ライフサイエンスコーパス: activin receptor-like kinase

1 liferation at a high level by stimulation of activin-receptor-like kinases.

2 r binding affinities for the type I receptor activin receptor like kinase 1 (ALK1), ALK2 and ALK3.

3 It includes the activin receptor like kinase 1 gene (ACVRLK1 or ALK1), a

4 d crossveinless 2 (CV2), both induced by the activin receptor like-kinase 1 (ALK1) when stimulated by

5 2 is caused by loss of function mutations in activin receptor-like kinase 1 (ACVRL1 or ALK1).

6 re linked to HHT: endoglin (ENG) in HHT1 and activin receptor-like kinase 1 (ACVRL1; ALK1) in HHT2.

7 Activin receptor-like kinase 1 (Acvrl1; Alk1) is a type

8 We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Al

9 Activin receptor-like kinase 1 (ALK-1) has homology to t

10 Activin receptor-like kinase 1 (ALK-1), an orphan recept

11 ns were used to determine the involvement of activin receptor-like kinase 1 (ALK1) and ALK5 downstrea

12 Loss-of-function mutations in the activin receptor-like kinase 1 (Alk1) are linked to hemo

13 t of BMPRII receptor is mediated through the activin receptor-like kinase 1 (ALK1) but not the ALK3 r

14 Loss-of-function variations in activin receptor-like kinase 1 (ALK1) cause type 2 hered

15 dent on the endoglin signaling pathway using activin receptor-like kinase 1 (ALK1) Fc blocking peptid

16 Signaling through high-affinity activin receptor-like kinase 1 (ALK1) in endothelial cel

17 The activin receptor-like kinase 1 (ALK1) is a transforming

18 The activin receptor-like kinase 1 (ALK1) is a type I recept

19 Activin receptor-like kinase 1 (ALK1) is an endothelial

20 Activin receptor-like kinase 1 (ALK1) is an endothelial

21 Activin receptor-like kinase 1 (ALK1) is an endothelial-

22 e insight into this question by studying the activin receptor-like kinase 1 (ALK1) pathway.

23 Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an important

24 s crucial for endothelial cell signaling via activin receptor-like kinase 1 (ALK1), a pathway central

25 Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1), a transforming gr

26 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1), ALK2, and ALK3 an

27 lk between the insulin receptor and endoglin/activin receptor-like kinase 1 (ALK1), an endothelial ce

28 Activin receptor-like kinase 1 (ALK1), an endothelial ce

29 -of-function mutations in the genes encoding activin receptor-like kinase 1 (ALK1), endoglin, Smad4,

30 pro-domain-complexed BMP9 to type I receptor activin receptor-like kinase 1 (ALK1), type II receptors

31 In zebrafish embryos, arterial expression of activin receptor-like kinase 1 (alk1), which encodes a T

32 UBAC conjugates linear ubiquitin chains onto Activin receptor-like kinase 1 (ALK1), which is responsi

33 Activin receptor-like kinase 1 (ALK1)-mediated endotheli

34 g was reduced in TbetaRII(+/-) ECs; however, activin receptor-like kinase 1 (ALK1)-mediated Smad1/5 p

35 mutations in one of several genes, including activin receptor-like kinase 1 (ALK1).

36 quiescence through its endothelial receptor activin receptor-like kinase 1 (ALK1).

37 emorrhagic telangiectasia type 2 (HHT2) with activin receptor-like kinase 1 (ALK1; ACVRL1) mutations

38 e arterial-specific TGFbeta type I receptor, activin receptor-like kinase 1 (ALK1; ACVRL1), causes he

39 Subsequent activation of activin receptor-like kinase 1 enhances expression of No

40 The activin receptor-like kinase 1 gene (ALK-1) is the secon

41 Small interfering RNA knockdown of activin receptor-like kinase 1 inhibited the BMP9-induce

42 e the physiologic role of BMP9, BMP10, ALK1 (activin receptor-like kinase 1), and SMAD7 in vivo.

43 letion of ETS1 decreased the levels of Alk1 (activin receptor-like kinase 1), Cldn5 (claudin 5), Sox1

44 to the lack of MGP induces expression of the activin receptor-like kinase 1, a BMP type I receptor, i

45 bone morphogenetic protein receptor type 2, activin receptor-like kinase 1, endoglin, and mothers ag

46 ovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1.

47 Activin receptor-like kinases 1-7 (ALK1-7) regulate a co

48 ta-receptor proteins, including endoglin and activin-receptor-like kinase 1 (ALK1), and BMPR2.

49 pulmonary vascular endothelial expression of activin-receptor-like kinase 1 in normal and diseased pu

50 We identified amino acid changes in activin-receptor-like kinase 1 that were inherited in su

51 s-of-function mutations in the gene encoding activin receptor-like kinase-1 (ACVRL1).

52 Activin receptor-like kinase-1 (ALK1) is an endothelial

53 LK1-Fc, a BMP9 ligand trap consisting of the activin receptor-like kinase-1 extracellular domain, exa

54 endogenous BMP-2 ligand and ALK-1 receptor (activin receptor-like kinase-1; known to activate Smads

55 IL-1beta reduced the number of activin receptor-like kinase 2 (ALK-2) and ALK-3 recepto

56 dependent upon the type I TGFbeta receptor, activin receptor-like kinase 2 (ALK2), and the downstrea

57 sease driven by gain-of-function variants in activin receptor-like kinase 2 (ALK2), the most common v

58 xpression of type I TGFbeta receptors, chick activin receptor-like kinase 2 and 5 increased with a 2.

59 Constitutively active activin receptor-like kinase 2 inhibited Galpha(i2) prom

60 increased with a 2.3-fold higher increase in activin receptor-like kinase 2.

61 f the pVent reporter, which is downstream of activin receptor-like kinase 2.

62 landscape surrounding DIPG has revealed that activin receptor-like kinase-2 (ALK2) constitutes a pote

63 Activin receptor-like kinase-2 (ALK2) is the only type I

64 c ossification in transgenic mice expressing activin receptor-like kinase-2 (ALK2) Q207D, a constitut

65 pe II receptor and the type I receptor Alk2 (activin receptor-like kinase-2) decreased.

66 hogenetic protein signaling, most likely via activin receptor-like kinase 3.

67 Activin receptor-like kinase 4 (ALK4), a type I TGF-beta

68 ely with the ECDs of native type I receptors activin receptor-like kinase 4 (ALK4), ALK7, or ALK3.

69 sociate with either nodal or the type I ALK (activin receptor-like kinase) 4 receptor in coimmunoprec

70 n granulosa cells via type I receptors (i.e. activin receptor-like kinase-4/5 (ALK4/5)) and SMAD2/3 t

71 mouse model with conditional inactivation of activin receptor-like kinase 5 (ALK5) in the mouse uteru

72 Activin receptor-like kinase 5 (Alk5) inhibitor (Alk5i),

73 Activin receptor-like kinase 5 (ALK5) is the major type

74 to the TGF-beta type I receptor (also termed activin receptor-like kinase 5 (ALK5)), in a similar fas

75 growth factor beta receptor I (TGF-betaRI) (activin receptor-like kinase 5 [ALK-5]) and TGF-beta rec

76 he p3TP-lux reporter, which is downstream of activin receptor-like kinase 5 and had no effect on the

77 hese data are consistent with a role for the activin receptor-like kinase 5 in the progression of idi

78 potential of a well-characterized and potent activin receptor-like kinase 5 inhibitor, SB525334 [6-(2

79 at, conversely, the type I TGF-beta receptor activin receptor-like kinase 5 is dispensable for trypsi

80 Aberrant signaling via TGF-beta receptor I/activin receptor-like kinase 5 may be important for both

81 min preferentially induces activation of the activin receptor-like kinase 5 pathway of TGF-beta recep

82 pid acting, and mediated by TGF-beta-induced activin receptor-like kinase 5 signaling in endothelial

83 hic PAH and imply that strategies to inhibit activin receptor-like kinase 5 signaling may have therap

84 oter activity, whereas constitutively active activin receptor-like kinase 5 stimulated Galpha(i2) pro

85 n a small increase in TGF-beta signaling via activin receptor-like kinase 5 to maintain early integri

86 TGFbetaRI kinase/activin receptor-like kinase 5 was inhibited with pharma

87 ylated via JAK1 and acts as a critical ALK5 (activin receptor-like kinase 5) downstream signaling mol

88 ed the TGF-beta type 1 receptor (also termed activin receptor-like kinase 5) in renal epithelial cell

89 ve inhibitor of the type 1 TGF-beta receptor activin receptor-like kinase 5, orally active) to inhibi

90 ced expression of BMP2 through activation of activin receptor-like kinase 5.

91 or-beta superfamily receptors and found that activin receptor-like kinase-6 extracellular domain most

92 However, activin receptor-like kinase 7 (ALK7), one of the TGFbet

93 dependent signaling via the type I receptor, activin receptor-like kinase 7 (ALK7).

94 ur variants in the gene ACVR1C (encoding the activin receptor-like kinase 7 receptor expressed on adi

95 nt lost-a-fin (laf) is defective in the gene activin receptor-like kinase 8 (alk8), which encodes a n

96 When activated by BMP9, activin receptor-like kinase (ALK) 1 induces HOXD3 expre

97 etween pro- and anti-angiogenic signaling by activin receptor-like kinase (ALK) 1, 5, and TGF-beta ty

98 Several type I receptors exist although activin receptor-like kinase (ALK) 5 mediates the majori

99 I receptor serine/threonine kinase known as activin receptor-like kinase (ALK) 5.

100 , which was impeded by ALK5 knockdown and by activin receptor-like kinase (ALK) receptor inhibitor SB

101 those induced by the receptor serine kinase, activin receptor-like kinase (ALK)-2.

102 factor 6 (ARF6) leads to crosstalk with the activin receptor-like kinase (ALK)-SMAD1/5 pathway.

103 inhibition was dependent on type I receptor activin receptor-like kinase (ALK)3-dependent phosphoryl

104 BMP-binding TGF-beta superfamily receptors, activin receptor-like kinase (ALK)3/6, and the Smad2/3 p

105 1542) that was identified as an inhibitor of activin receptor-like kinase (ALK)5 (the TGF-beta type I

106 nase domain of the TGF-beta type I receptor [activin receptor-like kinase (ALK)5] and the substrate,

107 Activin receptor-like kinase (ALK)7 is a type I serine/t

108 Inhibition of activin receptor-like kinase (ALK-1) abolished the induc

109 ized the chicken homologues of two mammalian activin receptor-like kinases (ALK), ALK2 and ALK5, and

110 As type I activin receptor-like kinases (ALKs) are necessary for S

111 TGFbeta1 levels, endothelial TGFbetaRI/ALK1 (activin receptor-like kinase), and TGFbetaRI/ALK5 expres

112 K), transforming growth factor beta receptor/activin receptor-like kinase beta, estrogen receptor, an

113 in zebrafish embryos harboring a mutation in activin receptor-like kinase I (alk1), which encodes a T

114 treatment with Fstl3 or by a pharmacological activin receptor-like kinase inhibitor.

115 treatment of SB-431542, an inhibitor of the activin receptor-like kinase receptors, to enhance myoge

116 anti-activin A-blocking Ab or inhibitors of activin receptor-like kinase receptors.