ライフサイエンスコーパス: active metabolite

1 cleavage for the release of the biologically active metabolite.

2 d in biotransformation of clopidogrel to its active metabolite.

3 as the site of covalent modification by the active metabolite.

4 enhance the conversion of clopidogrel to its active metabolite.

5 ation of flutamide and hydroxyflutamide, its active metabolite.

6 e key enzyme required to convert PQ into its active metabolite.

7 ndex, and PK by plasma levels of prasugrel's active metabolite.

8 er to deplete bioactive retinoids or to form active metabolites.

9 oxide metabolites produced by FMOs are often active metabolites.

10 amount of drug available for conversion into active metabolites.

11 te a response to endogenously produced redox-active metabolites.

12 e more deterministically assembled than less active metabolites.

13 thotrexate, and pemetrexed to produce highly active metabolites.

14 production of toxins and other biologically active metabolites.

15 alysis to determine the presence of possible active metabolites.

16 ting that this could be attributed to highly active metabolites.

17 ene (CYP2D6), oxidizes tamoxifen to its most active metabolites.

18 ct possible parent compounds that might have active metabolites.

19 leoside analogues into powerful biologically active metabolites.

20 Higher levels of the active metabolite 1 alpha,25-dihydroxyvitamin D (1 alpha

21 25(OH)D(3) and its active metabolite 1,25(OH)(2)D(3), both enhance corneal

22 vity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3.

23 on of 25-hydroxyvitamin D(3) (25D(3)) to its active metabolite 1,25D(3).

24 Midazolam has a clinically active metabolite, 1-hydroxymidazolam.

25 2) and 4.15 hours, respectively; whereas the active metabolite 17-aminogeldanamycin had a t(1/2) of 7

26 -hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1alpha,25-dihydroxyvitamin D(3) (1,25

27 aptohept-4-enoic acid moiety to generate the active metabolite 2, which is an extraordinarily potent

28 thus establishing the stereochemistry of the active metabolite 2.

29 assive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (MQ), ca

30 larval molting and metamorphosis through its active metabolite 20-hydroxyecdysone (20E).

31 Systemically administered EDHB and its active metabolite 3,4-dihydroxybenzoic acid accumulated

32 Low concentrations of tamoxifen or its active metabolite 4-hydroxytamoxifen (OHT) induce estrog

33 tumor retention of cyclophosphamide and its active metabolite, 4-hydroxycyclophosphamide.

34 Tamoxifen has biologically active metabolites: 4-hydroxytamoxifen (4OHT) and endoxi

35 tate (NNN-5'-OAc), a stable precursor of the active metabolite 5'-hydroxy(+/-)-N'-nitrosonornicotine

36 Folic acid and its active metabolite, 5-methyltetrahydrofolate, increase en

37 inhibition in yields of the physiologically active metabolite 5alpha-dihydrotestosterone (DHT) in HG

38 nts, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) ca

39 drolysis of the glucuronide conjugate of the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)

40 omide was dosed to a targeted blood level of active metabolite, A77 1726, of 50 microg/ml to 100 micr

41 drug class would enhance liver levels of the active metabolite adefovir diphosphate (ADV-DP) and/or d

42 t convert vitamin A to its main biologically active metabolite, all-trans RA.

43 Its biologically active metabolite, all-trans retinoic acid (ATRA), exhib

44 vitamin A to enzymes for metabolism into an active metabolite, all-trans retinoic acid (atRA), where

45 Vitamin A and its active metabolite, all-trans retinoic acid (RA), regulat

46 ur results showed that the production of the active metabolite (AM) from 2-oxoclopidogrel by human li

47 formation of a glutathionyl conjugate of the active metabolite (AM) of clopidogrel and the covalent m

48 cement of an anti-METH scFv for METH and its active metabolite amphetamine (AMP), through the introdu

49 ed biotransformation of clopidogrel into its active metabolite and decreased efficacy of clopidogrel

50 Generation of clopidogrel active metabolite and inhibition of platelet function we

51 n by comparison of its induction between the active metabolite and its parent compound (B[a]PDE versu

52 nverted in rat or mouse plasma solely to two active metabolites and had significantly enhanced oral b

53 lleles showed excessive levels of thiopurine active metabolites and toxicity.

54 CYP)1A2, which converts clopidogrel into its active metabolite, and prior studies suggest greater inh

55 tion, decreases plasma levels of clopidogrel active metabolite, and retards and diminishes its effect

56 s with long-term adjuvant therapy, examining active metabolites, and considering chemoprevention all

57 rate this point, we use the example of redox-active metabolites, and in particular phenazines, which

58 ities recently entering the marketplace have active metabolites, and many more are (or have been) in

59 Plasma levels of ticagrelor and its active metabolite AR-C124910XX were determined.

60 zymes responsible for the formation of these active metabolites are unknown.

61 hine lowers the plasma levels of clopidogrel active metabolite as well as its effects on platelets.

62 s were drawn for thrombelastograpy (TEG) and active metabolite assay.

63 to C(64)H(104)O(33) and the putatively found active metabolite at m/z 1283.58 [M + formic-H](-) corre

64 uted uracil analogue is converted to several active metabolites but the mechanism of cytotoxicity has

65 duced the area under the curve levels of its active metabolite by 34% (p = 0.001).

66 Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for

67 te that PPD is selectively hydrolyzed to the active metabolite by hiCE.

68 n attenuate metabolism of clopidogrel to its active metabolite by inhibiting various hepatic CYP450 e

69 l and prasugrel require biotransformation to active metabolites by cytochrome P450 (CYP) enzymes.

70 Vitamin D3 (vitD3) and its active metabolite, calcitriol (1,25-(OH)(2)D(3)), affect

71 eudomonas aeruginosa produces colorful redox-active metabolites called phenazines, which underpin bio

72 tions as low as 2.6 muM) four distinct redox-active metabolites called phenazines.

73 lts show that modulating extracellular redox-active metabolites can influence the fitness of a biofil

74 Ceftaroline fosamil, the prodrug form of the active metabolite ceftaroline, is a new broad-spectrum p

75 The active metabolite, ceftaroline, demonstrates in vitro ac

76 sayed for concentrations of imatinib and its active metabolite, CGP74588.

77 At steady-state, clopidogrel active metabolite (clopidogrel(AM)) pharmacokinetics var

78 sitivity of RZx (~ 53 mV/pH), secreted redox-active metabolites/compounds from whole cells are likely

79 ; P=0.47), despite yielding higher prasugrel active metabolite concentration (ng/mL; 62.3+/-82.6 vers

80 d with chewed prasugrel, which led to higher active metabolite concentration but not greater IPA comp

81 genesis in in vitro studies and implies that active metabolites contribute to its in vivo pharmacolog

82 ous to the relationship of proguanil and its active metabolite cycloguanil.

83 next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposu

84 has a longer half-life and exposure than its active metabolite decitabine.

85 The area under the curve for clopidogrel active metabolite decreased significantly with esomepraz

86 ucoma drugs tested only metipranolol and its active metabolite, desacetylmetipranolol, blunted the SN

87 mplex interactions between testosterone, its active metabolite DHT, and androgen receptors.

88 9 alleles have significantly lower levels of active metabolite, diminished platelet inhibition, and h

89 inistration resulted in the formation of the active metabolite, diminution of tumor vasculature, and

90 technique that can detect hundreds of redox-active metabolites down to the level of femtograms on co

91 supplementation on the formation of flavour active metabolites during wine fermentation, we evaluate

92 n situ monitoring of the production of redox-active metabolites (e.g., pyocyanin) during the course o

93 umor activity of ICT2588 was superior to its active metabolite, exhibiting reduced toxicity, improved

94 PARADOX demonstrated lower clopidogrel active metabolite exposure and PD effects of clopidogrel

95 Prasugrel was associated with greater active metabolite exposure and PD effects than clopidogr

96 mary endpoint) and mean MPA was similar, but active metabolite exposure was lowered by 38%.

97 s have demonstrated that triphosphate is the active metabolite for both these purine nucleoside analo

98 analog inhibitors, including the clinically active metabolite formed by sofosbuvir, to elucidate key

99 mercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel

100 t even the spontaneous release of NPY (or an active metabolite) from recurrent mossy fibers is suffic

101 18 to be more efficiently converted into its active metabolite, gemcitabine triphosphate (dFdCTP), an

102 ducts proved useful in the identification of active metabolites generated by either in vitro or in vi

103 has been associated with reduced clopidogrel active metabolite generation and higher ex vivo platelet

104 f a PPI with clopidogrel reduces clopidogrel active metabolite generation and subsequent platelet inh

105 The concentrations of clopidogrel active metabolite had no significant difference (P = 0.2

106 h attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to s

107 and compared the effect of bupropion and its active metabolite hydroxybupropion on mouse homomeric 5-

108 Preferential hydrolysis of ICT2588 to its active metabolite (ICT2552) was observed in tumor homoge

109 ecent findings have identified lactate as an active metabolite in cell signalling, although its effec

110 ate are made available for the generation of active metabolites in platelets when the NEFA binding ca

111 earthworms possess a class of unique surface-active metabolites in their gut, which we term 'drilodef

112 ells transduced in situ, and accumulation of active metabolites in tumors).

113 ir in plasma, and tenofovir diphosphate, the active metabolite, in cervical tissue and dried blood sp

114 lethal and sub-lethal doses of TCBZ and its active metabolites, in order to collect EVs and evaluate

115 The conversion of tamoxifen to active metabolites involves several cytochrome P450 (CYP

116 ion with dithiothreitol, confirming that the active metabolite is linked to a cysteinyl residue of CY

117 Deficiency in vitamin D and its active metabolites is a pathologic feature of chronic ki

118 oped to release the doxorubicin-formaldehyde active metabolite, is tethered via derivatized ethylene

119 elta(9)THC) is metabolized to only one major active metabolite, it has been reported that several maj

120 report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M.

121 (SC-51) is rapidly converted in vivo to the active metabolite L-N6-(1-iminoethyl)lysine (L-NIL).

122 ibed natural substance largazole (1) and its active metabolite largazole thiol (2) is described.

123 (TDM), which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a

124 ogrel have significantly reduced clopidogrel active metabolite levels and high on-treatment platelet

125 ent data have surfaced demonstrating altered active metabolite levels of clopidogrel in patients harb

126 The most active metabolite M2 had almost no toxicity to CCD-18Co

127 the way for further developing the NL-loaded active metabolites, M2 or M13, as novel targeted therape

128 These active metabolites may prolong the parent compound's psy

129 All of these active metabolites may prolong the parent compound's psy

130 ment (thionamides such as carbimazole or its active metabolite methimazole are the drugs of choice).

131 TGN) are currently being considered as major active metabolites, methylthioinosine nucleotides seem t

132 DMF and, more so, its active metabolite, monomethyl fumarate, are known agonis

133 neurons, and behavioral changes due to TLR4 active metabolite, morphine-3-glucuronide (M3G) exposure

134 The serum concentration of the active metabolite N-desethylamiodarone correlates with t

135 omilast and roflumilast; the latter (and its active metabolite N-oxide) is more selective and potent

136 ted but less is known about its biologically active metabolite, N-desmethylclozapine.

137 dies have reported that both nitrate and its active metabolite, nitrite, have therapeutic activity in

138 Since 8 is the likely active metabolite of 1 and a significant number of deriv

139 like cycloguanil, however, 1a (WR99210), the active metabolite of 1, has retained in vitro potency ag

140 The actions of the active metabolite of 1,25-(OH)2D3 (1,25-D) are mediated

141 The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydr

142 lves 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydr

143 levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable am

144 stance to monodesethylamodiaquine (MDAQ; the active metabolite of AQ) than to CQ, whereas a pfcrt all

145 Benzo[a]pyrene diol epoxide (BPDE), the active metabolite of benzo[a]pyrene present in tobacco s

146 Norbuprenorphine (NBUP) is the primary active metabolite of BUP.

147 Ticagrelor, dipyridamole and the active metabolite of clopidogrel (CAM), an alternative P

148 tein mass corresponds to the addition of the active metabolite of clopidogrel to CYP2B6.

149 reduction of 32.4% in plasma exposure to the active metabolite of clopidogrel, as compared with nonca

150 allele had significantly lower levels of the active metabolite of clopidogrel, diminished platelet in

151 strated that cordycepin 5'-triphosphate, the active metabolite of cordycepin, can be formed not only

152 Almost 30% of the variability in SN-38 (the active metabolite of CPT-11) AUC is explained by ABCC1 1

153 With the combination therapy of SN-38 (the active metabolite of CPT-11) followed by flavopiridol, t

154 sensor, which emits light in response to the active metabolite of cytosine arabinoside (ara-C, cytara

155 l variability in blood concentrations of the active metabolite of dabigatran etexilate and influence

156 Retinoic acid, an active metabolite of dietary vitamin A, acts as a ligand

157 e is metabolised to monomethyl fumarate, the active metabolite of dimethyl fumarate, reduces circulat

158 , we show that 20-hydroxyecdysone (20E), the active metabolite of ecdysone that is induced by environ

159 hosphorylase (PNP) that locally converts the active metabolite of F-araAMP to a highly diffusible sub

160 tions and in complex with norfluoxetine, the active metabolite of fluoxetine (Prozac) and a state-dep

161 ecently demonstrated that FTY-phosphate, the active metabolite of FTY720, acts as a full agonist for

162 We thus examined whether morphine, the active metabolite of heroin, has the ability to inhibit

163 Purpose Palifosfamide is the active metabolite of ifosfamide and does not require pro

164 ure to cytotoxic concentration of SN-38, the active metabolite of irinotecan (0.1 microM) alone and i

165 Their response to oxaliplatin, to SN38, the active metabolite of irinotecan (drugs active in colon c

166 nized anti- Trop-2 antibody, conjugated with active metabolite of irinotecan (SN-38), on Trop-2 posit

167 a synergistic activity of 5c with SN-38 (the active metabolite of irinotecan) and 5-fluorouracil on c

168 platin, 5-fluorouracil (5-FU), or SN-38 (the active metabolite of irinotecan) induced Notch-1 intrace

169 d 7-ethyl-10-hydroxycamptothecin (SN-38; the active metabolite of irinotecan), two S-phaseselective a

170 porter that confers resistance to SN-38 (the active metabolite of irinotecan), was readily detected i

171 e to, but reduces the toxicity of, SN38 (the active metabolite of irinotecan).

172 rifampicin-induced resistance to SN-38, the active metabolite of irinotecan, in LS174T cells.

173 y 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan, in p53-null compared wi

174 how for the first time that SN38, the potent active metabolite of irinotecan, induces c-Jun NH(2)-ter

175 ates in vitro with sensitivity to SN-38, the active metabolite of irinotecan.

176 t that reduces the elimination of SN-38, the active metabolite of irinotecan.

177 o SN38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of irinotecan.

178 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan.

179 mproving the therapeutic index of SN-38, the active metabolite of irinotecan.

180 p-2 for the selective delivery of SN-38, the active metabolite of irinotecan.

181 We show that the active metabolite of leflunomide, a drug approved for tr

182 Prior studies suggest that A77 1726, the active metabolite of leflunomide, inhibits the activity

183 lpropanolamine (PPA) (1) and ST-1059 (2, the active metabolite of midodrine), supporting the hypothes

184 ncentrations of mycophenolic acid (MPA), the active metabolite of MMF, and outcomes in 85 patients wi

185 Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a drug that

186 Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, an effective

187 d the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropo

188 etoprofen, etodolac, and nabumetone) and the active metabolite of nabumetone (6-methoxy-2-naphthylace

189 7,8,9,10-tetrahydro benzo[a]pyrene (BPDE, an active metabolite of PAHs) induced cytotoxicity, mutagen

190 Prednisolone (the principal active metabolite of prednisone) metabolism was determin

191 TIZ and RM-4848, the active metabolite of RM-5038, were shown to stimulate in

192 4 inhibitor roflumilast N-oxide (RNO) is the active metabolite of roflumilast approved as a treatment

193 This compound is an active metabolite of tamoxifen, a selective estrogen rec

194 ulated that concentrations of endoxifen, the active metabolite of tamoxifen, are a better predictor o

195 The active metabolite of tenofovir prodrugs, tenofovir-dipho

196 optimization, to improve the binding of the active metabolite of the anti-inflammatory drug leflunom

197 cy are comparable or superior to MRE269 (the active metabolite of the clinical compound NS-304) with

198 possible to demonstrate that vedelianin, an active metabolite of the family of prenylated stilbenes

199 Mizoribine monophosphate (MZP) is the active metabolite of the immunosuppressive agent mizorib

200 agents soman and sarin, and of paraoxon, the active metabolite of the insecticide parathion.

201 ound to gemcitabine diphosphate (GemdP), the active metabolite of the mechanism-based chemotherapeuti

202 1-Methyl-4-phenylpyridinium (MPP(+)), the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,

203 oxide homeostasis and suggest that it is an active metabolite of the organic nitrates that can be us

204 in-2-yl)phenyl)-3-(pyridin-4-yl)urea (2), an active metabolite of the potent PI3 kinase inhibitor PKI

205 Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is

206 Benzo(a)pyrene diol epoxide (BPDE), an active metabolite of the tobacco carcinogen benzo(a)pyre

207 Retinoic acid (RA) is the active metabolite of vitamin A and whether it directly r

208 a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differenti

209 herein that all-trans-retinoic acid (RA), an active metabolite of vitamin A that is known to induce m

210 Retinoic acid (RA), an essential active metabolite of vitamin A, controls numerous physio

211 unctionality.IMPORTANCE ATRA, a biologically active metabolite of vitamin A, exerts pleiotropic biolo

212 All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcripti

213 All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling

214 All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is an essential signalin

215 tem (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from

216 Retinoic acid (RA), the main biologically active metabolite of vitamin A, is known to promote gut

217 effect of all-trans retinoic acid (ATRA), an active metabolite of vitamin A, on the neuropathology an

218 Retinoic acid (RA), an active metabolite of vitamin A, plays a critical role in

219 All-trans-retinoic acid (atRA), the major active metabolite of vitamin A, plays a role in many bio

220 Retinoic acid, an active metabolite of vitamin A, plays essential signalin

221 Here we report that ATRA, an active metabolite of vitamin A, restores mechanical quie

222 For example, the active metabolite of vitamin A, retinoic acid (RA), has

223 The active metabolite of vitamin A, retinoic acid (RA), is a

224 All-trans-retinoic acid (atRA) is the active metabolite of vitamin A.

225 All-trans-retinoic acid (atRA) is the active metabolite of vitamin A. atRA is also used as a d

226 The active metabolite of vitamin D (1,25-dihydroxyvitamin D(

227 hus, we investigated the role of calcitriol (active metabolite of vitamin D) in the regulation of Th9

228 It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(

229 study, we hypothesized that the biologically active metabolite of vitamin D, 1,25(OH)2D3, inhibits hu

230 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(

231 The active metabolite of vitamin D, 1alpha,25-dihydroxyvitam

232 Since the discovery of the active metabolite of vitamin D, i.e., 1alpha,25-dihydrox

233 amin D3 (1alpha,25(OH)2D3), the biologically active metabolite of vitamin D3 To further investigate t

234 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, inhibits the proliferat

235 iously we demonstrated that the biologically active metabolites of 17beta-oestradiol, 2-hydroxyoestra

236 op1cc in biochemical assays, we propose that active metabolites of 4NQO trap Top1cc by forming DNA ad

237 We speculate that the active metabolites of clopidogrel and CS-747 form disulf

238 A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM and endoxifen, is by

239 hylhexyl phthalate (MEHP) is one of the main active metabolites of the plasticizer di(2-ethylhexyl) p

240 provide comparable systemic exposure to the active metabolites of the prior, stable tetrabenazine re

241 ing compounds for the synthesis of the other active metabolites of these PAHs thought to be involved

242 The capacity for quantification of active metabolites of vitamin D (VitD) is highly valuabl

243 ts produce an enormous array of biologically active metabolites, often with stereochemical variations

244 the peak plasma concentration of clopidogrel active metabolite (omeprazole > esomeprazole > lansopraz

245 stool concentrations of fidaxomicin and its active metabolite OP-1118 were measured.

246 Plasma concentrations of CI-1040 and its active metabolite, PD 0184264, increased in a less than

247 We examined PD and active metabolite pharmacokinetics (PKs) with prasugrel

248 ug PDM) and as a monoamine releaser (via the active metabolite PM).

249 logic profile and its ability to deliver two active metabolites, potentially simplifying HCV treatmen

250 cessed by dendritic cells and T cells to the active metabolite, providing a mechanism for the local r

251 onin 2A receptors (5-HT2ARs) by psilocybin's active metabolite, psilocin.

252 the high functional versatility of the redox-active metabolite pyocyanin and the susceptibility of ar

253 (1) Plasma levels of R348's active metabolite R333 sustained high for 8 hr or more,

254 Blood levels of R348 and of its active metabolite R333 were measured.

255 R788, a prodrug of active metabolite R406, has been shown to be an inhibito

256 The V(max) for production of the active metabolites ranged from 10.8 to 27.7 pmol/min/mg

257 tration to mice and Wistar rats generated an active metabolite recovered from the rodent's brains.

258 sphamide and irinotecan (CPT-11), into their active metabolites, respectively.

259 ssential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)(2)D3) for

260 is known about the role of vitamin A and its active metabolite, retinoic acid (RA) in host defenses a

261 retinol (vitamin A) to its transcriptionally active metabolite, retinoic acid (RA).

262 SK 256066, roflumilast, and its biologically active metabolite roflumilast N-oxide generally potentia

263 ral levels of the prodrug irinotecan and its active metabolite SN-38 compared with free irinotecan.

264 ed PEG conjugates of the irinotecan (CPT-11) active metabolite SN-38 via a phenyl ether that release

265 UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38.

266 endent on redox properties and generation of active metabolites such as quinone methides.

267 Its active metabolite, T-705-ribose-5'-triphosphate (T-705-R

268 ntrations of tenofovir, emtricitabine, their active metabolites (tenofovir diphosphate [TFVdp] and em

269 Leflunomide and its active metabolite teriflunomide inhibited protein aggreg

270 umatic fluorescent drug leflunomide into its active metabolite teriflunomide through isoxazole ring o

271 lized in rats, but MDC is the only centrally active metabolite that could contribute to overall effec

272 50 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y(1)(2) a

273 l molecules would benefit the study of redox-active metabolites that are produced by microbial biofil

274 h agents undergo intracellular processing to active metabolites that disrupt RNA and DNA metabolism.

275 Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platele

276 omics results helped to prioritize potential active metabolites that modulated the hypothermic respon

277 s that PAHs are transformed enzymatically to active metabolites that react with DNA to form adducts t

278 lism leads to the generation of biologically active metabolites that regulate cell growth and prolife

279 oA modulating the generation of biologically active metabolites that regulate mitochondrial bioenerge

280 d that vitamin A, retinol, functions through active metabolites: the visual chromophore 11-cis-retina

281 an inactive prodrug; it is converted to its active metabolite through the cytochrome P450 (CYP3A4) p

282 eportedly reduce clopidogrel's metabolism to active metabolite, thus attenuating its inhibition of pl

283 Concentration of the primary active metabolite, TLK236, increased proportionate to ez

284 TAF is formulated to deliver the active metabolite to target cells more efficiently than

285 is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than

286 vir impairs the conversion of 25(OH)D to the active metabolite, utilization of 25(OH)D may have been

287 a 7-fold lower rectal tissue ratio of PrEP's active metabolites vs competing deoxynucleotides compare

288 Oseltamivir carboxylate (oseltamivir's active metabolite) was recovered from two waste water tr

289 rther suggest that potentially biochemically active metabolites were more deterministically assembled

290 ationship suggested the presence of a common active metabolite which may preclude this series of comp

291 ch has been focused on the identification of active metabolites, which are crucial for selenium chemo

292 both the parent compound ranolazine and its active metabolites, which have shown potent blocking eff

293 ic, antagonistic; (iv) drugs converted to an active metabolite with a similar mode of action.

294 pedunculata studied is a potential source of active metabolites with a positive effect on human healt

295 foods like soy and tomatoes are composed of active metabolites with anti-inflammatory effects.

296 resuscitation to promote renal excretion of active metabolite, withholding the doses and timely mana

297 ical models by enhancing accumulation of its active metabolite within the tumor microenvironment.

298 their abilities to convert amifostine to its active metabolite WR-1065, amifostine may not only prote

299 the absence or presence of amifostine or its active metabolite WR-1065.

300 WR-2721 is a prodrug and is converted to its active metabolite, WR-1065, by alkaline phosphatases in