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1 ypermutation and class switch recombination (activation-induced cytidine deaminase).
2 onally activating the B cell-specific factor activation-induced cytidine deaminase.
3 ength and repeat density that are targets of activation-induced cytidine deaminase.
4 ccur in genomic DNA similar to the action of activation-induced cytidine deaminase.
5 factors, Pax5, IRF4, and Blimp-1, and of the activation-induced cytidine deaminase.
6 during the repair of DNA breaks initiated by activation-induced cytidine deaminase.
7 suggesting that p53 inhibits the activity of activation-induced cytidine deaminase.
8 o impaired upregulation of the gene encoding activation-induced cytidine deaminase.
9 ocation occurs in mature B cells mediated by activation-induced cytidine deaminase.
10 when their antigen receptors are damaged by activation-induced cytidine deaminase.
11 l activity, or off-targeting activity of the activation-induced cytidine deaminase.
12 eptin and Pontin were shown to interact with activation-induced cytidine deaminase.
13 nsducer and activator of transcription 3 and activation-induced cytidine deaminase.
14 switch through regulating the expression of activation-induced cytidine deaminase.
15 after the generation of dG:dU mismatches by activation-induced cytidine deaminase.
16 tream CH genes as well as expression of AID (activation-induced cytidine deaminase), a DNA-editing en
17 cription is associated with up-regulation of activation-induced cytidine deaminase, a key element of
19 intron, perhaps a self-regulating aspect of activation-induced cytidine deaminase action that is con
20 ve tumors, supporting a link between EBV and activation-induced cytidine deaminase (AICDA) activity.
22 at specific genes involved in SHM, including activation-induced cytidine deaminase (AICDA) and uracil
27 L5, shows a mutational pattern suggestive of activation-induced cytidine deaminase (AID) activity.
29 ds to rapid induction of the genomic mutator activation-induced cytidine deaminase (AID) and AID-depe
30 B cells triggered the enhanced expression of activation-induced cytidine deaminase (AID) and also sti
32 c acid-dependent cytidine deaminases include activation-induced cytidine deaminase (AID) and Apobec3G
34 at BRIT1 is recruited to the Igh locus in an activation-induced cytidine deaminase (AID) and H2AX-dep
36 genesis, we used MEFs ectopically expressing activation-induced cytidine deaminase (AID) and observed
37 F directly controlled the expression of both activation-induced cytidine deaminase (AID) and of germl
39 The introduction of DSBs is initiated by activation-induced cytidine deaminase (AID) and requires
43 occurs as a consequence of the expression of activation-induced cytidine deaminase (AID) by Ag-activa
48 by processing G.U mismatches generated when activation-induced cytidine deaminase (AID) deaminates C
50 g to c-myc/IgH translocations are created by activation-induced cytidine deaminase (AID) during antib
51 imulation of B cell proliferation, repressed activation-induced cytidine deaminase (AID) expression,
52 demethylation and genome rearrangements via activation-induced cytidine deaminase (AID) followed by
57 f autoimmune disease, elevated expression of activation-induced cytidine deaminase (AID) in recircula
79 ns convert single-strand nicks instigated by activation-induced cytidine deaminase (AID) into the dou
110 d presenting as GC B cells with constitutive activation-induced cytidine deaminase (AID) mutator acti
116 s switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID) that catalyz
118 Secondary Ig gene diversification relies on activation-induced cytidine deaminase (AID) to create U:
120 cells prevent harmful R loops, we used human activation-induced cytidine deaminase (AID) to identify
121 by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch
124 by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to switch re
126 This was associated with less targeting of activation-induced cytidine deaminase (AID) to the Igh l
127 somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamina
128 Ig variable regions requires the activity of activation-induced cytidine deaminase (AID) which has pr
132 cting directly with the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3gamma
133 s undergo rapid clonal expansion and express activation-induced cytidine deaminase (AID), a DNA mutat
134 (MCL), we analyzed the expression levels of activation-induced cytidine deaminase (AID), a key playe
135 inciple experiments, we apply this screen to activation-induced cytidine deaminase (AID), a poorly so
136 c diversification processes are catalyzed by activation-induced cytidine deaminase (AID), a potent DN
138 rmed pockets populated by B cells expressing activation-induced cytidine deaminase (AID), an enzyme a
142 o-step process: (i) DNA lesions initiated by activation-induced cytidine deaminase (AID), and (ii) le
143 on the action of the B cell specific enzyme, activation-induced cytidine deaminase (AID), and can be
144 ases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 tra
145 re transcription and the trans-acting factor activation-induced cytidine deaminase (AID), and must be
147 d somatic hypermutation (SHM), which require activation-induced cytidine deaminase (AID), and plasma
148 tation (SHM) of Ig genes is initiated by the activation-induced cytidine deaminase (AID), and require
149 creased in class switch recombination (CSR), activation-induced cytidine deaminase (AID), and stabili
150 critical elements of that machinery, such as activation-induced cytidine deaminase (AID), as well as
151 inding site in the 3'-untranslated region of activation-induced cytidine deaminase (AID), designated
152 ients with mutations in AICDA, which encodes activation-induced cytidine deaminase (AID), display an
153 cell cycle, proliferation and expression of activation-induced cytidine deaminase (AID), DNA repair
154 r joining of distal DNA lesions initiated by activation-induced cytidine deaminase (AID), in the abse
157 s switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), the activit
162 s switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which conve
163 unoglobulin switch (S) regions, and requires activation-induced cytidine deaminase (AID), which conve
164 s requires transcription and is triggered by activation-induced cytidine deaminase (AID), which conve
165 bination is initiated by the B cell-specific activation-induced cytidine deaminase (AID), which deami
168 anonical NF-kappaB pathway, thereby inducing activation-induced cytidine deaminase (AID), which is cr
169 l center B cells including the expression of activation-induced cytidine deaminase (AID), which is es
171 including one lacking the DNA-editing enzyme activation-induced cytidine deaminase (AID), which is re
172 ith hyper-IgM syndromes who are deficient in activation-induced cytidine deaminase (AID), which is re
173 o generate genomic instability in B cells as activation-induced cytidine deaminase (AID), which media
174 n and somatic hypermutation are initiated by activation-induced cytidine deaminase (AID), which prefe
175 switch recombination (CSR) are initiated by activation-induced cytidine deaminase (AID), which prefe
177 lass switch recombination (CSR), which joins activation-induced cytidine deaminase (AID)-dependent do
178 ne or IgH locus of B lymphocytes induced for activation-induced cytidine deaminase (AID)-dependent Ig
179 SBs in splenic IgM(+) B cells stimulated for activation-induced cytidine deaminase (AID)-dependent Ig
180 nse, B cells undergo rapid proliferation and activation-induced cytidine deaminase (AID)-dependent re
182 ination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced muta
184 ccurs through the deliberate introduction of activation-induced cytidine deaminase (AID)-instigated D
185 Tomato)) to monitor B cells having undergone activation-induced cytidine deaminase (AID)-mediated som
205 g RNA (siRNA)-mediated knockdown showed that activation-induced cytidine deaminase (AID, also known a
206 ng gene segment (V(D)J) recombination, or by activation-induced cytidine deaminase (AID, also known a
208 und genetics, we used CRISPR-Cas9 to disrupt activation-induced cytidine deaminase (AID; Aicda) direc
210 ggers B-ALL development through induction of activation-induced cytidine deaminase (AID; also known a
211 titutions, consistent with the activities of activation-induced-cytidine deaminase (AID) and the A-T
214 (immature/T1) B cells constitutively express activation-induced cytidine deaminase and B lymphocyte-i
216 n-associated DNA-modifying events, involving activation-induced cytidine deaminase and DNA polymerase
217 lucidated, involving cytosine deamination by activation-induced cytidine deaminase and generation of
218 ner dependent on CD40L and ICOS and inducing activation-induced cytidine deaminase and Ig class switc
219 nses and are orchestrated by the activity of activation-induced cytidine deaminase and many proteins
221 n the Ig loci are responsible for recruiting activation-induced cytidine deaminase and promoting its
222 tors IRF4 and Blimp-1, and altered levels of activation-induced cytidine deaminase and sphingosine-1-
223 ermutation (SHM), deamination of cytidine by activation-induced cytidine deaminase and subsequent DNA
224 cally enriched for autoreactivity, expresses activation-induced cytidine deaminase and T-bet, and exh
225 genotoxic stress and liganded AR, including activation-induced cytidine deaminase and the LINE-1 rep
226 , B lymphocytes activate NF-kappaB to induce activation-induced cytidine deaminase and, therefore, Ig
227 3K signaling enhanced the expression of AID (activation-induced cytidine deaminase) and accelerated C
228 ith germinal center formation, expression of activation-induced cytidine deaminase, and affinity matu
229 te defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcrip
230 er centroblasts, follicular dendritic cells, activation-induced cytidine deaminase, and IL-21(+)PD1(+
231 urn, this led to proliferation, induction of activation-induced cytidine deaminase, and the productio
232 B cells up-regulate the CSR-inducing enzyme, activation-induced cytidine deaminase, and undergo CSR f
233 TET oxidases and, more controversially, the activation-induced cytidine deaminase/APOBEC deaminases
234 rminal center B cells, lesions introduced by activation-induced cytidine deaminase are processed by m
235 immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by u
236 y conservation in jawed vertebrates, we used activation-induced cytidine deaminase as a marker to mon
237 e-induced maturation protein-1 (BLIMP-1) and activation-induced cytidine deaminase as well as the pro
238 ctional B cell activation with expression of activation-induced cytidine deaminase, as well as local
239 eas an enhanced APOBEC3A-based CBE(6), human activation-induced cytidine deaminase-based CBE(7), and
240 lls with the generation of U:G mismatches by activation-induced cytidine deaminase but differ in thei
241 nal evolution of Ig V regions, expression of activation-induced cytidine deaminase, clonal H chain sw
242 as well as transgenic mice (quasimonoclonal, activation-induced [cytidine] deaminase-Cre-tamoxifen-de
244 yelinating disease, germline IgM produced in activation-induced cytidine deaminase-deficient mice (ai
245 plasmacytomas from uracil N-glycosylase and activation-induced cytidine deaminase-deficient mice.
246 ient), in switched Igs and hypermutated IgM (activation-induced cytidine deaminase-deficient), or ful
247 FtL-specific B-1a to mount dominant IgM and activation-induced cytidine deaminase-dependent IgG anti
248 consistently accumulated high frequencies of activation-induced cytidine deaminase-dependent IgH locu
249 were accompanied by ongoing duplications and activation-induced cytidine deaminase-dependent somatic
251 fficult to uncouple because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda)
252 ass switch recombination are mediated by the activation-induced cytidine deaminase enzyme and under A
253 ind to murine B lymphocytes thereby inducing activation-induced cytidine deaminase expression and Ig
254 e that oncogenic viruses can directly induce activation-induced cytidine deaminase expression and onc
255 cl-2 function, are associated with increased activation-induced cytidine deaminase expression, and co
258 o steps: the generation of uracils in DNA by activation-induced cytidine deaminase, followed by their
259 nd that CRISPR/Cas9-mediated ablation of the activation-induced cytidine deaminase gene required for
260 and circle transcripts and to upregulate the activation-induced cytidine deaminase gene through in vi
261 e ELS features and support functional GL7(+)/activation-induced cytidine deaminase(+) germinal center
262 hough the enzyme critical to both processes, activation-induced cytidine deaminase, has been identifi
264 , Teng et al. and Dorsett et al. report that activation-induced cytidine deaminase in B cells is repr
265 firmed the role of the miR-155 target Aicda (activation-induced cytidine deaminase) in this process a
266 hese germinal center-like tumors arose by an activation-induced cytidine deaminase-independent pathwa
268 of TRAF6, enhances NF-kappaB activation and activation-induced cytidine deaminase induction, and boo
270 ally delete Dicer in activated B cells where activation-induced cytidine deaminase is highly expresse
272 are recruited to dU:dG mispairs generated by activation-induced cytidine deaminase-mediated deaminati
273 notable feature in SAMHD1 deficiency during activation-induced cytidine deaminase-mediated genomic i
274 -acting DNA elements essential for targeting activation-induced cytidine deaminase-mediated sequence
275 e primarily synonymous, and likely caused by activation-induced cytidine deaminase-mediated somatic h
276 an agonistic anti-TACI antibody could induce activation-induced cytidine deaminase mRNA in those with
277 TACI by an agonistic antibody showed loss of activation-induced cytidine deaminase mRNA induction in
278 Furthermore, pax-5 mRNA was decreased and activation-induced cytidine deaminase mRNA was increased
280 monstrate the use of Cpf1 (Cas12a) and nCas9-activation-induced cytidine deaminase (nCas9-Target-AID)
281 A and C-to-T substitutions that parallel the activation-induced cytidine deaminase nucleotide exchang
282 to prevent excessive DNA strand breakage at activation-induced cytidine deaminase off-target genes,
284 rentiation), and a 2- to 6-fold increase for activation-induced cytidine deaminase, PAX5, and the non
286 ion and CSR both require the B-cell-specific activation-induced cytidine deaminase protein (AID), whi
288 mutations, expressed germ-line Cgamma1- and activation-induced cytidine deaminase-specific transcrip
289 cells from an immunized individual to study activation-induced cytidine deaminase targeting and foun
290 s S site location because sequences with few activation-induced cytidine deaminase targets generate m
292 variable region sequences rarely targeted by activation-induced cytidine deaminase, the enzyme respon
293 eficiency is combined with overexpression of activation-induced cytidine deaminase, the hotspot lengt
294 SR and, thus, is not essential for targeting activation-induced cytidine deaminase to S regions, as w
296 ough p110delta can regulate transcription of activation-induced cytidine deaminase via Akt, repressio
297 s were found within ectopic lymphoid tissue, activation-induced cytidine deaminase was expressed, and
298 switch recombination (CSR) is instigated by activation-induced cytidine deaminase, which converts cy
299 ass switch recombination (CSR) is induced by activation-induced cytidine deaminase, which initiates a