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1 alcohol-exposed or aged mice (where JNK2 is activated).
2 derably outpaces any 1,5-H shift and instead activates 1,5-methoxy migration, giving methoxy-migrated
3 rease in calcium and reactive oxygen species activate a large conductance channel in the inner mitoch
5 TM1 binds to insulin receptor, which in turn activates a nuclear factor kappa B-dependent metabolic p
6 , we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca(2+) extrusion
10 ES cell telomeres devoid of TRF2 instead activate an attenuated telomeric DNA damage response tha
11 Ss) are a class of sensors that use light to activate an electrochemical reaction on the surface of a
12 t exposure of leukemia cells to daunorubicin activated an integrated stress response-like transcripti
13 ls with genetically deleted cyclin Ds, which activate and confer specificity to CDK4/6, can compensat
14 Our data suggest that MAIT cells are highly activated and become dysfunctional during clinical sepsi
15 ctivation reported for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in th
21 on with C. burnetii, both TFEB and TFE3 were activated, as demonstrated by the transport of these pro
24 d these cells were identified as a subset of activated astrocytes located predominately in the white
26 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) as key signaling pathways
27 whereby acquisition of founder mutations in activated B cells favors the development of aberrant MBs
28 nuclear factor kappa-light-chain-enhancer of activated B cells)-dependent inflammation, caspase-depen
29 d to unfavorable outcome were age >18 years; activated B-cell (ABC) DLBCL profile, HGBCL, NOS, high g
30 tial lead compound led to tumor stasis in an activated B-cell-like (ABC) diffuse large B-cell lymphom
32 termine three-dimensional (3D) structures of activated beta-arrestin2 stabilized by phosphorylated mu
41 eptide (AgRP)-expressing neurons are acutely activated by caloric need, and this acute activation pro
42 viral DREADD (designer receptor exclusively activated by designer drugs) strategy to manipulate vHPC
44 d a distinct population of GABAergic neurons activated by GA in the mouse central amygdala (CeA(GA) n
45 tor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, the pungent compound
48 ease entities, show that common targets (TE) activated by the same drug (5-azacytidine) elicit an imm
50 The nucleus of the solitary tract (NTS) is activated by vagal afferents from the gastrointestinal t
51 eta3, a prototypic adhesion receptor, can be activated by various mechanical stimuli including stretc
57 yielded a cell-permeable proteomimetic that activates cell proliferation via regulation of the Hippo
61 , we discovered that chromosomal instability activates cGAS/STING signaling but strongly suppresses i
66 transduced along polymer chains, is used to activate covalent bonds in mechanosensitive molecules (m
68 ther Ca(V)2 channels, including high voltage-activated currents that are larger in external Ba(2+) th
69 ically start the cell-cycle entry program by activating cyclin-dependent protein kinase 4/6 (CDK4/6).
70 ator of mitochondrial function that directly activates cytochrome c oxidase in the mitochondria and f
71 encing, we show that these cells are largely activated DCs acquiring features compatible with lymph n
72 the mitogen-activated protein kinase (MAPK) activating death domain protein, regulates various cellu
74 ee of the five compounds exhibited thermally activated delayed fluorescence (TADF) in spite of a rela
75 and nutrient deprivation can up-regulate and activate DinB/pol IV, the bacterial ortholog of Polkappa
77 t aligned with this central oncogenic driver activate divergent pathways and subvert transformation.
78 pose that the allosteric mechanism of nickel-activated DNA binding by HpNikR is driven by conformatio
82 elucidate the structure of an agonist-bound activated DRD2-G(i) complex reconstituted into a phospho
84 HIV encodes an aspartyl protease that is activated during, or shortly after, budding of viral par
85 ability of storage lesion-induced RBC-MVs to activate each zymogen of the intrinsic pathway was asses
88 othrombotic and attractive to phagocytes and activated endothelial cells and thus contributes to the
89 capture (Hi-C) analysis revealed multiplex, activated enhancer-promoter configurations encompassing
90 e, we report on the characterization of acyl-activating enzymes (AAEs) that catalyze the formation of
91 carrier-protein) synthases, peroxisomal acyl-activating enzymes, ATP binding cassette (ABC) transport
92 cer cells expressing wild-type (WT) ER or an activating ESR1 mutation, Y537S-ER, were used to generat
94 trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphin
97 ntitumor effect, indicating that early, self-activating expression of anti-PD-L1-gamma1 can overcome
98 ivation lowered surface BCR, CD19 and B cell-activating factor receptor and increased expression of p
99 onal antibodies for selective binding to the activating Fcgamma receptor FcgammaRIIa results in enhan
101 bed in the distal limb ectoderm, where it is activated following the rule of temporal colinearity.
104 mplexes, a conventional ternary complex that activates G proteins and an inverse-coupled binary compl
106 conventional T lymphocytes or recombination-activating gene (Rag) failed to show rescue of mutant co
107 KLF) is a transcription factor that globally activates genes involved in erythroid cell development.
110 pathway through the NF-kappaB transcription-activating group P65 by phosphorylation and nuclear tran
111 that LGR4 promotes the normal hair cycle by activating HF stem cells and by influencing the activiti
114 -900 IgG sequences from ~2,200 IgG-secreting activated human memory B cells, activated ex vivo, demon
115 rst evidence that the expression of IL-3R on activated human Th cells is modulated by IL-4, and IL-3
120 l types, promoters with high basal H3K4me2/3 activate in spite of some residual H3K27me3, compared to
122 Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosc
125 sentinels of innate immune defence that are activated in response to diverse stimuli, including path
126 s, whereas APOBEC signature targeting C>G is activated in the intermediate phase of disease progressi
127 The MAPK pathway is often found to be highly activated in TNBC, however the precise functions of the
128 o determine pathological processes that were activated, inactivated, or unchanged vs. RVD with no int
133 es, we examined the mechanism by which E449K activates Int for gp3-independent attL x attR recombinat
134 ether these findings show that the ubiquitin-activated interaction trap (UBAIT) fusion system can eff
137 e-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-
138 (phox), and to the RAC-binding domain of p21-activated kinase, consistent with our earlier findings.
141 er regulator" is necessary and sufficient to activate lineage-specific genes while restricting the ge
142 vivo, selects for rare subsets of HBECs that activate low levels of telomerase activity to maintain s
143 and age-specific gene changes in the mTORC1-activated lung mesenchyme and establishes the importance
145 MdbHLH3 transcriptionally suppresses and activates MdPIN1 and MdGH3-2, respectively, by specifica
147 T in vivo with (i) 11C-PK-11195, a marker of activated microglia and a proxy index of neuroinflammati
149 n a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domai
150 atalysis was constitutively elevated without activating mutations, suggesting a non-genetic basis for
152 ned by exothermic combustion of mechanically-activated nanostructured metallic precursors in nitrogen
153 ity may exhibit disease reciprocity in which activated neutrophils are mutually shared to create coll
160 onstrate the triazole as an effective LG for activating nucleophilic substitution reactions on tyrosi
161 developed a miRNA regulation system that is activated only when HSPCs are recruited to and different
162 ecific DNA motifs, thereby serving to either activate or repress transcription of specific genes invo
166 edited cells (BAR-Seq) and show that editing activates p53, which substantially shrinks the HSC clona
167 ibiting cancer cell growth and viability and activating p53-dependent transcription factor activity i
169 , we used arousing stimuli to experimentally activate participants' noradrenergic system while record
174 neuroprotective effects of pharmacologically activating PKM2 via ML-265, a small molecule activator o
175 response system, pituitary adenylate cyclase-activating polypeptide (PACAP), and its cognate receptor
178 d depend on downstream recruitment of Ca(2+)-activated potassium channels to the plasma membrane.
181 s where the initial challenge simultaneously activates pre-emptive protection against the second impe
182 ort-term high-fat-diet (HFD) feeding of mice activates prepronociceptin (PNOC)-expressing neurons in
184 Ill Patients with Septic Shock) and $30,911 (Activated Protein C and Corticosteroids for Human Septic
186 l cell line, we investigated the role of AMP-activated protein kinase (AMPK), a master regulator of e
190 ed NF-kappaB activator 1 (Act1), p38 mitogen-activated protein kinase (MAPK), Jun NH2-terminal kinase
191 ranscription factors are released by mitogen-activated protein kinase (MAPK)-stimulated acetylation t
192 ense variants in MAPK1, encoding the mitogen-activated protein kinase 1 (i.e., extracellular signal-r
194 ranscription (STAT) (ruxolitinib) or mitogen-activated protein kinase kinase (MEK) (trametinib) and w
197 gnal-regulated kinase), JNK, and p38 mitogen-activated protein kinases as well as NFkappaB (nuclear f
198 RK2 family comprises the abscisic acid (ABA)-activated protein kinases SnRK2.2, SnRK2.3, SnRK2.6, SnR
199 binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like neural stem
200 ellular membrane traffic, and one of the Arf-activating proteins, GBF1, is a cellular factor required
203 n does not require the use of stoichiometric activating reagents, and avoids the use of explosive rea
204 the nuclear receptor peroxisome proliferator-activated receptor (PPAR) delta as key regulator of oste
205 utase 2), PGC1alpha [peroxisome proliferator-activated receptor (PPAR) gamma-coactivator 1alpha], PPA
207 n to be regulated by peroxisome proliferator-activated receptor alpha (PPARalpha), suggesting that FA
210 activation increased peroxisome proliferator-activated receptor gamma activity and reduced proliferat
212 on between legs, but peroxisome proliferator-activated receptor gamma coactivator 1-alpha and oxidati
213 acid, a PPAR-gamma (peroxisome proliferator-activated receptor gamma) agonist that stimulates mitoch
214 ssion of PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator 1), a Parkin downst
215 , necroptosis, and apoptosis (PANoptosis) by activating receptor-interacting Ser/Thr kinase 3 (RIPK3)
218 compete for the cA4 ligand, a canonical cA4-activated ribonuclease activity in the Csx1 domain and a
222 ximal FC of 28% was observed for the electro-activated sample obtained by using Anolyte_450mA-50 min.
223 3.9 angstrom resolution cryo-EM structure of activated Schizosaccharomyces pombe Arp2/3 complex bound
224 Our findings demonstrate that aberrantly activated SE upregulates CHPT1 expression and confers En
225 dimethylaminopropyl)-carbodiimide) (NHS/EDC)-activated self-assembled monolayers (SAMs) of 6-mercapto
227 factors are key drivers of inflammation that activate sets of genes in response to inflammatory signa
230 ters and enhancers convey cell-type specific activating signals, insulators prevent the cross-talk of
233 etween mutant calreticulin, ERp57, and STIM1 activated SOCE and generated spontaneous cytosolic Ca2+
234 In vitro, IL6 treatment of MDSC-like cells activated STAT3, increased expression of DNMT1 and DNMT3
238 f DNGR-1 maps to its signaling domain, which activates SYK and NADPH oxidase to cause phagosomal dama
239 It is possible to defeat this mechanism and activate T cells with solution ligands by cross-linking
241 in several cancer-specific neoantigens that activate T-cells indicating that they are cancer vaccine
243 ients with comorbidity had larger numbers of activated T cells compared with patients who had fewer r
246 mes, Tat must be released in order for it to activate the HIV-1 LTR promoter and facilitate HIV-1 vir
248 eover, these Z nucleotides are shown to also activate the nonrelated response regulators ArcA, CpxR,
251 MPRSS2 suggests that both host proteases can activate the S glycoprotein during the process of syncyt
252 rturbation can be sensed by P. aeruginosa to activate the T6SS even when the disruption is generated
253 recurrent intronic variant predicted to cis-activate the TAL1 oncogene, a finding validated in vivo
254 ytoplasmic kinase-endoribonuclease module to activate the transcription factor XBP1s, which facilitat
257 race to identify endogenous substances that activated the same receptors as opiates resulted in the
258 opic investigations, free reactants could be activated the same way by the local pressurized CO(2) mi
261 hatidylinositol (4, 5)-bisphosphate (PIP(2)) activates the channel; a secondary anionic lipid site ha
263 permidine on the surface, which specifically activates the PIP(3)-pathway to induce phagocytic uptake
265 x4 depletion promotes 8-OHG release and thus activates the TMEM173/STING-dependent DNA sensor pathway
266 and the GDNF-GFRalpha1 complex binds to and activates the transmembrane RET tyrosine kinase to signa
267 in folding in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)-a signalin
268 to investigate the therapeutic potential of activating the aryl hydrocarbon receptor (AHR) to limit
271 ding ability is critical for its function in activating the Hippo pathway in response to osmotic stre
273 phaly by delaying mitosis and pathologically activating the mitotic surveillance pathway in the devel
274 izing cytosolic chromatin fragments and then activating the stimulator of interferon genes (STING) cy
275 lls adapt to increased antibody synthesis by activating the unfolded protein response (UPR) under the
276 ochondria can also serve as a cGAS ligand to activate this pathway and trigger extensive inflammatory
280 ute liver failure; however, TGFbeta1 must be activated to bind its receptor and generate downstream e
282 ocytes (hiPSC-CM) demonstrated that ERRgamma activates transcription of genes involved in virtually a
283 tone acetyltransferase (HAT) activities that activates transcription of key protooncogenes, including
284 issue of Blood, Huang et al have identified activating transcription factor 4 (ATF4) as a novel regu
286 rt defective Treg cells into powerful, super-activated Treg cells (SuperTreg cells) that can resolve
288 s cancer cells with GRP78 overexpression via activating unfolded protein response-mediated apoptosis.
291 e the importance of balanced vaccine-induced activating versus suppressive immune responses in afford
292 becestat metabolite-responsive T-cell clones activated via a pharmacological interactions pathway in
293 The Fanconi anaemia pathway of ICL repair is activated when a replication fork stalls at an ICL(2); t
294 19 and prostaglandin E(2) receptor subtype 3 activated with iloprost showed a similar reaction to dep
298 TP receptor because prostaglandin F receptor activated with U46619 and prostaglandin E(2) receptor su