ライフサイエンスコーパス: activation domain

1 through direct interaction with an E-protein activation domain.

2 on Mediator for the ATF6alpha transcription activation domain.

3 ytic attack upon mutation of residues in the activation domain.

4 NRF-2beta, which contains the transcription activation domain.

5 ions to the human estrogen receptor and VP16 activation domain.

6 activities that augment the functions of the activation domain.

7 a microsatellite-associated transcriptional activation domain.

8 effect does not require its transcriptional activation domain.

9 lexes with HIF-2alpha through the C-terminal activation domain.

10 ite that we identified within the N-terminal activation domain.

11 ctivation by p53, through binding to the p53 activation domain.

12 hydrophobic leucines, functions as a strong activation domain.

13 ng of the locus from a silent to a conserved activation domain.

14 in the presence or absence of the C-terminal activation domain.

15 -kappaB subunit endowed with a transcription activation domain.

16 acts as a cell-type-specific transcriptional activation domain.

17 but not a mutant lacking the transcriptional activation domain.

18 d GABPbeta, which contains the transcription activation domain.

19 BD, leading to substantial compaction of the activation domain.

20 rin, dependent on the Meis2d transcriptional activation domain.

21 t SIM in KLF4 functions as a transcriptional activation domain.

22 as a deadenylase but lacks a transcriptional activation domain.

23 e promoter activation by contacting the MotA activation domain.

24 ired for PC2 binding and contains the PLAGL2 activation domain.

25 NA binding domain with 76 amino acids in the activation domain.

26 nal coactivators to the more potent SREBP-1a activation domain.

27 fundamental for transactivation by the IE62 activation domain.

28 oA-I's central loop, which overlaps the LCAT activation domain.

29 nsus HCF-1 binding site on PRC and the NRF-2 activation domain.

30 transcriptional activation by the Rta acidic activation domain.

31 y, and is independent of the transcriptional activation domain.

32 eir T3 and nuclear localization signals, and activation domain.

33 ing of its calcium release-activated calcium activation domain.

34 or silenced by Gal80 when fused to the Gal4 activation domain.

35 atory protein Gal4 DNA binding and AP-2alpha activation domains.

36 ese LC sequences function as transcriptional activation domains.

37 s encoding its DNA-binding and transcription-activation domains.

38 iption factor containing two transcriptional activation domains.

39 ular lipid composition of immunoisolated TCR activation domains.

40 ignal transduction between the catalytic and activation domains.

41 ins share two highly conserved transcription activation domains.

42 of diversification in cis depends on the E2A activation domains.

43 , has separable cyclin box and transcription activation domains.

44 we show that, unlike the HEB E-protein, the activation domain 1 (AD1) of E2A has specifically reduce

45 s a conserved amino-terminal RING domain, an activation domain 1 (AD1), and an acidic carboxyl-termin

46 als that LMP1, through its carboxyl-terminal activation domain 1 (LMP1-CTAR1), activates both STAT3 a

47 tif interaction with an F-box-like region in activation domain 1 of TIF2.

48 basic domain enhances, whereas a mutation in activation domains 1-2 and deletion of the proline-rich

49 We also found that activation domains 1-2 and the proline-rich domain are r

50 tion of a novel E-protein activation domain (activation domain 3 [AD3]) with the TAF homology (TAFH)

51 cation occurs at four lysines within the Rta activation domain (426, 446, 517, and 530) and that sumo

52 es an acidic nine-amino-acid transcriptional activation domain (9aaTAD) and a loss-of-function mutati

53 vity requires direct interaction with an ATR activation domain (AAD)-containing partner.

54 nd TOPBP1 contain experimentally defined ATR activation domains (AADs) that are mostly unstructured a

55 Mediator occupancy, whereas removal of both activation domains abolishes it.

56 ted through interaction of a novel E-protein activation domain (activation domain 3 [AD3]) with the T

57 expression of ATF3 bereft of the C-terminal activation domain acts as a dominant negative factor, in

58 through its Ca(2+) release-activated Ca(2+) activation domain, acutely inhibits gating, and causes l

59 osphorylation or deletion of a 14-amino-acid activation domain (AD) located on the linker connecting

60 nal activator containing a C-terminal acidic activation domain (AD) of 34 amino acids.

61 tending previous studies that the N-terminal activation domain (AD) of ETV5 interacts with Mediator s

62 evious studies have shown that Lys-28 in the activation domain (AD) of Tat is essential for HIV-1 tra

63 (AS) to map and characterize a 41-amino acid activation domain (AD) within the Rap1 C terminus.

64 transcription via a C-terminal transcription activation domain (AD).

65 otein through masking of its transcriptional activation domain (AD).

66 n N-terminal p10 regions and C-terminal Cdk5 activation domains (AD).

67 In contrast, the N-terminal activation domain, AD1, is required for a newly describe

68 They contain at least two activation domains, AD1 and AD2.

69 Acidic transcription activation domains (ADs) are encoded by a wide range of

70 Transcriptional activation domains (ADs) are generally thought to be int

71 e, do intrinsically disordered transcription activation domains (ADs) use sequence-specific motifs, o

72 NFAT5 has three intrinsically ordered (ID) activation domains (ADs).

73 155) bind the amino-terminal transcriptional activation domain AF-1, which has not been targeted for

74 The Gcn4 N-terminal activation domain also cross-links to the Mediator subun

75 ins, including a DNA-binding/transcriptional activation domain and a large extracellular domain.

76 PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP,

77 a chimeric protein of Eve1 fused to the Gal4 activation domain and gene-knockdown approaches, we inve

78 hain, but Arg-320 is well defined within the activation domain and is not accessible to proteolysis i

79 athway terminating at segment 215-217 in the activation domain and the other pathway terminating at t

80 tated the association of Nox1 with the NoxA1 activation domain and was necessary for NADPH oxidase co

81 site in the Hsf1 C-terminal transcriptional activation domain and with an additional site that we id

82 at selected ZF-TFs function with alternative activation domains and in multiple cell lines.

83 ten binding sites in the ASCIZ transcription activation domain, and high DYNLL1 levels inhibit the tr

84 a p73 isoform with a potent transcriptional activation domain, and loss of TAp73 predisposes mice to

85 nserved coactivator complexes, transcription activation domains, and the cooperation of these factors

86 Further, the IE62 activation domain appears to selectively interact with a

87 ALE DNA binding domain and the transcription activation domain are separated and each fused to protei

88 tions of hybrid activators with Gal4 or VP16 activation domains are diminished in class D mutants as

89 ght-induced degradation, and transcriptional activation domains are located at the N-terminal 150-ami

90 In this study, we show that both activation domains are required for optimal E2A-dependen

91 tional domains, i.e., the cyclin box and the activation domain, are necessary for the overall enhance

92 intracellular amino acid position in the GS activation domain as the engineered constitutively activ

93 uncations reveals a critical transcriptional activation domain at aa 31 to 185 and a nuclear localiza

94 inc fingers at the C-terminus and a putative activation domain at the N-terminus.

95 teraction results in the dissociation of the activation domain-ATPase complex via an allosteric proce

96 fic monoclonal antibody 225.28S and a T-cell activation domain based on combinations of CD28, 4-1BB,

97 Jab1 (Jun activation domain binding protein 1), integrated into CO

98 inhibitor, the COP9 signalosome subunit jun activation-domain binding protein 1 (Jab1), leading to i

99 Jun activation domain-binding protein 1 (JAB1) is a multifun

100 Jun activation domain-binding protein 1 (JAB1) is overexpres

101 We now report that the nuclear Jun activation domain-binding protein 1 (Jab1) may transduce

102 Jun activation domain-binding protein 1 (JAB1) regulates ubi

103 the Adr1 regulatory domain inhibits an Adr1 activation domain but not a heterologous activation doma

104 h typical TALEs, iTALEs lack a transcription activation domain but retain nuclear localization motifs

105 egative form of Egr-1, which lacks the trans activation domain but retains the DNA-binding domain, in

106 P-1 proteins contain defined transcriptional activation domains, but BATF and the closely related BAT

107 y, the recruitment of multiple transcription activation domains by a single sgRNA, modified to contai

108 Overexpression of the CRAC activation domain (CAD) of STIM1 resulted in a decrease

109 tify a minimal, highly conserved 107-aa CRAC activation domain (CAD) of STIM1 that binds directly to

110 We find that the central activation domain (cAD) of the yeast activator Gcn4 func

111 mains, the transmembrane region and the CRAC activation domain (CAD), and can promote the association

112 ng of Orai1 to STIM1 and to the soluble CRAC activation domain (CAD).

113 Recently, we defined a minimal CRAC activation domain (CAD; residues 342-448) that binds dir

114 coiled-coil 1, CC1; coiled-coil 2, CC2; CRAC activation domain, CAD) to this process are not well und

115 The VP16 activation domain can recruit various transcriptional co

116 that replacement of key residues within the activation domain causes these zymogens to spontaneously

117 resulted in the absence of the essential MYB activation domain coding region.

118 for the first time, direct evidence that TCR activation domains comprise a distinct molecular lipid c

119 chanism of IE62 transactivation is an acidic activation domain comprising the N-terminal 86 amino aci

120 interacts directly with the transcriptional activation domain (conserved region 3 [CR3]) of adenovir

121 RS-4 interacts with both the transcriptional activation domain (conserved region 3) and the N-termina

122 observed that AL2 lacking its transcription activation domain could reverse TGS in reproductive plan

123 gh the action of a conserved transcriptional activation domain, CR3.

124 The individual Gcn4 activation domains cross-link to three common targets, G

125 or, namely, human HDAC3 with the deacetylase activation domain (DAD) from the human SMRT co-repressor

126 p53 bound to the SMRT deacetylase activation domain (DAD), which mediates HDAC3 binding an

127 tone deacetylase 3 through their deacetylase activation domain (DAD).

128 quires stable binding to a nucleosomal site; activation domain-dependent recruitment of co-factors in

129 riptional activators in that it contains two activation domains, designated AD1 and AD2, which are re

130 s provides increased regulatory control over activation domain dominance.

131 indicating a crucial role for the N-terminal activation domain during acetate metabolism.

132 both constitutive and wild-type VirG-tandem activation domain effectors.

133 in human cells by tethering transcriptional activation domains either directly to a nuclease-null Ca

134 However, deletion of a 14 amino acid activation domain encompassing S742 and S747 inhibits ch

135 the receptor binding domain (RBD) and the F activation domain (FAD).

136 tion D516N mutation in HMR's transcriptional activation domain, fails to induce the thermoresponsive

137 tein, lacking the C-terminal transcriptional activation domain (Fli-1(DeltaCTA)).

138 nding domain of CREB-binding protein and the activation domain from the p160 transcriptional co-activ

139 the interaction between two IDP domains: the activation domain from the p160 transcriptional co-activ

140 hypersensitive site required transcriptional activation domains from TFE3 and PU.1, respectively.

141 ng transcriptional activator based on tandem activation domains from the Drosophila fushi tarazu and

142 Therefore, the E protein activation domains function redundantly in promoting B c

143 the I2 and R regions contain portions of the activation domain, functionally linking DNA binding and

144 s of an EWSR1-derived strong transcriptional activation domain fused, in-frame, to the DNA-binding do

145 , we also found that while a transcriptional activation domain fusion, CebpFlagWdr68, functionally su

146 fusing zinc finger peptides to repression or activation domains, genes can be selectively switched of

147 ariants, is part of the second transcription activation domain in Gis1 and is essential for both the

148 or modeling of the solution structure of the activation domain in the absence and presence of ERRgamm

149 from a preferential inactivation of the AF2 activation domain in the GR LBD of Dex-bound, but not DA

150 binds to the relatively uncharacterized tau2 activation domain in the hinge region of GR.

151 the primordium and a stable Wnt/beta-catenin activation domain in the leading region of the primordiu

152 o's activation using p65-Rta transcriptional activation domains in addition to VP64.

153 e distinct functionalities for the E protein activation domains in B lymphocytes and macrophages.

154 identified potent classical transcriptional activation domains in the C termini of several tail modu

155 Targets of the tandem Gcn4 acidic activation domains in transcription preinitiation comple

156 Last, Cyc8-Tup1 can interact with activation domains in vivo.

157 we reveal unique features of the interferon activation domain, including a set of beta-sheets and lo

158 ich contain a DNA-binding domain but lack an activation domain) interact with YAP (which lacks a DNA-

159 es by NMR spectroscopy reveal that the Oaf1p activation domain interacts with the Gal11p/MED15 KIX do

160 ng domain, and a single metalloid binding or activation domain is located at the interface of the two

161 rylation at three sites in its transcription activation domain is necessary for SRC-YAP1-mediated tra

162 Surprisingly, however, neither activation domain is required for E2A to rescue B lympho

163 The Tat trans activation domain is required for RON degradation, and t

164 Autoacetylation of lysine-290 within the activation domain is required for stabilizing the intera

165 This suggested that an activation domain is required for stable binding, and co

166 A second domain, the activation domain, is tightly associated with the PAT do

167 mulates tyrosine phosphorylation of the VAV3 activation domain, known to be required for guanine nucl

168 broadly, these findings suggest that kinase activation domains may be previously unappreciated sites

169 suggest that the N terminus contains a true activation domain, mediating interactions with TFIID, me

170 mutant ICP4 molecule lacking the C-terminal activation domain (n208) efficiently activates many earl

171 We suggest that the dephosphorylated activation domain normally interacts with CBS1 and/or CB

172 nd TGS reversal required the transcriptional activation domain of AL2.

173 Kctd15 binds specifically to the activation domain of AP-2alpha and efficiently inhibits

174 least in part by specifically binding to the activation domain of AP-2alpha, thereby blocking the fun

175 HSP70 interacts strongly with the N-terminal activation domain of ATF5, which is expected to be rigid

176 e activity of the N-terminal transcriptional activation domain of Brn-3a is increased following RA tr

177 domain was identified for APH proteins, the activation domain of c-Jun was very important in the obs

178 NME7, TPX2, and the putative activation domain of CDK5RAP2 h gamma-TuRC-mediated nucl

179 equence motif present in the transcriptional activation domain of class A-HSFs.

180 in leads to an enhancement of binding by the activation domain of CREB (phosphorylated kinase-inducib

181 region within the N-terminal transcriptional activation domain of E2A-PBX1, termed the PCET motif, wh

182 fingers, in combination with the gain of the activation domain of ENL or of other partner proteins, m

183 constitutively active FoxM1 construct or the activation domain of FoxM1 to the cyclin B1 gene promote

184 constitutively active FoxM1 construct or the activation domain of FoxM1 to the cyclin B1 gene promote

185 We show that Rb binds to the C-terminal activation domain of FoxM1b.

186 F644 and WIZ interact with the transcription activation domain of G9a and GLP, respectively.

187 al structure of a complex between the acidic activation domain of Gal4p and Gal80p.

188 ex with a peptide from the carboxyl-terminal activation domain of Gal4p reveals the existence of a di

189 ndicated that the C-terminal transcriptional activation domain of GLI1 and SMARCA2's central domains,

190 that this motif is part of the transcription activation domain of Glis3.

191 However, despite its being the major activation domain of GRs, knowledge of AF1 structure/fun

192 We show that two phiXXphiphi motifs in the activation domain of HBZ mediate binding to a single sur

193 ion, and native states in the folding of the activation domain of human procarboxypeptidase A2 (ADA2h

194 Our study identifies the central cleavage/activation domain of IL-33 (amino acids 66-111) as an im

195 CblD, CblC, and the activation domain of methionine synthase share several d

196 important for cobalamin trafficking, and the activation domain of methionine synthase.

197 complexation of KIX with the transcriptional activation domain of mixed-lineage leukemia protein lead

198 ly bind two polypeptide ligands, such as the activation domain of MLL and the kinase-inducible activa

199 t Mxr1 residues 212-225 and mapped the major activation domain of Mxr1 to residues 246-280, and showe

200 Although the activation domain of Noxa1 was not required for Duox fun

201 Binding of the E1B protein to the activation domain of p53 inhibits p53-dependent transcri

202 le positioning of the N-terminal part of the activation domain of PGC-1alpha, favorable for assembly

203 Inhibitory antibodies targeting the activation domain of PR3 could be exploited as highly se

204 Acidic residues in the activation domain of protein C are thought to electrosta

205 Phosphorylation of the activation domain of protein kinase C (PKC) isoforms is

206 ucture of the human RNMT in complex with the activation domain of RAM.

207 The transcriptional activation domain of RelB, but not RelA, directly intera

208 of zebrafish SLIP1 bound to the translation-activation domain of SLBP and identified the determinant

209 of KLF3 plus the MADS box and transcription activation domain of SRF are implicated in this synergy.

210 The SH2 dimerization and activation domain of STAT3 is frequently mutated in pati

211 se (EGR)-binding domain of NAB2 fused to the activation domain of STAT6.

212 ly converting an inhibitory aptamer into the activation domain of the activator, we also introduced a

213 In this study, we show that AF1, an ID activation domain of the glucocorticoid receptor (GR), a

214 A peptide that mimics a putative activation domain of the Nox1 activator subunit NOXA1 (N

215 BD) of transcription coactivator CBP and the activation domain of the p160 steroid receptor coactivat

216 lanine (pBpa) throughout the transcriptional activation domain of the prototypical eukaryotic transcr

217 ivin binds to the N-terminal transcriptional activation domain of the STAT3 dimer and represses STAT3

218 ata demonstrate a mechanism through which ID activation domain of the steroid receptors and other sim

219 Most notably, we find that the activation domain of the Wee1 kinase is also required fo

220 CPR3-7 preferentially bound to the so-called activation domain of the zymogen and changed the conform

221 assembly in which Mediator was bound to the activation domain of viral protein 16 (VP16).

222 utant protein fused with the transcriptional activation domain of VP16, suggesting a causal relations

223 nner dependent mostly on the presence of the activation domain of VP16.

224 We map the transcriptional activation domain of ZLD to a central region characteriz

225 ligand-independent and the ligand-dependent activation domains of estrogen receptor alpha.

226 y was utilized, in which the DNA binding and activation domains of Gal4 and VP16, respectively, were

227 at Hsp70 interacts with both transcriptional activation domains of Hsf1 in the related yeast Lachance

228 Thus, the context-specific function of the activation domains of NFAT can be potentiated by DNA-dir

229 ses the possibility that the function of the activation domains of NFATp is dimer-specific.

230 Our finding that deletion of the activation domains of S. cerevisiae Med2 and Med3, as we

231 is transcriptionally activated by tethering activation domains of several transcription factors that

232 y masking and inhibiting the transcriptional activation domains of the recruiting proteins, not by ac

233 Furthermore, we show that the 'activation domain' of Cdc20 associates with the Apc6 and

234 t, peptides derived from the phosphoacceptor activation domain on ATF2 (peptides 4 and 5) were recogn

235 dr1 activation domain but not a heterologous activation domain or artificially recruited Mediator, co

236 was inhibited either by deletion of the VP16 activation domain or by chemical inhibition of RNA polym

237 on of tau (aa 2-18), termed the "phosphatase activation domain (PAD)", is hidden within native Tau in

238 PGC-1alpha activation domain (PGC-1alpha(2-220)) is intrinsically d

239 H and R helices mediate CLH-3b regulation by activation domain phosphorylation.

240 nding of the phosphorylated kinase-inducible activation domain (pKID) of CREB, and intrinsically diso

241 ation domain of MLL and the kinase-inducible activation domain (pKID) of CREB, using distinct interac

242 e intrinsically-disordered YAP transcription activation domain prevented the formation of YAP condens

243 rowth signaling by mutation of the Shc/FRS-2 activation domain prohibited Erk activation and eliminat

244 y ablate PAX interacting (with transcription-activation domain) protein 1 (PTIP), a key component of

245 he NFATp monomer, even in the absence of its activation domains, recruits bZIP proteins to canonical

246 bservations indicate that Hsf1, via its dual activation domains, recruits holo-Mediator to HSP promot

247 rylation sites or C-terminal transcriptional activation domain, restores positive selection in SRF nu

248 ted form of CBF2 lacking its transcriptional activation domain resulted in a cold-stimulated increase

249 argets Q167 and Q189 within the constitutive activation domain, resulting in cleavage of IRF7.

250 ants by directly tethering the minimal STIM1 activation domain (S) to Orai1 (Orai1-SS channels), indi

251 at truncation of either its N- or C-terminal activation domain significantly reduces Mediator occupan

252 ly by Tyr-172 inserting into a cavity in the activation domain stabilizing the S1 substrate-binding p

253 pment in mice expressing p53 transcriptional activation domain (TAD) mutants.

254 Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase E

255 of CBP/p300, and second, the transcriptional activation domain (TAD) of RelA binds to the TAZ1 domain

256 lacking the conserved Notch1 transcriptional activation domain (TAD) show attenuated Notch1 function

257 ion by tethering an autonomous transcription activation domain (TAD) to an intended gene promoter at

258 trans-activation, including an acidic trans-activation domain (TAD), a serine-rich tract (SRT), and

259 hrough its unique C-terminal transcriptional activation domain (TAD).

260 s a potent N-terminal acidic transcriptional activation domain (TAD).

261 rans-activation mediated by the acidic trans-activation domain (TAD).

262 pha (the p73 isoform that contains the trans-activation domain) target gene and activates the express

263 e work presented here, we show that the IE62 activation domain targets the human Mediator complex via

264 The EDLL motif represents a potent plant activation domain that can be used as a tool to confer t

265 cally, we determined that KLF16 possesses an activation domain that couples to histone acetyltransfer

266 cts with CycD2 through a discreet N-terminal activation domain that is essential for the cardiogenic

267 gest that the Vpx amino terminus contains an activation domain that serves as the binding site for a

268 1 channels by increasing the number of STIM1 activation domains that are directly tethered to ORAI1 c

269 In addition to a previously identified activation domain, this region contains a previously unc

270 ruiting multiple copies of a transcriptional activation domain to a nuclease-deficient CRISPR/Cas9 pr

271 Mutation of one proline residue in the activation domain to an alanine (P59A) yields a protein

272 direct dCas9 fused to a VP64 transcriptional activation domain to increase expression of endogenous h

273 By fusing transcription activation domain to Pseudomonas aeruginosa type I-F Cas

274 Fusing the Tat activation domain to some splicing factors, particularly

275 Fusion of a TCF C-terminal activation domain to SRF.V194E effectively restores ERK-

276 ivity could be used to recruit transcription activation domains to specific promoters.

277 The contribution of the two Gcn4 activation domains to transcription was gene specific an

278 ctive Cpf1 nuclease fused to transcriptional activation domains to tune the expression of endogenous

279 h lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric tran

280 haracterized lung cancer mutation in this JM activation domain (V665M) constitutively activates EGFR

281 pha independent of the HIF-2alpha C-terminal activation domain via enzyme/substrate interactions, p30

282 n be largely substituted by the heterologous activation domain VP16.

283 Although no activation domain was identified for APH proteins, the a

284 the MS2 coat protein linked to transcription activation domains, was reported to induce otherwise sil

285 Moreover, by using dCas9 linked to an activation domain, we can either enhance or suppress tar

286 esides near the center of the protein's LCAT activation domain, we determined whether its oxidation b

287 pervariability maps to important binding and activation domains, we hypothesized that vCXCL-1s differ

288 effect of mutations in the C-terminal trans-activation domain were characterized.

289 Interestingly, TCR activation domains were also enriched in plasmenyl phosp

290 oxA2 induces Arx through its transcriptional activation domain whereas Nkx2.2, induced by Shh, abolis

291 is mediated by a cytosolic C-terminal trans-activation domain, which carries a conserved Thr (T460)

292 ed by phosphorylation of a carboxy-terminus "activation domain," which disrupts its interaction with

293 ctivator-binding domains that bind each Gcn4 activation domain with micromolar affinity.

294 s of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain

295 In keeping with the presence of an activation domain within Nkx6, we also report that Nkx6

296 sence of two repression domains and a single activation domain within this transcription factor.

297 Activation domains within coactivators are likely an imp

298 Classical activation domains within DNA-bound eukaryotic transcrip

299 We have identified distinct DNA-binding and activation domains within the critical transcription fac

300 ex of T cells engineered to express powerful activation domains without the associated safety concern