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1 alcohol-exposed or aged mice (where JNK2 is activated).
5 t exposure of leukemia cells to daunorubicin activated an integrated stress response-like transcripti
6 Our data suggest that MAIT cells are highly activated and become dysfunctional during clinical sepsi
7 ctivation reported for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in th
9 ) and cholesterol biosynthesis pathways were activated, and specific cytokine and chemokine receptors
10 lyze the C-N bond formation reaction between activated aryl halides and amines at low catalytic loadi
12 on with C. burnetii, both TFEB and TFE3 were activated, as demonstrated by the transport of these pro
13 behavioral consequences, we chemogenetically activated astrocytes in the DMS using GFAP promoter-driv
15 d these cells were identified as a subset of activated astrocytes located predominately in the white
17 neurons, whereas interneurons were strongly activated at a latency preceding that found in projectio
19 e actin filament nucleator Arp2/3 complex is activated at cortical sites in Schizosaccharomyces pombe
20 ed at constant trapping voltage, ions can be activated at their secular frequencies and all MS/MS exp
21 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) as key signaling pathways
23 whereby acquisition of founder mutations in activated B cells favors the development of aberrant MBs
24 nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor that blocks IL-1beta maturat
25 nuclear factor kappa-light-chain-enhancer of activated B cells)-dependent inflammation, caspase-depen
26 Single-cell RNA sequencing analyses detected activated B cells, germinal centre B cells and ASCs with
27 d to unfavorable outcome were age >18 years; activated B-cell (ABC) DLBCL profile, HGBCL, NOS, high g
28 tial lead compound led to tumor stasis in an activated B-cell-like (ABC) diffuse large B-cell lymphom
29 termine three-dimensional (3D) structures of activated beta-arrestin2 stabilized by phosphorylated mu
30 Mechanistically, DEPTOR depletion not only activated both mTORC1 and mTORC2 signals to promote cell
32 his study was to assess the repeatability of activated brown adipose tissue (BAT) radiomic features.
34 erol from the PM to the ER is believed to be activated by a lipid-sensing peptide(s) in the ER that c
39 eptide (AgRP)-expressing neurons are acutely activated by caloric need, and this acute activation pro
40 a chelation-assisted leaving group could be activated by Cu(OTf)(2) and avoided the use of harsh Lew
41 viral DREADD (designer receptor exclusively activated by designer drugs) strategy to manipulate vHPC
46 d a distinct population of GABAergic neurons activated by GA in the mouse central amygdala (CeA(GA) n
47 rotein kinase (AMPK) is a key energy sensor, activated by glucose limitation to resolve nutrient supp
48 tor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, the pungent compound
50 cardiac regeneration enhancers are not only activated by injury, but surprisingly, they are also act
52 hat can be synergistically and independently activated by membrane voltage and intracellular Ca(2+).
54 r 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors.
57 van Krevelen redox mechanism where CH(4) is activated by reaction with a hematite surface oxygen fir
60 ire activity in (higher threshold) afferents activated by the muscle twitch evoked by electrical stim
61 G protein-coupled receptors OX(1) and OX(2), activated by the neuropeptides OX-A and OX-B, is firmly
62 ease entities, show that common targets (TE) activated by the same drug (5-azacytidine) elicit an imm
63 showed that both promoters and enhancers are activated by the same transcription factors in different
65 The nucleus of the solitary tract (NTS) is activated by vagal afferents from the gastrointestinal t
66 eta3, a prototypic adhesion receptor, can be activated by various mechanical stimuli including stretc
71 port a critical role for ER Ca(2+) depletion-activated Ca(2+) current in mediating Ca(2+)-induced ins
76 in (IL)-1beta, pro-IL-18, and gasdermin-D by activated caspase-1 resulted in the cellular release of
77 xpressed by different immune cells including activated CD4(+)Foxp3(+) regulatory T cells (Tregs) and
79 on transformed MDSCs into myeloid cells that activated CD8(+) T cell-mediated immunity against cancer
83 onal analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulati
85 RMS; n = 7) were isolated using fluorescence activated cell sorting for bulk RNA sequencing (RNA-Seq)
91 photophysical properties of the bound, light-activated chromophore, zinc protoporphyrin IX, (PPIX)Zn.
92 s also express Ano1, which encodes a Ca(2+) -activated Cl(-) conductance that serves as a primary pac
97 e describe here the presence of mechanically activated currents in melanoma cells that are dependent
98 ther Ca(V)2 channels, including high voltage-activated currents that are larger in external Ba(2+) th
99 encing, we show that these cells are largely activated DCs acquiring features compatible with lymph n
101 nic light-emitting diodes based on thermally activated delayed fluorescence (TADF) from donor-accepto
102 ee of the five compounds exhibited thermally activated delayed fluorescence (TADF) in spite of a rela
103 iplet-exciton behaviours including thermally activated delayed fluorescence (TADF), room-temperature
104 sm involving contributions of both thermally activated delayed fluorescence and phosphorescence.
105 ociation (EID) was compared to collisionally activated dissociation (CAD) on a series of agrochemical
107 pose that the allosteric mechanism of nickel-activated DNA binding by HpNikR is driven by conformatio
110 elucidate the structure of an agonist-bound activated DRD2-G(i) complex reconstituted into a phospho
113 HIV encodes an aspartyl protease that is activated during, or shortly after, budding of viral par
114 ction is associated with proinflammatory and activated effector memory T cells in the blood, evidence
116 othrombotic and attractive to phagocytes and activated endothelial cells and thus contributes to the
117 capture (Hi-C) analysis revealed multiplex, activated enhancer-promoter configurations encompassing
118 trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphin
121 MP-dependent regulation of hyperpolarization-activated f-(HCN4) channels has been abolished (HCN4-CNB
124 bed in the distal limb ectoderm, where it is activated following the rule of temporal colinearity.
127 ed with Ku70/80 and DNA in both inactive and activated forms at resolutions of 3.7 angstrom overall a
130 iptome of developing nodules revealed highly activated glycolysis, fatty acid (FA), 2-monoacylglycero
131 increased chorda tympani nerve activity and activated gustatory neurons in the rostral nucleus tract
132 es a broader substrate scope, including less-activated (hetero)aryl bromides and electron-deficient (
133 reaction between the carbon radical and the activated heteroarene but also accelerates the electron
137 -900 IgG sequences from ~2,200 IgG-secreting activated human memory B cells, activated ex vivo, demon
138 rst evidence that the expression of IL-3R on activated human Th cells is modulated by IL-4, and IL-3
141 tor (FGF) dependent signalling is frequently activated in cancer by a variety of different mechanisms
145 Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosc
148 strates that inflammatory processes are also activated in pancreatic islets from obese animals and hu
149 sentinels of innate immune defence that are activated in response to diverse stimuli, including path
150 oncanonical 5' cap-binding protein eIF3d was activated in response to metabolic stress in human cells
151 nistration of miR-127, which is functionally activated in target cells, inhibits growth and spontaneo
152 cell death pathways and key upstream sensors activated in the context of Candida and Aspergillus infe
153 s, whereas APOBEC signature targeting C>G is activated in the intermediate phase of disease progressi
155 The MAPK pathway is often found to be highly activated in TNBC, however the precise functions of the
156 mplex theories as to how these receptors are activated in vivo, complicating pharmacological advances
157 o determine pathological processes that were activated, inactivated, or unchanged vs. RVD with no int
159 ether these findings show that the ubiquitin-activated interaction trap (UBAIT) fusion system can eff
162 e-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-
163 (phox), and to the RAC-binding domain of p21-activated kinase, consistent with our earlier findings.
164 mium mediates the persistence of classically activated lung macrophages to exacerbate lung injury.
165 and age-specific gene changes in the mTORC1-activated lung mesenchyme and establishes the importance
167 increase in the spleen, suggesting that PnV-activated macrophages were led preferentially to the tum
168 polarization (classically and alternatively activated macrophages: M1 and M2, respectively) were stu
170 T in vivo with (i) 11C-PK-11195, a marker of activated microglia and a proxy index of neuroinflammati
172 ce by pharmacological removal of chronically activated microglia using a colony stimulating factor 1
173 BBB, target and deliver drugs selectively to activated microglia/macrophages at the sites of injury,
174 s, the Gclm knockout mouse, oxidative stress activated MMP9 (matrix metalloprotease 9) via its redox-
175 ngly light-harvesting antenna sizes by light-activated Nab1 repression of CAO expression as a functio
176 ned by exothermic combustion of mechanically-activated nanostructured metallic precursors in nitrogen
177 ded to therapy had an increased abundance of activated natural killer cells and a newly identified CD
179 ity may exhibit disease reciprocity in which activated neutrophils are mutually shared to create coll
186 developed a miRNA regulation system that is activated only when HSPCs are recruited to and different
189 osteroventral pallidum, and volume of tissue activated overlap with this map was significantly correl
191 observed an increased frequency of partially activated pDCs in the blood before detection of HIV RNA.
195 EBV-infected T cells had an effector memory activated phenotype, whereas EBV-infected B cells expres
199 d depend on downstream recruitment of Ca(2+)-activated potassium channels to the plasma membrane.
203 Ill Patients with Septic Shock) and $30,911 (Activated Protein C and Corticosteroids for Human Septic
206 l cell line, we investigated the role of AMP-activated protein kinase (AMPK), a master regulator of e
207 irtuin 1 (SIRT1), forkhead box O (FoxO), AMP-activated protein kinase (AMPK), peroxisome proliferator
210 dentified multiple components of the mitogen activated protein kinase (MAPK) pathway enhancing GFP(ra
212 is differentially regulated through mitogen-activated protein kinase (MAPK) signaling or genetic alt
214 ed NF-kappaB activator 1 (Act1), p38 mitogen-activated protein kinase (MAPK), Jun NH2-terminal kinase
215 ranscription factors are released by mitogen-activated protein kinase (MAPK)-stimulated acetylation t
216 emely potent allosteric inhibitor of mitogen-activated protein kinase (MAPK)/extracellular-signal-reg
217 ense variants in MAPK1, encoding the mitogen-activated protein kinase 1 (i.e., extracellular signal-r
218 independently of energy stress-mediated AMP-activated protein kinase activation and possibly through
220 the synthesis of biologically important AMP-activated protein kinase deprived of any metal Pd contam
221 ranscription (STAT) (ruxolitinib) or mitogen-activated protein kinase kinase (MEK) (trametinib) and w
226 neutrophils displayed increased p38 mitogen-activated protein kinase-dependent Ripk1-independent IL-
227 ts of CsA involve at least two of the stress-activated protein kinases (GCN2 and PERK) that act on th
229 gnal-regulated kinase), JNK, and p38 mitogen-activated protein kinases as well as NFkappaB (nuclear f
230 RK2 family comprises the abscisic acid (ABA)-activated protein kinases SnRK2.2, SnRK2.3, SnRK2.6, SnR
232 the nuclear receptor peroxisome proliferator-activated receptor (PPAR) delta as key regulator of oste
233 utase 2), PGC1alpha [peroxisome proliferator-activated receptor (PPAR) gamma-coactivator 1alpha], PPA
234 ed and recombinant human tryptases, protease activated receptor 2 agonist and antagonist peptides, an
235 suppressed the activation of EGFR, protease-activated receptor 2, nucleotide-binding domain, leucine
237 n to be regulated by peroxisome proliferator-activated receptor alpha (PPARalpha), suggesting that FA
240 activation increased peroxisome proliferator-activated receptor gamma activity and reduced proliferat
243 on between legs, but peroxisome proliferator-activated receptor gamma coactivator 1-alpha and oxidati
244 metabolism regulator peroxisome proliferator-activated receptor gamma was associated with accumulatio
245 acid, a PPAR-gamma (peroxisome proliferator-activated receptor gamma) agonist that stimulates mitoch
246 otein kinase (AMPK), peroxisome proliferator-activated receptor-alpha (PPAR-alpha), and mammalian tar
247 ssion of PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator 1), a Parkin downst
251 compete for the cA4 ligand, a canonical cA4-activated ribonuclease activity in the Csx1 domain and a
252 ximal FC of 28% was observed for the electro-activated sample obtained by using Anolyte_450mA-50 min.
253 3.9 angstrom resolution cryo-EM structure of activated Schizosaccharomyces pombe Arp2/3 complex bound
254 Our findings demonstrate that aberrantly activated SE upregulates CHPT1 expression and confers En
255 dimethylaminopropyl)-carbodiimide) (NHS/EDC)-activated self-assembled monolayers (SAMs) of 6-mercapto
258 pective, these results suggest that soil and activated sludge microbial communities, although certain
259 use of this model for denitrification in the activated sludge model, which can easily be integrated i
260 It binds many protein partners, including activated Smad proteins and the NuRD co-repressor comple
262 etween mutant calreticulin, ERp57, and STIM1 activated SOCE and generated spontaneous cytosolic Ca2+
264 In vitro, IL6 treatment of MDSC-like cells activated STAT3, increased expression of DNMT1 and DNMT3
265 selectivity filter of KirBac1.1 in the open-activated state but that it may not directly enter the s
271 ceptors represent a highly conserved, stress-activated system involved in diverse cancer-related hall
273 ients with comorbidity had larger numbers of activated T cells compared with patients who had fewer r
276 race to identify endogenous substances that activated the same receptors as opiates resulted in the
277 opic investigations, free reactants could be activated the same way by the local pressurized CO(2) mi
279 ascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (A
283 ute liver failure; however, TGFbeta1 must be activated to bind its receptor and generate downstream e
284 nin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated
285 nzyme (IRE1) is one ER stress sensor that is activated to splice the bZIP60 mRNA that produces a trun
286 rt defective Treg cells into powerful, super-activated Treg cells (SuperTreg cells) that can resolve
291 eleased, Na(+) accumulated in the terminals, activated vesicular Na(+)/H(+) exchanger, and regulated
292 becestat metabolite-responsive T-cell clones activated via a pharmacological interactions pathway in
293 The Fanconi anaemia pathway of ICL repair is activated when a replication fork stalls at an ICL(2); t
294 that resolves stalled translation events is activated when ribosomes collide and form disome, trisom
295 19 and prostaglandin E(2) receptor subtype 3 activated with iloprost showed a similar reaction to dep
299 TP receptor because prostaglandin F receptor activated with U46619 and prostaglandin E(2) receptor su