ライフサイエンスコーパス: actinin

1 including DEB-1 (vinculin) and ATN-1 (alpha-actinin).

2 llipodia (fimbrin), and stress fibers (alpha-actinin).

3 mic domain of ICAM-2 binds directly to alpha-actinin.

4 -3 binding blocks its interaction with alpha-actinin.

5 2 with the cytoskeletal linker protein alpha-actinin.

6 h observations of cells overexpressing alpha-actinin.

7 y staining for z-line proteins such as alpha-actinin.

8 networks crosslinked with palladin and alpha-actinin.

9 act expressed the cardiomyocyte marker alpha-actinin.

10 adhesions and binds to both actin and alpha-actinin.

11 regular pattern mainly by the protein alpha-actinin.

12 ystallographic structures of actin and alpha-actinin.

13 n the Z-disk is the actin cross-linker alpha-actinin.

14 ivation in the presence and absence of alpha-actinin.

15 s accumulate in the caps together with alpha-actinin.

16 ected Z lines and were cross-linked by alpha-actinin.

17 interaction with the actin crosslinker alpha-actinin.

18 tor of Entamoeba and higher eukaryotic alpha-actinins.

19 ns of microbial pathogens or the human alpha-actinin 1 (HuACTN1) homolog.

20 show that perturbations to formin and alpha-actinin 1 activity selectively inhibited stress fiber as

21 While Dyn2 binds directly to both alpha-actinin 1 and alpha-actinin 4, only the interaction with

22 vels of smn, cofilin 1, profilin 2 and alpha-actinin 1 did not affect smn morphant motor axon outgrow

23 ve sister paralogs-myosin IIB (MYH10), alpha-actinin 1, and filamin A-had lower expression differenti

24 which encodes the cytoskeletal protein alpha-actinin 1, in 10 of 239 consecutive probands with an inh

25 In this study, we assessed the role of alpha actinin-1 (ACTN1), one of the two alpha actinin isoforms

26 CLP36 interacted with both alpha-actinin-1 and -4 in breast cancer cells.

27 Decreases in actin-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related protein

28 motif (residues 1,646-1,664) bound to alpha-actinin-1 and to apo-calmodulin (apoCaM).

29 mutations, which impair apoCaM but not alpha-actinin-1 binding, decreased single-channel open probabi

30 47A and Y1649A mutations, which impair alpha-actinin-1 but not apoCaM binding, but not the F1658A and

31 EC1 ectodomain, or alternatively of an alpha-actinin-1 mutant that inhibits F-actin bundling, increas

32 Depletion of either alpha-actinin-1 or -4 inhibited breast cancer cell migration.

33 Time-lapse imaging reveals that alpha-actinin-1 puncta within actomyosin bundles move more qui

34 flet of the plasma membrane, including alpha-actinin-1, moesin, 14-3-3 protein zeta/delta, annexin A1

35 xpression and activation of moesin and alpha-actinin-1, which associate with actin filaments and the

36 rescued by the actin bundling protein alpha-actinin-1.

37 skeleton remodeling factors, including alpha-actinin-1.

38 s revealed its localization complementary to actinin-1.

39 ich a novel disease-causing variant in alpha-actinin 2 (ACTN2) was identified by next-generation sequ

40 ed regulation of Entamoeba histolytica alpha-actinin-2 (EhActn2) with features expected for the commo

41 evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to opt

42 sh can be rescued by overexpression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from zebrafis

43 We have further demonstrated that alpha-actinin-2 competes with calcineurin for binding to calsa

44 een actn2 and actn3, the phenotypes of alpha-actinin-2 deficient zebrafish can be rescued by overexpr

45 gh-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore its fun

46 of other sarcomeric proteins including alpha-actinin-2, alpha-sarcomeric actin and tropomyosin were a

47 alpha-Actinin-2, which is differentially expressed in alpha-ac

48 d with dose-dependent up-regulation of alpha-actinin-2, z-band alternatively spliced PDZ-motif and my

49 ature stop codon in ACTN3 resulting in alpha-actinin-3 deficiency (the ACTN3 577XX genotype) is commo

50 l polymorphism (R577X) in ACTN3 causes alpha-actinin-3 deficiency in approximately 18% of the global

51 s no associated disease phenotype, but alpha-actinin-3 deficiency is detrimental to sprint and power

52 alpha-Actinin-3 deficiency occurs in approximately 16% of the

53 This suggests that alpha-actinin-3 deficiency reduces muscle performance at basel

54 Here, we have shown that alpha-actinin-3 deficiency results in increased calcineurin ac

55 Mechanistically, we show that alpha-actinin-3 deficiency triggers an increase in oxidative m

56 imary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to optimize their function

57 Here, we investigate the effects of alpha-actinin-3 expression level by comparing the muscle pheno

58 Loss of alpha-actinin-3 is associated with reduced power and enhanced

59 We show reduction in alpha-actinin-3 mRNA and protein in HET muscle compared with W

60 pression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from zebrafish or human.

61 viduals, suggesting dose-dependency of alpha-actinin-3, while others have shown no difference between

62 , which is differentially expressed in alpha-actinin-3-deficient muscle, has higher binding affinity

63 Mutations in alpha-actinin 4 (ACTN4) are linked to familial forms of focal

64 tion (K255E) of the actin cross-linker alpha-actinin 4 (ACTN4) causes its binding kinetics to be inse

65 ing affinity of the actin cross-linker alpha-actinin 4 (ACTN4) in cells modulates cytoplasmic mobilit

66 In this study, we demonstrated that alpha actinin 4 (ACTN4), an actin-cross-linking protein known

67 utations in the actin-binding protein, alpha-actinin 4 (ACTN4), are linked to focal segmental glomeru

68 racting with the actin-binding protein alpha-actinin 4 during tumor cell invasion.

69 Specific disruption of the Dyn2-alpha-actinin 4 interaction blocks the ability of PDAC cells t

70 a-actinin 4, only the interaction with alpha-actinin 4 is required to promote tumor cell invasion.

71 sue additionally reveals that elevated alpha-actinin 4 or Dyn2 expression are predictive of poor surv

72 cle myosin IIA (MYH9) and IIC (MYH14), alpha-actinin 4, and filamin B, were highly expressed in pancr

73 the C-terminal tails of both Dyn2 and alpha-actinin 4, and these proteins interact at invasive struc

74 units of the vacuolar ATPase, small GTPases, actinin 4, and, of special interest, components of the e

75 s directly to both alpha-actinin 1 and alpha-actinin 4, only the interaction with alpha-actinin 4 is

76 tegrin-linked kinase, laminin-521, and alpha-actinin 4.

77 actin-bundling protein alpha-actinin (alpha-actinin) 4 is critical for tumor cell migration and remo

78 mass spectrometric analysis identified alpha-actinin-4 (ACTN4) as an MTBP-interacting protein.

79 cur within the actin binding domain of alpha-actinin-4 (ACTN4) cause an autosomal dominant form of fo

80 omodimeric actin cross-linking protein alpha-actinin-4 (ACTN4) during cell migration involves signali

81 alpha-Actinin-4 (ACTN4), a key regulator of the actin cytoskel

82 rther increased binding of MICAL-L2 to alpha-actinin-4 (ACTN4), a protein involved in GLUT4 transloca

83 Genetic mutations in alpha-actinin-4 (ACTN4)-an important actin crosslinking cytosk

84 Furthermore, a point mutation of alpha-actinin-4 (K255E) associated with FSGS failed to support

85 cortical mechanical tension, rendering alpha-actinin-4 a catch bond in physiological tension ranges.

86 Functional silencing of alpha-actinin-4 abolished spine elongation and turnover stimul

87 We found that mechanical force induces alpha-actinin-4 and actin accumulation at the cell junction in

88 n-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related protein 2/3 complex subunit

89 ynaptopodin forms a complex containing alpha-actinin-4 and beta-catenin and interacts with myosin II,

90 our approach to the actin cross-linker alpha-actinin-4 and show that the cross-linking time of alpha-

91 by metabotropic signaling and identify alpha-actinin-4 as a critical effector of structural plasticit

92 Our study identified alpha-actinin-4 as a novel NHERF1 interaction partner and prov

93 ension-sensitive upstream regulator of alpha-actinin-4 as synaptopodin.

94 Actinin-4 associates with lamellipodia and has been impl

95 /CD2AP colocalizes with E-cadherin and alpha-actinin-4 at the apical junction in polarized Madin-Darb

96 ation of the podocyte-specific protein alpha-actinin-4 by the UPS depended on oxidative modification

97 immunoprecipitation studies showed the alpha-actinin-4 carboxyl-terminal region specifically interact

98 Knockdown of alpha-actinin-4 decreased total junctional actin and inhibited

99 Knockdown of synaptopodin and alpha-actinin-4 decreases the strength of cell-cell adhesion,

100 shown that actin cross-linkers such as alpha-actinin-4 exhibit mechanosensitive properties in their b

101 podocytes, treatment with C3a reduced alpha-actinin-4 expression and promoted ILK-dependent nuclear

102 te loss and changes in ILK, Snail, and alpha-actinin-4 expression.

103 nd show that the cross-linking time of alpha-actinin-4 homodimers increases approximately twofold wit

104 To study the functions of actinin-4 in human keratinocytes, we used shRNA to gener

105 Together, our data indicate a role for actinin-4 in regulating the steering mechanism of kerati

106 This function of alpha-actinin-4 in spine dynamics was underscored by gain-of-f

107 ound that silencing of either EWI-2 or alpha-actinin-4 increased cell infectivity.

108 Here alpha-actinin-4 induced spine head enlargement, a morphologica

109 The NHERF1/alpha-actinin-4 interaction increased alpha-actinin-4 ubiquiti

110 Actinin-4 knockdown keratinocytes lack polarity, assembl

111 tion with spinophilin, but not through alpha-actinin-4 or Arp3.

112 These findings demonstrate that alpha-actinin-4 plays an important role in coupling actin nucl

113 alpha-Actinin-4 specifically localized to sites of actin incor

114 nge requiring the C-terminal domain of alpha-actinin-4 that binds to CaMKII, an interaction we showed

115 point mutation at lysine 255 in human alpha-actinin-4 to glutamate increases the binding affinity re

116 /alpha-actinin-4 interaction increased alpha-actinin-4 ubiquitination and decreased its expression le

117 alpha-Actinin-4, an actin cross-linking protein, was identifie

118 HERF3 and another ligand such as NHE3, alpha-actinin-4, and PKCalpha, promoting formation of NHE3 mac

119 ding those of podocin, nephrin, neph1, alpha-actinin-4, and vimentin.

120 ne, encoding the actin-binding protein alpha-actinin-4, are a rare cause of autosomal dominant famili

121 a(2+)-sensitive actin-binding protein, alpha-actinin-4, as a novel group 1 mGluR-interacting partner

122 on prevents junctional accumulation of alpha-actinin-4, vinculin, and actin.

123 Intercellular tension also induces alpha-actinin-4-dependent recruitment of vinculin to the cell

124 In actinin-4-knockdown keratinocytes, focal contact area is

125 nail and downregulation of nephrin and alpha-actinin-4.

126 o, including diminished proteolysis of alpha-actinin-4.

127 of infected cells and association with alpha-actinin-4.

128 vitro actin assembly assay identified alpha-actinin-4/focal segmental glomerulosclerosis 1 (FSGS1) a

129 eported that an actin-binding protein, alpha-actinin (ACTN)4, was dysregulated in placentas from earl

130 nd located in the last intron of the alpha 1 Actinin (Actn1) gene.

131 alpha-Actinins (ACTNs) are a family of proteins cross-linking

132 gy, and expressed the MEC markers SMA, alpha-actinin, adenylate cyclase II, and vimentin.

133 Here, we identified alpha-actinin Ain1, a contractile ring ABP, as another Fim1 co

134 en Dyn2 and the actin-bundling protein alpha-actinin (alpha-actinin) 4 is critical for tumor cell mig

135 The T. vaginalis alpha-actinin amino acid sequence and the sequences of the epi

136 to detect any of the epitopes or other alpha-actinin amino acid sequences.

137 zed accumulation of actin, myosin, and alpha-actinin and a complete loss of myofibrillar organization

138 PLM synaptogenesis was independent of alpha-actinin and ENA-VASP, both of which bind to the N-termin

139 alpha-Actinin and Ena/VASP proteins bind to the stress fiber r

140 on of key sarcomeric proteins, such as alpha-actinin and filamin C, and is essential for maintenance

141 strates, including the z-disc proteins alpha-actinin and filamin C.

142 in, other cytoplasmic proteins such as alpha-actinin and filamin can directly interfere with talin-me

143 lar understanding of the mechanisms of alpha-actinin and filamin catch-bonding behavior.

144 successfully predicted which mammalian alpha-actinin and filamin paralogs would be mechanoaccumulativ

145 motors and actin cross-linkers such as alpha-actinin and filamin, accumulate in response to internall

146 of actin association in both wild-type alpha-actinin and in the K225E mutant.

147 lates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and

148 eropositive in response to trichomonad alpha-actinin and its truncated protein (ACT-P2) (positive con

149 IP6K1 physiologically associates with alpha-actinin and localizes to focal adhesions.

150 mislocalization of the Z-disk proteins alpha-Actinin and muscle LIM protein 84B.

151 Furthermore, alpha-actinin and myosin minifilaments turned over significant

152 ntrolled by zyxin and binding partners alpha-actinin and p130Cas, but not vasodilator-stimulated phos

153 ependent growth, co-precipitation with alpha-actinin and production of localized and disseminated tum

154 Cas and two other adhesion molecules, alpha-actinin and talin, were also significantly slower in the

155 A single interaction of alpha-actinin and titin turns out to be surprisingly weak if f

156 ecific protein-1), and cardiomyocytes (alpha-actinin and troponin I).

157 H3GL2 expression and decreased RAC-1, FAK, A-Actinin and Vinculin expression.

158 s filaments with desmin and also binds alpha-actinin and vinculin.

159 ffold protein (actin), a cross-linker (alpha-actinin), and a motor (myosin).

160 ins), adherens junctions (VE-cadherin, alpha-Actinin), and the basement membrane (Collagen IV), were

161 its C-terminal SH3 domains in an ATN-1(alpha-actinin)- and ALP-1(ALP/Enigma)-dependent manner, where

162 re, we show that non-muscle myosin II, alpha-actinin, and filamin accumulate to mechanically stressed

163 eparated by the actin bundling protein alpha-actinin, and is mechanically coupled to noncontractile d

164 mutant ZASP interact with alpha-actin, alpha-actinin, and myotilin.

165 verexpression of the actin crosslinker alpha-actinin, and rheology measurements reveal that changes i

166 lling VBS peptides derived from talin, alpha-actinin, and Shigella IpaA out of the vinculin head doma

167 ulations with the K237E mutant chicken alpha-actinin--and evaluate the mechanism of alpha-actinin bin

168 lso serves as a molecular scaffold for alpha-actinin, another key actin crosslinker.

169 unofluorescence staining with the anti-alpha-actinin antibody (a z-line marker) showed that nearly al

170 ArgBP2gamma binding to alpha-actinin appears to underlie its ability to localize to s

171 tation, and 3) surprisingly, actin and alpha-actinin are present in two discrete z-layers.

172 alpha-Actinins are actin-binding proteins that can be broadly

173 Although alpha-actinins are better known to cross-link actin filaments

174 alpha-Actinins are major F-actin bundlers that are inhibited b

175 These findings identify epitopes of alpha-actinin as candidate serodiagnostic targets and suggest

176 ro experiments of motility assays with alpha-actinins as molecular force sensors.

177 embryos results in the accumulation of alpha-actinin associated with severely impaired contractile fu

178 nts and the muscle-specific isoform of alpha-actinin at the PM of differentiated myotubes.

179 ion, changing spacing and alignment of alpha-actinin bands due to increase in proteolytic activity of

180 We map a small alpha-actinin binding region in ArgBP2 (residues 192-228) that

181 actinin--and evaluate the mechanism of alpha-actinin binding to actin.

182 ted here was to evaluate the impact of alpha-actinin binding to ICAM-2 on the phenotype of NB tumor c

183 Furthermore, mutations inhibiting the alpha-actinin-binding activity abolished the ability of CLP36

184 pressing ICAM-2 variants with modified alpha-actinin-binding domains differed from cells expressing I

185 ressed variants of ICAM-2 with mutated alpha-actinin-binding domains, and compared the impact of ICAM

186 We show that the actin-binding protein alpha-actinin binds to the C-terminal surface targeting motif

187 The calmodulin-like domain of alpha-actinin binds to the Z-repeats of titin.

188 n the formation of distinct fascin- or alpha-actinin-bundled domains.

189 les, with no enhancement on fimbrin or alpha-actinin bundles.

190 soluble and interacted with sarcomeric alpha-actinin by coimmunoprecipitation, while alpha-synemin an

191 Regulation of alpha-actinin by IP6K1 requires its kinase activity.

192 reduction of cardiac myocyte proteins (alpha-actinin, cardiac myosin-binding protein C, and cardiac t

193 Knockdown of alpha-actinin causes aberrant rigidity sensing, loss of CUs, l

194 th high seeding density exhibited more alpha-actinin(+) cells and less nuclear YAP expression.

195 s and higher length-to-width ratios of alpha-actinin(+) cells.

196 ow in an in vitro assay that talin and alpha-actinin compete for binding to beta3 integrins, but coop

197 It has been shown that alpha-actinin competes with talin for binding to the cytoplasm

198 actin cytoskeleton by talin, and then alpha-actinin competes with talin to bind beta3 integrins.

199 on of CLP36 or disruption of the CLP36-alpha-actinin complex in breast cancer cells substantially inh

200 Our data suggest that the EWI-2-alpha-actinin complex is involved in the regulation of the act

201 n, tropomyosin, troponins) and Z-band (alpha-actinin) components and promotes their degradation.

202 vity with robust expression of cardiac alpha-actinin, connexin 43, myosin light chain 2a, alpha/beta-

203 ter protein, ArgBP2, is a component of alpha-actinin containing stress fibers and inhibits migration.

204 network consisting of actin filaments, alpha-actinin cross-linking proteins, and non-muscle myosin II

205 ctions with the actin cytoskeleton via alpha-actinin (DeltaABD) abrogated migratory responses to TGFb

206 The data suggest the presence of alpha-actinin-dependent and alpha-actinin-independent mechanis

207 sistently, we find opposite effects of alpha-actinin depletion and expression of mutants on substrate

208 Surprisingly, only one-fourth of alpha-actinin dimers were bound to two actin filaments.

209 in domains are densely packed, whereas alpha-actinin domains consist of widely spaced parallel actin

210 epletion of the focal adhesion protein alpha-actinin enhances force generation in initial adhesions o

211 Finally, alpha-actinin enters NAs periodically and in clusters that tra

212 and the range of levels of identity of alpha-actinin epitopes with HuACTN1 was 0% to 50%.

213 Comparison of the T. vaginalis alpha-actinin epitopes with proteins in data banks, such as Tr

214 n cytoskeleton, bundle-like sarcomeric alpha-actinin expression, higher pacing beat rate at lower thr

215 disrupting nonfocal adhesion proteins (alpha-actinin, F-actin, and myosin II) and subcellular organel

216 proteins, including beta-III-spectrin, alpha-actinin, filamin, and dystrophin.

217 he competition between tropomyosin and alpha-actinin for binding actin.

218 ial adhesion and force generation) and alpha-actinin for integrin binding.

219 Expression of an alpha-actinin fragment containing the integrin binding domain,

220 demonstrate that calmodulin displaces alpha-actinin from their shared binding site on alpha11.2 upon

221 Disruption of alpha-actinin function by dominant-negative or small hairpin R

222 ch contains orthologoues of each human alpha-actinin gene, including duplicated copies of actn3.

223 that shares actin-binding domains with alpha-actinin had a strong inhibitory effect on PC2(iv) channe

224 nt sarcomeres that are cross-linked by alpha-actinin homodimers.

225 ctivity and is more dynamic than human alpha-actinin HsACTN4.

226 Our results suggest that alpha-actinin impairs integrin signaling by both undermining t

227 mponent of the Z-disc (about 1 per 400 alpha-actinin) important for myofibrillar development and mech

228 results may shed light on the role of alpha-actinin in cellular mechanotransduction and focal adhesi

229 Palladin coexists with alpha-actinin in stress fibers and focal adhesions and binds t

230 detailed understanding of the role of alpha-actinin in transmitting tension between actin filaments

231 alpha-actinins in particular are the major actin crosslinkers

232 The actin-bundling protein alpha-actinin increased PC2(iv) channel function in the presen

233 resence of alpha-actinin-dependent and alpha-actinin-independent mechanisms, and indicate that the in

234 odel for NA assembly whereby transient alpha-actinin-integrin complexes help nucleate NAs within the

235 re we directly observe that fascin and alpha-actinin intrinsically segregate to discrete bundled doma

236 alpha-Actinin is an actin cross-linker and may act as a mechan

237 alpha-Actinin is an essential actin cross-linker involved in c

238 The interaction with alpha-actinin is blocked by CaMKII autophosphorylation at Thr-

239 te that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non

240 The cytoskeletal protein alpha-actinin is shared between these two force-producing syst

241 with force generation, suggesting that alpha-actinin is the main link transmitting force between inte

242 lpha actinin-1 (ACTN1), one of the two alpha actinin isoforms expressed in keratinocytes, in skin cel

243 We have further validated alpha-actinin isoforms, phospholamban, dystrophin, alphaB-crys

244 sordered actomyosin bundles induced by alpha-actinin knockdown led to higher than normal tension and

245 our to six layers of links, presumably alpha-actinin, linking antiparallel overlapping ends of the ac

246 rmation with the actin-binding protein alpha-actinin, linking membrane-bound CD13 to the cytoskeleton

247 nts within the Z-band is devoid of any alpha-actinin links and is likely to be the location of cappin

248 The alpha-actinin links run diagonally between connected pairs of

249 When mixed, fascin and alpha-actinin mutually exclude each other by promoting their o

250 g protein (ZASP)/Cypher interacts with alpha-actinin, myotilin, and other Z-disc proteins via the PDZ

251 omen and men that were unreactive with alpha-actinin (negative control sera) failed to detect any of

252 to pure palladin or pure [Formula: see text]-actinin networks.

253 aveolin, Rab5a in early endosomes, and alpha-actinin, often in relationship to cortical actin.

254 d with zyxin variants that lack either alpha-actinin or Ena/VASP-binding capacity display compromised

255 larization on soft substrates, whereas alpha-actinin overexpression prevented polarization on stiff s

256 al cells with dexamethasone treatment, alpha-actinin overexpression, or RhoA overexpression caused in

257 se results also suggest that the zyxin/alpha-actinin/p130Cas module may ensure that motile cells in a

258 also showed that composite networks of alpha-actinin/palladin/actin behave very similar to pure palla

259 have demonstrated that the sarcomeric alpha-actinins play a role in the regulation of calcineurin si

260 Specifically, alpha-actinin plays distinct roles in regulating alphaIIbbeta3

261 Furthermore, we showed that alpha-actinin promote talin association with beta1-integrin by

262 Once adhesions have matured, alpha-actinin recruitment correlates with force generation, su

263 Thus, alpha-actinin recruits Ca(V) 1.2 to defined surface regions an

264 al ABPs, such as cortactin, myosin, or alpha-actinin, regulate leukocyte extravasation by controlling

265 d that the interplay between talin and alpha-actinin regulates signal transmission via controlling th

266 alpha-Actinin regulates the immune synapse formation and is re

267 In contrast, alpha-actinin remained nearly unchanged in both samples.

268 it distinct responses, with myosin and alpha-actinin responding to dilation, and filamin mainly react

269 curved and flattened structure of the alpha-actinin rod has a distinct fit into the map.

270 The molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its assoc

271 IP6K1 deletion disrupts alpha-actinin's intracellular localization and function.

272 ation trajectory is generated in which alpha-actinin's vinculin-binding site swings out of the rod do

273 n myotubes induced a loss of actin and alpha-actinin sarcomeric organization, whereas CHC depletion i

274 In intact cells, alpha-actinin selectively stabilizes CaMKII association with G

275 nding proteins, including spectrin and alpha-actinin, serve as molecular linkages between the actin c

276 be, in which the cross-linking protein alpha-actinin SpAin1 bundles the actin filament network.

277 filaments of mixed polarity like other alpha-actinins, SpAin1 has lower bundling activity and is more

278 g of a titin immunoglobulin domain and alpha-actinin spectrin repeats.

279 Cortexillins I-III are members of the alpha-actinin/spectrin subfamily of Dictyostelium calponin hom

280 e AMPAR regulatory protein) binding to alpha-actinin-stabilized PSD-95, and extracellular interaction

281 We conclude that alpha-actinin stabilizes Ca(V)1.2 at the plasma membrane and t

282 that a highly seropositive reaction to alpha-actinin suggests exposure to T. vaginalis.

283 g of vinculin and, to a lesser extent, alpha-actinin, talin, and filamin, to phosphomimetic Cav1Y14D

284 show that the F-actin-binding protein alpha-actinin targets CaMKIIalpha to F-actin in cells by bindi

285 orces on matrices, unveiling a role of alpha-actinin that is different from its well-studied function

286 muscles exhibit normal localization of alpha-actinin, the nebulin M1M2M3 domain, Tmod3, and cytoplasm

287 Force transmitted through alpha-actinin then triggers adhesion maturation.

288 f EWI-2 with the actin-binding protein alpha-actinin; this association was regulated by PIP2.

289 encing phosphorylation of both FAK and alpha-actinin through its product 5-IP7.

290 Thus, tropomyosin acts as a check on alpha-actinin to achieve intermediate levels of myosin stacks

291 ent actin-bundling proteins fascin and alpha-actinin to distinct networks is an intrinsic behavior, f

292 nterlace with perijunctional actin and alpha-actinin to form a continuous belt of muscle-like sarcome

293 Binding of alpha-actinin to the IQ motif of Ca(V) 1.2 supports its surfac

294 ajor mechanosensitive pathway in which alpha-actinin triggers adhesion maturation by linking integrin

295 Deletion of IP6K1 abolishes alpha-actinin tyrosine phosphorylation, which is known to be r

296 ng myosin II activity or knocking down alpha-actinin, we found that both promoted cell polarization o

297 is correlated with a third component, alpha-actinin, which upon CRISPR knockout led to reduced plasm

298 Specific 15-mer peptide epitopes of alpha-actinin with low to no identity with other proteins were

299 p52 is required for the association of alpha-actinin with the flight muscle Z-disc, and for normal sa

300 results suggest a model where multiple alpha-actinin/Z-repeat interactions cooperate to ensure long-t