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1 ding affinity when compared with the caspase-activated form.
2 c model structure of full-length MotB in its activated form.
3 thrombin mediated secondary cleavage) of the activated form.
4 an occupy multiple conformations even in the activated form.
5 sistent with existing scattering data for an activated form.
6 on or its switch from an inactive form to an activated form.
7 proteins to analyze the structures of their activated forms.
8 ential transition of DNA-PK from inactive to activated forms.
9 ed between the red (dark) and far red (light-activated) forms.
10 ting the equilibrium between the resting and activated forms ~200-fold, so that the resting form of R
11 er a monosaccharide employing its nucleotide-activated form, acting as a Leloir glycosyltransferase.
13 in p65-NFkappaB protein were in reduced and activated forms after hypoxia, thereby being blocked by
14 arge Stokes shifts in both pre-activated and activated forms, allowing simultaneous use with common d
16 In addition, expression of both p53 and its activated form as well as the expression of p53 target g
17 om S. cerevisiae in apo form and in the PI4P-activated form at 2.8 angstrom and 3.3 angstrom resoluti
18 ed with Ku70/80 and DNA in both inactive and activated forms at resolutions of 3.7 angstrom overall a
19 reversibly binds growth factors and, in its activated form, binds to low density lipoprotein recepto
20 olecular models of truncated PLCbeta2 in its activated form complexed with Gbetagamma and in the cata
21 suggesting that inhibitors selective for the activated form could provide a high therapeutic index.
22 of individuals: loss of FXIIIa (transamidase-activated form) crosslinking leads to defects in blood c
23 e created by ligating NH2-terminal truncated activated forms (Delta) to the estrogen receptor (ER) ho
24 transformation of the zymogenic FXIII to its activated form especially in the context of FXIIIA and F
25 res that LC3 effectively redistributes in an activated form from nucleus to cytoplasm, where it plays
26 e wild-type form are receptor dependent, the activated form (Go-GTP) can signal when the receptor is
27 s AMP, to the phosphorylated, constitutively activated form, "GPa." However, activation of GP in this
28 tures of legumain in the zymogenic and fully activated form in complex with different substrate analo
29 P (10 muM) increased the expression of CD11b activated form in eosinophils from healthy, but not asth
30 re, recent data show that Hsp90 exists in an activated form in malignant cells but in a latent inacti
31 are constitutively present in lipid rafts in activated forms in HTLV-1-infected T cells that express
34 hibitor 4-(tert-butyl)phenylacetylene, whose activated form is known to attach to the distal-pocket T
37 n-like processing of Sde2 into a short-lived activated form may function as a checkpoint to ensure pr
39 ely facilitates interaction with the agonist-activated form of a G-protein-coupled receptor (R*) and
41 ng antibodies recognizing the phosphorylated/activated form of AKT kinases, we observed elevated phos
42 nsgenic mice expressing a membrane-targeted, activated form of Akt under control of the 2',3'-cyclic
44 ells ectopically expressing a constitutively activated form of Akt3 or endogenously expressing mutant
47 precursor cells, we conditionally express an activated form of an FGF receptor or delete the FGF rece
48 compound failed to significantly suppress an activated form of another RTK, the Drosophila epidermal
49 Moreover, the co-expression of Cat-1 and an activated form of Arf6 in fibroblasts was sufficient to
50 Studies in Drosophila have revealed that an activated form of Armadillo, the effector of Wnt signall
55 In converse, conditional expression of an activated form of beta-Catenin leads to expansion of Nkx
57 encoding either a stabilized, constitutively activated form of beta-catenin or a dominant negative fo
59 mportance, we have targeted expression of an activated form of beta-catenin to the urothelium of tran
63 to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a membe
64 gle-molecule level: C3b, the proteolytically activated form of C3, and factor H (FH), the surface-sen
66 tion, whereas expression of a constitutively activated form of CaMKII mimicked the effects of morphin
67 nogenic soft agar assay and detection of the activated form of caspase-3 and cleavage of poly(ADP-rib
69 genesis of C431 resulted in a constitutively activated form of CBS that could not be further activate
70 Cat-1 from NIH3T3 fibroblasts expressing an activated form of Cdc42 (Cdc42 F28L), or from the human
71 We demonstrate that CRL4(CDT2) targets the activated form of CHK1 for destruction in the nucleoplas
74 nesis and lipolysis, forced expression of an activated form of CREBH protein in the liver significant
76 uorescein, fluorescein and resorufin with an activated form of cyclic trimetaphosphate to give interm
77 clease-coupled DNA methylation assay with an activated form of Dnmt1 engineered to lack the replicati
78 ratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that
79 tudies, the effects of a novel conditionally activated form of EGF-R, v-ErbB:ER, on the morphological
81 somal maturation assay and observed that the activated form of EhRab35 significantly increased the ra
82 xide synthase (r(part) = 0.46, P = 0.02), an activated form of endothelial nitric oxide synthase.
83 gested that evaluation of the phosphorylated/activated form of ErbB-2 might be more precise in defini
86 Mutant tibiae have increased levels of the activated form of ERK1/2, consistent with the idea that
88 y, FHL2 interacted more efficiently with the activated form of ERK2 than with the dephosphorylated fo
92 ed receptor kinases (GRKs) phosphorylate the activated form of G protein-coupled receptors leading to
93 ounced with the mutationally or functionally activated form of Galpha(13) compared to that of wild-ty
96 ounced with the mutationally or functionally activated form of Galpha13 as compared with the wild-typ
98 Conversely, expression of a constitutively activated form of GSK3beta sensitized cancer cells to mT
99 e report that expression of a constitutively activated form of HIF2alpha (P405A, P530A, and N851A, na
100 of inhibitors shows higher affinity for the activated form of Hsp90 compared to our earlier 8-sulfan
103 We investigated whether mice that express an activated form of IKKbeta in the esophageal epithelia de
104 uced platelet aggregation, expression of the activated form of integrin alphaIIbbeta3, and exposure o
105 ells engineered to express human SERT and an activated form of integrin beta3 exhibited enhanced SERT
106 the structural features associated with the activated form of Itk, we have solved the NMR structure
111 umors that developed in mice that express an activated form of Kras (Kras(LSL-G12D/+);Ptf1a(Cre/+) mi
113 m with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreati
114 2H/+);Pdx-1-Cre (KPC) mice, which express an activated form of Kras in pancreatic tissues, develop pa
115 ic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, a
116 some detail in bacteria and plants, but the activated form of l-Rha and the corresponding biosynthet
117 rved following overexpression of Pitx2 or an activated form of Lef1, suggesting an effect on cell pro
119 ferentially interact with the phosphorylated/activated form of MAD, and Nup93 acts to recruit the imp
120 defects due to loss of Msk are rescued by an activated form of MAPK or the secreted epidermal growth
122 xpressed dominant-negative or constitutively activated form of MEK5 to inhibit or activate the MEK5-E
123 lpha/beta activity, and the expression of an activated form of MKK6 (an immediate upstream activator
125 ction in myogenic processes, we expressed an activated form of mouse calcineurin A in Drosophila and
126 yzed hydroacylation between aldehydes and an activated form of N=N bond was achieved under mild condi
130 -inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like
131 l of Notch1 in solid tumors, we expressed an activated form of Notch1 (N1ICD) in the developing mouse
134 :nicd1a transgenic embryos overexpressing an activated form of notch1, nicd1a, displayed increased cp
135 the effects of conditional expression of an activated form of NOTCH2 (pL2.Lgr5.N2IC), conditional de
138 nhibition induced apoptosis, as evidenced by activated form of PARP, caspases-3 and was suppressed by
141 Subsequent studies demonstrated that an activated form of PI 3-kinase restored Rac GTP loading i
142 , but not HIV infection alone, contained the activated form of PKR, which localized predominantly to
143 dy specific for the tyrosine-phosphorylated, activated form of PLCgamma1, we now show that chronic mo
144 ing SKN-1, the MEDs, PAL-1, and the Wnt/MAPK-activated form of POP-1, are responsible for activating
145 cretion by strains containing a mutationally activated form of prfA, the key regulator of L. monocyto
146 t that hES cells localize a conformationally activated form of proapoptotic BAX to the trans Golgi ne
147 on of 3'-phosphoinositol lipids (PI3Ps), the activated form of Rac, a small GTPase, and F-actin.
149 We investigated whether expression of the activated form of Ras in gastric chief cells of mice lea
154 This phenotype can be recapitulated using an activated form of RhoA and rescued by inhibiting Rho-kin
156 solid tumors, we established a conditionally activated form of ROCK II by fusing the kinase domain to
158 luble guanylyl cyclase (sGC) itself, the NO -activated form of sGC, and phosphodiesterase(s) (PDE).
159 re known mutations predicted to result in an activated form of Shp2, whereas six are new mutations.
160 In this study, the biosynthesis of this activated form of sialic acid completely from endogenous
164 -Tyr containing proteins, an antibody to the activated form of Src-family PTKs was used to localize a
165 othelial cell-specific overexpression of the activated form of SREBP2 synergized with hyperlipidemia
166 Stat3 protein levels and the levels of the activated form of Stat3 (pStat3) at P12, P15, P18, and P
168 pression were increased by overexpressing an activated form of Stat3 but decreased by attenuation of
169 , while the introduction of a constitutively activated form of Stat3 into immortalized human breast e
170 ereas the overexpression of a constitutively activated form of STAT3 promoted HSC senescence through
171 igodendrocytes; (2) the overexpression of an activated form of STAT5 prevents alpha-amino-3-hydroxy-5
172 Transgenic mice expressing a constitutively activated form of STAT5b have been shown previously to c
174 n addition, we demonstrate expression of the activated form of STAT6, a mediator of IL-4 signaling, b
176 the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the a
177 C-893 selectively killed cells expressing an activated form of the anabolic oncogene Ras in vitro and
178 gulated by the polarized distribution of the activated form of the Cdc42 protein, rather than by the
179 Transgenic mice expressing a constitutively activated form of the cellular homologue Akt2 specifical
180 ate that albicin specifically recognizes the activated form of the complex, allowing more efficient i
181 neered to inducibly express a constitutively activated form of the cyclic AMP-dependent protein kinas
182 Conversely, expressing a constitutively activated form of the Drosophila JAK kinase (hop(Tum-l))
184 is required to stabilize the lifetime of the activated form of the enzyme against reoxidation of Fe(H
185 ss spectrometry data show that the TIH-bound activated form of the enzyme closely resembles the inhib
186 )(III) couple), the kinetic stability of the activated form of the enzyme has been greatly diminished
188 hat while the thermodynamic stability of the activated form of the enzyme is unchanged (characterized
191 ) to the Golgi complex is initiated when the activated form of the GTPase Sar1p recruits the Sec23p-S
192 ted cells is rescued by the expression of an activated form of the immediate upstream p38-activating
194 d levels of expression of fibronectin and an activated form of the integrin alphavbeta3, which coordi
195 Here, we describe a mouse line expressing an activated form of the K-Cl cotransporter Slc12a4 (Kcc1),
196 ctive form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin, determined
197 ne to enforce expression of a constitutively activated form of the Notch 4 receptor, we show that sig
198 wo known clock components [Lfng mRNA and the activated form of the Notch receptor (cleaved Notch intr
199 ory progenitors, we transiently expressed an activated form of the Notch1 receptor (NICD) using a com
202 inant antibody (scFvSCE5), which targets the activated form of the platelet-integrin glycoprotein IIb
203 s a crucial factor for stabilizing the light activated form of the protein, and have been used to pro
205 he intracellular domain of Notch, a dominant activated form of the receptor, is sufficient to prevent
207 steady-state level of the phosphorylated or activated form of the response regulator CheY dictates t
209 unt of PKMzeta protein and the amount of the activated form of this kinase, phospho-PKMzeta (p-PKMzet
212 isplay substantially increased levels of the activated form of transforming growth factor beta, a pot
214 Furthermore, selective expression of an activated form of UNC-43 in ADF neurons is sufficient to
215 nic mice that overexpressed a constitutively activated form of YAP (YAP(S127A)), and measured protein
217 ed as key reagents for the origin of life as activated forms of acetate analogous to acetyl-CoA.
218 characterized by combined overexpression of activated forms of AKT and neuroblastoma Ras viral oncog
219 the TGF-beta signaling pathway by expressing activated forms of ALK-1 and ALK-5, type I receptors for
221 phila Arfaptin protein directly binds to the activated forms of Arf6 and Rac1 GTPases, and mutants in
222 sponse, characterized by the accumulation of activated forms of ATM and Chk2 as well as nuclear foci
224 d in mice through the combined expression of activated forms of both KRas and Akt in glial progenitor
225 (RCAS)/TVA system to transfer genes encoding activated forms of BRAF, KRas, Akt and Cre to nestin-exp
226 ion has attracted considerable interest, and activated forms of BRAF, such as BRAF(V600E), have becom
230 o the cytoplasm and the nucleus, whereas the activated forms of calpain-7 and -10 are found only in t
233 Da protein that formed a stable complex with activated forms of Cdc42 and thereby showed characterist
234 three-dimensional structures of the apo and activated forms of DtxR show conformational changes in t
235 ther contexts, and MsEphrin colocalizes with activated forms of endogenous Src in the leading process
236 etastases of uveal melanoma patients express activated forms of ERBB2 (the coreceptor for ERBB3) and
238 partate receptor subunit NR2B as well as the activated forms of extracellular signal-regulated kinase
240 veral multiple myeloma cell lines expressing activated forms of FGFR3, NDGA generally resulted in a d
241 efects are associated with low levels of the activated forms of focal adhesion kinase (FAK) and extra
242 alian cells that these RhoGEFs interact with activated forms of G alpha 12 or G alpha 13 through thei
246 NSP1 can induce degradation of inactive and activated forms of IAD-containing IRF proteins (IRF3 to
250 tact, TCR microclusters are colocalized with activated forms of Lck, ZAP-70, and the linker for activ
252 nonical Wnt signaling stimulated by Wnt1 and activated forms of LRP5 (low density lipoprotein recepto
255 edium, is between the intermediate and fully activated forms of MMP-2 induced by membrane type 1-MMP.
256 rmined by analysis of the phosphorylated and activated forms of mTORC1 signaling proteins in the pref
258 MM cells from all the patients expressed the activated forms of NF-kappaB and STAT3 but to a variable
259 marrow of 22 MM patients and checked for the activated forms of NF-kappaB and STAT3 by immunocytochem
261 and brain, we injected retroviruses encoding activated forms of Notch1, Notch2, or Notch3 into embryo
263 We show that, in Dictyostelium discoideum, activated forms of RasC prolong the time course of TORC2
269 ted with high levels of immunoreactivity for activated forms of the BDNF receptor TrkB and beta1-inte
271 tromal tumors (GISTs) express constitutively activated forms of the KIT receptor tyrosine kinase prot
272 ption factor lhx1a, and forced expression of activated forms of the lhx1a gene product rescued nephri
275 Cell type- or region-specific expression of activated forms of the oncoproteins Harvey-Ras and AKT i
277 asses of FLT3 mutations cause constitutively activated forms of the receptor that are found in signif
280 L-cmk decreased the nuclear content of SKI-1-activated forms of transcription factors SREBP-1, SREBP-
281 GF treatment results in the translocation of activated forms of TrkA to lipid rafts, and this localiz
283 sformed by IL-27R contain elevated levels of activated forms of various signaling proteins, including
288 ncogenic stress and that the phosphorylated (activated) form of MSK1 is significantly increased in th
289 ocalization of the phosphorylated, therefore activated, form of cJun, a JNK target in dorsal root gan
290 rom an inactive cytosolic conformation to an activated form on membranes entails four distinct events
293 creases total levels of STAT3 as well as its activated forms, resulting in decreased levels of the tu
294 enes that drive growth, targeting mutated or activated forms (such as the EGFR-Her2/Nneu pathway) has
298 rface-immobilized catalysts present in their activated form under varying intensities of simulated so
299 ter migrating bands, indicating processed or activated forms, was confirmed at the protein level.
300 different solvents leads to two polymorphic activated forms with very different pore openings, marke