional actin-binding protein, mediates cell death involving the

179 lant-specific Networked (NET) superfamily of actin-binding proteins, members of which localize to the

180 We find that the actin-binding protein, Moesin, is essential for NB proli

181 ral membrane proteins (Clmn, Nckap1) and one actin-binding protein (Mpp5) that link F-actin to the pl

182 Here, we identify the actin-binding protein myristoylated alanine-rich C-kinas

183 o and in vivo, but little is known about the actin-binding proteins necessary to mediate this respons

184 The actin-binding protein nonmuscle tropomyosin (Tm) provide

185 a process closely involving a host of other actin-binding proteins, notably the actin-related protei

186 linositol 3,4,5-trisphosphate-interacting, F-actin-binding protein, participates in actin rearrangeme

187 that filamin A (FLNA), a large cytoskeletal actin-binding protein, physically interacts with HIF-1al

188 The actin-binding protein plastin 3 (PLS3) has been identifi

189 Actin filaments and associated actin binding proteins play an essential role in governi

190 Filamentous actin and associated actin binding proteins play an essential role in governi

191 assembly factors, we found that the small G-actin binding protein profilin directly inhibits Arp2/3

192 uces the expression of the gene encoding the actin-binding protein profilin 1.

193 ind actin monomers directly, formins use the actin-binding protein profilin to dynamically load actin

194 Previously, we showed that the actin-binding protein profilin-1 (pfn) plays a role in a

195 The actin-binding protein profilin-1 (Pfn1) inhibits tumor g

196 e found that siRNA-mediated silencing of the actin-binding protein profilin-1 in cancer cells caused

197 more stretches of polyproline that bind the actin-binding protein profilin.

198 G-actin binding protein, profilin-1, colocalized in the te

199 rst time, direct evidence of the role of the actin-binding protein profilin1 (Pfn1) in VASP-mediated

200 Conversely, how different sets of actin-binding proteins properly sort to distinct actin f

201 ated by phosphorylation of the transporters, actin binding proteins (radixin and myristoylated alanin

202 CLAMP is an actin-binding protein, rather than a microtubule-binding

203 Actin and actin-binding proteins regulate chromatin and gene expre

204 Numerous actin-binding proteins regulate the dynamics of actin st

205 sm by which caldesmon, and potentially other actin-binding proteins, regulates the interactions of ac

206 alpha-Catenin (alpha-cat) is an actin-binding protein required for cell-cell cohesion.

207 The role of synaptopodin (SP), an actin-binding protein residing in dendritic spines, in s

208 Filamins are a family of actin-binding proteins responsible for diverse biologica

209 chemotactic responses, we identified a novel actin-binding protein serving to modulate cell migration

210 or ectopic apical constriction driven by the actin-binding protein Shroom and during embryonic wound

211 striction of ectoderm cells triggered by the actin-binding protein Shroom3.

212 SHTN1 (shootin1) and show that, unlike known actin-binding proteins, SHTN1's actin binding activity i

213 Actin-binding protein sorting is critical for the self-o

214 Because Asef2 interacts with the F-actin-binding protein spinophilin, which localizes to sp

215 Importantly, other actin-binding proteins such as fimbrin and espin show hi

216 Actin dynamics is also regulated by actin-binding proteins, such as the actin-related protei

217 we identified the dominant regulation of the actin-binding protein synaptopodin (SYNPO).

218 Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to p

219 Mammalian profilin is a small actin binding protein that catalyzes the exchange of nuc

220 Synaptopodin, an actin binding protein that is important in maintaining p

221 Dystrophin is an actin binding protein that is thought to stabilize the c

222 show that gene inactivation of cortactin, an actin binding protein that modulates actin dynamics and

223 mical targets of LIMK2 belong to a family of actin binding proteins that are potent modulators of act

224 In the course of studying actin binding proteins that regulate the organization of

225 the coordinated action of a large number of actin binding proteins that reorganize the actin cytoske

226 lphaE-catenin is an allosterically regulated actin-binding protein that binds the cadherin.beta-caten

227 at alphaT-catenin is a constitutively active actin-binding protein that can physically couple the cad

228 extensions involves flightless I (FliI), an actin-binding protein that contains a leucine-rich-repea

229 Talin is a major actin-binding protein that controls both the inside-out

230 Filamin A (FLNa) is an actin-binding protein that cross-links F-actin into netw

231 Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the re

232 ADD1 (adducin-1) is an actin-binding protein that has been shown to play import

233 Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and re

234 Twinfilin 2a (Twf2a) is a small actin-binding protein that inhibits actin filament assem

235 Cofilin is a key actin-binding protein that is critical for controlling t

236 LIM and SH3 protein 1 (LASP1) is a unique actin-binding protein that is expressed in a wide range

237 Cofilin-2 is an actin-binding protein that is predominantly expressed in

238 MARCKS is an actin-binding protein that modulates vascular endothelia

239 Fascin is an evolutionarily conserved actin-binding protein that plays a key role in forming f

240 Afadin is a Rap-regulated, actin-binding protein that promotes cadherin complex ass

241 PFN1 is a small actin-binding protein that promotes formin-based actin p

242 One of these is Phactr1, an actin-binding protein that recruits protein phosphatase

243 Filamin A (FLNa) is an actin-binding protein that regulates cell motility, adhe

244 Ms1/STARS is a novel muscle-specific actin-binding protein that specifically modulates the my

245 e identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive prope

246 Spectrin is a membrane-associated actin-binding protein that, like neurofilament, has been

247 alpha-Actinins are actin-binding proteins that can be broadly divided into

248 depolymerizing factors (ADFs) are a group of actin-binding proteins that contribute to reorganization

249 Tropomyosins are widespread actin-binding proteins that influence numerous cellular

250 indicate that ExoY represents a new class of actin-binding proteins that modulate the actin cytoskele

251 lutionarily conserved, modular, multidomain, actin-binding proteins that organize the actin cytoskele

252 Filamins are actin-binding proteins that participate in a wide range

253 Filamins (FLNs) are large dimeric actin-binding proteins that regulate actin cytoskeleton

254 cortex is a thin layer of actin, myosin, and actin-binding proteins that subtends the membrane of ani

255 Unusually for F-actin binding proteins, the DNGR-1 ligand binding domain

256 Devoid of all known canonical actin-binding proteins, the prevalent parasite Giardia l

257 Vinculin is an actin-binding protein thought to reinforce cell-cell and

258 Filamin B (FlnB) is an actin-binding protein thought to transduce signals from

259 cient wound healing, but the contribution of actin-binding proteins to contraction of the extracellul

260 transcriptome data for different classes of actin-binding proteins to demonstrate that increased mRN

261 ical mechanisms that target distinct sets of actin-binding proteins to distinct actin filament popula

262 ipid bilayer coupled via membrane-associated actin-binding proteins to dynamic actin filaments and my

263 nt, controlling the spatiotemporal access of actin-binding proteins to specialized actin networks.

264 Furthermore, we identified PHACTR1, an actin-binding protein, to be positively regulated by TGF

265 ing edge of the closing VBW that express the actin-binding protein transgelin (TAGLN) and TGFbeta rec

266 iated muscle contraction is regulated by the actin binding proteins tropomyosin and troponin.

267 yotic cells express multiple isoforms of the actin-binding protein tropomyosin that help construct a

268 are predicted to be remote homologues of the actin-binding protein tropomyosin.

269 onstitution system to test roles for the key actin-binding proteins tropomyosin, capping protein, and

270 chemoresistance by a direct targeting of the actin-binding protein twinfilin 1, which promotes epithe

271 P), the Rac GTPases MIG-2 and CED-10 and the actin binding protein UNC-115 (abLIM) are dedicated UNC-

272 ng sites (VBSs) from different nonhomologous actin-binding proteins use conserved helical motifs to a

273 his study demonstrates the various ways that actin-binding proteins use physical properties to tune t

274 eletal and muscle functions are regulated by actin binding proteins using a variety of mechanisms.

275 requires that this reaction be regulated by actin-binding proteins via allosteric effects on the act

276 the cytoskeleton in IECs via changes in the actin-binding proteins VIL1 and GSN.

277 The actin-binding protein villin (Vil1) is used as a marker

278 s F-actin-severing activity, the microvillar actin-binding protein villin drives both apical microvil

279 y, we demonstrated that Jak3 interacted with actin-binding protein villin, thereby facilitating cytos

280 We studied the actin-binding proteins villin 1 (VIL1) and gelsolin (GSN

281 localization is specific to Fascin, as other actin-binding proteins, Villin and Profilin, do not exhi

282 dy, we show that in mouse B lymphocytes, the actin binding protein vinculin localizes to the ring-sha

283 alphaE-catenin also binds to the F-actin-binding protein vinculin, which also appears to be

284 ough alphaE-catenin, and also recruits the F-actin-binding protein vinculin.

285 l change that exposes a cryptic site for the actin-binding protein vinculin.

286 The SRF target gene and actin-binding protein, vinculin, is sufficient to overco

287 Because vinculin (VCL) is an actin-binding protein, we asked whether it participates

288 Subsequently many other nonmuscle actin-binding proteins were identified and characterized

289 Palladin is a key cytoskeletal actin binding protein whose normal function is to enable

290 chemical analysis revealed CORO1C, another F-actin binding protein, whose direct binding to PLS3 is d

291 to-inhibited and found in a complex with the actin-binding protein WIP.

292 Drebrin is an actin filament (F-actin)-binding protein with crucial roles in neuritogene

293 Synaptopodin is another actin-binding protein with a more restricted expression

294 Filamin A (FLNA) is an actin-binding protein with a well-established role in th

295 Srv2/CAP is a conserved actin-binding protein with important roles in driving ce

296 Tropomyosins comprise a large family of actin-binding proteins with critical roles in diverse ac

297 y to study the association kinetics of seven actin-binding proteins with G-actin.

298 sizes of the interfaces formed by the seven actin-binding proteins with G-actin.

299 -plastin synthesis and the functions of this actin-binding protein, with a special interest in chemor

300 esses and require the activities of multiple actin-binding proteins working in concert.