ライフサイエンスコーパス: activation

1 of beta-ionone, an antagonist for G protein activation.

2 Ankmy2 knockout requires both cilia and Gli2 activation.

3 allows us to estimate the range of effector activation.

4 ocation of a CaM shuttle, and nuclear CaMKIV activation.

5 (n = 32) primarily increased hTLR7 and hNOD2 activation.

6 uncharged tRNA accumulation and Gcn2 kinase activation.

7 orming exercises that elicited little muscle activation.

8 n, rather than focusing on peripheral immune activation.

9 thrombotic effect via inhibition of platelet activation.

10 tors that eventuates in transcription factor activation.

11 th both central and peripheral innate immune activation.

12 es MYC levels, which is counteracted by ERK1 activation.

13 plex I), RIPK1 ubiquitination, and NF-kappaB activation.

14 (2+) rise accelerated G(i/o) -mediated TRPC4 activation.

15 stress in renal tubular cells with ATF3/ATF4 activation.

16 (2+) transient shape to properties of IP(3)R activation.

17 bstrate binding domain of cpSRP43 drives its activation.

18 ined increase induced by muscarinic receptor activation.

19 uins share some DSB-binding capacity and DDR activation.

20 different patterns of kinematics and muscle activations.

21 l stabilization of spliced mRNAs upon T cell activation, although the stability of intron-retained tr

22 At this l-fucose dose, complement activation and acute post-ischemic kidney injury are pre

23 The increase in platelet activation and aggregation could partially be attributed

24 Src, Lyn, and Fyn are essential for platelet activation and also involved in megakaryocyte (MK) devel

25 pate in tandem or cooperative small-molecule activation and catalysis.

26 s define AP-1 as the key link between T cell activation and chromatin remodeling.

27 stration of rIFN-beta resulted in microglial activation and complement C3-dependent synapse eliminati

28 sense, such an approach mimics the modes of activation and control in enzyme catalysis and the reali

29 sed on differential responsiveness to Ci-VSP activation and different rates of current rundown in rup

30 associated with reduced astrocyte/microglia activation and downregulation of the transcriptional reg

31 RIC interneurons, induced intestinal UPR(ER) activation and extended longevity, and exposure to stres

32 Analogous photoredox catalysis enables C-H activation and H/D exchange in a number of additional su

33 ronment provide unique insights into channel activation and inactivation mechanisms.

34 Therefore, both activation and inactivation of PVCV occurred in aged pla

35 echanism for post-translational beta-catenin activation and is required to complete EGA.

36 or both ligand-independent signaling pathway activation and ligand-responsive signaling hyperactivati

37 velopment are thought to restrict motor unit activation and limit exercise tolerance.

38 ly induced metabolic stress, along with AMPK activation and mTORC1 pathway suppression, which subsequ

39 me profiling displayed that TGF-beta pathway activation and ossification-related processes were signi

40 cal adhesion proteins that regulate integrin activation and outside-in signaling.

41 mediates costimulatory signals important for activation and persistence of cytotoxic T lymphocytes.

42 In addition to GCN2 activation and reduced total translation, the reduced ch

43 vaccination and provides a mechanism for the activation and regulation of NK cells by Ebola glycoprot

44 ally be attributed to increased MAPK pathway activation and thromboxane generation.

45 erneurons during lethargus favors strong RIS activation and thus sleep.

46 g excitation intensities, reflecting thermal activation and triplet-triplet exciton annihilation proc

47 s, Yap/Taz accumulated upon Myc/beta-catenin activation and were required not only for the ensuing pr

48 syndrome (UCS) refers to the altered muscle activations and movement patterns in scapulae along with

49 onribosomal peptide biosynthesis, fatty acid activation, and beta-lactone formation.

50 II responses, early CD4(+) and CD8(+) T cell activation, and counterregulation by the co-receptors BT

51 s under basal conditions, during sympathetic activation, and in heart failure is a major determinant

52 a bacterial kinase that requires IP6 for its activation, and may aid future work on the function of t

53 with amiloride, an inhibitor of plasminogen activation, and measured changes in plasmin (ogen) uria.

54 on EGF12 allowed LFNG to inhibit JAG1-NOTCH2 activation, and O-fucosylation on EGF9 was important for

55 ral therapy (ART) on HIV suppression, immune activation, and quality of life (QoL).

56 y, IL-33 levels, type 2 innate lymphoid cell activation, and T(h)2 cell differentiation were found in

57 The pathways promoting excessive activation are incompletely understood, with limited exp

58 f tau ~ 5-6 s, likely shortened by enzymatic activation as is the case with the Co-C5' bond of B(12).

59 c challenge to control the mode of substrate activation as well as origin of enantio- and diastereose

60 ured soluble markers of interleukin 1 (IL-1) activation at 4 different time points before the case's

61 uced helplessness and increased NAc neuronal activation at night.

62 ntibody partially downregulated mTOR pathway activation but showed no effect on viability.

63 ylation occurred independently of beta(1)-AR activation, but was abolished after pharmacological PKA

64 ate that SARM1 homo-octamer avoids premature activation by assuming a packed conformation, with order

65 nistic insights into receptor-operated TRPC4 activation by coincident G(q/11) and G(i/o) pathways and

66 t out to understand the heterogeneity of HbF activation by developing techniques to purify and profil

67 We aimed to examine if moderate Nrf2 activation by disruption of Keap1 impacts bone metabolis

68 e binding partner, demonstrating that IRAK-1 activation by disturbed flow required Nck1 in vitro and

69 is strongly dependent on their intracellular activation by host cellular kinases to yield ultimately

70 nceptual analysis of the general phenomenon "activation by inhibition" using bacterial and human HtrA

71 site has been identified, which augments the activation by PIP(2); and cholesterol inhibits the chann

72 oted the initiation of hepatic stellate cell activation by stimulating GPR55 and activation of ACC.

73 rom TrpB that are crucial for its allosteric activation by TrpA.

74 nfection and tissue damage, but its aberrant activation can lead to autoinflammatory diseases.

75 e central brain was blocked by transient dFB activation, confirming an acute disconnect from the exte

76 The NADH photo-activation coupled with EPR is broadly applicable to tra

77 of Yap in T cells results in enhanced T-cell activation, differentiation, and function, which transla

78 ized inside the synapse and their respective activation during glutamate release are still unclear.

79 which results in macrophage infiltration and activation during Kras-driven PDAC in mice.

80 and have strong similarities to task-evoked activations(e.g., magnitude, temporal profile) within th

81 n (gamma), Binding affinity (K(d)), Receptor activation Efficacy (epsilon), and constitutive activity

82 Imbalanced 5-HT1A/2A activation, either through receptor-specific drug intake

83 CRISPR/dCas9-mediated Foxp3-transcriptional activation elicits CNS2 demethylation.

84 implanted in human subjects and showed that activations emerge spontaneously and have strong similar

85 , with temperatures that are consistent with activation energy barriers of ~10 +/- 3 kcal/mol.

86 angement to cyanopyridine N-imide 40 with an activation energy of 43 kcal/mol.

87 receptor upregulation, L-type Ca(2+) channel activation, enhanced spine Ca(2+) transients, nuclear tr

88 g TSHRs (HEK-TSHR cells), we found that TSHR activation exhibits an "inverted U-shaped dose-response

89 ll antigen receptor (BCR) signals induce Syk activation followed by rapid phosphatase-mediated desens

90 bsequent histological analysis confirmed Wnt activation following local beta-NGF injections.

91 ng to excessive pro-growth signaling pathway activations frequently occurs in cancers.

92 et conformation for capsaicin-mediated TRPV1 activation gating, and reveals multiple ligand-channel i

93 al or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis.

94 echanistic scenarios of the cooperative bond activation have been identified by DFT and DLPNO-CCSD(T)

95 The exact mechanism of GrlA activation, however, remained unknown.

96 oid follicles (ILFs) constitute steady-state activation hubs containing group 3 innate lymphoid cells

97 PAG1 deficiency increased airway epithelial activation, ILC2 expansion, and T(H) 2 differentiation.

98 Transcriptional activation in both adipose tissue and liver as well as s

99 gy (PH) domain of P-Rex1 is required for its activation in cells.

100 We demonstrate that Notch activation in human tonsil-derived stage 3 (CD34(-)CD117

101 upregulates LAT1 expression and induces mTOR activation in IL-17(+) gammadelta and T(H)17 cells.

102 regarding how to assess and address patient activation in kidney disease to facilitate best practice

103 ion and activation of GABAergic and neuronal activation in mice regardless of cirrhosis compared with

104 t sevoflurane caused an increase in neuronal activation in primary somatosensory cortex of young mice

105 the negative feedback control of macrophage activation in response to bacterial infection.

106 define the kinetics and selectivity of gene activation in response to microbial ligands; however, th

107 to apoptosis along with increased caspase 3 activation in response to TNFalpha.

108 ite linker reported the highest fluorescence activation in stably transduced mammalian cells upon DEN

109 In fact, higher activation in the CA1 and DG was associated with lower v

110 t CFH is critical for controlling complement activation in the liver, and in its absence, AP activati

111 ehog signalling as a rheostat to control BMP activation in the progenitor niche to determine regenera

112 o be largely inadequate in reducing platelet activation in the vast majority of patients with ET.

113 le of the apparently avian-specific neuronal activation in the VMH of zebra finch parents.

114 In LX-2 cells, FXR activation increased peroxisome proliferator-activated r

115 in/+)Ffar2(-/-) mice had an altered state of activation, increased death, and higher production of IL

116 and decreased the astroglial and microglial activation induced by DSS.

117 A) receptor blocker), suggesting a GABAergic activation induced by OTR.

118 TRPV1 activation induced only a small and transient increase i

119 tage and Ca(2+), and that voltage and Ca(2+) activations interact, less is known about the mechanisms

120 version of Yen1, showing that its premature activation interferes with the response to perturbed rep

121 bromodomain and extraterminal (BET) protein activation is a druggable epigenetic mechanism of diseas

122 The regioselectivity of C-H activation is dominated by steric considerations and the

123 The G(i/o) -mediated TRPC4 activation is dually dependent on and bimodally regulate

124 Transcription activation is enhanced by elongating the crRNA.

125 Subsequent origin activation is under control of multiple protein kinases

126 , where a pivotal role is played by platelet activation, it would be arguable that diets with protect

127 e activated macrophages caused stellate cell activation, leading to liver injury, by a mechanism invo

128 ivation in the liver, and in its absence, AP activation leads to chronic inflammation and promotes he

129 In infected cells, NucC activation leads to complete destruction of the bacteria

130 alcium permeability, auxiliary subunits, and activation levels and show that Zn(2+) inhibits AMPARs i

131 -forms involving phosphorylation of the four activation-loop threonine residues and binding of ATP-Mg

132 HIF-1alpha activation lowered surface BCR, CD19 and B cell-activati

133 Residues involved in amidase activation map to a previously identified groove in the

134 DC phenotype evidenced by a decrease of the activation marker CD86 and an increase in IL-10 producti

135 This detailed understanding of the receptor activation may aid in the development of more specific d

136 spine injury and the modulation of caspase 3 activation may benefit neurons from spine loss in diseas

137 To dissect the activation mechanism, structural homology was used to id

138 sm contrasts with the generally assumed GPCR activation mechanism, which proceeds through an opening

139 Maternal immune activation (MIA) disrupts the central innate immune syst

140 imal models demonstrate that maternal immune activation (MIA) elevates inflammatory cytokine levels i

141 have enabled novel multifunctional substrate activation modes and unprecedented selectivity manifolds

142 s similar to the MS pups, while chemogenetic activation normalised it in the MS animals.

143 ain), TmAAE3 and TmAAE13 as suitable for the activation of 4-methylbutyric acid (N-debenzoyl-N-(2-met

144 The activation of 41BB costimulatory signals by agonistic Ab

145 ate cell activation by stimulating GPR55 and activation of ACC.

146 Thus, the activation of acetate in distinct subcellular compartmen

147 istration of lidocaine to the dura prevented activation of all neuronal classes but not the initiatio

148 TLR9 are deficient in both exercise-induced activation of AMPK and plasma membrane localization of t

149 In the absence of AC6, activation of AMPK mobilizes Kif19a into autophagosomes

150 ogram to induce ABCB1 through remodeling and activation of an ATF4-bound, stress-responsive enhancer.

151 ical changes in skin cell biology, including activation of an immune response, a switch in cell metab

152 ulate revascularization largely by paracrine activation of angiogenic functions in the peri-ischemic

153 revealed that high doses of BrdU lead to the activation of apoptotic cellular events as evidenced by

154 nt/beta-catenin signaling via PHB1-dependent activation of Axin1.

155 The dual activation of both reaction partners, chiral Lewis-base

156 TmAAE5 as the most efficient enzymes for the activation of butyric acid (Taxol D side chain), TmAAE13

157 Hepatocellular activation of c-Jun was demonstrated by nuclear transloc

158 F6 expression in melanoma cells affected the activation of CAFs.

159 with no evidence of augmented cell death by activation of caspase 3.

160 follicular IgG2c-producing plasma cells, and activation of CD4 and CD8 T cells.

161 r accumulation of genetic lesions drives the activation of cell death to eliminate cells with defecti

162 th CcMADS19 repression, thereby allowing the activation of CiFT2 the following cold season.

163 h breast cancer cells in vitro, MCs hindered activation of cMET, a master regulator of the basal prog

164 Dysregulation, impairment or inadvertent activation of complement components contribute to the pa

165 Activation of cytotoxic CD8(+) T cells by cross-priming

166 r immune control: increased infiltration and activation of cytotoxic T lymphocytes (CTLs) and CD103+

167 pression of CRY is associated with decreased activation of dopamine 1 receptor-expressing medium spin

168 on the plasma membrane is able to induce the activation of downstream MAPK/ERK and PI3K/Akt signaling

169 This inhibited STING polymerization and activation of downstream signaling events.

170 ogation of miR-223 expression, likely due to activation of E2F1, a known repressor of miR-223 transcr

171 We find aberrant activation of early B cell factor 1 (EBF1) to promote tr

172 Activation of EGFR signaling in the ALA neuron has previ

173 l that superoxide mediates neighbor-neighbor activation of energy-dissipating ion channels, while hyd

174 , and simultaneously promoted expression and activation of estrogen receptor (ESR1/ER) and its target

175 es were associated with intense synchronized activation of excitatory layer 2/3 pyramidal neurons (PN

176 ansporters are believed to prevent excessive activation of extrasynaptically located receptors that c

177 s in higher degrees of neuroinflammation and activation of GABAergic and neuronal activation in mice

178 Activation of gammadelta T cells can be elicited by buty

179 The activation of gene networks associated with adaptive imm

180 dal steroids have stimulatory effects on the activation of growth and reproductive axes, but the exis

181 s that cause ribosome stalling, with maximal activation of Hel2 observed at a lower frequency of stal

182 Activation of Hoxb1 in embryonic stem cells arrests card

183 as Diaph1 or mDia1) for the myofibroblastic activation of HSCs.

184 plantation (OLT) patients (n = 35) decreased activation of hTLR4- and hTLR9-transfected cells, wherea

185 show that transient inactivation of dMSNs or activation of iMSNs is capable of suppressing cue-induce

186 We tested whether activation of inwardly rectifying potassium (K(IR) ) cha

187 nd that this interaction plays a role in the activation of its GTase activity by FtsN, which may cont

188 re commonly de-regulated in PDAC tumors upon activation of KRAS and inactivation of TP53.

189 lmonary cell types indicated recruitment and activation of lymphatic endothelial cells.Conclusions: A

190 ning of the T helper 1 response, alternative activation of macrophages, efferocytosis, and upregulati

191 However, the HA proteases involved in the activation of many viral strains remain unidentified.

192 harbor activating NRAS mutations leading to activation of MAPK kinase (MEK) and extracellular signal

193 Altogether, selective activation of MC(1) is a viable strategy to induce cellu

194 genesis of ASD is not known, but it involves activation of microglia.

195 his repression occurs, at least in part, via activation of microRNA miR-7.

196 Activation of mitogen-activated protein kinases and NFka

197 Continuous activation of MYC activity is potentially lethal.

198 involves in situ formation and photoinduced activation of N-chloroamines to give aminium radicals th

199 nction of IKK2 and its co-factor NEMO in the activation of oncogenic c-Jun N-terminal kinase (JNK) si

200 ase LATS2, and this effect led to subsequent activation of oncogenic YAP.

201 diac fibroblast phenotype through mechanical activation of p38-YAP-TEAD signaling, which likely contr

202 SPRR3 loss resulted in reduced activation of PDGFRbeta in fibroblasts.

203 city toward murine fibroblasts and prevented activation of primary bone marrow-derived dendritic cell

204 by the emergence of myofibroblasts and early activation of pro-fibrotic signaling pathways before adv

205 ception of cytokinin ultimately leads to the activation of proteins belonging to the type-B Response

206 Our models explain how the activation of pyramidal cells or PV(+) cells can trigger

207 thrombin-induced ERK1/2 phosphorylation and activation of Ras homolog gene family member A.

208 FT components leaving the cilium, but not in activation of retrograde IFT.

209 s unclear, although it is thought to inhibit activation of RIPK3 and necroptosis(8).

210 the ARM-TIR interaction caused constitutive activation of SARM1 and thereby led to axonal degenerati

211 mains obscure, but understanding of both the activation of silent gene clusters and the ecological fu

212 we explored the mechanisms underlying MHV68 activation of SINE ncRNAs.

213 Recapitulating this transient activation of SST interneurons using chemogenetics simil

214 nderstanding how copper active sites achieve activation of strong C-H bonds.

215 logical profile and impaired recruitment and activation of T cells.

216 We found that constitutive activation of TFEB is the main driver of the kidney abno

217 g winter, suppress branching by simultaneous activation of TFL1 and repression of the LAP1 pathway.

218 y, patients with psoriasis displayed reduced activation of the AHR pathway and increased CYP1A1 enzym

219 Activation of the aptazyme, inserted in the 3' UTR of th

220 macrophages, and fibroblasts leads to robust activation of the B2 family of SINEs in a cell-autonomou

221 High calpain activity coincided with activation of the calpain-2 isoform but not with calpain

222 pheral rings, that prevents dimerization and activation of the catalytic domains.

223 Activation of the central SNAREpins associated with Syna

224 of both reaction partners, chiral Lewis-base activation of the electrophile and light activation of t

225 Activation of the glucocorticoid receptor (GR) by the sy

226 o vasoconstriction, leukocyte adherence, and activation of the immune response.

227 , this outgroup deficit was reflected in the activation of the inferior frontal gyrus.

228 nd inflammation through mechanisms involving activation of the inflammasome in macrophages.

229 It is well known that activation of the kappa opioid receptor system modulates

230 hock was immune to the IED, but chemogenetic activation of the LC before the weak conditioning protoc

231 s studies demonstrate an association between activation of the maternal immune system during pregnanc

232 reased G-CSF was accompanied by an increased activation of the NF-kappaB signaling pathway in bone ma

233 ase activation of the electrophile and light activation of the nucleophile, enables the stereoselecti

234 clear, it has been suggested that antidromic activation of the primary motor cortex (M1) plays a sign

235 iated translation arrest leads to the futile activation of the ribosome rescue systems.

236 ne demethylase UTX (also known as KDM6A) and activation of the RTK FGFR3, two events that commonly co

237 f neurons in the ACC receives S1 inputs, and activation of the S1 axon terminals increases the respon

238 Activation of the T cell receptor (TCR) results in bindi

239 ction that NQO1 induction by pharmacological activation of the transcription factor nuclear erythroid

240 ssion of the IL-2 receptor alpha-subunit and activation of the transcriptional regulator STAT5.

241 strocyte-released thrombospondins (TSPs) and activation of their neuronal receptor, alpha2delta-1.

242 2 RNA, release of B2 RNA from chromatin, and activation of thermal stress genes.

243 ons disrupted Pavlovian reward learning, and activation of these cells promoted the acquisition of an

244 ics isoflurane and sevoflurane increased the activation of TLR9, while propofol attenuated it.

245 Activation of Tnfa and its receptors or major chemokine

246 ered a role for B cells in the induction and activation of Tregs during FV infection.

247 i/o) pathways and shed light on how aberrant activation of TRPC4 may occur under pathological conditi

248 mportant extension of this chemistry for the activation of tyrosine residues that project into soluti

249 , and exposure to stress led to splicing and activation of xbp-1 in these neurons.

250 Phosphorylation, and thereby activation, of response regulators has been demonstrated

251 tic changes occurring during transcriptional activation, only demethylation of histones and cytosine-

252 nsity and/or morphology can result in immune activation or, as recently implicated, in providing an e

253 is of monocyte subsets and signaling pathway activation patterns in conventional monocytes and pMos r

254 Yet, despite a close resemblance of such activation patterns to those seen during the correspondi

255 a-clade viruses had less stable HA proteins (activation pH 5.5-5.9) than pandemic clade (pH 5.0-5.5).

256 a with the ability to assign TFs to specific activation points in the model.

257 Further, downstream of inflammasome activation, polymorphisms that cause loss of gasdermin D

258 These data demonstrate that LPAR2 receptor activation prevents and mitigates gamma-irradiation-indu

259 We provide evidence that the promoter activation rate is influenced by both enhancer and promo

260 etal-catalyzed, template-directed remote C-H activation reactions of alcohols, carboxylic acids, sulf

261 ogether, results showed that ethanol affects activation, recruitment, phagocytosis and killing functi

262 humidity <100%) in the fluctuation-dominant activation regime.

263 CD8+ cells additionally showed activation-related metabolic remodeling deficits and dec

264 the magnitude of antimicrobial MR1-dependent activation remained as potent and polyfunctional as with

265 Full-length AR and AR-V7 transcription activation required both PRMT5 and pICln but not MEP50.

266 ting that disturbed flow-induced endothelial activation required IRAK-1.

267 Blocking NF-kappaB activation rescued FXR signaling and partially ameliorat

268 finity, CCL2 scavenging efficiency, and cell activation sensitivity.

269 onditions with identical visual stimulation, activation shifted the decision criterion selectively wh

270 Although they respond differently to given activation stimuli, proper validation of suitable refere

271 e S(N)2 reaction channel (less-destabilizing activation strain).

272 Moreover, plant iron stress triggers immune activation, suggesting that sensing of iron depletion is

273 calcium flux, cell polarization, and ERK1/2 activation, suggesting that TrkA is an important player

274 sorders and is usually designated macrophage activation syndrome in those settings.

275 kine signature similar to that of macrophage activation syndrome/hemophagocytic lymphohistiocytosis.

276 highly efficient candidate for hexanoic acid activation (Taxol C side chain), and TmAAE4 as suitable

277 cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor de

278 titute a signaling pathway downstream of MMP activation that is involved in promoting the transient s

279 ate the signaling pathway downstream of PAR4 activation that leads to such events.

280 e mechanism(s) of RBC-MV-induced coagulation activation, the ability of storage lesion-induced RBC-MV

281 thesis/secretion kinetics (CCL3/4/5) and low activation thresholds (CCL1/3/4/5/XCL1); and T(M) chemok

282 r damage by inducing macrophage and platelet activation through the TLR4 pathway.

283 Catheterization laboratory (cath lab) activation time is a newly available process measure for

284 l the segregation of oncogenic STAT5 and ERK activation to competing clones.

285 osis that increases in magnitude upon T cell activation to support T cell growth even under amino aci

286 ate status epilepticus and CaMKIIa Gq DREADD activation) triggered increased microglial process calci

287 Prenatal TLR7 activation via administration of the selective agonist i

288 exclusively innervated by GRP fibers, whose activation via optogeneics and chemogenetics in the skin

289 tion molecules that contribute to complement activation via the lectin pathway.

290 buried solvent particles; (2) applying high activation voltages in the interface of tandem-TIMS resu

291 Glial activation was more robust in the inferior retina and mo

292 This latter mode of activation was therefore selected to access aliphatic su

293 Activations were thus a compensation mechanism needed on

294 ecule (ICAM)-1 are biomarkers of endothelial activation, which has been implicated in the pathogenesi

295 inases that either promote or inhibit origin activation, which is important for genome maintenance.

296 Inhibiting IRE1alpha blocked stellate cell activation, which then decreased proliferation and migra

297 involved in the stress response, and higher activation with acute mental stress may indicate a more

298 igher compared to those extracted by electro-activation with maximal value of 52% for the conventiona

299 unts of leukotriene B4 (LTB4) in vitro after activation with zymosan or immune complexes, compared wi

300 Noninvasive strategies detecting T-cell activation would allow for early diagnosis and possibly