ライフサイエンスコーパス: activated channel

1 ctivated K(+) channel that is also a stretch-activated channel.

2 ing nor identical to the endogenous swelling-activated channel.

3 factor required for Ca2+ to inhibit the cGMP-activated channel.

4 s suggesting that these drugs also block the activated channel.

5 ng sites at different depths within the NMDA-activated channel.

6 gical values of membrane potential close the activated channel.

7 indicates its possible identity as a stretch-activated channel.

8 ting in pore closure of the PCB95 and Ca(2+)-activated channel.

9 echanoelectrical feedback (MEF), via stretch-activated channels.

10 etween depolarization- and hyperpolarization-activated channels.

11 f plasma membrane-associated calcium release-activated channels.

12 has recently been demonstrated for rod cGMP-activated channels.

13 ated channels was similar to that of stretch-activated channels.

14 ed via a cGMP cascade to the control of cGMP-activated channels.

15 es in the Ca(2+) affinity between rested and activated channels.

16 ished by gadolinium, an inhibitor of stretch-activated channels.

17 m with the properties of endogenous swelling-activated channels.

18 tion by CaMKII is the 'on' bipolar cell cGMP-activated channels.

19 lcium signals in T cells occur via depletion-activated channels.

20 ted channels is lower than that of capsaicin-activated channels.

21 of these otherwise long-lasting high-voltage-activated channels.

22 rescent MTS reagents also labeled Cys-430 in activated channels.

23 ing able to form homomeric cyclic-nucleotide-activated channels.

24 ed channels and inositol 1,4,5-trisphosphate-activated channels.

25 be classified as either low or high voltage-activated channels.

26 lar Mg2+ stabilized the open state of NAD(+)-activated channels.

27 not dependent on Ca2+ influx through stretch activated channels.

28 of rhodopsin and to transitions in the cGMP-activated channels.

29 iminated by gadolinium, a blocker of stretch-activated channels.

30 mobilization independent of calcium release-activated channels.

31 ctions between calcium-permeable and calcium-activated channels.

32 standing related mechanisms in other voltage-activated channels.

33 lular calcium influx through calcium-release-activated channels.

34 on resulted from a decrease in the number of activated channels.

35 channel conductance and not in the number of activated channels.

36 that MDIMP preferentially blocks low-voltage-activated channels.

37 distinguished by signalling through stretch-activated channels.

38 ction with the external potential in voltage-activated channels.

39 dynamic behaviour of post-synaptic glutamate-activated channels.

40 ion transport as ion pumps or directly light-activated channels.

41 c offset in the local electric field seen by activated channels.

42 sually permit Ca influx through high-voltage-activated channels.

43 between the N-cadherin JMD and these voltage-activated channels.

44 The role of hyperpolarization-activated channel 1 (HCN1) in stress responses to witnes

45 on 0.5 microM gamma-aminobutyric acid (GABA)-activated channels (10 +/- 1 pS) in inside-out or outsid

46 ber increased cytosolic ATP-, lumenal Ca(2+)-activated channel activities to a nearly maximum level.

47 On the contrary, cytosolic ATP-activated channel activities were decreased as lumenal C

48 c side of the bilayer increased lumenal Ca2+-activated channel activities, suggesting that it lowered

49 nels may contribute to the increased stretch-activated channel activity observed in mdx myofibers.

50 K 293 cells, which showed pH-dependent (acid-activated) channel activity.

51 r potassium channels and two different light-activated channels, all of which have an effect on Vmem

52 results suggest that the opening of stretch-activated channels allows ions, including Ca2+, to enter

53 lpha1A, alpha1B, and alpha1E) or low voltage-activated channels (alpha1G).

54 TRPC2,3,6 and 7 are widely accepted as DAG-activated channels, although TRPC3 can also be regulated

55 Unitary ionic currents from stretch-activated channels and [Ca2+]i images were recorded simu

56 milar; dofetilide appears to primarily block activated channels and has a much lower affinity for clo

57 ity using layer-specific expression of light-activated channels and indicator dyes.

58 ensitivity as compared to other mechanically activated channels and that resting tension can drive ch

59 tches had the same chord conductance as GABA-activated channels and were gabazine-resistant.

60 at dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may c

61 alcium-selective pore of the calcium release activated channel, and alpha-SNAP is necessary for its f

62 in creating these signal: Rho/ROCK, stretch-activated channels, and 'Molecular Strain Gauges.' We al

63 TP) channel agonists diazoxide and pinacidil activated channels, and both compounds inhibited insulin

64 between 6.0 and 6.5, as expected for proton-activated channels, and current-voltage dependence did n

65 Low-voltage-activated channels are called 'T' type because their cur

66 In heart, G-protein-activated channels are complexes of two homologous prote

67 are AF-selective, whereas drugs that target activated channels are not.

68 spines through voltage-sensitive and ligand-activated channels, as well as through Ca(2+) release fr

69 e, a rare feature only reported for the acid-activated channel ASIC3.

70 describes a physiologically relevant stretch-activated channel, at both the single-channel and whole-

71 ker) and gadolinium(III) chloride (a stretch-activated channel blocker) did not alter the level of ac

72 sis by adding gadolinium chloride (a stretch-activated channel blocker) to the saline (0.008 g.mL-1)

73 +) on the single N-methyl-D-aspartate (NMDA)-activated channel burst duration and frequency and on th

74 th TEA, Tris or choline, eliminating stretch-activated channels but suggesting that if transmembrane

75 y gadolinium (Gd3+), an inhibitor of stretch-activated channels, but is independent of extracellular

76 provides evidence that occupancy of the NMDA-activated channel by Mgi2+ destabilizes the closed state

77 r residue conserved in all hyperpolarization-activated channels, by Ala substitution produced a depol

78 urrent, a four-state model in which the NMDA-activated channel can close while blocked by Mgi2+ is pr

79 using Cre-dependent expression of the light-activated channel Channelrhodopsin-2.

80 d its function to maintain these low voltage-activated channels closed at resting membrane potentials

81 The dendritic arborization and voltage-activated channel complement of rat neocortical pyramida

82 g on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organi

83 at the MEF effects, depending on the stretch-activated channels' conductances and reversal potentials

84 NMDA (100 nm) activated channels corresponding to four chord conductan

85 lowed by Ca(2+) entry through Ca(2+) release-activated channels (CRACs).

86 The open, activated channel creates the high-affinity binding site

87 iescent cell-attached or inside-out patches, activated channel currents with similar properties to SO

88 EK293 cells exhibit increased basal and GPCR-activated channel currents, and increased Ca(2+) fluores

89 ular toxicity and increased constitutive and activated channel currents.

90 The density of the small-conductance Ca(2+)-activated channel decreased along the apical dendrite, w

91 how that hypotonic shock generates a stretch-activated channel-dependent calcium pulse in yeast.

92 ative of nearly every family of mechanically activated channel described so far have underscored thei

93 ting mechanism and pharmacology from stretch-activated channels described previously.

94 indicating that calcium channels and calcium-activated channels do not participate in shaping the pre

95 o the postsynaptic calyx through low-voltage-activated channels driven by changes in cleft [K(+)] as

96 lipid-mediated modifier of cationic stretch-activated channels, eliminated the voltage and divalent

97 Light-activated channels exhibited similar unitary currents, r

98 Acid-sensing ion channels (ASICs) are proton-activated channels expressed in neurons of the central a

99 membrane proteins, which encompasses calcium-activated channels for ions and lipids.

100 alpha1G and alpha1H and to the high voltage-activated channels formed by alpha1Ebeta3.

101 els were blocked by gadolinium; the receptor-activated channels formed upon expression of higher leve

102 ns BKCa channels primarily operate as ligand-activated channels gated by intracellular Ca(2+) and tha

103 o this compound following which persistently activated channels gated dynamically in the absence of a

104 modulin neither bound with high affinity nor activated channel gating.

105 is a major determinant for hyperpolarization-activated channel gating.

106 molecular determinant for hyperpolarization-activated channel gating.

107 ed MSHA, whereas other inhibitors of stretch-activated channels (Gd(3+), ruthenium red, SKF96365) did

108 Disruption of mechanically activated channels has been shown to impact (a) the deve

109 nel recordings show that capsaicin- and acid-activated channels have the same conductance, that the t

110 ls with the same property (cyclic nucleotide-activated channels) have been reported that are involved

111 ors, hyperpolarization and cyclic nucleotide-activated channels (HCNCs) and a separate target that ha

112 e voltage-gated channel Kv1.3 and the Ca(2+)-activated channel IKCa1.

113 Piezo1 is a stretch-activated channel important to muscle contractile dynami

114 f either beta- or gamma-ENaC block the basal-activated channel in a concentration-dependent fashion.

115 FA reduces the mean open time of single NMDA-activated channels in a concentration-dependent manner w

116 f an inhibitory tract, mutations in the loop activated channels in a subunit-specific manner.

117 spider venom that is known to block stretch-activated channels in animal cells, but the spontaneous

118 of membrane ionic conductances and receptor-activated channels in CNS neurons and, via these mechani

119 on of the BK channel opener NS11021 directly activated channels in control epithelia; however, under

120 attached patch conditions, RANTES (20 ng/ml) activated channels in EoL-1 cells when applied to the re

121 te functional expression of two mechanically activated channels in human TM cells.

122 ere identified as components of mechanically activated channels in mammals.

123 ese data highlight the importance of stretch-activated channels in pregnancy maintenance and parturit

124 The absence of Zn(2+)-activated channels in rats and mice may explain why this

125 The increased affinity of the cGMP-activated channels in response to a fall in [Ca2+] has t

126 anical distention-induced opening of stretch-activated channels in smooth muscle cells.

127 e identified critical functions for receptor-activated channels in the endoplasmic reticulum that all

128 tivation, and allowing the average number of activated channels in the membrane patch (N(A)) to be ac

129 igate the action of cytoplasmic Ca2+ on cGMP-activated channels in the outer segment.

130 R-type high voltage-activated channels inactivate fully in a few hundred mil

131 ately 70 000) did not pass through the gamma-activated channel, indicating an upper limit to the pore

132 ng, whereas treatment with a calcium-release-activated channel inhibitor rescues the ligand-activated

133 InsP3-activated channels invariably inactivated, with average

134 tive, tetrodotoxin-resistant, sodium (Na(+))-activated channel involved in regulating Na(+) homeostas

135 The entry of Ca2+ through stretch-activated channels is also amplified by Ca2+ release fro

136 The calcium permeability of heat-activated channels is lower than that of capsaicin-activ

137 ntial vanilloid isoform 4 (TRPV4), a stretch-activated channel, is required to maintain ocular hypert

138 alter gating of the plant hyperpolarization-activated channel, KAT1.

139 levels over time, involving extrinsic Ca(2+)-activated channels late during activation.

140 nsistent with CaMKII phosphorylation of cGMP-activated channels leading to a voltage-dependent reduct

141 increasing the number or activity of stretch activated channels leads to an increase in period and am

142 cation channel, zTrpa1b, coupled with photo-activated channel ligands, such as optovin and 4g6.

143 Ca2+ influx through L-type voltage-activated channels (LTCs) is particularly effective at a

144 strate that the properties of this optically activated channel make it a suitable proxy for studying

145 This mechanical strain suggests that stretch-activated channels may constitute a mechanism to explain

146 Two classes of glutamate-activated channels mediate excitation at central synapse

147 Binding of alpha2beta1 integrin and stretch-activated channels mediate M migration and mechanosensin

148 , P/Q- and R-type channels, the high voltage-activated channels most intimately associated with presy

149 chanisms (transducer adaptation, low-voltage-activated channels, nonquantal transmission, and spike t

150 The Ca(2+)-activated channel of intermediate-conductance (KCa3.1) i

151 Like the light-activated channel of the cell, it is non-selective among

152 of a highly Ca(2+)-permeable class of light-activated channels of Drosophila photoreceptors.

153 endent inhibition of non-L-type high-voltage-activated channels of the Ca(v)2 family.

154 nium (III) chloride (an inhibitor of stretch-activated channels) only blocked the activation of ERK1/

155 ane, Ca2+-permeable cation channels (stretch-activated channels) opened and a global increase in [Ca2

156 ), capacitative Ca2+ entry, and Ca2+ release-activated channel opening (CRAC), and often underlies th

157 tes the cooperation with the calcium release-activated channel Orai1 in directing localized cytoskele

158 The decision depends on a mechanically activated channel, OSCA/TMEM63, which is conserved from

159 r-derived cGAMP into macrophages via the ATP-activated channel P2X7R.

160 be highly dependent on the concentration of activated channels per dyadic cleft and on the intermemb

161 This study thus identifies a Ca(2+)-activated channel permeable to Ca(2+) and critical for C

162 ased proliferation is induced by the stretch-activated channel Piezo1 and involves calcium-triggered

163 ecome too crowded, they activate the stretch-activated channel Piezo1 to trigger extrusion of cells t

164 Moreover, disruption of a stretch-activated channel, Piezo1, in zebrafish prevents extrusi

165 for the pore-forming subunit of low voltage-activated channel proteins has not been unequivocally id

166 cluded that the TPCs function as a PI(3,5)P2 activated channels regulated by mTORC1, but not by NAADP

167 Mallotoxin-activated channels remain incrementally sensitive to Ca2

168 st, the pore of the ATP, caffeine and Ca(2+)-activated channel remains open in the presence of Ca(2+)

169 tion of channels did not gate as low voltage-activated channels, requiring stronger depolarizations t

170 dephosphorylation of 'on' bipolar cell cGMP-activated channels, resulting in a rise in the sensitivi

171 anodine receptor (RyR) and (iii) the stretch-activated channel (SAC) in both single myocytes and mult

172 We tested the hypothesis that both stretch-activated channels (SACs) and intracellular calcium ([Ca

173 Stretch-activated channels (SACs) have been found in myocardial

174 Stretch-activated channels (SACs) have been found in smooth musc

175 Stretch-activated channels (SACs) have been shown in other prepa

176 block voltage-gated Ca(2+) channels, stretch-activated channels (SACs), or the Na(+)-Ca(2+) exchanger

177 integrated changes in caveolin-3 and stretch-activated channels (SACs).

178 MscL, a stretch-activated channel, saves bacteria experiencing hypo-osmo

179 se presynaptic terminals reveals single NMDA-activated channels, showing multiple conductance levels,

180 ation of both ERK1/2 and p38 kinase, stretch-activated channels, small GTPase proteins, and extracell

181 hese results suggest that EcPutA achieves an activated channeling state during the approach to steady

182 ese amino acids on transition from closed to activated channel states reveals movement in this region

183 hannels, which results from stabilization of activated channel states.

184 of both the Ca(2+)- and the Ca2+/nucleotide-activated channels, suggest a mechanism for channel open

185 ull-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lipid nanodisc

186 Channelrhodopsin-2 (ChR2) is a light-activated channel that can conduct cations of multiple v

187 Cardiac mitoBK(Ca) is a calcium- and voltage-activated channel that is sensitive to paxilline with a

188 subunit of a class of Ca(2+)-selective light-activated channels that carry the bulk of the phototrans

189 tials and distal dendritic hyperpolarization-activated channels that mediated site independence of so

190 7-P9) type I hair cells acquired low-voltage-activated channels that shortened the rise time of the r

191 T1+minK, channels by preferentially blocking activated channels, that it unblocks upon repolarization

192 cell-attached patches (i.e. they are stretch-activated channels), they differ in their ability to tra

193 mediated transmission, and, by using a light-activated channel to excite the network, we demonstrate

194 tion of Piezo2, a low-threshold mechanically activated channel, to acute ocular pain, we characterize

195 tration in germ cells through a mechanically activated channel, transmembrane channel-like.

196 hlin with the cell surface bound and stretch-activated channel TREK-1.

197 alcium influx through the TRP and TRPL light-activated channels triggers a complex regulatory hierarc

198 sembled those ascribed to one class of light-activated channels, TRP.

199 Detection of thermal IR requires the heat-activated channel TRPA1, which is expressed in neurons a

200 2) revealed new proteins, including a Ca(2+)-activated channel TRPM5, for MUC5AC secretion.

201 that inhibiting Ca2+ influx through stretch-activated channels using various compounds, including a

202 g the vanilloid receptor-related osmotically activated channel (VR-OAC) from the rat, mouse, human, a

203 named vanilloid receptor-related osmotically activated channel (VR-OAC), functions in vivo in the tra

204 Neither stretch-activated channel was detected in the grain protoplasts

205 caused by RANTES, indicating that the RANTES-activated channel was the Ca2+ -activated K+ channel.

206 oncentration dependent and the Po of the ATP-activated channel was unaffected by membrane voltage, re

207 s mechanosensitive (ie, swelling- or stretch-activated) channels was tested.

208 ough stimulation of Ca(2+) permeable stretch activated channels, we hypothesised a role for Piezo1 in

209 Consistent with the presence of stretch-activated channels, we show that Ca2+ influx is triggere

210 -1592, -1460 and -1754) block the open NMDA-activated channel were studied at membrane voltages (Vm)

211 The homogenate-activated channels were Ca2+ sensitive, selective for Ca

212 The stretch-activated channels were inhibited by a spider venom that

213 d toxin inhibition, as if toxin affinity for activated channels were low.

214 The L-Pro-activated channels were not affected by either L- or D-A

215 at Gd3+-sensitive, poorly selective, stretch-activated channels were not involved.

216 Oxidant-activated channels were observed to display two gating m

217 Tg- and CCh-activated channels were permeable to Na(+) and Ba(2+), b

218 The IAV protein forms a hypotonically activated channel when expressed in cultured cells; in f

219 inked to the control of a G-protein and cGMP-activated channels which functions to generate high syna

220 s not useful in the investigation of stretch-activated channels which may underlie the myogenic respo

221 ltered the activity of either class of L-Arg-activated channels, which were blocked by micromolar con

222 t studies have focused on the agonist-bound, activated channel while assigning a lesser role to the a

223 ure-dependent gating properties of a stretch-activated channel with a current/voltage plot indicating

224 cribe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature co

225 the conformational transitions of a calcium-activated channel with real cryo-EM particles.

226 , we treated patches containing irreversibly activated channels with 100 microg/mL trypsin and discov

227 Pentobarbital alone (100 microM) activated channels with conductance (30 +/- 2 pS) and ki

228 icles (GUVs), forms voltage-gated and Ca(2+)-activated channels with the key features of mPTP.

229 receptor-mediated currents or forms glycine-activated channels with the NR1 subunit alone.

230 l tissues, whereas KCNQ1 function as voltage-activated channels with very slow kinetics in cardiac ti

231 c L-type voltage-gated calcium (high voltage-activated) channel with accessory proteins beta and alph