ライフサイエンスコーパス: action potential firing

1 volume remained constant during the repeated action potential firing.

2 tability and decreased temporal precision in action potential firing.

3 nous release contributes to the precision of action potential firing.

4 ial segment that was identified by analyzing action potential firing.

5 be switched between by brief periods of NGFC action potential firing.

6 ance, leading to a concomitant adjustment in action potential firing.

7 at resulted in nociceptor depolarization and action potential firing.

8 the muscle whereas GABAergic bursts suppress action potential firing.

9 activation enables excitable cells to adjust action potential firing.

10 ar calcium transients triggered by bursts of action potential firing.

11 ease in the stimulus threshold for the first action potential firing.

12 annels that are prominently activated during action potential firing.

13 duction in Shaker increases the frequency of action potential firing.

14 lity and plays a critical role in modulating action potential firing.

15 ed by a delayed depolarization that triggers action potential firing.

16 cotrophs, leading to a sustained increase in action potential firing.

17 and-inducible, and reversible suppression of action potential firing.

18 ne properties occurs in vivo, in response to action potential firing.

19 transient increase in p(open) in response to action potential firing.

20 ransmitter release with Ca(2+) influx during action potential firing.

21 dition, beta1 is required for high-frequency action potential firing.

22 u potential capable of triggering repetitive action potential firing.

23 on, activation of AMPA or NMDA receptors, or action potential firing.

24 on by converting synaptic input to output as action potential firing.

25 kinetics that support high-frequency, narrow action potential firing.

26 cterized role in neurotransmitter-stimulated action potential firing.

27 difference to pain because of attenuation of action potential firing.

28 rapidly decreases in response to repetitive action potential firing.

29 ent forms of sodium current and to sustained action potential firing.

30 ion cues through modulation of their rate of action potential firing.

31 (2P) channel exhibit marked accommodation of action potential firing.

32 hR antagonist, and (3) tetrodotoxin to block action potential firing.

33 derlie the neuronal M current that regulates action potential firing.

34 rease the speed and regularity of repetitive action potential firing.

35 lity of transmitter release during bursts of action potential firing.

36 hibited robust, spontaneous "pacemaker-like" action potential firing.

37 larizing currents and tetrodotoxin abolished action potential firing.

38 ity at -38 mV of -44 pA pF(-1) and supported action potential firing.

39 es in interneurons that triggered repetitive action potential firing.

40 spikes that trigger and shape the pattern of action potential firing.

41 s to a degree that was sufficient to abolish action potential firing.

42 eceptors, which are activated in response to action potential firing.

43 erties and responded to kainate with intense action potential firing.

44 oportionately to synaptic integration during action potential firing.

45 g membrane potential below the threshold for action potential firing.

46 to activate nitric oxide synthase, increased action potential firing.

47 ors with 1 nM BPA increases the frequency of action potential firing.

48 al scale mechanisms that account for altered action potential firing.

49 stently exhibit reduced input resistance and action potential firing.

50 in cellular depolarization and ganglion cell action potential firing.

51 ve contributions to synaptic integration and action potential firing.

52 hed, however there is a failure to establish action potential firing.

53 -activated cryptochrome to increase neuronal action potential firing.

54 these effects of MF exposure evoke increased action potential firing.

55 n in the coupling of GABAA-R conductances to action potential firing.

56 ated ion channels, enabling light to control action-potential firing.

57 Ca(2+) imaging, we have observed hyperactive action-potential firing.

58 zation by the monosynaptic EPSP and multiple action potential firings.

59 as apparent across a wide frequency range of action potential firing (6-22 Hz) and dendritic excitati

60 2/7.3 at voltages close to the threshold for action potential firing (-60 mV) but generally had reduc

61 rization of cell membranes and inhibition of action potential firing, accompanied by a rapid inhibiti

62 racellular recording showed that concomitant action potential firing activity in putative GABAergic a

63 tes for the first 15-25 APs during bursts of action potential firing, after which it slows with incre

64 Y1, P2Y12, and P2Y13 agonist) also increased action potential firing, an effect blocked by the select

65 reliably reproduce the observed increase in action potential firing and altered action potential wav

66 synaptic inputs, but does not require axonal action potential firing and backpropagation.

67 atic MORs in POMC neurons robustly inhibited action potential firing and Ca(2+) activity despite dese

68 and temporal profile of inhibition of axonal action potential firing and dendritic spike generation.

69 lication of Abeta to cortical slices induced action potential firing and enhanced excitatory postsyna

70 , do not display a tuft, and exhibit regular action potential firing and little sag.

71 rent (I(A)) plays an active role in neuronal action potential firing and may contribute to modulating

72 cNIC enhanced action potential firing and modified spike waveform char

73 iminated by tetrodotoxin--a drug that blocks action potential firing and network activity--or by anta

74 3/Nav1.7 interaction reduced the heat-evoked action potential firing and nociceptive behavior.

75 This hyperpolarization was not triggered by action potential firing and not accompanied by an increa

76 al ganglia circuitry, changes in the rate of action potential firing and pattern of activity in the g

77 osition persisted after chronically blocking action potential firing and postsynaptic receptors but w

78 m-activated potassium (SK) channels regulate action potential firing and shape calcium influx through

79 , thereby establishing a direct link between action potential firing and somatic [Ca2+]i in light-sti

80 ng [Ca(2+)](o) with enhanced conductance and action potential firing and strongly elevated [Ca(2+)](i

81 ward current and resulting sADP may modulate action potential firing and subsequent GnRH release.

82 ing in membrane depolarization and increased action potential firing and subsequent stimulation of in

83 in vitro development suggest that changes in action potential firing and synaptic activity may be sec

84 tion of neuronal excitability, the timing of action potential firing and synaptic integration and pla

85 Action potential firing and synaptic responses were reco

86 roperties required to maintain high rates of action potential firing and transmitter release.

87 ransient biochemical events such as neuronal action-potential firing and RhoA activation in growth co

88 izing resting membrane potential, increasing action potential firing, and facilitating responses to s

89 tial, decreased GnRH neuron excitability and action potential firing, and hyperpolarized membrane pot

90 Similarly, the sodium currents and action potential firing are also impaired in the GABAerg

91 Plateau depolarizations and bursts of action potential firing are thought to depend on the mat

92 e delayed rectifier currents, which regulate action potential firing, are encoded by heteromeric Kv2

93 These data identify temporal kinetics of action potential firing as critical components regulatin

94 duced by hyperosmolarity, high potassium, or action potential firing at 30 Hz to produce synaptic dep

95 e majority of Re neurons exhibit spontaneous action potential firing at rest.

96 IPSPs gave rise to a rebound excitation and action potential firing at the termination of the burst.

97 er functioning of synapses during repetitive action potential firing, because deficiencies in this pr

98 o membrane depolarization and an increase in action potential firing but this stimulation of electric

99 nd noninvasive optical means for controlling action potential firing, but the genes encoding these ch

100 ding Ca(2+) spike frequencies resulting from action potential firing, but this has not been investiga

101 and inflammatory pain; (2) sanshool inhibits action potential firing by blocking voltage-gated sodium

102 We report that sustained action potential firing by CWCs evokes endocannabinoid r

103 Inhibiting CN neuron action potential firing by local application of the gamm

104 the period of enhanced glutamate release and action potential firing by postsynaptic neurons.

105 at the axonal initial segment and regulates action potential firing by setting the density of the ax

106 Last, we modeled action potential firing by simulating eight currents dir

107 insic UBC excitability, reducing spontaneous action potential firing by slowing maximum depolarizatio

108 Some neurotransmitters can facilitate action potential firing by suppression of a low voltage-

109 ll as its influence on Na channel gating and action potential firing, by studying cultured cerebellar

110 During action potential firing, calcium signals in basal dendri

111 vironmental stimuli, coded in the pattern of action potential firing, can be very sensitive to the te

112 P)-sensitive component of I(h) and abolished action potential firing caused by an elevation of cAMP i

113 Cholesterol modulation of BK channels alters action potential firing, colonic ion transport, smooth m

114 ater use-dependent inactivation, and reduced action potential firing compared with wild-type cells.

115 maturation of resting membrane potential and action potential firing, decreased synaptic activity and

116 at these subtle alterations in the timing of action potential firing differentially regulates hundred

117 ntrast, basal release that is independent of action potential firing does not require RIM.

118 ntaneous activity, with correlated bursts of action potential firing dominating network activity.

119 hole-cell electrophysiology to determine how action potential firing drives calcium responses within

120 ed muscle membrane and the failure of muscle action potential firing during challenge with agents kno

121 , increases both duration of the upstate and action potential firing during the upstate.

122 Cholinergic bursts concur with facilitated action potential firing, elevated cytosolic [Ca(2+)] and

123 chanical threshold by 50% and increasing the action potential firing elicited by a P2X2/3 agonist to

124 MA reduces neuronal action potential firing elicited by mechanical stimuli i

125 Although the patterns of action potential firing elicited in this cell population

126 while changes in the rate and statistics of action-potential firing encode information about the ens

127 simulated EPSPs enhanced the rate of ongoing action potential firing, evoked by somatic simulated EPS

128 enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstine

129 important regulators of neuronal and cardiac action potential firing (excitability) and have major ro

130 terminations of multiple cable parameters in action potential-firing fibres including Rin and lambda

131 both receptor types leads to an increase in action potential firing frequency and a rise in the intr

132 ntial upstroke velocity but markedly reduced action potential firing frequency in intracardiac neuron

133 g potential and is an important modulator of action potential firing frequency in many excitable cell

134 yperpolarization and a dramatic reduction of action potential firing frequency in rat sympathetic neu

135 relevant concentrations, ranolazine reduced action potential firing frequency of hippocampal neurons

136 onic GS967-treatment had no impact on evoked action potential firing frequency of interneurons, but d

137 the LS and showed that TMEM16B regulates the action potential firing frequency of LS neurons.

138 d its stable analogue exendin-4 increase the action potential firing frequency of MCs by decreasing t

139 put occurred at 5 Hz, similar to the average action potential firing frequency of tonically active TI

140 g pattern, while having no impact on overall action potential firing frequency or UP and DOWN states.

141 ransient increase followed by a reduction in action potential firing frequency recorded from GABAergi

142 TRH increased the action potential firing frequency recorded from GABAergi

143 hat activation of OXTRs in the CeL increased action potential firing frequency recorded from neurons

144 KII inhibition suppresses glucose-stimulated action potential firing frequency.

145 in input resistance, impedance amplitude and action-potential firing frequency across the somato-apic

146 harge in isolated brainstem preparations and action potential firing from CO2 -sensitive neurons in b

147 ticonvulsant lamotrigine selectively reduced action potential firing from dendritic depolarization, w

148 We recorded action potential firing from the terminals of individual

149 ecordings (n = 42) revealed that patterns of action potential firing generated by concerted somatic a

150 voltage-gated Na(+) channels responsible for action potential firing have specialized mechanisms that

151 ers, which could explain a stronger shift in action potential firing in 112A/A mice.

152 or tetrodotoxin-sensitive sodium channels in action potential firing in a discrete subpopulation of s

153 CCh depolarized and evoked action potential firing in a fraction of PCs and increas

154 Y) evokes rapid depolarization and increased action potential firing in a subset of circadian and aro

155 FGF14 is required for spontaneous and evoked action potential firing in adult Purkinje neurons, there

156 However, dopamine altered action potential firing in an extremely rapid (<1s) and

157 f GABA depolarized beta-cells and stimulated action potential firing in beta-cells exposed to glucose

158 neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pat

159 creased the probability of SR input to drive action potential firing in CA1 pyramidal neurons, which

160 ) mice, making it nearly impossible to evoke action potential firing in CA2 pyramidal neurons.

161 PACAP stimulation did not evoke action potential firing in chromaffin cells but did caus

162 stimulation levels that produced repetitive action potential firing in control model neurons, depola

163 se of proinflammatory neuropeptides from and action potential firing in cutaneous nociceptors.

164 Notably, the preferred angle of phase-locked action potential firing in each basal ganglia structure

165 probably to influence the precise timing of action potential firing in either individual or ensemble

166 s heat stimuli could not evoke the sustained action potential firing in FGF13-deficient DRG neurons.

167 electively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals.

168 frequencies rapidly and reversibly increased action potential firing in HA cells, an effect that was

169 functional properties of hNav1.5 and alters action potential firing in heterologous expression syste

170 to LTP induction during synaptically driven action potential firing in hippocampal CA1 pyramidal neu

171 s have severely impaired sodium currents and action potential firing in hippocampal GABAergic inhibit

172 C14 decreases outward currents and increases action potential firing in hippocampal neurons.

173 with these behavioral results, CNO decreased action potential firing in isolated sensory neurons from

174 ng sequentially both synaptic potentials and action potential firing in large populations of DGCs, we

175 llow rapid and dynamic control of OSN-driven action potential firing in MCs through changes in gap ju

176 demonstrate that TTX-sensitive Na(V)s drive action potential firing in menthol-sensitive sensory neu

177 n is the transformation of synaptic input to action potential firing in mitral and tufted (M/T) cells

178 ordings showed that OH cell firing inhibited action potential firing in most MCH neurons, an effect t

179 c pain is therefore initiated by HCN2-driven action potential firing in Na(V)1.8-expressing nocicepto

180 cium dyes and allowed visualization of tonic action potential firing in neurons and high resolution f

181 Nav1.7 mutation could induce high-frequency action potential firing in nociceptive neurons and that

182 The rate of action potential firing in nociceptors is a major determ

183 rpolarizes membrane potential and suppresses action potential firing in OX neurons in mouse hypothala

184 The precise inhibition affected action potential firing in PCs in two distinct ways.

185 Moreover, the timing of action potential firing in PNs is not phase-locked to os

186 of sprouted mossy fibers reliably triggered action potential firing in postsynaptic dentate granule

187 This conductance is sufficient to drive action potential firing in response to acid stimuli, is

188 freshly isolated DRG neurons showed reduced action potential firing in response to current injection

189 Importantly, EtOH inhibited interneuron action potential firing in response to KA-R activation b

190 med that such hyperpolarization enhances RGC action potential firing in response to subsequent depola

191 ht into the mechanism that produces rhythmic action potential firing in SCN.

192 ct of carbachol on inhibition of spontaneous action potential firing in sinoatrial node cells.

193 entiation that does not require postsynaptic action potential firing in the axon.

194 er conditions of elevated Mg(2+) and lack of action potential firing in the axons, although how this

195 -mediated sPSC frequency and the decrease in action potential firing in the GnRH cells.

196 sensory neurons (SNs) via the interaction of action potential firing in the SN coupled with the relea

197 Circadian oscillations in spontaneous action potential firing in the suprachiasmatic nucleus (

198 rons, and PACAP was further shown to augment action potential firing in these cells.

199 promotes enhanced excitatory drive and tonic action potential firing in these neurons.

200 sticity of ionic currents leads to increased action potential firing in vitro and increased strength

201 Blocking action potential firing in vitro increased presynaptic e

202 enhanced fear memory consolidation and drove action potential firing in vitro.

203 tal synaptic transmission, and increased MSN action potential firing in vivo.

204 double-projecting vCA1 neurons also induced action potential firings in the mPFC neurons that projec

205 mining the shape, duration, and frequency of action-potential firing in excitable cells.

206 both necessary and sufficient for sustained action-potential firing in tactile afferents.

207 vation caused prolonged inhibition (>9 s) of action-potential firing in thalamic projection neurons o

208 Possible modulators of action potential firing include the HCN ion channels, wh

209 ordings from lamina I neurons, we found that action potential firing induces calcium responses within

210 tic sites on the rate and pattern of ongoing action potential firing is determined using multisite wh

211 rons is potentiated and hypocretin-1-induced action potential firing is facilitated, potentially expl

212 uring the circadian cycle, but the effect on action potential firing is modulated by postsynaptic pro

213 ane excitability, to maintain consistency of action potential firing, is critical for stable neural c

214 ouse extensor digitorum longus (EDL) fibres, action potential firing leads to substantial changes in

215 latform to rapidly generate large numbers of action-potential firing mDA neurons after 25 days of dif

216 ing prolonged, complex trains of presynaptic action potential firing (mean frequency, 48 Hz).

217 eads to increased sodium current (I(Na)) and action potential firing, mimicking the response by these

218 In addition, MCH suppressed action potential firing MSNs through K(+) channel activa

219 urons, depolarization block and cessation of action potential firing occurred in T226M model neurons.

220 Because action potential firing occurs only during the depolariz

221 f synaptic inhibition triggered by transient action potential firing of a single thalamic relay neuro

222 eurons increased or decreased, respectively, action potential firing of GABAergic NTS neurons and dow

223 IP1) and Ca2+ signaling in cell lines and on action potential firing of GnRH neurons in brain slices.

224 hreshold, GRP-induced Ca(2+) transients, and action potential firing of GRPR(+) neurons.

225 n IO neurons, leading to markedly diminished action potential firing of IO neurons in TMEM16B knockou

226 Finally, we found that repetitive action potential firing of PFC pyramidal neurons suppres

227 Action potential firing of serotonin dorsal raphe neuron

228 rdings show that cannabidiol reduces overall action potential firing of striatal neurons.

229 cluding KCNQ2/3 channels, and attenuated the action potential firing of superior cervical ganglion ne

230 d single CCK cells could transiently inhibit action potential firing of synaptically coupled PV cells

231 ity of these lines for precisely controlling action-potential firing of GABAergic, cholinergic, serot

232 t optogenetic activation of phasic and tonic action-potential firing of NR neurons during memory acqu

233 les different wavelengths of light to switch action potential firing on and off.

234 nergic signaling does not interfere with the action potential firing pattern, pharmacological ablatio

235 ritic processes that transformed the ongoing action potential firing pattern, promoting action potent

236 mEC were preferentially affected, such that action potential firing patterns in dorsal mEC-SCs were

237 itability, with a shift from phasic to tonic action potential firing patterns in KO neurons.

238 were used for stimulating and inhibiting the action potential firing patterns of SH-SY5Y human neurob

239 role in regulating membrane excitability and action potential firing patterns.

240 uisitely sensitive to the temporal nature of action potential firing patterns.

241 o cells in these subregions led to different action potential firing patterns.

242 phs display highly heterogeneous spontaneous action-potential firing patterns and their resting membr

243 Action potential firing probability was reliably phase-l

244 ypophysial nerve terminals and increased the action potential firing probability.

245 dynamically regulates membrane excitability, action potential firing properties, and long term potent

246 vely regulate resting membrane potential and action potential firing properties.

247 This tonic inhibition strongly modifies action potential firing properties.

248 or prolonged application of capsaicin, their action potential firing quickly adapted.

249 dent membrane depolarization, an increase in action potential firing rate and decrease in amplitude o

250 s in Shaw and Shal currents drive changes in action potential firing rate and that these rhythms are

251 HCN2 modulates action potential firing rate in nociceptive neurons and

252 MMW stimulation significantly increased the action potential firing rate in oocytes coexpressing vol

253 posure led to an increase in the single-unit action potential firing rate in vivo in VTA dopamine neu

254 gs, we found that TRH robustly increased the action potential firing rate of these neurones.

255 ibility, ie, effects changes in the rhythmic action potential firing rate, by impacting on these very

256 pond to dopamine with a severe depression in action potential firing rate, while pyramidal neurons do

257 citatory/inhibitory balance and an increased action potential firing rate.

258 r nociceptors from Trpa1(-/-) mice exhibited action potential firing rates 50% lower than those in wi

259 rons display rhythms of activity with higher action potential firing rates and more positive resting

260 Neuronal intrinsic properties control action potential firing rates and serve to define partic

261 Action potential firing rates are diminished owing to sl

262 tified TRPM7 blocker FTY720 has no effect on action potential firing rates of wild-type SAN cells.

263 electrical coupling of neurons and increased action potential firing rates.

264 enhanced neuronal intrinsic excitability and action potential firing rates.

265 subunits may affect temporal integration of action potential firing rates.

266 ibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding

267 es developmental changes to support the high action-potential firing rates required for auditory info

268 ) concentrations (100 pm) to 100 nm enhanced action potential firing, reduced afterhyperpolarizing po

269 provement in neurite outgrowth and increased action potential firing relative to injected isolated ce

270 During action potential firing, resonance of the spike output m

271 nts unexpectedly persisted in the absence of action potential firing, revealing, to our knowledge, th

272 Investigation of action potential firing shows that Scn1b null DRG neuron

273 In contrast, under active, action potential firing states, ACh excited c-ACs, but i

274 During action potential firing, the rate of synapsin dissociati

275 ated synaptic potentials reach threshold for action potential firing, the signal propagates leading t

276 eased Na channel availability may facilitate action potential firing, these results suggest a mechani

277 pressed spontaneous firing and increased the action potential firing threshold of patient-derived neu

278 uts can cause persistent changes in rates of action potential firing, through a mechanism that remain

279 itized colonic sensory neurons by increasing action potential firing to current injection and depolar

280 c neurons must maintain occasional bursts of action-potential firing to attract and keep synaptic con

281 e specific for KA-Rs, as EtOH did not affect action potential firing triggered by AMPA receptor-media

282 Action potential firing triggers transmitter release fro

283 tromedial hypothalamus (VMH), leptin-induced action potential firing was enhanced, whereas nuclear pS

284 Furthermore, enhanced action potential firing was only observed upon concurren

285 Although axonal action potential firing was required to trigger persiste

286 r action potentials, however, the pattern of action potential firing was shaped by the distribution o

287 t Ca2+ influx through VGCCs, activated after action potential firing, was the primary source for ligh

288 Finally, from the action potential firing, we estimated that </=19 odorant

289 oncentrations and the fractional decrease in action potential firing when GABA(A)-Rs were blocked in

290 raised the ICMS current intensity to induce action potential firing whereas the agonist 8-OH-DPAT ha

291 interfere with thermally induced changes in action potential firing, whereas loss of trpv1 abolished

292 or the implementation of this cooperation is action potential firing, which begins in the axon, but w

293 tained plateau depolarizations and bursts of action potential firing, which resembled cortical UP and

294 urons showed deficits in sodium currents and action potential firing, which were rescued by a Nav1.1

295 arlier peak times and consequently generated action potential firing with shorter latencies than ipsi

296 a2+ responses could be blocked by preventing action potential firing with tetrodotoxin.

297 (lLNvs) in Drosophila melanogaster increase action potential firing within seconds in response to li

298 nce the same activity pattern in response to action potential firing within the parent presynaptic ne

299 ones, serotonin abolished the rhythmicity of action potential firing without affecting spike frequenc

300 je neurons attenuates spontaneous and evoked action potential firing without measurably affecting the