ライフサイエンスコーパス: actinomycete

1 Streptomyces coelicolor (VanS(SC)), a model Actinomycete.

2 lite are dispersed in separate regions in an Actinomycete.

3 s coelicolor, the model antibiotic-producing actinomycete.

4 ficult-to-treat animal- and human-pathogenic actinomycete.

5 of this facultative intracellular pathogenic actinomycete.

6 n in Actinomadura kijaniata, a soil-dwelling actinomycete.

7 erse bacteria ranging from proteobacteria to actinomycetes.

8 occur exclusively in morphologically complex actinomycetes.

9 ction of distant ssgB orthologues from other actinomycetes.

10 is functionally conserved in all sporulating actinomycetes.

11 s as well as other natural product-producing actinomycetes.

12 roduced by Mycobacterium smegmatis and other actinomycetes.

13 in Mycobacterium tuberculosis and many other actinomycetes.

14 he major low molecular weight (LMW) thiol in Actinomycetes.

15 ng clinically significant species of aerobic actinomycetes.

16 rganisms considered to belong to the aerobic actinomycetes.

17 ) and is the predominant thiol found in most actinomycetes.

18 le of labeling trehalose glycolipids in live actinomycetes.

19 r recognized species, and 22 as unidentified actinomycetes.

20 nown members of this family are found in the actinomycetes.

21 Ins) and is the major thiol produced by most actinomycetes.

22 f the alpha- and beta-Proteobacteria and the Actinomycetes.

23 n of organic Ags, most commonly thermophilic actinomycetes.

24 cer Saccharopolyspora erythraea and in other actinomycetes.

25 l strain improvement of antibiotic-producing actinomycetes.

26 bacteria, 93 nocardiae, and 30 other aerobic actinomycetes.

27 olates of all clinically significant aerobic actinomycetes.

28 ally significant species and taxa of aerobic actinomycetes.

29 n identified as a major thiol in a number of actinomycetes.

30 orthologs being present in at least 10 other Actinomycetes.

31 class of cyclic heptapeptides isolated from actinomycetes.

32 ic compounds may be especially important for actinomycetes.

33 n-sulfur [Fe-S] proteins present only in the actinomycetes.

34 ivating enzymes from a diverse collection of actinomycetes.

35 odification strategy in antibiotic-producing actinomycetes.

36 e is known about RLA in antibiotic-producing actinomycetes.

37 mycothiol, the low molecular weight thiol of actinomycetes.

38 phosphorylation of GlgE is widespread among actinomycetes.

39 the regulation of developmental processes in Actinomycetes.

40 the role of BldD is conserved in sporulating actinomycetes.

41 can hinder the introduction of DNA into many actinomycetes; (2) self-replicating plasmid-cloning vect

42 the hotspot for finding antibiotic-producing actinomycetes across the globe.

43 The antibiotic kijanimicin produced by the actinomycete Actinomadura kijaniata has a broad spectrum

44 Forazoline A, produced by the marine actinomycete Actinomadura sp. WMMB-499, is a unique PK/N

45 another subset of DHQS-like proteins in the actinomycete Actinosynnema mirum and the myxobacterium S

46 The actinomycetes, although not all the Actinobacteria, are

47 A recently isolated from the lichen-derived actinomycete Amycolatopsis sp. YIM 130923.

48 revious co-culture screen, we found that one actinomycete, Amycolatopsis sp. AA4, inhibited aerial hy

49 ry metabolite isolated from a marine-derived actinomycete and displays inhibitory activity against TN

50 47 BGCs ranging from 10 to 113 kb from both Actinomycetes and Bacilli with ~100% efficiency.

51 re found predominantly in genomic islands of Actinomycetes and Clostridia, which, together with their

52 of apoptotic protein domains was detected in Actinomycetes and Cyanobacteria, which suggests a major

53 Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharid

54 Mycothiol is a novel thiol produced only by actinomycetes and is the major low molecular weight thio

55 Mycothiol is a novel thiol produced only by actinomycetes and is the major low-molecular-weight thio

56 e analysis of polyketide synthases (PKSs) in actinomycetes and other Gram-positive bacteria.

57 s are important natural products produced by Actinomycetes and other organisms via the polymerization

58 GSH was absent in all actinomycetes and some of the other gram-positive bacter

59 IRs are the longest reported thus far for an actinomycete, and are proposed to represent the chromoso

60 ontuberculous mycobacteria, 4 (0.3%) aerobic actinomycetes, and 2 (0.2%) isolates from theM. tubercul

61 rculous mycobacteria, 145 (11%) were aerobic actinomycetes, and 98 (7%) wereMycobacterium tuberculosi

62 clusters for the synthesis of antibiotics in actinomycetes, and also for the synthesis of antibiotics

63 been purified from eucaryotes, gram-positive actinomycetes, and archaea.

64 CofE is found in archaea, the aerobic actinomycetes, and cyanobacteria.

65 ry proteins, some of which are found only in actinomycetes, and is elicited by both extracellular and

66 Fungi, actinomycetes, and Plasmodium spp. also synthesize PABA

67 xamination of six cultures ruled out aerobic actinomycetes, and they were omitted from the study.

68 amino acid sequence similarity with several actinomycete antibiotic export proteins.

69 ome, not available in most eubacteria except Actinomycetes, appears to contribute to Mtb's resistance

70 Actinomycetes are a group of gram-positive bacteria that

71 Cultivated bacteria such as actinomycetes are a highly useful source of biomedically

72 Actinomycetes are a phylogenetically diverse bacterial g

73 Marine actinomycetes are a prolific but underexploited source f

74 lly rich genus further documents that marine actinomycetes are a significant resource for drug discov

75 Actinomycetes are apparently unique among bacteria in th

76 Actinomycetes are excellent sources for novel bioactive

77 that type I methanotrophs, methylotrophs and actinomycetes are important organisms involved in using

78 Actinomycetes are increasingly recognized as pathogenic

79 WhiB-like proteins of actinomycetes are known to co-ordinate iron-sulfur (Fe-S

80 y metabolites that have been discovered from actinomycetes are often in the form of biosynthetic hybr

81 o improve secondary-metabolite production in actinomycetes are potentially numerous, but have been li

82 While soil-dwelling actinomycetes are renowned for secreting natural product

83 olved in the entire pathway in gram-positive actinomycetes are still limited.

84 culture broth extracts of two marine-derived actinomycetes associated with the family Streptomycetace

85 Although actinomycete bacteria are one of the primary sources of

86 -aromatic polyketide biosynthesis within the Actinomycete bacteria that is responsible for the format

87 on encoding clavusporins is widespread among actinomycete bacteria, suggesting a prevalent role for c

88 ith their hosts include fungi, oomycetes and actinomycete bacteria.

89 ptidases have only been found in animals and actinomycete bacteria.

90 nd in the majority of cellulolytic fungi and actinomycete bacteria.

91 multicellular differentiation in sporulating actinomycete bacteria.

92 nt in anthelmintic avermectins isolated from actinomycete bacteria.

93 nic amino acid 3,5-dihydroxyphenylglycine in actinomycetes bacteria responsible for the production of

94 biotic and spore pigment biosynthesis in the actinomycetes bacteria.

95 CHY1 resembles actinomycete (bacterial) chymotrypsins (family S2) rathe

96 bably arose by lateral gene transfer from an actinomycete bacterium.

97 vely processed for the cultivation of marine actinomycetes belonging to the genus Salinispora.

98 tion factors that are present throughout the actinomycetes but absent from other organisms.

99 equencing to identify members of the aerobic actinomycetes, but the study also shows that a high degr

100 ry metabolism and, sometimes, sporulation in actinomycetes by binding to specific receptor proteins,

101 8 Mycobacterium species and 11 other aerobic actinomycetes by the presence or absence of BstEII recog

102 s has been made on antibiotic discovery from actinomycetes by using high-throughput fermentation, iso

103 Glycosylation is unusual among actinomycete carotenoids, and sioxanthin joins a rare gr

104 Conversely, actinomycete chymotrypsins are much more closely related

105 (PRA) for routine identification of aerobic actinomycete clinical isolates were evaluated for 299 cu

106 homologues (all from members of the aerobic actinomycetes) coded for proteins homologous over the en

107 mportance of c-di-GMP-dependent signaling in actinomycete colony morphology and development and ident

108 ate that MSH production is restricted to the actinomycetes, could have significant implications for t

109 d solid medium for mycobacterial and aerobic actinomycetes culture and demonstrates that solid medium

110 analysis of 21,494 mycobacterial and aerobic actinomycetes cultures performed over 10 months to deter

111 mycetes) and new sources (for example, other actinomycetes, cyanobacteria and uncultured bacteria).

112 Kutznerides are actinomycete-derived antifungal nonribosomal hexadepsipe

113 Kutznerides, actinomycete-derived cyclic depsipetides, consist of six

114 and highly efficient synthesis of the marine actinomycete-derived natural product saliniketal B.

115 tional regulator PnbR in proteobacteria, the actinomycete-derived pnb locus (4-NBA degradation struct

116 y identified a TetR-family repressor for the actinomycete-derived pnb operon that recognizes 10(-8) M

117 Although marine-derived actinomycetes display strain-level genomic and chemodive

118 Mycobacteria and other actinomycetes do not produce glutathione but make mycoth

119 Among other aerobic actinomycetes, each group most closely resembled the ass

120 ch would help explain why sphIR unlike other actinomycete ENase genes seemed to be expressed in E. co

121 e detection and treatment of infections with actinomycetes, especially those caused by mycobacteria.

122 MSH was found at significant levels in most actinomycetes examined.

123 ncoded by Rv2672 is conserved exclusively in actinomycetes, exhibits both lipase and protease activit

124 ods have demonstrated that indigenous marine actinomycetes exist in the oceans and are widely distrib

125 Although actinomycete extracts have traditionally been screened u

126 olymerase-binding protein that occurs in the actinomycete family of bacteria and is regulated by the

127 terium tuberculosis and other members of the actinomycete family produce mycothiol (MSH or acetylcyst

128 m tuberculosis and many other members of the Actinomycetes family produce mycothiol, i.e., 1-d-myo-in

129 duced by bacteria, particularly those of the Actinomycetes family(2).

130 y Mycobacterium tuberculosis, members of the Actinomycetes family, to maintain an intracellular reduc

131 the saline culture of a new group of marine actinomycetes, for which we have proposed the name "Mari

132 Progress has been made to isolate novel actinomycetes from samples collected at different marine

133 robial culture extracts prepared mostly from actinomycetes from soil in Japan.

134 estigate the chemical ecology of free-living actinomycetes from the genus Pseudonocardia.

135 The ggh-A ORF has features typical of an actinomycete gene including high GC content (70.5%) and

136 WhiB-like proteins exclusive to the GC-rich actinomycete genera play significant roles in pathogenes

137 gas vesicle gene clusters in members of the actinomycete genera Streptomyces, Frankia and Rhodococcu

138 hat display the codon preferences typical of actinomycete genes.

139 robe for new RIF-associated genes in several actinomycete genomes, we identified a heretofore unknown

140 icolor that is well represented in sequenced actinomycete genomes.

141 Members of the marine actinomycete genus Salinispora constitutively produce a

142 e data derived from 75 strains of the marine actinomycete genus Salinispora for pathways associated w

143 The marine actinomycete genus Salinispora maintains extraordinary l

144 three closely related species of the marine actinomycete genus Salinispora reveals extraordinary bio

145 zed the genomes of 119 strains of the marine actinomycete genus Salinispora, which is currently compr

146 Members of the actinomycete genus Streptomyces are non-motile, filament

147 Two related actinomycetes, Glycomyces sp. strain NRRL B-16210 and St

148 longing to the genus Corynebacterium and the actinomycete group of organisms.

149 ologous protein expression in members of the actinomycete group, including codon usage, post-translat

150 des sp. L-11A, classified as a gram-positive actinomycete, harbours a complete CHL metabolic pathway.

151 Recent screening of marine actinomycetes has led to the discovery of a new lineage

152 The soil actinomycetes have been important sources of antibiotics

153 n (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activi

154 combined with milleri group streptococci and actinomycetes in 33% and 26% of cases, respectively.

155 gical manipulation of organisms (principally actinomycetes) in which complex polyketides have thus fa

156 y characterized Nocardiopsis, a soil-derived actinomycete, in stationary phase.

157 , S. oralis, and S. sanguis, as well as oral actinomycetes, including A. viscosus, A. odontolyticus,

158 was conserved across mycobacteria and other actinomycetes, including an AT-rich sequence that was li

159 Most actinomycetes, including Mycobacterium tuberculosis, do

160 ative regulators of the sigma factor SigB in actinomycetes, including pathogens like Mycobacterium tu

161 The genomes of many actinomycetes, including the soil dwelling bacterium Str

162 ion and morphological differentiation during actinomycete interactions.

163 ut the roles of these molecules in mediating actinomycete interactions.

164 The tip growth of filamentary actinomycetes is investigated within the framework of la

165 sulfur proteins found exclusively within the actinomycetes, is required for the late stages of sporul

166 Screens for environmental actinomycete isolates carrying frontalamide-like biosynt

167 Amplicons from all aerobic actinomycete isolates lacked BstEII recognition sites, t

168 , we detected the pepM gene in ~5% of random actinomycete isolates.

169 ardia species isolates, and 61 other aerobic actinomycetes isolates under routine clinical laboratory

170 etabolite identification studies in multiple actinomycetes, it has been proposed that cholesterol sid

171 angucycline-type antibiotics produced by the actinomycete, Kibdelosporangium sp. MJ126-NF4, contain a

172 of antifungal natural products from the soil actinomycete Kutzneria sp. 744 contain two sets of chlor

173 scovery of cholesterol catabolic pathways in Actinomycetes led us to the hypothesis that if enzymes e

174 to identify piperazyl compounds in the rare actinomycete Lentzea flaviverrucosa DSM 44664.

175 icin is a potent lantibiotic produced by the actinomycete Microbispora corallina and contains unique

176 tent type I lantibiotic produced by the rare actinomycete Microbispora corallina that is in preclinic

177 g macrolide antibiotic mycinamicin II in the actinomycete Micromonospora griseorubida.

178 secondary metabolite SF2312, produced by the actinomycete Micromonospora, was reported to display bro

179 ether putative gas vesicle proteins in these actinomycetes might actually be involved in flotation or

180 elium development and stress response in the actinomycetes, might be under the regulation of as yet u

181 throughput fermentation, isolation of marine actinomycetes, mining genomes for cryptic pathways, and

182 and sensitive GC measurements, that the soil actinomycete Mycobacterium smegmatis mc(2)155 constituti

183 re we show that an obligate aerobe, the soil actinomycete Mycobacterium smegmatis, adopts an anaerobe

184 It is circular, like those of the pathogenic actinomycetes Mycobacterium tuberculosis and Corynebacte

185 Microbiology showed actinomycetes (n = 7) and mixed bacteria (n = 9).

186 cteria (RGM) and nocardiae and other aerobic actinomycetes (NAA).

187 The nocardioazines are actinomycete natural products that feature a pyrroloindo

188 xides (epoxyalkanes) by the alkene-utilizing actinomycete Nocardia corallina B276 was investigated.

189 clic beta-lactam antibiotics produced by the actinomycete Nocardia uniformis subsp. tsuyamanensis ATC

190 s a monocyclic beta-lactam isolated from the actinomycete Nocardia uniformis that shows moderate anti

191 s a monocyclic beta-lactam isolated from the actinomycete Nocardia uniformis, which shows moderate ac

192 Here, pnbBA from the actinomycete Nocardioides sp. strain LMS-CY was biochemi

193 (QY071) and chlOR(L-11A) completely from the actinomycete Nocardioides spp. were found to act on the

194 Recent fermentation studies have identified actinomycetes of the marine-dwelling genus Salinispora a

195 ns, DpgA-D, required for the biosynthesis by actinomycetes of the nonproteinogenic amino acid monomer

196 nhibitory effects of marine sediment-derived actinomycetes on the SARS-CoV-2 main protease (3CLpro),

197 r the control of the sigmaR homologue in the actinomycete pathogen Mycobacterium tuberculosis.

198 that the sigmaR system also functions in the actinomycete pathogen Mycobacterium tuberculosis.

199 modified peptide lantibiotic produced by the actinomycete Planomonospora alba.

200 ndous diversity and novelty among the marine actinomycetes present in marine environments.

201 These marine actinomycetes produce different types of new secondary m

202 Oral actinomycetes produce fructosyltransferase (FTF) enzymes

203 The highly aerobic actinomycetes produce mycothiol, a conjugate of N-acetyl

204 at Amycolatopsis sp. AA4, a so-called "rare" actinomycete, produces a novel siderophore, amychelin, w

205 Some insects form symbioses in which actinomycetes provide defense against pathogens by makin

206 Gordonia species are aerobic actinomycetes recently recognized as causing human disea

207 Ergothioneine, also produced by actinomycetes, remains a mystery despite many years of s

208 Rare actinomycetes represent an underexploited source of new

209 Genome sequencing of actinomycetes reveals an untapped reservoir of biosynthe

210 The soil-dwelling, saprophytic actinomycete Rhodococcus equi is a facultative intracell

211 Molecular typing of the actinomycete Rhodococcus equi is insufficiently develope

212 etabolism of acetone was investigated in the actinomycete Rhodococcus rhodochrous (formerly Nocardia

213 mparative studies of the propylene-oxidizing actinomycete Rhodococcus rhodochrous strain B276 showed

214 In contrast to another Actinomycete, Rhodococcus erythropolis, Mtb's beta-chain

215 se biosynthetic gene cluster from the marine actinomycete Saccharomonospora sp. CNQ-490 and produced

216 bly line polyketide synthase produced by the actinomycete Saccharopolyspora erythraea that synthesize

217 th of several strains of the obligate marine actinomycete Salinispora arenicola has led to the identi

218 nd B are unusual polyketides from the marine actinomycete Salinispora arenicola that inhibit ornithin

219 metabolites produced by the obligate marine actinomycete Salinispora tropica (strain CNB-392), the p

220 hydrogenase/reductase enzyme from the marine actinomycete Salinispora tropica that is involved in the

221 el cyanosporasides C-F (3-6) from the marine actinomycetes Salinispora pacifica CNS-143 and Streptomy

222 of characterized cytochrome P450 enzymes in actinomycete secondary metabolic pathways are strictly s

223 It is thought that soil microbes, likely actinomycetes, serve as the main global sink for troposp

224 species, Nocardia species, and other aerobic actinomycetes) showed 100% specificity and sensitivity.

225 ganic compound produced by a wide variety of Actinomycete soil organisms, myxobacteria, and cyanobact

226 Streptomyces and other bacterial actinomycete species produce many important natural prod

227 he primary vegetative sigma factors in other actinomycete species.

228 ogeny-guided approach to mine the genomes of Actinomycetes species for glycopeptides with novel targe

229 thologs of VlmL were identified in two other actinomycetes species that also contain orthologs of the

230 yrolactone signalling system, members of the actinomycete-specific Wbl class of regulatory proteins a

231 the natural product compound produced by the actinomycete strain "S149" which is capable of inducing

232 el dichloropyrrole-containing compounds from actinomycete strain AJS-327 that unexpectedly harbors in

233 ne cluster, named ari, from the thermophilic actinomycete strain Amycolatopsis arida.

234 Cultivation of actinomycete strain CNQ-418, retrieved from a deep ocean

235 olated from the saline culture of the marine actinomycete, strain CNQ-140, identified as a member of

236 study suggests that coculturing inefficient actinomycete strains could be a promising approach for t

237 Extracts of 75 actinomycete strains from two locations, Nogas Island in

238 Out of 2212 marine sediment-derived actinomycete strains isolated from 11 geographical sites

239 detailed resistance mechanism of CHL/TAP by actinomycete strains isolated from soil and livestock ma

240 t unlike the linear chromosomes of the model actinomycete Streptomyces coelicolor A3(2) and the close

241 e non-pathogenic, non-glycopeptide-producing actinomycete Streptomyces coelicolor carries a cluster o

242 Concomitant expression of these genes in the actinomycete Streptomyces coelicolor produced epothilone

243 s biosynthesis in the genome-minimized model actinomycete Streptomyces coelicolor provided the 57.6 k

244 one of 18 cytochrome P450 (CYP) genes in the actinomycete Streptomyces coelicolor, ordered active sit

245 yotes and in one of the Ku homologs from the Actinomycete Streptomyces coelicolor.

246 The actinomycete Streptomyces scabies 87-22 is the causal ag

247 discovered from the Arctic sponge associated actinomycete Streptomyces somaliensis 1107 using a genom

248 ces coelicolor, with a similar role in other actinomycetes such as Mycobacterium tuberculosis.

249 The regulation of disulphide stress in actinomycetes such as Streptomyces coelicolor is known t

250 Actinomycetes, such as Mycobacterium species, are Gram-p

251 f [4Fe-4S]-containing proteins found only in actinomycetes, such as Streptomyces and Mycobacteria.

252 t proteasome core in Mycobacteria and allied actinomycetes suggested that additional elements of this

253 ose of related ('erm-type') genes from other actinomycetes suggests that the combined presence of tlr

254 ce within their galleries, as a model insect/actinomycete system.

255 evertheless, Streptomyces hygroscopicus, the actinomycete that produces GdA, has evolved an Hsp90 fam

256 n of organic Ags, most commonly thermophilic actinomycetes that cause farmer's lung disease.

257 millimolar levels by mycobacteria and other actinomycetes that do not make glutathione.

258 many of these genes is almost certainly the actinomycetes that make the antibiotics and therefore ne

259 istic association with filamentous bacteria (actinomycetes) that produce antibiotics that suppress th

260 ight thiol, unique to mycobacteria and other actinomycetes, that performs a role analogous to glutath

261 compound libraries largely impractical, and actinomycetes, the main source of natural product compou

262 Unlike proteasomes isolated from other Actinomycetes, the open-gate Mtb mutant 750 kDa particle

263 toxification enzymes are novel and unique to actinomycetes, thereby representing potential antimycoba

264 llular cellulases in the cellulose-degrading actinomycete Thermobifida fusca is controlled by a trans

265 ecently sequenced genome of the thermophilic actinomycete Thermobifida fusca revealed an orphan nonri

266 In addition, the level of the major actinomycete thiol buffer, mycothiol, was fourfold lower

267 ding an overview of the physiology of a soil actinomycete, this study presents insights on the transc

268 abolizing ACADs in M. tuberculosis and other actinomycetes through bioinformatic analysis.

269 athway appears to be negatively regulated in actinomycetes through the phosphorylation of GlgE by Pkn

270 scovopsis on the one hand and the ant-fungus-actinomycete tripartite mutualism on the other.

271 cultivation-resistant, poorly characterized actinomycete, Tropheryma whippelii.

272 roducts and biological diversity, and marine actinomycetes turn out to be important contributors.

273 enera (totaling 43 species) of other aerobic actinomycetes using both the MALDI-TOF MS manufacturer's

274 al interactions within a set of 20 sequenced actinomycetes were carried out.

275 Actinomycetes were the most quantitatively important mic

276 RbpA), encoded by Rv2050, is specific to the actinomycetes, where it is highly conserved.

277 tive intracellular, Gram-positive, soilborne actinomycete which can cause severe pyogranulomatous pne

278 orneol (2-MIB) produced by cyanobacteria and actinomycetes, which are the major sources for "earthy"

279 ycan present in Mycobacterium spp. and other actinomycetes, which constitutes a major component of th

280 Sixty years ago, the actinomycetes, which include members of the genus Strept

281 t small molecular weight thiol found only in actinomycetes, which include mycobacteria.

282 Phylogenetically related rifampin-resistant actinomycetes with mutations mapping to clinically domin