ライフサイエンスコーパス: activation mechanism

1 errupt distinct sequential steps of the ATF6 activation mechanism.

2 pockets that shed new light on the G-protein activation mechanism.

3 ore detailed hypotheses of the full receptor activation mechanism.

4 ey would shed light on LpoB function and its activation mechanism.

5 DUOX1 or the homolog NOX2, depending on the activation mechanism.

6 n its composition, functional importance and activation mechanism.

7 s may share a common ligand binding mode and activation mechanism.

8 s followed by mutagenic analysis to test the activation mechanism.

9 r recently established reduction-coupled oxo activation mechanism.

10 uctural change plays a secondary role in the activation mechanism.

11 fungus were important steps in the caspase-1 activation mechanism.

12 DFT studies support a ligand-assisted water activation mechanism.

13 ied rapidly, while conserving the allosteric activation mechanism.

14 are discussed in the context of the receptor activation mechanism.

15 an and tissue development through an unknown activation mechanism.

16 us to propose a novel model for the receptor activation mechanism.

17 provides a conceptual framework for the TCR activation mechanism.

18 lps to shed light on PKCalpha regulation and activation mechanism.

19 ng a role for Nef homodimer formation in the activation mechanism.

20 ngth BAK has hampered full dissection of its activation mechanism.

21 motor and consistent with a cargo-dependent activation mechanism.

22 for future studies on dissection of the RdRp activation mechanism.

23 lar structures, indicative of a step-by-step activation mechanism.

24 tures we propose the individual steps of the activation mechanism.

25 t the molecular level to understand the gene activation mechanism.

26 cooperate with talin to support the integrin activation mechanism.

27 ting a regulatory role for fragment 1 in the activation mechanism.

28 er key regulatory regions and propose a Mec1 activation mechanism.

29 tion follows an unprecedented metalloradical activation mechanism.

30 thogenicity and providing insights into TBK1 activation mechanism.

31 complementing existing suggestions on IP(3)R activation mechanism.

32 rkovian spreading depends on a specific edge activation mechanism.

33 which has limited our understanding of their activation mechanism.

34 FRET is an essential tool for unraveling its activation mechanism.

35 constitutively via the same transcriptional activation mechanism.

36 cidates common and specific features of this activation mechanism.

37 kinase A (PKA) is a well-characterized CREB activation mechanism.

38 domain of the toxin might be involved in the activation mechanism.

39 in features of kinases that impact on their activation mechanisms.

40 and the main core provides insights into its activation mechanisms.

41 s, along with a variety of specificities and activation mechanisms.

42 xchange GDP for GTP, similar to small GTPase activation mechanisms.

43 ling between the voltage- and cNMP-dependent activation mechanisms.

44 ly related and may share common assembly and activation mechanisms.

45 ries of target genes via threshold-dependent activation mechanisms.

46 distinct atomic motions that confer distinct activation mechanisms.

47 ional, posttranscriptional, or translational activation mechanisms.

48 the specificity of ligand-binding and likely activation mechanisms.

49 legumains encode distinct, isoform-specific activation mechanisms.

50 c noise might be an additional factor in the activation mechanisms.

51 on its ability to effectively nullify immune activation mechanisms.

52 id generation in response to nonclassical MC activation mechanisms.

53 either telomere recombination or telomerase activation mechanisms.

54 In mammals, a shared activation mechanism allows for coordinate regulation of

55 Blm10, have provided insights to proteasome activation mechanisms, although the biological functions

56 Here, we examine the divergence of activation mechanisms among nine vertebrate MLKL ortholo

57 structures offer important insights into the activation mechanism and allosteric modulation of muscar

58 ClpP1P2 activity, its unusual activation mechanism and ClpC1 ATPase represent attracti

59 Resolving the activation mechanism and dimerization state of these rec

60 Furin shows a complex activation mechanism and exists in at least four defined

61 ding further insight into the channel's acid-activation mechanism and rectification behavior.

62 e results present a new view of the platelet activation mechanism and reveal principal mechanistic fe

63 The activation mechanism and roles of each accessory protein

64 The data reveal the activation mechanism and show that overall splicing effi

65 Here we studied the activation mechanism and subcellular compartment in whic

66 our data give important insight in the LRRK2 activation mechanism and, most importantly, explain the

67 receptors that form inflammasomes, but their activation mechanisms and biological purposes have not y

68 and structural biologists, due to its unique activation mechanisms and broad implications in cancer,

69 nding the upstream pathway may delineate Rac activation mechanisms and its role in maintaining vascul

70 osite to that in classical potassium channel activation mechanisms and open a passage lateral to the

71 he transduction pathway, indicating distinct activation mechanisms and reflecting the different pharm

72 rm channel orthologues that employ different activation mechanisms and serve different functions.

73 hat receptors can use a combination of these activation mechanisms and that technical limitations can

74 the novel types of ubiquitin-mediated signal-activation mechanism, and previously unexpected synergis

75 injury in mice, perhaps via a GPCR-mediated activation mechanism, and suggest that inhibition of Pan

76 physiological role of HdeB in bacteria, its activation mechanism, and the structural requirements fo

77 f surface lattice oxygen and identifying the activation mechanism are crucial for the development and

78 ough most integrins contain beta1, canonical activation mechanisms are based on studies of the platel

79 verge to modulate TPC activity, and proposed activation mechanisms are controversial.

80 tions of our study for the assignment of C-H activation mechanisms are discussed.

81 r findings reveal that G-protein-binding and activation mechanisms are fundamentally different betwee

82 Apoptotic caspase activation mechanisms are well defined, yet inactivation

83 Structural comparisons reveal a quaternary activation mechanism arising from rigid-body movements b

84 chemical analysis of this enzyme reveals its activation mechanism as well as structural features impo

85 e existence of multiple ligand dependent RyR activation mechanisms associated with distinct conformat

86 nd the P site tRNA and illuminate the GTPase activation mechanism at previously unresolved detail.

87 its ortholog from S. thermophilus reveals an activation mechanism based on a toggle switch involving

88 An activation mechanism based on encapsulated ultrasmall ga

89 A unique fluorogen activation mechanism based on two spectroscopic changes,

90 t through a physical clustering-based kinase activation mechanism but instead promoted spindle associ

91 search article, we suggested an MCM helicase activation mechanism, but were limited in discussing the

92 point of convergence of distinct complement activation mechanisms, but its involvement in periodonti

93 cial residues play a central role in the sGC activation mechanism by coupling the coiled-coil domain

94 2+) responses, indicating a highly efficient activation mechanism by local ATP.

95 We provide the first insight into the activation mechanism by mutations in the linker between

96 However, the precise activation mechanism by which catalytic IKK subunits gai

97 sis revealed that allosteric and orthosteric activation mechanisms can be described by the same schem

98 ted GCK mutations share a strikingly similar activation mechanism, characterized by a population shif

99 among species via a well-documented indirect activation mechanism, conflicting results have been repo

100 udies reveal the molecular basis of a common activation mechanism conserved in all Class F receptors,

101 oter OFF times, consistent with a multi-step activation mechanism consisting of 10 or more inactive s

102 t mGluR1 upregulation as a novel feedforward activation mechanism contributing to 5-HT(2A)R-mediated

103 ing elevated CO2 The majority of known SLAC1 activation mechanisms depend on abscisic acid (ABA) sign

104 Our underlying allosteric activation mechanism derives from a collection of inacti

105 mily, RidA and CnoX, whose thiol-independent activation mechanism differs from that of Hsp33 and requ

106 nsmitting the signal employing a unique GPCR activation mechanism, distinct from other multi-domain G

107 Furthermore, this activation mechanism distinguishes Btk from other Tec fa

108 ents are perturbed, different charge carrier activation mechanisms dominate the transport properties

109 hes, we sought to distinguish the epigenetic activation mechanisms downstream of TGFbeta that mediate

110 receptors differs completely from thrombin's activation mechanism due to biased signaling via either

111 hrough the maintenance of telomeres, but the activation mechanism during carcinogenesis remains uncle

112 phagy, which is initiated by a distinct Atg1 activation mechanism during starvation.

113 Currently, understanding about NF-kappaB activation mechanism emphasizes IkappaB-tethered complex

114 Cells lacking this activation mechanism fail to proliferate after hyperosmo

115 We report on a combined activation mechanism for a class B G-protein-coupled rec

116 beling experiments revealed a novel gamma-CH activation mechanism for AD of alcohols.

117 ble druglike properties and an intracellular activation mechanism for enzyme-mediated release of a nu

118 Our data reveal a unique activation mechanism for GABA(B) receptor that involves

119 We characterize a novel activation mechanism for glycogen synthase kinase-3 (GSK

120 of the results, we propose a new inside-out activation mechanism for integrin alpha(IIb)beta(3) and

121 latory and core factors may provide a common activation mechanism for mRNA 3' processing, splicing, a

122 Together our data provide an assembly and activation mechanism for NorR.

123 ing evidence to indicate carboxylation as an activation mechanism for phenanthrene degradation.

124 In this study, a CaM-independent activation mechanism for smMLCK by mechanical release of

125 Our study reveals an activation mechanism for SNARE complex assembly, and unc

126 The activation mechanism for the IL-36 pathway is proposed t

127 Collectively, this work suggests a biphasic activation mechanism for the Nlrc4 inflammasome in which

128 The present work suggests the activation mechanism for the wild-type CRAC channel is l

129 However, the activation mechanism for these Diaphanous-related formin

130 We propose a novel activation mechanism for TRPC1 SOCs in VSMCs, in which s

131 Altogether, we present a DAG-mediated activation mechanism for TRPC4/5 channels tightly regula

132 We further propose a calcium-dependent activation mechanism for Vasohibin proteins.

133 moter and the AhR receptor, implicating drug activation mechanisms for ABCB6 similar to those found i

134 tivation comparable with previously reported activation mechanisms for EGFR and HER4.

135 s Review, we provide an in-depth analysis of activation mechanisms for kinases in cancer, highlight r

136 And 2) in the allosteric activation mechanism, G protein allosterically triggers

137 tailed structural information about the PDE6 activation mechanism hampers efforts to develop therapeu

138 While the Syt1 Ca(2+) activation mechanism has been well-characterized, how Sy

139 also activates gene expression, although an activation mechanism has not been reported.

140 ecent years, and a coherent picture of their activation mechanisms has begun to emerge.

141 y high cost and complex syntheses, and their activation mechanisms have not been well-understood.

142 studies on direct and indirect Fur-mediated activation mechanisms have revealed novel global regulat

143 psin-II conformation obtained by the natural activation mechanism; i.e., illumination of the prebound

144 This activation mechanism illustrates a new paradigm for viri

145 reat potential to systematically analyze the activation mechanism in CNG and HCN channels, at both th

146 ate the presence and importance of this TFEB activation mechanism in kidneys in a mouse model of oxal

147 , and PHIP can be used for understanding the activation mechanism in metal-free catalytic systems in

148 1 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-phospho-Se

149 rphan LRR-RKs and to identify their receptor activation mechanism in single transgenic lines.

150 rovides a compelling and unifying allosteric activation mechanism in STKR1 kinases that reconciles a

151 We present evidence of a sequential activation mechanism in the STIM1 cytosolic domains wher

152 Our data suggest a receptor activation mechanism in which binding of ligand or antib

153 These results suggest an Hsp90 activation mechanism in which cross-monomer contacts med

154 l domain of AccR is monomeric, we propose an activation mechanism in which phosphorylation of Asp(60)

155 uring autoactivation, the data support a cis-activation mechanism in which the activating protease bi

156 FXIIa may activate fXI through a trans-activation mechanism in which the protease binds to 1 su

157 a movement that is generally associated with activation mechanisms in class A GPCRs.

158 vated at membrane microdomains with distinct activation mechanisms in response to different physiolog

159 amines were consistent with an electrophilic activation mechanism; in contrast, the DAC functioned as

160 A handful of unique toehold activation mechanisms, including toehold-exchange, assoc

161 dependent and NLRP3-independent inflammasome activation mechanisms induce CNV.

162 No analogous small molecule-induced enzyme activation mechanism involving dissociation and re-assoc

163 vide multiple criteria that distinguishes an activation mechanism involving Ras dimerization from ano

164 tudies suggest a 'cooperative small-molecule activation' mechanism involving spontaneous arene reduct

165 We have previously shown that the activation mechanism is an acylation event directed by a

166 ement dlk-1 mutants, suggesting that the DLK activation mechanism is conserved.

167 The activation mechanism is consistent with fatty acid induc

168 diated gene expression and that this initial activation mechanism is different from and independent o

169 Understanding the C-C bond activation mechanism is essential for developing the sel

170 In-depth knowledge of the pCRP activation mechanism is essential to develop therapeutic

171 The DLK activation mechanism is ideally suited for rapid and spa

172 e seen in CRP, suggesting that a common cAMP activation mechanism is present.

173 nervous system, but the understanding of p75 activation mechanism is still incomplete.

174 n of the activation loop is the most ancient activation mechanism; it is fully developed in the oldes

175 nding is a key step in the receptor-mediated activation mechanism leading to root nodule development

176 H density and likely involves an allylic C-H activation mechanism, like the molecular W(IV)-oxo speci

177 s to emit NIR fluorescence through a turn-ON activation mechanism makes them promising candidate prob

178 This gradual activation mechanism may also explain how SYK maintains

179 t that the design and screening of different activation mechanisms may help to identify macromolecula

180 the combined data reveal the ligand-induced activation mechanism of a new family of DNA-binding prot

181 results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a mole

182 heir associated calculated conductances) the activation mechanism of AM2.

183 Nevertheless, the activation mechanism of caspase-8 remains unclear.

184 tructures reveal important insights into the activation mechanism of CB1 and provide a molecular basi

185 ed knowledge of the dynamics involved in the activation mechanism of CB1 is lacking.

186 ist pairs provide important insight into the activation mechanism of CB2.

187 The canonical activation mechanism of cGAS entails dsDNA-binding and d

188 Here, we report an unexpected activation mechanism of cGAS in which Mn2+ activates mon

189 The activation mechanism of class B G-protein-coupled recept

190 insights about the allosteric modulation and activation mechanism of class C GPCRs.

191 s, we provide a detailed view of a multistep activation mechanism of FAK initiated by phosphatidylino

192 cence resonance energy transfer to probe the activation mechanism of full-length mammalian group II m

193 the complex motions that underlie the unique activation mechanism of GABA(B).

194 Our results provide insight into the activation mechanism of glutamate receptors and the comp

195 ndings highlight an evolutionarily conserved activation mechanism of GPHRs and will further promote t

196 nsmembrane region, as well as a G(i)-coupled activation mechanism of human SMO.

197 Abs have been invaluable in deciphering the activation mechanism of integrins, but similar reagents

198 s, we present a structural framework for the activation mechanism of metabotropic glutamate receptor

199 and computational analyses reveal a two-step activation mechanism of MLL family proteins.

200 approach harnesses the native targeting and activation mechanism of myosin VI, allowing direct infer

201 However, the activation mechanism of other GPCR classes remains more

202 protein dynamics underlies the DNA-dependent activation mechanism of PARP-1.

203 This is paralleled by a different activation mechanism of PKD1 and PKD2 during oxidative s

204 To fully understand the activation mechanism of PlcR, we took a closer look at t

205 Beyond revealing an upstream activation mechanism of PTEN, our data introduce the con

206 d within its binding pocket can occur in the activation mechanism of rhodopsin.

207 haq coupled GPCRs, resembling the well-known activation mechanism of RhoGEFs activated by Galpha12/13

208 and structural data that reveal an exquisite activation mechanism of SAMHD1 via combined action of bo

209 e a fundamental understanding to explain the activation mechanism of surface oxygen sites.

210 Despite intense study, the pH-dependent activation mechanism of the AM2 channel has to date not

211 nderstanding of the precise conformation and activation mechanism of the BCR must take into account t

212 The activation mechanism of the classical transient receptor

213 cular dynamics (MD) simulations to probe the activation mechanism of the kinase domain of Fibroblast

214 esults provide fundamental insights into the activation mechanism of the KOR and suggest that "functi

215 Understanding the activation mechanism of the mu-opioid receptor (mu-OR) a

216 The activation mechanism of the nitric oxide receptor has be

217 the characteristics, molecular identity and activation mechanism of the shear stress-sensitive curre

218 ure has brought invaluable insights into the activation mechanism of this essential methyltransferase

219 Thus, N-terminal degradation is the common activation mechanism of this innate immune sensor.

220 Our work shed first light into the activation mechanism of TLR2/TLR1 by a noncanonical agon

221 These results indicate that the activation mechanism of TRPA1 may involve N-terminal con

222 These findings identify a new activation mechanism of TRPC1-based SOCs in VSMCs, and a

223 findings of the present study identify a new activation mechanism of TRPC1-based SOCs in VSMCs, and a

224 The activation mechanism of TRPP2 is unknown, which signific

225 ighlight functional similarities between the activation mechanisms of ATM, phosphatidylinositol 3-kin

226 substrate selection while maintaining common activation mechanisms of CARD-mediated dimerization.

227 Stimulated by recent insights into the activation mechanisms of class F receptors from structur

228 These findings highlight plasticity in the activation mechanisms of closely related Rab GTPases.

229 tructural analyses reveal autoinhibitory and activation mechanisms of mitochondrial transcription fac

230 antagonists and prove useful for elucidating activation mechanisms of other receptors.

231 erve as a paradigm for the poorly understood activation mechanisms of protein cysteine residues.

232 Thus, our results reveal two different activation mechanisms of Rap1b as well as novel function

233 Finally, similarities between the oxygen activation mechanisms of the monooxygenases and cytochro

234 mportance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain

235 The intramolecular activation mechanisms of the TSHR appear to be distinct

236 t is important to elucidate both binding and activation mechanisms of this peptide.

237 Rather an allosteric or 'parallel activation' mechanism of energy consuming and producing

238 of receptors that display a wide variety of activation mechanisms, often involving ligand-dependent

239 igands on the cluster), in contrast with the activation mechanism on conventional gold nanocatalysts.

240 al studies have provided insight into the NO activation mechanism, precise molecular-level details ha

241 n p110delta (N334K, E525K, E1021K) mimic the activation mechanisms previously discovered for oncogeni

242 Establishment of an aGPCR activation mechanism provides a rational platform for th

243 l, and computational approaches, we find the activation mechanism reconfigures atomic interactions be

244 tructural studies of GPCRs, details of their activation mechanism remain unclear.

245 merization, but extracellular regulation and activation mechanisms remain unclear.

246 The TPC activation mechanism remains controversial, which has ma

247 However, the Ca(2+)-dependent activation mechanism remains elusive.

248 ero-hexamers formed by LRRC8 proteins, their activation mechanism remains elusive.

249 nscriptional activity; however, the receptor activation mechanism remains poorly understood.

250 ment by modulating a lineage-specific P-TEFb activation mechanism, revealing potential strategies tow

251 wn about their physiological function(s) and activation mechanism(s).

252 However, a fundamental activation mechanism shared by all protein kinases is ph

253 is compensated for by alternative signaling activation mechanisms, Src family kinase (SFK) signaling

254 To dissect the activation mechanism, structural homology was used to id

255 using mutant of TorsinA is defective in this activation mechanism, suggesting a loss-of-function mech

256 This activation mechanism suggests an intriguing functional r

257 The oligomeric state and activation mechanism that enable p75(NTR) to mediate the

258 , and provides an integrative picture of the activation mechanism that explains the seemingly contrad

259 s that the Arp2/3 complex participates in an activation mechanism that includes additional diffuse co

260 em and, for the first time, reveal an oxygen activation mechanism that involves carbanion intermediat

261 activity of ARAF, this study reveals an ARAF activation mechanism that is different from that of CRAF

262 e transcription elongation factor b (P-TEFb) activation mechanism that is known to drive adult megaka

263 This implies a nonproteolytic activation mechanism that is reminiscent of, yet distinc

264 186 CII owes its potent activity to activation mechanisms that are dependent on both the sig

265 Consistent with the two-step activation mechanism, the mechanism-based pan-E1 inhibit

266 hat contain nitro groups, their bioreductive activation mechanisms, their toxicities, and approaches

267 go, followed by studies of IgE receptors and activation mechanisms, this review provides a historic p

268 LOV) by exploiting its natural spring-loaded activation mechanism through rational insertion of the l

269 ) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff e

270 mmandeers a cellular dynein-dependent mTORC1 activation mechanism to maintain stress-resistant mTORC1

271 rylation to be an essential layer of the Akt activation mechanism to regulate its physiological funct

272 AF dimerization is part of the physiological activation mechanism, together with phosphorylation, and

273 us identifies a plant Ca(2+) channel and its activation mechanisms underlying stomatal closure during

274 An examination of the aryl halide activation mechanism using radical probes was undertaken

275 e cysteine oxidation mechanism and that this activation mechanism variably involves DUOX1 and NOX2.

276 s, it does not use the previously identified activation mechanism via covalent cysteine modification.

277 Four possible modes of dual activation mechanism via hydrogen bonds were considered.

278 that the linker actively participates in the activation mechanism via intramolecular interactions, un

279 Evaluation of the phenoxide activation mechanism was complicated by the concurrent a

280 This activation mechanism was dependent on TLR2, but not on T

281 The activation mechanism was determined by NMR analysis.

282 A direct activation mechanism was explicitly demonstrated using a

283 The importance of this activation mechanism was made evident, as dysregulation

284 To elucidate the IL-36 activation mechanism, we considered all possible binding

285 e the model's assumption of an autocatalytic activation mechanism, we imaged cells expressing markers

286 Leveraging both activation mechanisms, we engineer a fully noncooperativ

287 Three sequential steps in the activation mechanism were identified.

288 therefore suggest a novel enzyme inhibition/activation mechanism where a disulfide loop inhibits Pla

289 mputed six-membered carboxylate-assisted C-H activation mechanism where the deprotonating carboxylate

290 We propose and validate an activation mechanism where the n-aniline ring of fentany

291 Our data suggest an activation mechanism where, upon extracellular ligand bi

292 Our results support an activation mechanism whereby collagen induces lateral as

293 We present a novel co-activation mechanism whereby CRP is placed at a non-opti

294 ide mechanistic insight and supported a dual activation mechanism, whereby ternary adducts form in th

295 acts with CaM will help in understanding the activation mechanism, which may provide insights for new

296 sm contrasts with the generally assumed GPCR activation mechanism, which proceeds through an opening

297 eceptor have provided a detailed view of its activation mechanism, which we review here.

298 A better understanding of receptor activation mechanisms will allow us to engage in structu

299 We propose a multiscale activation mechanism with a complex energy landscape, wh

300 that betaarrs have a conserved structure and activation mechanism, with plasticity of their structura